WO1998009601A3 - Process to prepare pharmaceutical compounds - Google Patents

Process to prepare pharmaceutical compounds Download PDF

Info

Publication number
WO1998009601A3
WO1998009601A3 PCT/US1997/015668 US9715668W WO9809601A3 WO 1998009601 A3 WO1998009601 A3 WO 1998009601A3 US 9715668 W US9715668 W US 9715668W WO 9809601 A3 WO9809601 A3 WO 9809601A3
Authority
WO
WIPO (PCT)
Prior art keywords
pharmaceutical compounds
prepare pharmaceutical
compounds
prepare
cryptophycin compounds
Prior art date
Application number
PCT/US1997/015668
Other languages
French (fr)
Other versions
WO1998009601A2 (en
Inventor
Andrew H Fray
Michael J Martinelli
Eric D Moher
Original Assignee
Lilly Co Eli
Univ Hawaii
Univ Wayne State
Andrew H Fray
Michael J Martinelli
Eric D Moher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Hawaii, Univ Wayne State, Andrew H Fray, Michael J Martinelli, Eric D Moher filed Critical Lilly Co Eli
Priority to AU43343/97A priority Critical patent/AU4334397A/en
Priority to EP97941436A priority patent/EP0934250A4/en
Priority to IL12864397A priority patent/IL128643A0/en
Priority to CA002264527A priority patent/CA2264527A1/en
Priority to JP10512938A priority patent/JP2001500128A/en
Priority to BR9711695-5A priority patent/BR9711695A/en
Publication of WO1998009601A2 publication Critical patent/WO1998009601A2/en
Publication of WO1998009601A3 publication Critical patent/WO1998009601A3/en
Priority to IL128643A priority patent/IL128643A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

This invention provides novel cryptophycin compounds and a process for preparing cryptophycin compounds.
PCT/US1997/015668 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds WO1998009601A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU43343/97A AU4334397A (en) 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds
EP97941436A EP0934250A4 (en) 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds
IL12864397A IL128643A0 (en) 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds
CA002264527A CA2264527A1 (en) 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds
JP10512938A JP2001500128A (en) 1996-09-06 1997-09-05 Method for producing a medicinal composition
BR9711695-5A BR9711695A (en) 1996-09-06 1997-09-05 Process for preparing pharmaceutical compounds
IL128643A IL128643A (en) 1996-09-06 1999-02-21 Process for preparing cryptophycin compounds and some new intermediates

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2543796P 1996-09-06 1996-09-06
US60/025,437 1996-09-06

Publications (2)

Publication Number Publication Date
WO1998009601A2 WO1998009601A2 (en) 1998-03-12
WO1998009601A3 true WO1998009601A3 (en) 1998-04-23

Family

ID=21826065

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015668 WO1998009601A2 (en) 1996-09-06 1997-09-05 Process to prepare pharmaceutical compounds

Country Status (9)

Country Link
EP (1) EP0934250A4 (en)
JP (1) JP2001500128A (en)
KR (1) KR20010029475A (en)
AU (1) AU4334397A (en)
BR (1) BR9711695A (en)
CA (1) CA2264527A1 (en)
HU (1) HUP0000212A3 (en)
IL (2) IL128643A0 (en)
WO (1) WO1998009601A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19911088A1 (en) * 1999-03-12 2000-09-28 Fraunhofer Ges Forschung Assembly device for manually assembling mechanical, electromechanical and/or optical components has device for operating mounting tool as well as operation element for moving assembly head
EP2289549A3 (en) 1999-10-01 2011-06-15 Immunogen, Inc. Immunoconjugates for treating cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427706T2 (en) * 1993-12-21 2001-10-25 Univ Hawaii Honolulu CRYPTOPHYCINE
US5952298A (en) * 1993-12-21 1999-09-14 The University Of Hawaii Cryptophycins
EP0830136B1 (en) * 1995-03-07 2004-10-20 University Of Hawaii New cryptophycins from synthesis
JP2000501067A (en) * 1995-08-30 2000-02-02 イーライ・リリー・アンド・カンパニー Pharmaceutical compounds
EP0869786B1 (en) * 1995-12-22 2003-03-05 Eli Lilly And Company Pharmaceutical compounds
ATE201018T1 (en) * 1996-02-27 2001-05-15 Lilly Co Eli CRYPTOPHYCIN DERIVATIVES AND THEIR USE AS ANTIMICROTUBULAR AGENTS

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS ON STN, No. 1997:113412, MOORE RICHARD E., "Isolation, Characterization and Synthesis of New Cryptophycin Compounds as Anticancer Agents"; & WO,A,96 40184, (19 December 1996). *
DATABASE CAPLUS ON STN, No. 1997:140250, MOORE et al., "New Cryptophycins for Inhibition of Cell Proliferation"; & WO,A,96 39829, (19 December 1996). *
DATABASE CAPLUS ON STN, No. 1997:244384, MOORE et al., "Cryptophycin Derivatives for Disrupting the Microtubule System"; & WO,A,97 07798, (06 March 1997). *
DATABASE CAPLUS ON STN, No. 1997:257479, MOORE et al., "Cryptophycins from Aberrant Biosynthesis"; & WO,A,97 08334, (06 March 1997). *
DATABASE CAPLUS ON STN, No. 1997:503417, SHIU CHUAN, "Preparation of Novel Cryptophycin Compounds as Anti-Microtubule Agents"; & WO,A,97 23211, (03 July 1997). *
DATABASE CAPLUS ON STN, No. 1997:604154, NORMAN B.H. et al., "Preparation of New Cryptophycin Derivatives and Their Use as Anti-Microtubule Agents"; & EP,A,792 875, (03 August 1997). *
J. AM. CHEM. SOC., 08 March 1995, Vol. 117, No. 9, BARROW et al., "Total Synthesis of Cryptophycins. Revision of the Structures of Cryptohycins A and C", pages 2479-2490. *
J. ORG. CHEM., 06 September 1996, Vol. 61, No. 18, REJ et al., "Total Synthesis of Cryptophycins and their 16-(3-Phenylacryloyl) Derivatives", pages 6289-6295. *

Also Published As

Publication number Publication date
IL128643A0 (en) 2000-01-31
EP0934250A2 (en) 1999-08-11
WO1998009601A2 (en) 1998-03-12
HUP0000212A3 (en) 2001-12-28
EP0934250A4 (en) 2004-08-11
IL128643A (en) 2006-04-10
JP2001500128A (en) 2001-01-09
AU4334397A (en) 1998-03-26
BR9711695A (en) 2000-03-08
HUP0000212A2 (en) 2000-07-28
KR20010029475A (en) 2001-04-06
CA2264527A1 (en) 1998-03-12

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