WO1998002552A3 - Vaccine compositions - Google Patents

Vaccine compositions Download PDF

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Publication number
WO1998002552A3
WO1998002552A3 PCT/GB1997/001837 GB9701837W WO9802552A3 WO 1998002552 A3 WO1998002552 A3 WO 1998002552A3 GB 9701837 W GB9701837 W GB 9701837W WO 9802552 A3 WO9802552 A3 WO 9802552A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
encoding
vertebrate
gut
pathogen
Prior art date
Application number
PCT/GB1997/001837
Other languages
French (fr)
Other versions
WO1998002552A2 (en
Inventor
Paul Andrew Barrow
Arthur Keith Turner
Original Assignee
Animal Health Inst
Paul Andrew Barrow
Arthur Keith Turner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Animal Health Inst, Paul Andrew Barrow, Arthur Keith Turner filed Critical Animal Health Inst
Priority to AU34529/97A priority Critical patent/AU3452997A/en
Priority to EP97930649A priority patent/EP0938565A2/en
Publication of WO1998002552A2 publication Critical patent/WO1998002552A2/en
Publication of WO1998002552A3 publication Critical patent/WO1998002552A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

A vaccine composition comprising an avirulent mutant of a cellular pathogen which colonizes the vertebrate gut, the mutant being characterised by having a functional deletion of a gene encoding a protein involved in the electron transport chain or ATP synthase. The pathogen may be Salmonella or E. coli. The vertebrate may be calves or chicks. The gene may be a nuo (encoding a sub-unit of NADH dehydrogenase I) or a cyd (encoding a cytochrome) gene. The mutants provoke an immune response and also inhibit colonization of the gut by other pathogens.
PCT/GB1997/001837 1996-07-11 1997-07-08 Vaccine compositions WO1998002552A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU34529/97A AU3452997A (en) 1996-07-11 1997-07-08 Vaccine compositions
EP97930649A EP0938565A2 (en) 1996-07-11 1997-07-08 Vaccine compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9614618.8 1996-07-11
GBGB9614618.8A GB9614618D0 (en) 1996-07-11 1996-07-11 Vaccine compositions

Publications (2)

Publication Number Publication Date
WO1998002552A2 WO1998002552A2 (en) 1998-01-22
WO1998002552A3 true WO1998002552A3 (en) 1998-03-05

Family

ID=10796768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1997/001837 WO1998002552A2 (en) 1996-07-11 1997-07-08 Vaccine compositions

Country Status (4)

Country Link
EP (1) EP0938565A2 (en)
AU (1) AU3452997A (en)
GB (1) GB9614618D0 (en)
WO (1) WO1998002552A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
US7344855B2 (en) 2002-02-27 2008-03-18 Dsm Ip Assets B.V. Fermentation process
FR2862068B1 (en) * 2003-11-06 2007-10-12 Metabolic Explorer Sa OPTIMIZED MICROORGANISM STRAINS FOR NADPH CONSUMPTION BIOSYNTHESIS PATHWAYS

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
A. BERCHIERI JR AND P. A. BARROW: "In vitro characterization of intra-generic inhibition of growth in Salmonella typhimurium", JOURNAL OF GENERAL MICROBIOLOGY, vol. 137, 1991, pages 2147 - 2153, XP002047681 *
BARBER L.Z., FRAENKEL G., DOUGAN G., BARROW P.A., . *
BARBER L.Z., FRAENKEL G., DOUGAN G., BARROW P.A:: "The nuo locus in Salmonella typhimurium contributes to the genus-specific inhibit cultures and to virulence", . *
BIRGIT M. PRÜSS, JENNIFER M. NELMS, CHANKYU PARK, AND ALAN J. WOLFE: "Mutations in NADH:Ubiquinone Oxidoreductase of Escherichia coli Affects Growth on Mixed Amino Acids", JOURNAL OF BACTERIOLOGY, vol. 176, no. 8, April 1994 (1994-04-01), pages 2143 - 2150, XP002047683 *
C. DAWN ARCHER AND THOMAS ELLIOTT: "Transcriptional Control of the nuo Operon Which Encodes the Energy-Conserving NADH Dehydrogenase of Salmonella typhimurium", JOURNAL OF BACTERIOLOGY, vol. 177, no. 9, May 1995 (1995-05-01), pages 2335 - 2342, XP002047680 *
C. DAWN ARCHER, XIUHUA WANG, AND THOMAS ELLIOTT: "Mutants defective in the energy-conserving NADH dehydrogenase of Salmonella typhimurium identified by a decrease in energy-dependent proteolysis after carbon starvation", PROC. NATL. ACAD. SCI. USA, vol. 90, November 1993 (1993-11-01), pages 9877 - 9881, XP002047684 *
DATABASE EMBL l42521; 18 July 1995 (1995-07-18), XP002048944 *
DATABASE EMBL Q60010; 1 November 1996 (1996-11-01), XP002048960 *
G. NEIL GREEN, HONG FANG, RUEY-JEN LIN, GAIL NEWTON, MICHAEL MATHER, CHRISTOS D. GEORGIOU AND ROBERT B. GENNIS: "The Nucleotide Sequence of the cyd Locus Encoding the Two Subunits of the Cytochrome d terminal oxidase Complex of Escherichia coli", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 263, no. 26, 15 September 1988 (1988-09-15), pages 13138 - 13143, XP002047682 *
THOMAS M. DEVLIN: "Textbook of Biochemistry With Clinical Correlations", 1992, WILEY-LISS, INC., NEW-YORK, XP002047685 *

Also Published As

Publication number Publication date
EP0938565A2 (en) 1999-09-01
GB9614618D0 (en) 1996-09-04
WO1998002552A2 (en) 1998-01-22
AU3452997A (en) 1998-02-09

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