WO1998017284A3 - Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy - Google Patents
Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy Download PDFInfo
- Publication number
- WO1998017284A3 WO1998017284A3 PCT/CA1997/000794 CA9700794W WO9817284A3 WO 1998017284 A3 WO1998017284 A3 WO 1998017284A3 CA 9700794 W CA9700794 W CA 9700794W WO 9817284 A3 WO9817284 A3 WO 9817284A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- heparin
- hiv
- mimetics
- cap
- gene therapy
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU47691/97A AU4769197A (en) | 1996-10-22 | 1997-10-21 | Inhibition of cap-independent protein synthesis by heparin or heparin mimetics thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2873696P | 1996-10-22 | 1996-10-22 | |
US60/028,736 | 1996-10-22 | ||
US3201896P | 1996-11-22 | 1996-11-22 | |
US60/032,018 | 1996-11-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998017284A2 WO1998017284A2 (en) | 1998-04-30 |
WO1998017284A3 true WO1998017284A3 (en) | 1998-08-20 |
Family
ID=26704031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1997/000794 WO1998017284A2 (en) | 1996-10-22 | 1997-10-21 | Inhibition of cap-independent protein synthesis and hiv-tar translation by heparin or heparin mimetics, and methods for gene therapy |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4769197A (en) |
WO (1) | WO1998017284A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2435637A1 (en) | 2001-01-23 | 2002-08-01 | Massachusetts Institute Of Technology | Solid- and solution -phase synthesis of heparin and other glycosaminoglycans |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2907303A1 (en) * | 1978-02-24 | 1979-09-06 | Demetrios P Papahadjopoulos | PROCESS FOR ENCAPSULATING BIOLOGICALLY ACTIVE SUBSTANCES |
JPS59222410A (en) * | 1983-06-01 | 1984-12-14 | Terumo Corp | Pharmaceutical preparation of liposome for keeping drug |
WO1992013524A1 (en) * | 1991-02-07 | 1992-08-20 | A. Nattermann & Cie. Gmbh | Pharmaceutical for treating viral diseases |
JPH07145038A (en) * | 1993-11-26 | 1995-06-06 | Terumo Corp | Constituent component for membrane of small closed cell |
JPH0827030A (en) * | 1994-07-08 | 1996-01-30 | Terumo Corp | Medicine carrier recognizing kidney |
-
1997
- 1997-10-21 AU AU47691/97A patent/AU4769197A/en not_active Abandoned
- 1997-10-21 WO PCT/CA1997/000794 patent/WO1998017284A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2907303A1 (en) * | 1978-02-24 | 1979-09-06 | Demetrios P Papahadjopoulos | PROCESS FOR ENCAPSULATING BIOLOGICALLY ACTIVE SUBSTANCES |
JPS59222410A (en) * | 1983-06-01 | 1984-12-14 | Terumo Corp | Pharmaceutical preparation of liposome for keeping drug |
WO1992013524A1 (en) * | 1991-02-07 | 1992-08-20 | A. Nattermann & Cie. Gmbh | Pharmaceutical for treating viral diseases |
JPH07145038A (en) * | 1993-11-26 | 1995-06-06 | Terumo Corp | Constituent component for membrane of small closed cell |
JPH0827030A (en) * | 1994-07-08 | 1996-01-30 | Terumo Corp | Medicine carrier recognizing kidney |
Non-Patent Citations (13)
Title |
---|
CHANNAVAJJALA ET AL.: "CELL SURFACE HEPARIN PROTEOGLYCAN MEDIATE ATTACHMENT TO BASIC DOMAIN OF HIV-1 TAT PROTEIN", AIDS RES. HUMAN RETROV., vol. 10, no. suppl. 3, 1994, pages s77, XP002056009 * |
DATABASE WPI Section Ch Week 8505, Derwent World Patents Index; Class B05, AN 85-027827, XP002056019 * |
DATABASE WPI Section Ch Week 9531, Derwent World Patents Index; Class B04, AN 95-237131, XP002056018 * |
DATABASE WPI Section Ch Week 9614, Derwent World Patents Index; Class A96, AN 96-136210, XP002056017 * |
GREENBERG ET AL.: "Effect of Protein Synthesis Inhibitors on Growth Factor Activation of c-fos, c-myc, and Actin Gene Transcription", MOL. CELL. BIOL., vol. 6, no. 4, 1986, pages 1050 - 1057, XP002056016 * |
HALPER ET AL.: "Modulation of Growth of Human Carcinoma SW-13 Cells by Heparin and Growth Factors", J. CELL. PHYS., vol. 141, no. 1, 1989, pages 16 - 23, XP002056011 * |
HOWELL ET AL.: "LOW MOLECULAR WEIGHT HEPARIN INHIBITS INFECTIVITY AND PREVENTS REPLICATION OF HIV-1 IN T CELLS", BLOOD, vol. 84, no. 10 suppl. 1, 1994, pages 701a, XP002056015 * |
MANALAYSAY ET AL.: "Inhibition of Mesothelial Cell Growth and Protein Synthesis by Heparin", ADV. PERITON. DIAL., vol. 11, 1995, pages 239 - 242, XP002056007 * |
MEYLAN ET AL.: "Influence of Host Cell Type and V3 Loop of the Surface Glycoprotein on Susceptibility of Human Immunodeficiency Virus Type 1 to Polyanion Compounds", ANTIMICROBIAL AGENTS CHEMOTHER., vol. 38, no. 12, 1994, pages 2910 - 2916, XP002056014 * |
REILLY ET AL.: "Rat Vascular Smooth Muscle Cells Immortalized with SV40 Large T antigen Possess Defined Smooth Muscle Inhibition by Heparin", J. CELL. PHYS., vol. 142, no. 2, 1990, pages 342 - 351, XP002056012 * |
WACKER ET AL.: "Spezifische und unspezifische Hemmung der zellfreien Proteinsynthese mit Polyanionen", Z. NATURFORSCH. B, vol. 22, no. 4, 1967, pages 413 - 417, XP002056008 * |
WALDMAN ET AL.: "Heparin as inhibitor of mammalian protein synthesis. II. Degree of sulfation. Related sulfated mucopolysaccharides", BIOCHIM. BIOPHYS. ACTA, vol. 343, no. 2, 1974, pages 324 - 329, XP002056010 * |
WITVROUW ET AL.: "Sulfated polysaccharides Extracted from Sea Algae as Potential Antiviral Drugs", GEN. PHARMAC., vol. 29, no. 4, 1997, pages 497 - 511, XP002056013 * |
Also Published As
Publication number | Publication date |
---|---|
WO1998017284A2 (en) | 1998-04-30 |
AU4769197A (en) | 1998-05-15 |
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