WO1998002453A3 - Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor - Google Patents

Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor Download PDF

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Publication number
WO1998002453A3
WO1998002453A3 PCT/BE1997/000084 BE9700084W WO9802453A3 WO 1998002453 A3 WO1998002453 A3 WO 1998002453A3 BE 9700084 W BE9700084 W BE 9700084W WO 9802453 A3 WO9802453 A3 WO 9802453A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
vip1
vip2
higher selectivity
peptidic ligands
Prior art date
Application number
PCT/BE1997/000084
Other languages
French (fr)
Other versions
WO1998002453A2 (en
Inventor
Philippe Gourlet
Patrick Robberecht
Andre Vandermeers
Magali Woelbroeck
Original Assignee
Univ Bruxelles
Philippe Gourlet
Patrick Robberecht
Andre Vandermeers
Magali Woelbroeck
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bruxelles, Philippe Gourlet, Patrick Robberecht, Andre Vandermeers, Magali Woelbroeck filed Critical Univ Bruxelles
Publication of WO1998002453A2 publication Critical patent/WO1998002453A2/en
Publication of WO1998002453A3 publication Critical patent/WO1998002453A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention is related to a peptidic ligand having a higher selectivity for the VIP1 receptor than for the VIP2 receptor. The present invention is also related to the diagnostic device, the pharmaceutical composition comprising said ligand and to their use.
PCT/BE1997/000084 1996-07-15 1997-07-15 Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor WO1998002453A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP96870092 1996-07-15
EP96870092.2 1996-07-15
EP96870121.9 1996-09-19
EP96870121 1996-09-19

Publications (2)

Publication Number Publication Date
WO1998002453A2 WO1998002453A2 (en) 1998-01-22
WO1998002453A3 true WO1998002453A3 (en) 1998-02-26

Family

ID=26144403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE1997/000084 WO1998002453A2 (en) 1996-07-15 1997-07-15 Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor

Country Status (1)

Country Link
WO (1) WO1998002453A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2379604A1 (en) * 1999-09-28 2001-04-05 Bayer Corporation Pituitary adenylate cyclase activating peptide (pacap) receptor 3 (r3) agonists and their pharmacological methods of use
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
JP2004500906A (en) 1999-11-12 2004-01-15 ルーベン，　レオ Cardiac device for electrical and chemical modulation and vasoactive intestinal peptide for treatment of cardiopulmonary disorders
GB0016441D0 (en) * 2000-07-04 2000-08-23 Pharmagene Lab Limited Therapeutic method
US7507714B2 (en) 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
US6750194B1 (en) * 2000-10-23 2004-06-15 The Procter & Gamble Company Methods of identifying compounds for regulating muscle mass or function using vasoactive intestinal peptide receptors
US20050203009A1 (en) * 2004-03-12 2005-09-15 Bayer Pharmaceuticals Corporation VPAC1 selective antagonists and their pharmacological methods of use
WO2006023358A1 (en) * 2004-08-18 2006-03-02 Eli Lilly And Company Selective vpac2 receptor peptide agonists
EP1915393A1 (en) * 2005-08-11 2008-04-30 Eli Lilly And Company Selective vpac2 receptor peptide agonists
US7582608B2 (en) 2005-10-26 2009-09-01 Eli Lilly And Company Selective VPAC2 receptor peptide agonists
US20100112566A1 (en) * 2006-09-22 2010-05-06 Edgar Kyle A VIPR1S as Modifiers of the E2F/RB Pathway and Methods of Use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0536741A2 (en) * 1991-10-11 1993-04-14 F. Hoffmann-La Roche Ag Cyclic VIP analogs

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0536741A2 (en) * 1991-10-11 1993-04-14 F. Hoffmann-La Roche Ag Cyclic VIP analogs

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
M. SVOBODA ET AL.: "Molecular Cloning and Functional Characterization of a Human VIP Receptor from SUP-T1 Lymphoblasts", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 205, no. 3, 30 December 1994 (1994-12-30), ORLANDO, FL US, pages 1617 - 1624, XP002049506 *
P. GOURLET ET AL.: "The Long-Acting Vasoactive Intestinal Polypeptide Agonist RO 25-1553 is Highly Selective of the VIP2 Receptor Subclass", PEPTIDES, vol. 18, no. 3, 1997, pages 403 - 408, XP002049505 *
P. ROBBERECHT AND P. GOURLET: "Intérêt des récepteurs recombinants dans l'élaboration d'agonistes et d'antagonistes des récepteurs du VIP et du PACAP", JOURNAL DE PHARMCIE DE BELGIQUE, vol. 51, no. 3, May 1996 (1996-05-01) - June 1996 (1996-06-01), pages 165 - 169, XP002049504 *

Also Published As

Publication number Publication date
WO1998002453A2 (en) 1998-01-22

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