WO1998004243A1 - Preparation of colored powders/granulates by means of a fluid bed drying apparatus - Google Patents

Preparation of colored powders/granulates by means of a fluid bed drying apparatus Download PDF

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Publication number
WO1998004243A1
WO1998004243A1 PCT/US1997/011367 US9711367W WO9804243A1 WO 1998004243 A1 WO1998004243 A1 WO 1998004243A1 US 9711367 W US9711367 W US 9711367W WO 9804243 A1 WO9804243 A1 WO 9804243A1
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WO
WIPO (PCT)
Prior art keywords
excipient
colored
dextrose
fdc
fluid bed
Prior art date
Application number
PCT/US1997/011367
Other languages
French (fr)
Inventor
Robert W. Shen
Original Assignee
Pharmacia & Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Company filed Critical Pharmacia & Upjohn Company
Priority to AU35107/97A priority Critical patent/AU3510797A/en
Publication of WO1998004243A1 publication Critical patent/WO1998004243A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/40—Colouring or decolouring of foods
    • A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Definitions

  • the present invention relates to powders/granulates, and more particularly colored powders/granulates, and the use of a fluid bed drying apparatus (with a spraying apparatus) for applying a suitable coloring agent to said powders/granulates.
  • the spraying apparatus of fluid bed drying apparatus have been used to spray a binder liquid (e.g. starch paste) or coating liquid (e.g waxes, fats and oils) from a nozzle for granulating or coating while they are fluidized by a fluidizing gas introduced from the bottom of the apparatus of a fluid bed machine.
  • a binder liquid e.g. starch paste
  • coating liquid e.g waxes, fats and oils
  • the basic design of a typical fluid bed drying machine is center around the product container.
  • the product container is an inverted truncated cone which has a reinforced screen in its bottom. The purpose of the screen is to allow sufficient air flow through the product bed without product passing down through into the inlet plenum, or air handling section.
  • a cylindrical deceleration zone Directly above the product container is a cylindrical deceleration zone called expansion chamber.
  • the present invention includes methods of making colored excipients by means of spray drying of a colorant solution (can be a natural or synthetic FDC color, such as caramel, FDC Blue #1, Blue #2, Yellow #5, Yellow #6 and Red #40) to food and pharmaceutical excipients.
  • a colorant solution can be a natural or synthetic FDC color, such as caramel, FDC Blue #1, Blue #2, Yellow #5, Yellow #6 and Red #40
  • the process of the present invention can be utilized to spray a solution of a colorant (preferably a color approved for use with foods, drugs and/or cosmetics; for example caramel, beta carotene, FDC Blue #1, Blue #2, Yellow #5, Yellow #6 and Red #40), compatible with the excipient(s) to which it is to be applied.
  • the process variables of the present invention include:
  • Batch size and will vary depending upon the particular fluid bed machine utilized and the particle size of the particular excipient (powder/granulate) to be colored.
  • the particle size of the excipient may vary from about 500 to 40 microns, preferably from about 500 to 40 microns. A person skilled in the art can readily determine the appropriate process variables so as to produce an elegant colored product.
