WO1997049812A3 - Process for extracting and purifying recombinant, non-lipidised osp-protein - Google Patents

Process for extracting and purifying recombinant, non-lipidised osp-protein Download PDF

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Publication number
WO1997049812A3
WO1997049812A3 PCT/AT1997/000136 AT9700136W WO9749812A3 WO 1997049812 A3 WO1997049812 A3 WO 1997049812A3 AT 9700136 W AT9700136 W AT 9700136W WO 9749812 A3 WO9749812 A3 WO 9749812A3
Authority
WO
WIPO (PCT)
Prior art keywords
lipidised
osp
extracting
protein
purifying recombinant
Prior art date
Application number
PCT/AT1997/000136
Other languages
German (de)
French (fr)
Other versions
WO1997049812A2 (en
Inventor
Artur Mitterer
Christa Tauer
Ian Livey
Friedrich Dorner
Original Assignee
Immuno Ag
Artur Mitterer
Christa Tauer
Ian Livey
Friedrich Dorner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immuno Ag, Artur Mitterer, Christa Tauer, Ian Livey, Friedrich Dorner filed Critical Immuno Ag
Priority to EP97926912A priority Critical patent/EP0973909A2/en
Priority to JP10501944A priority patent/JP2000516444A/en
Publication of WO1997049812A2 publication Critical patent/WO1997049812A2/en
Priority to NO985902A priority patent/NO985902L/en
Publication of WO1997049812A3 publication Critical patent/WO1997049812A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A recombinant, non-lipidised OspC is disclosed, as well as a process for preparing Osp-proteins and vaccines which contain these recombinant proteins.
PCT/AT1997/000136 1996-06-21 1997-06-19 Process for extracting and purifying recombinant, non-lipidised osp-protein WO1997049812A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP97926912A EP0973909A2 (en) 1996-06-21 1997-06-19 Process for extracting and purifying recombinant, non-lipidised osp-protein
JP10501944A JP2000516444A (en) 1996-06-21 1997-06-19 Method for recovering and purifying recombinant non-lipidated Osp protein
NO985902A NO985902L (en) 1996-06-21 1998-12-16 Process for extracting and purifying recombinant, non-lipidized Osp protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0110696A AT405940B (en) 1996-06-21 1996-06-21 METHOD FOR OBTAINING AND PURIFYING RECOMBINANT, NON-LIPIDED OSP PROTEIN
ATA1106/96 1996-06-21

Publications (2)

Publication Number Publication Date
WO1997049812A2 WO1997049812A2 (en) 1997-12-31
WO1997049812A3 true WO1997049812A3 (en) 1999-11-04

Family

ID=3506722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT1997/000136 WO1997049812A2 (en) 1996-06-21 1997-06-19 Process for extracting and purifying recombinant, non-lipidised osp-protein

Country Status (7)

Country Link
EP (1) EP0973909A2 (en)
JP (1) JP2000516444A (en)
AT (1) AT405940B (en)
CA (1) CA2259636A1 (en)
CZ (1) CZ425398A3 (en)
NO (1) NO985902L (en)
WO (1) WO1997049812A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1645283A1 (en) * 2004-10-08 2006-04-12 Chiron Behring GmbH & Co. KG Combination vaccine
EP2199303B1 (en) * 2008-12-12 2013-06-05 Euroimmun Medizinische Labordiagnostika AG Polypeptides and method for specific metering of antibodies for patients with a borrelia infection
CN114295745B (en) * 2021-12-23 2023-09-08 辽宁成大生物股份有限公司 Method for detecting dimethyl sulfoxide residue in varicella attenuated live vaccine
CN115267027B (en) * 2022-08-29 2023-05-02 上海市精神卫生中心（上海市心理咨询培训中心） Kit and detection method for detecting psychotropic drugs

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025596A2 (en) * 1993-04-29 1994-11-10 Immuno Aktiengesellschaft IMMUNOGENIC FORMULATION OF OspC ANTIGEN VACCINES FOR THE PREVENTION AND TREATMENT OF LYME DISEASE AND RECOMBINANT METHODS FOR THE PREPARATION OF SUCH ANTIGENS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5620862A (en) * 1993-11-24 1997-04-15 University Of Connecticut Methods for diagnosing early Lyme disease

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994025596A2 (en) * 1993-04-29 1994-11-10 Immuno Aktiengesellschaft IMMUNOGENIC FORMULATION OF OspC ANTIGEN VACCINES FOR THE PREVENTION AND TREATMENT OF LYME DISEASE AND RECOMBINANT METHODS FOR THE PREPARATION OF SUCH ANTIGENS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GONDOLF KB ET AL: "Isolation of an outermembrane protein complex from Borrelia burgdorgeri by n-butanol extraction and high-performance ion-exchange chromatography", JOURNAL OF CHROMATOGRAPHY., vol. 521, 1990, AMSTERDAM NL, pages 325 - 334, XP002041529 *
MA Y ET AL: "Borrelia burgdorferi outer surface lipoproteins OspA and OspB possess B-cell mitogenic and cytokine-stimulatory properties", INFECTION AND IMMUNITY., vol. 61, no. 3, 1993, WASHINGTON US, pages 3843 - 3853, XP002041528 *
PADULA S.J. ET AL: "Molecular characterization and expression of p23 (OspC) from a north american strain of Borrelia burgdorferi", INFECTION AND IMMUNITY., vol. 61, 1993, WASHINGTON US, pages 5097 - 5105, XP002049935 *
PROBERT W.S. ET AL: "Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen", INFECTION AND IMMUNITY., vol. 62, no. 5, 1994, WASHINGTON US, pages 1920 - 1926, XP002049934 *

Also Published As

Publication number Publication date
EP0973909A2 (en) 2000-01-26
NO985902D0 (en) 1998-12-16
AT405940B (en) 1999-12-27
CA2259636A1 (en) 1997-12-31
NO985902L (en) 1999-02-19
WO1997049812A2 (en) 1997-12-31
CZ425398A3 (en) 1999-03-17
JP2000516444A (en) 2000-12-12
ATA110696A (en) 1999-05-15

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