WO1998001100A3 - Method for treating homozygous familial hypercholesterolemia - Google Patents

Method for treating homozygous familial hypercholesterolemia Download PDF

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Publication number
WO1998001100A3
WO1998001100A3 PCT/US1997/011792 US9711792W WO9801100A3 WO 1998001100 A3 WO1998001100 A3 WO 1998001100A3 US 9711792 W US9711792 W US 9711792W WO 9801100 A3 WO9801100 A3 WO 9801100A3
Authority
WO
WIPO (PCT)
Prior art keywords
familial hypercholesterolemia
homozygous familial
day
treating
treating homozygous
Prior art date
Application number
PCT/US1997/011792
Other languages
French (fr)
Other versions
WO1998001100A2 (en
Inventor
Yale B Mitchel
Jonathan A Tobert
Original Assignee
Merck & Co Inc
Yale B Mitchel
Jonathan A Tobert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617898.3A external-priority patent/GB9617898D0/en
Application filed by Merck & Co Inc, Yale B Mitchel, Jonathan A Tobert filed Critical Merck & Co Inc
Priority to AU42289/97A priority Critical patent/AU4228997A/en
Publication of WO1998001100A2 publication Critical patent/WO1998001100A2/en
Publication of WO1998001100A3 publication Critical patent/WO1998001100A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Homozygous familial hypercholesterolemia can be treated in patients suffering with this condition by administering a therapeutically effective amount of simvastatin. Dosages above 40 mg/day, and more particularly at or above 80 mg/day, were found to effectively reduce the LDL cholesterol levels in these patients.
PCT/US1997/011792 1996-07-09 1997-07-03 Method for treating homozygous familial hypercholesterolemia WO1998001100A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU42289/97A AU4228997A (en) 1996-07-09 1997-07-03 Method for treating homozygous familial hypercholesterolemia

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US2142096P 1996-07-09 1996-07-09
US60/021,420 1996-07-09
GBGB9617898.3A GB9617898D0 (en) 1996-08-28 1996-08-28 Method for treating homozygous familial hypercholesterolemia
GB9617898.3 1996-08-28
US2935196P 1996-10-31 1996-10-31
US60/029,351 1996-10-31

Publications (2)

Publication Number Publication Date
WO1998001100A2 WO1998001100A2 (en) 1998-01-15
WO1998001100A3 true WO1998001100A3 (en) 1998-02-12

Family

ID=27268450

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US1997/011792 WO1998001100A2 (en) 1996-07-09 1997-07-03 Method for treating homozygous familial hypercholesterolemia
PCT/US1997/012426 WO1998001116A1 (en) 1996-07-09 1997-07-03 Therapy for combined hyperlipidemia
PCT/US1997/010867 WO1998001119A2 (en) 1996-07-09 1997-07-03 Pharmaceutical compositions comprising simvastatin

Family Applications After (2)

Application Number Title Priority Date Filing Date
PCT/US1997/012426 WO1998001116A1 (en) 1996-07-09 1997-07-03 Therapy for combined hyperlipidemia
PCT/US1997/010867 WO1998001119A2 (en) 1996-07-09 1997-07-03 Pharmaceutical compositions comprising simvastatin

Country Status (2)

Country Link
AU (3) AU3667297A (en)
WO (3) WO1998001100A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493576B2 (en) 2007-08-23 2016-11-15 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030212996A1 (en) * 1996-02-08 2003-11-13 Wolzien Thomas R. System for interconnection of audio program data transmitted by radio to remote vehicle or individual with GPS location
CN1197565C (en) * 1998-09-30 2005-04-20 沃尼尔·朗伯公司 Method for preventing or delaying catheter-based revascularization
NZ527852A (en) 2001-03-28 2005-03-24 Schering Corp Enantioselective synthesis of azetidinone intermediate compounds
AU2002358468A1 (en) * 2001-12-21 2003-07-15 Rigshospitalet Igamete recruitment and developmental competence in mammals by inhibiting the de novo sterol biosynthesis and/or promoting sterol efflux
AR040588A1 (en) 2002-07-26 2005-04-13 Schering Corp PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4806564A (en) * 1987-05-26 1989-02-21 Merck & Co., Inc. Antihypercholesterolemic beta-lactones

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997849A (en) * 1989-06-23 1991-03-05 Merck & Co., Inc. Microbial transformation of simvastatin
US5393893A (en) * 1993-11-08 1995-02-28 Apotex, Inc. Process for producing simvastatin and analogs thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LANCET, November 1994, Vol. 19:344, "Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: The Scandinavian Simvastatin Survival Study (4S)", pages 1383-9. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9493576B2 (en) 2007-08-23 2016-11-15 Amgen Inc. Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)

Also Published As

Publication number Publication date
WO1998001100A2 (en) 1998-01-15
AU4326197A (en) 1998-02-02
AU4228997A (en) 1998-02-02
WO1998001116A1 (en) 1998-01-15
WO1998001119A2 (en) 1998-01-15
AU3667297A (en) 1998-02-02

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