  • the top spray apparatus of the fluid bed drying machine is positioned as low as possible above the bed of the machine in such a manner as to produce a uniform spray pattern.
  • the process parameters of the present invention are typically: Spray rate: production scale 200 Gm/min to 3000 Gm/min Inlet temperature: 60 degree C to 100 degree C
  • Atomization air 1 bar to 7 bars, preferably greater than 3 bars
  • Nozzle position lowest (about 10 inches above bed). 4) after spaying all of the liquid, dry the batch to 60 degree C in the fluid bed dryer.
  • a bubble gum flavor e.g. Robertet NV16508; 150 mg/unit dose
  • a bubble gum flavor e.g. Robertet NV16508; 150 mg/unit dose
  • the flavored/unflavored electrolyte formulation can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg. NaCl, 700 mg. Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0.5 mg FDC Red #40). Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement.
  • Dextrose preferably the dextrose having been delumped through a Comil model 196 with #2F083R037/42 screen; impeller number 2F 1601 175 or 2F 1601 221J. 3
  • spray rate 800 Gm/min
  • Atomization air 5-6 bars inlet air temp: 100 degree C outlet air temp: 50 degree C - 60 degree C
  • Nozzle pore 1.8 mm nozzle head: triple head
  • Nozzle position lowest possible The position of spray arms is such that the nozzle head is at the same height or just below the rolled "V" groves (bottom of the exhaust filter.
  • a dehumidification system is utilized and the dew point allowed to stabilize at about -5 to about -20 degrees C or below.
  • a bubble gum flavor e.g. Robertet NV16508
  • aspartame can be added to the pink colored dextrose.
  • An electrolyte replacement product can be prepared utilizing the pink 20 colored/flavored dextrose of this Example by adding milled salts to an Alma Blender: Sodium Chloride USP Powder 52.9 Kg
  • the colored/flavored dextrose is delumped through a Comil Model 196 (with #2F045R031 ⁇ 37 screen and impeller number 2F 1601 175 or 2F 1601 221).
  • the salts are premilled by a Comil Model 196 (with #2F024R018 ⁇ 23 screen and impeller number 2F 1601 175 or 2F 1601 221) before blending into the batch for 30 30 minutes.
  • the electrolyte replacement product can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg. NaCl, 700 mg. Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0.5 mg FDC Red #40). Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement.
  • Part B FDC Red #40 55 Gm
  • dextrose preferably the dextrose is delumped through a Comil model 196 with #2F045R031/37 screen].
  • a grape flavor e g Florasynth WL-26112, 300 mg/unit dose
  • aspartame can be added to the grape colored dextrose
  • An electrolyte replacement product can be prepared utilizing the grape colored/flavored dextrose of this Example by adding milled salts to an Alma Blender Sodium Chloride USP Powder 51 3Kg
  • the salts are premilled by Comil Model 196 (with #2F024R018/23 screen and impeller number 2F 1601 175 or 2F 1601 221) before blending into the batch for 30 minutes
  • the electrolyte replacement product can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg NaCl, 700 mg Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0 5 mg FDC Red #40) Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
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  • Medicinal Preparation (AREA)

