WO1998001557A3 - Mammalian chemokine reagents - Google Patents

Mammalian chemokine reagents Download PDF

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Publication number
WO1998001557A3
WO1998001557A3 PCT/US1997/010819 US9710819W WO9801557A3 WO 1998001557 A3 WO1998001557 A3 WO 1998001557A3 US 9710819 W US9710819 W US 9710819W WO 9801557 A3 WO9801557 A3 WO 9801557A3
Authority
WO
WIPO (PCT)
Prior art keywords
reagents
mammalian chemokine
chemokine reagents
chemokines
mammalian
Prior art date
Application number
PCT/US1997/010819
Other languages
French (fr)
Other versions
WO1998001557A2 (en
Inventor
Kurt C Gish
Thomas J Schall
Alain Vicari
Albert Zlotnik
Wei Wang
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to JP10505213A priority Critical patent/JP2000514295A/en
Priority to EP97932238A priority patent/EP0909321A2/en
Priority to AU35749/97A priority patent/AU3574997A/en
Publication of WO1998001557A2 publication Critical patent/WO1998001557A2/en
Publication of WO1998001557A3 publication Critical patent/WO1998001557A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Novel chemokines from mammals, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said chemokines. Chemokine receptors are also provided. Methods of using said reagents and diagnostic kits are also provided.
PCT/US1997/010819 1996-07-05 1997-07-02 Mammalian chemokine reagents WO1998001557A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP10505213A JP2000514295A (en) 1996-07-05 1997-07-02 Mammalian chemokine reagent
EP97932238A EP0909321A2 (en) 1996-07-05 1997-07-02 Mammalian chemokine reagents
AU35749/97A AU3574997A (en) 1996-07-05 1997-07-02 Mammalian chemokine reagents

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US67581496A 1996-07-05 1996-07-05
US2832996P 1996-10-11 1996-10-11
US4859397P 1997-06-04 1997-06-04
US08/675,814 1997-06-04
US60/048,593 1997-06-04
US60/028,329 1997-06-04

Publications (2)

Publication Number Publication Date
WO1998001557A2 WO1998001557A2 (en) 1998-01-15
WO1998001557A3 true WO1998001557A3 (en) 1998-04-09

Family

ID=27363254

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010819 WO1998001557A2 (en) 1996-07-05 1997-07-02 Mammalian chemokine reagents

Country Status (4)

Country Link
EP (1) EP0909321A2 (en)
JP (1) JP2000514295A (en)
AU (1) AU3574997A (en)
WO (1) WO1998001557A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9133273B2 (en) 2010-11-19 2015-09-15 Eisai R&D Management Co., Ltd. Nucleic acids encoding neutralizing anti-CCL20 antibodies

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US5981231A (en) 1996-06-17 1999-11-09 Human Genome Sciences, Inc. Polynucleotides encoding chemokine β-15
WO1998021330A1 (en) * 1996-11-15 1998-05-22 Indiana University Foundation Exodus chemokine materials and methods
AU6871798A (en) * 1997-03-28 1998-10-22 Zymogenetics Inc. Human chemokine zsig-35
CA2287876A1 (en) * 1997-04-30 1998-11-05 F. Hoffmann-La Roche Ag Rat st38.2 chemokine
EP0974357A1 (en) 1998-07-16 2000-01-26 Schering-Plough Chemokines as adjuvants of immune response
AU5459599A (en) * 1998-08-17 2000-03-06 Schering Corporation Regulation of dendritic cell trafficking
US6645491B1 (en) 1999-02-03 2003-11-11 Schering Corporation Method for treating inflammatory conditions using an antibody to MIP-3α
CA2362091A1 (en) * 1999-02-03 2000-08-10 Schering Corporation Use of agonists or antagonists of mip-3a in therapy
US6329159B1 (en) 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
WO2001017558A2 (en) * 1999-09-08 2001-03-15 Schering Corporation Novel uses of mammalian ccr6 receptors and related reagents
CA2460321A1 (en) * 2001-09-20 2003-03-27 Schering Corporation Chemokines as adjuvants of immune response
US7375192B2 (en) 2002-05-01 2008-05-20 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
WO2005057220A2 (en) * 2003-12-05 2005-06-23 Oxagen Limited Agents modulating the activity of ccrl2 and methods of using the same
DK1809660T3 (en) * 2004-10-25 2014-10-20 Immune System Key Ltd THYMUS-SPECIFIC PROTEIN
WO2007122622A1 (en) * 2006-04-24 2007-11-01 Immune System Key Ltd. Method of treatment of a disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005856A1 (en) * 1994-08-23 1996-02-29 Human Genome Sciences, Inc. Human chemokine polypeptides
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996022374A1 (en) * 1995-01-19 1996-07-25 Incyte Pharmaceuticals, Inc. A new chemokine expressed in fetal spleen, its production and uses
WO1996024668A1 (en) * 1995-02-08 1996-08-15 Human Genome Sciences, Inc. Human chemokine beta-11 and human chemokine alpha-1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005856A1 (en) * 1994-08-23 1996-02-29 Human Genome Sciences, Inc. Human chemokine polypeptides
WO1996016979A1 (en) * 1994-11-29 1996-06-06 Incyte Pharmaceuticals, Inc. Expressed chemokines, their production and uses
WO1996022374A1 (en) * 1995-01-19 1996-07-25 Incyte Pharmaceuticals, Inc. A new chemokine expressed in fetal spleen, its production and uses
WO1996024668A1 (en) * 1995-02-08 1996-08-15 Human Genome Sciences, Inc. Human chemokine beta-11 and human chemokine alpha-1

