WO1998017666A3 - Process for the preparation of tetrahydro-5-oxo-pyrrolizine derivatives - Google Patents

Process for the preparation of tetrahydro-5-oxo-pyrrolizine derivatives Download PDF

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Publication number
WO1998017666A3
WO1998017666A3 PCT/EP1997/005812 EP9705812W WO9817666A3 WO 1998017666 A3 WO1998017666 A3 WO 1998017666A3 EP 9705812 W EP9705812 W EP 9705812W WO 9817666 A3 WO9817666 A3 WO 9817666A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
tetrahydro
oxo
pyrrolizine derivatives
pyrrolizine
Prior art date
Application number
PCT/EP1997/005812
Other languages
French (fr)
Other versions
WO1998017666A2 (en
Inventor
Damien Belotti
Janine Cossy
Original Assignee
Merckle Gmbh
Damien Belotti
Janine Cossy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle Gmbh, Damien Belotti, Janine Cossy filed Critical Merckle Gmbh
Priority to AU51881/98A priority Critical patent/AU5188198A/en
Publication of WO1998017666A2 publication Critical patent/WO1998017666A2/en
Publication of WO1998017666A3 publication Critical patent/WO1998017666A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to a process for the preparation of a compound of general formula (I) in which R1, R2, R and Ar are as defined in claim 1.
PCT/EP1997/005812 1996-10-21 1997-10-21 Process for the preparation of tetrahydro-5-oxo-pyrrolizine derivatives WO1998017666A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU51881/98A AU5188198A (en) 1996-10-21 1997-10-21 Process for the preparation of tetrahydro-5-oxo-pyrrolizine derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR96/12760 1996-10-21
FR9612760A FR2754819A1 (en) 1996-10-21 1996-10-21 PROCESS FOR THE PREPARATION OF TETRAHYDRO-5-OXO-PYRROLIZINES DERIVATIVES

Publications (2)

Publication Number Publication Date
WO1998017666A2 WO1998017666A2 (en) 1998-04-30
WO1998017666A3 true WO1998017666A3 (en) 1998-06-11

Family

ID=9496823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/005812 WO1998017666A2 (en) 1996-10-21 1997-10-21 Process for the preparation of tetrahydro-5-oxo-pyrrolizine derivatives

Country Status (3)

Country Link
AU (1) AU5188198A (en)
FR (1) FR2754819A1 (en)
WO (1) WO1998017666A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102464660B (en) * 2010-11-05 2013-12-11 天津药物研究院 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-pyrrolizine-5-acetate-butyl nitrate crystal, and preparation method and application thereof
CN102464659B (en) * 2010-11-05 2014-01-15 天津药物研究院 Licopyrinobuter compound crystal forms, preparation method, and use thereof

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 113, no. 21, 19 November 1990, Columbus, Ohio, US; abstract no. 191701, XP002057367 *
CHEMICAL ABSTRACTS, vol. 124, no. 15, 9 April 1996, Columbus, Ohio, US; abstract no. 202464u, XP002057366 *
D.-C. HA ET AL., TETRAHEDRON LETTERS, vol. 37, no. 15, 1996, OXFORD GB, pages 2577 - 2580, XP002057365 *
J. COSSY ET AL., TETRAHEDRON LETTERS, vol. 38, no. 15, 1997, OXFORD GB, pages 2677 - 2680, XP002057364 *
W.H. PEARSON ET AL., JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 22, 1990, EASTON US, pages 5719 - 5738 *
Y. LI AT AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 118, no. 3, 1996, DC US, pages 707 - 708 *

Also Published As

Publication number Publication date
AU5188198A (en) 1998-05-15
WO1998017666A2 (en) 1998-04-30
FR2754819A1 (en) 1998-04-24

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