Abstract

A method of making a colored food or pharmaceutical excipient using a fluid bed drying machine is disclosed. The colored excipients of the present invention have been found to have a uniform color appearance.

Description

PREPARATION OF COLORED POWDERS/GRANULATES BY MEANS OF A FLUID BED DRYING APPARATUS
BACKGROUND OF THE INVENTION
The present invention relates to powders/granulates, and more particularly colored powders/granulates, and the use of a fluid bed drying apparatus (with a spraying apparatus) for applying a suitable coloring agent to said powders/granulates.
Various fluid bed drying apparatus (with a spraying apparatus) are well- known in the pharmaceutical art [including, for example the Glatt (Model GPCG5) and the Aeromatic (Model S-7/1100L)] and are typically utilized to prepare granulates ("pellets") for use in preparing tablets or powders/granulates for oral suspension.
The spraying apparatus of fluid bed drying apparatus have been used to spray a binder liquid (e.g. starch paste) or coating liquid (e.g waxes, fats and oils) from a nozzle for granulating or coating while they are fluidized by a fluidizing gas introduced from the bottom of the apparatus of a fluid bed machine. The basic design of a typical fluid bed drying machine is center around the product container. The product container is an inverted truncated cone which has a reinforced screen in its bottom. The purpose of the screen is to allow sufficient air flow through the product bed without product passing down through into the inlet plenum, or air handling section. Directly above the product container is a cylindrical deceleration zone called expansion chamber. As air bubbles pass through the product bed, particles are carried upwards into the expansion chamber where the air velocity quickly diminishes to the point where it can no longer entrain particles. The material travels toward the walls of the expansion chamber, drops back into the product container and continue its cycling. At some height in the expansion chamber a nozzle is placed for application of the spraying liquid. The liquid is sprayed at a controlled rate into the randomly fluidized powder.
The application of a colorant by means of the spray apparatus in a fluid bed drying machine has not been previously described. SUMMARY OF THE INVENTION It has been surprisingly discovered that the use of the spray apparatus in a fluid bed drying machine provides a suitable means of preparing an elegant uniform fine powder having a color appearance of the sprayed excipient which is essentially the same in both solid and reconstituted form. The present invention provides a means of producing a colored excipient with a surprising color intensity and color uniformity with a small quantity of FDC approved color. The present invention includes methods of making colored excipients by means of spray drying of a colorant solution (can be a natural or synthetic FDC color, such as caramel, FDC Blue #1, Blue #2, Yellow #5, Yellow #6 and Red #40) to food and pharmaceutical excipients. DETAILED DESCRIPTION OF THE INVENTION The process of the present invention can be utilized to spray a solution of a colorant (preferably a color approved for use with foods, drugs and/or cosmetics; for example caramel, beta carotene, FDC Blue #1, Blue #2, Yellow #5, Yellow #6 and Red #40), compatible with the excipient(s) to which it is to be applied. The process variables of the present invention include:
1) Atomization air pressure
2) Liquid Spray rate
3) Product temp, inlet temperature 4) Nozzle pore size
5) Nozzle position
6) Batch size and will vary depending upon the particular fluid bed machine utilized and the particle size of the particular excipient (powder/granulate) to be colored. The particle size of the excipient may vary from about 500 to 40 microns, preferably from about 500 to 40 microns. A person skilled in the art can readily determine the appropriate process variables so as to produce an elegant colored product.
The top spray apparatus of the fluid bed drying machine is positioned as low as possible above the bed of the machine in such a manner as to produce a uniform spray pattern.
The process parameters of the present invention, are typically: Spray rate: production scale 200 Gm/min to 3000 Gm/min Inlet temperature: 60 degree C to 100 degree C
Outlet temperature: 25 degree to 60 degree C
Atomization air: 1 bar to 7 bars, preferably greater than 3 bars
Batch temperature: above 45 degree C
The following Examples further illustrate the subject invention.
Example 1) Pink Electrolyte Powder Formula: Part A: Dextrose USP Anhydrous 3.36 Kg
Sodium Citrate Hydrous USP 490 Gm
Sodium Chloride USP Powder, 150 mesh 195.3 Gm
Potassium Chloride USP Granule 252 Gm
Part B: Aspartame NF Powder 28 Gm
FDC Red #40 Dye 0.35 Gm
Water 1000 Ml
Description of Process: 1) Weigh and screen through a #12 mesh screen all the ingredients.
2) dissolve the red #40 into the water, then suspend aspartame in the colored solution with agitation.