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
A. P. VICARI ET AL: "TECK: a novel CC chemokine associated with T-cell development", THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 99, no. 1 part 2, January 1997 (1997-01-01), pages S246, XP002048195 *
A. ZABALLOS ET AL: "Molecular cloning and RNA expression of two new human chemokine receptor-like genes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 227, no. 3, 23 October 1996 (1996-10-23), ORLANDO, FL US, pages 846 - 853, XP002055490 *
A.P. VICARI ET AL: "TECK: A novel CC chemokine Specifically expressed by thymic dendritic cells and potentially involved in T cell development", IMMUNITY, vol. 7, August 1997 (1997-08-01), pages 291 - 301, XP002048197 *
C. NGUYEN ET AL: "MTA.F02.091 5'. a MTA adult mouse thymus library Mus musculus cDNA clone MTA.F02.091 5'end", EMBL DATABASE ENTRY MMW91616 ; ACCESSION NUMBER'91616, 10 July 1996 (1996-07-10), XP002048196 *
D.L.ROSSI ET AL: "Identification through bioinformatics of two new macrophage proinflammatory human chemokines", JOURNAL OF IMMUNOLOGY., vol. 158, no. 3, 1 February 1997 (1997-02-01), BALTIMORE US, pages 1033 - 1036, XP002055486 *
KUNIO HIESHIMA ET AL: "Molecular cloning of a novel CC Chemokine liver and activation-regulated chemokine (LARC) expressed in liver", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 272, no. 9, 28 February 1997 (1997-02-28), MD US, pages 5846 - 5853, XP002055489 *
L. HILLIER ET AL: "The WashU-Merck EST project;za74f04.s1 Homo sapiens cDNA clone 298303 3'", EMBL DATABASE ENTRY HS958307, ACCESSION NUMBER N73958, 23 March 1996 (1996-03-23), XP002048193 *
L. HILLIER ET AL: "za81g11.r1 Soares fetal lung NbHL19W Homo sapiens cDNA clone 299012 5'", EMBL DATABASE ENTRY HS519338, ACCESSION NUMBER W05519, 8 May 1996 (1996-05-08), XP002055484 *
MASATAKA BABA ET AL: "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 272, no. 23, 6 June 1997 (1997-06-06), MD US, pages 14893 - 14898, XP002055488 *
OSAMU YOSHIE ET AL: "Novel lymphocyte-specific CC chemokines and their receptors", JOURNAL OF LEUKOCYTE BIOLOGY, vol. 62, no. 5, November 1997 (1997-11-01), pages 634 - 644, XP002055491 *
RYU YOSHIDA ET AL: "molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 272, no. 21, 23 May 1997 (1997-05-23), MD US, pages 13803 - 13809, XP002055487 *
T.I. BONNER ET AL: "Cloning, tissue distribution and chromosomal localization of a potential G-protein-linked receptor", EMBL DATABASE ENTRY HS459841, ACCESSION NUMBER U45984, 5 April 1996 (1996-04-05), XP002055485 *
T.J. SCHALL ET AL: "Chemokines, Leukocyte trafficking, and inflammation", CURRENT OPINION IN IMMUNOLOGY, vol. 6, no. 6, December 1994 (1994-12-01), pages 865 - 873, XP002048194 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9133273B2 (en) 2010-11-19 2015-09-15 Eisai R&D Management Co., Ltd. Nucleic acids encoding neutralizing anti-CCL20 antibodies

Also Published As

Publication number Publication date
WO1998001557A2 (en) 1998-01-15
JP2000514295A (en) 2000-10-31
AU3574997A (en) 1998-02-02
EP0909321A2 (en) 1999-04-21

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