3) To the product container of a Glatt GPC5G fluid bed processor add all of ingredients of Part A.
3) Turn on the turbine, heat the batch until the bed temperature reaches 50 degree C. Start spraying the color/aspartame solution in accordance with the following parameters: Spray rate: 32 Gm/min Atomization air: 3 bar nozzle pore: 1.8 mm inlet air temp: 80 degree product temp: 48-52 degree C Outlet temp: 36-40 degree C
Nozzle position: lowest (about 10 inches above bed). 4) after spaying all of the liquid, dry the batch to 60 degree C in the fluid bed dryer.
If desired, a bubble gum flavor (e.g. Robertet NV16508; 150 mg/unit dose) can be added to the colored formulation prepared above.
The flavored/unflavored electrolyte formulation can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg. NaCl, 700 mg. Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0.5 mg FDC Red #40). Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement.
Example 2) Pink Bubble Gum Dextrose
Formula:
Part A:
Dextrose USP (Anhydrous) 492.8 Kg
Part B: FDC Red #40 dye 51 Gm
Purified Water 40 liter
Description of Process:
1) Dissolve dye into water. 2) To the Aeromatic S7 (1100L) product container add the
Dextrose [preferably the dextrose having been delumped through a Comil model 196 with #2F083R037/42 screen; impeller number 2F 1601 175 or 2F 1601 221J. 3) Turn on the turbine, heat the batch until the exhaust temperature reaches 50 degree C. Start spraying as the colorant according to following parameters: spray rate: 800 Gm/min Atomization air: 5-6 bars inlet air temp: 100 degree C outlet air temp: 50 degree C - 60 degree C
Nozzle pore: 1.8 mm nozzle head: triple head
Nozzle position: lowest possible The position of spray arms is such that the nozzle head is at the same height or just below the rolled "V" groves (bottom of the exhaust filter.
10
Note: a dehumidification system is utilized and the dew point allowed to stabilize at about -5 to about -20 degrees C or below.
4) After spraying all of the solution, dry the product
15 65 degree C. in the fluid bed dryer.
If desired, a bubble gum flavor (e.g. Robertet NV16508) and/or aspartame can be added to the pink colored dextrose.
An electrolyte replacement product can be prepared utilizing the pink 20 colored/flavored dextrose of this Example by adding milled salts to an Alma Blender: Sodium Chloride USP Powder 52.9 Kg
Potassium Chloride 68.3 Kg
Sodium Citrate Hydrous USP 132.7 Kg
Aspartame NF Powder 7.6 Kg
25 and 910 KG. of colored/flavored dextrose.
The colored/flavored dextrose is delumped through a Comil Model 196 (with #2F045R031 \37 screen and impeller number 2F 1601 175 or 2F 1601 221).
The salts are premilled by a Comil Model 196 (with #2F024R018\23 screen and impeller number 2F 1601 175 or 2F 1601 221) before blending into the batch for 30 30 minutes.
The electrolyte replacement product can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg. NaCl, 700 mg. Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0.5 mg FDC Red #40). Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement.
Example 3) Grape Colored Dextrose Formula: Part A:
Dextrose USP Anhydrous 441.3 Kg
Part B: FDC Red #40 55 Gm
FDC Blue #1 18 Gm
Purified water 40 Kg
Description of Process: 1) Dissolve color in purified water.
2) To the product container of a Aeromatic S7 (1100L) add dextrose [preferably the dextrose is delumped through a Comil model 196 with #2F045R031/37 screen].
3) Turn the turbine on, heat the batch to 60 degree C and start spraying as following spray rate : 800 gm min atomization air: 5-6 bars inlet air: 100 degree C outlet air: 50 - 60 degree C nozzle pore; 1.8 mm nozzle head: triple heads nozzle position: lowest possible
4) After all of the liquid is sprayed, dry the batch to 65 degree C. in the fluid bed dryer. If desired, a grape flavor (e g Florasynth WL-26112, 300 mg/unit dose) and/or aspartame can be added to the grape colored dextrose
An electrolyte replacement product can be prepared utilizing the grape colored/flavored dextrose of this Example by adding milled salts to an Alma Blender Sodium Chloride USP Powder 51 3Kg
Potassium Chloride USP Granule 66 5 Kg
Sodium Citrate Hydrous USP 129 Kg
Aspartame NF Powder 14 7 Kg and 883 KG of colored/flavored dextrose The colored/flavored dextrose is delumped through a Comil Model 196 (with
#2F045R031/37 screen and impeller number 2F 1601 175 or 2F 1601 221) and then added into the blender
The salts are premilled by Comil Model 196 (with #2F024R018/23 screen and impeller number 2F 1601 175 or 2F 1601 221) before blending into the batch for 30 minutes
The electrolyte replacement product can be packaged in unit-of-use packets containing about 6180 mg (each containing about 279 mg NaCl, 700 mg Sodium Citrate, 360 mg. KCl, 4800 mg dextrose, 40 mg aspartame and 0 5 mg FDC Red #40) Each packet can be dissolved in about eight ounces of water and taken orally for electrolyte replacement

Claims

Claims
1. A method of producing a colored excipient comprising the steps of a) preparing a color solution and b) applying said color solution to an excipient by means of a spray head apparatus in a fluid bed drying machine
2 The process of Claim 1 where the color solution is prepared from one or more FDC or natural colors selected from the group consisting of caramel, beta carotene, blue #1, blue #2, yellow #5, yellow #6, and Red #40
3 The process of Claim 2 where the FDC color is Red #40
4 The process of Claim 2 where the FDC color is Blue #1
5 The process of Claim 2 where the FDC colors are Red #40 and Blue #1
6. The process of Claim 1 where the FDC color is Red #40 and the excipient is a mixture of dextrose, sodium chloride, sodium citrate and potassium chloride
7 The process of claim 1 where the color solution consists of one or more colors and the excipient is a food or pharmaceutical ingredient
8 The process of claim 1 where the color solution consists of one or more colors and the excipient is dextrose
9 An electrolyte replacement product containing a colored excipient, said colored excipient prepared by applying a color solution to an excipient by means of a spray head apparatus in a fluid bed drying machine
10 An electrolyte replacement product in accordance with Claim 9 containing about 279 mg. NaCl, 700 mg. Sodium Citrate, 360 mg KCl, and 4800 mg dextrose
11. An electrolyte replacement product in accordance with Claim 9 wherein dextrose is a colored excipient.
12. An electrolyte replacement product in accordance with Claim 9 wherein dextrose is colored with a color solution containing FDC Red #40.
PCT/US1997/011367 1996-07-29 1997-07-11 Preparation of colored powders/granulates by means of a fluid bed drying apparatus WO1998004243A1 (en)

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Application Number Priority Date Filing Date Title
US2237396P 1996-07-29 1996-07-29
US60/022,373 1996-07-29

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273870A (en) * 2007-04-27 2008-11-13 Nipro Corp Oral solid preparation and method for producing the same
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10252181B2 (en) 2017-08-04 2019-04-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB619717A (en) * 1946-12-20 1949-03-14 Alfred Owen Morris Manufacture of tinted or coloured pulverulent substances
GB1121056A (en) * 1966-03-23 1968-07-24 Gen Foods Corp Beverage composition
DE2001741A1 (en) * 1970-01-16 1971-07-22 Exverbet Imp Und Exp Gmbh Colouring sugars
DE2652666A1 (en) * 1975-11-28 1977-06-08 Bayer Italia Spa Process for the production of a largely anhydrous, non-hydrolizing sugar orange granulate and its use as a partner in combination with hydrolysis-sensitive active pharmaceutical ingredients
DD247836A1 (en) * 1983-12-30 1987-07-22 Inst. F. Getreideverarbeitung,Dd PROCESS FOR PRODUCING GRANULATED INSTANT BEVERAGE POWDER
EP0328129A2 (en) * 1988-02-12 1989-08-16 Takeda Chemical Industries, Ltd. Yellow-colored solid matter and production thereof
WO1992000065A1 (en) * 1990-06-28 1992-01-09 The Upjohn Company Gelatin coated medicament and process for making same

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB619717A (en) * 1946-12-20 1949-03-14 Alfred Owen Morris Manufacture of tinted or coloured pulverulent substances
GB1121056A (en) * 1966-03-23 1968-07-24 Gen Foods Corp Beverage composition
DE2001741A1 (en) * 1970-01-16 1971-07-22 Exverbet Imp Und Exp Gmbh Colouring sugars
DE2652666A1 (en) * 1975-11-28 1977-06-08 Bayer Italia Spa Process for the production of a largely anhydrous, non-hydrolizing sugar orange granulate and its use as a partner in combination with hydrolysis-sensitive active pharmaceutical ingredients
DD247836A1 (en) * 1983-12-30 1987-07-22 Inst. F. Getreideverarbeitung,Dd PROCESS FOR PRODUCING GRANULATED INSTANT BEVERAGE POWDER
EP0328129A2 (en) * 1988-02-12 1989-08-16 Takeda Chemical Industries, Ltd. Yellow-colored solid matter and production thereof
WO1992000065A1 (en) * 1990-06-28 1992-01-09 The Upjohn Company Gelatin coated medicament and process for making same

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273870A (en) * 2007-04-27 2008-11-13 Nipro Corp Oral solid preparation and method for producing the same
EP1985288A3 (en) * 2007-04-27 2009-02-11 Nipro Corporation Oral solid preparation and method of manufacturing the same
US8426451B2 (en) 2007-04-27 2013-04-23 Nipro Corporation Oral solid preparation and method of manufacturing the same
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9551527B2 (en) 2010-09-27 2017-01-24 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10252181B2 (en) 2017-08-04 2019-04-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10625281B2 (en) 2017-08-04 2020-04-21 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
US10850244B2 (en) 2018-04-28 2020-12-01 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
US11090622B2 (en) 2018-04-28 2021-08-17 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions

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