WO1997049394A2 - Sold oral dosage forms of valsartan - Google Patents

Sold oral dosage forms of valsartan Download PDF

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Publication number
WO1997049394A2
WO1997049394A2 PCT/EP1997/003172 EP9703172W WO9749394A2 WO 1997049394 A2 WO1997049394 A2 WO 1997049394A2 EP 9703172 W EP9703172 W EP 9703172W WO 9749394 A2 WO9749394 A2 WO 9749394A2
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WO
WIPO (PCT)
Prior art keywords
oral dosage
solid oral
dosage form
pharmaceutically acceptable
valsartan
Prior art date
Application number
PCT/EP1997/003172
Other languages
French (fr)
Other versions
WO1997049394A3 (en
Inventor
Robert Frank Wagner
Yoshimitsu Katakuse
Takashi Taike
Fujiki Yamato
Manfred Kohlmeyer
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10795969&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1997049394(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to KR1020117011286A priority Critical patent/KR101208430B1/en
Priority to DK03027840T priority patent/DK1410797T3/en
Priority to IL12756497A priority patent/IL127564A0/en
Priority to EP97929209A priority patent/EP0914119B1/en
Priority to SK1784-98A priority patent/SK285902B6/en
Priority to AU33402/97A priority patent/AU724998C/en
Priority to PL97363524A priority patent/PL188271B1/en
Priority to DK97929209T priority patent/DK0914119T3/en
Priority to US09/202,805 priority patent/US6294197B1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Priority to BR9709956A priority patent/BR9709956A/en
Priority to PL97330709A priority patent/PL188233B1/en
Priority to JP10502269A priority patent/JP2000506540A/en
Priority to AT97929209T priority patent/ATE276750T1/en
Priority to CA002259148A priority patent/CA2259148C/en
Priority to DE69730834T priority patent/DE69730834T2/en
Priority to NZ333385A priority patent/NZ333385A/en
Priority to SI9730686T priority patent/SI0914119T1/en
Priority to KR1020097017936A priority patent/KR101161283B1/en
Priority to HU0203374A priority patent/HU229134B1/en
Publication of WO1997049394A2 publication Critical patent/WO1997049394A2/en
Priority to NO19986056A priority patent/NO317181B1/en
Priority to HK99105148A priority patent/HK1019858A1/en
Priority to US09/920,159 priority patent/US6485745B1/en
Publication of WO1997049394A3 publication Critical patent/WO1997049394A3/en
Priority to US10/251,009 priority patent/US6858228B2/en
Priority to NO20041287A priority patent/NO331739B1/en
Priority to IL195339A priority patent/IL195339A0/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Definitions

  • the invention relates to solid oral dosage forms containing valsartan, in particular solid oral dosage forms containing valsartan and hydrochlorothiazide (HCTZ) and a process of forming the same.
  • HCTZ hydrochlorothiazide
  • Valsartan - The angiotensin II receptor antagonist - Valsartan - is known to be effective in the treatment of congestive heart failure and reducing blood pressure irrespective of age, sex or race and is also well tolerated. Its combination with HCTZ is also known for the treatment of hypertension.
  • oral administration of such pharmaceutical agents as tablets or capsules has certain advantages over parenteral administration such as l.v. or ⁇ .m.: Diseases requiring treatment with painful injectable formulations are considered to be more serious than those conditions which can be treated with oral dosage forms.
  • parenteral formulations have to be administered in most cases by a physician or paramedical personnel.
  • valsartan is difficult to formulate and heretofore it has not been possible to make oral formulations in the form of tablets in a reliable and robust way.
  • Capsules are undesirable since large capsules must be used to accommodate effective amounts of active agent, which in the case of valsartan, is of low density and is therefore rather bulky
  • the active agent is present in an amount of more than 35 % by weight, preferably more than 50 % by weight based on the total weight of the solid oral dosage form.
  • the amount of active agent may be present in an amount of from 45 to 65 % by weight, e.g. 57 to 62 % by weight
  • Solid oral dosage forms according to the invention provide for the administration of the active substance in a smaller oral form than was heretofore possible for a given unit dose of active agent. Furthermore, the oral dosage forms obtained are stable both to the production process and during storage, e.g for 2 years in conventional packaging, e.g. sealed aluminium blister packs.
  • an amount is meant the amount of active agent which halts or reduces the progress of the condition being treated or which otherwise completely or partly cures or acts palliatively on the condition. Such an amount can be easily determined by a person skilled in the art by routine experimentation and with no undue burden
  • the active agent consists entirely of valsartan or a pharmaceutically acceptable salt thereof
  • the active agent is present in an amount of from 10 to 250 mg, more preferable 40 to 160 mg, most preferably 40 to 80 mg, e.g 40, 80 or 160 mg
  • the active agent valsartan is particularly suitable for combination with other active agents, e g HCTZ
  • valsartan or a pharmaceutically acceptable salt thereof, combined in a dose range from about 10 to 250 mg with hydrochlorothiazide in a dose range from about 6 to 60 mg, is suitable for more efficient treatment of hypertension
  • valsartan is found to have a greater efficacy in reducing elevated blood pressure to normal levels than it would have if used at the same dose range in monotherapy.
  • the diuretic agent when hydrochlorothiazide is being administered in combination with valsartan, the diuretic agent is more effective as compared to monotherapy at the dose range indicated
  • a dose range from about 50 and 100 mg valsartan or a pharmaceutically acceptable salt thereof and from about 10 to 30 mg hydrochlorothiazide
  • More preferred is a unit dose of about 80 mg valsartan and 12 5 mg or 25 mg of hydrochlorothiazide and 160 mg valsartan and 12 5 mg or 25 mg of hydrochlorothiazide.
  • the weight ratio of valsartan or a pharmaceutically acceptable salt thereof to hydrochlorothiazide is from about 1 :6 to about 42 1 , more preferably 2 1 to 13 1 , most preferably 2 1 to 10: 1.
  • the present invention particularly relates to a solid oral dosage form, which contain as the active agent a) a unit dose between about 10 and 250 mg, especially between about 50 and 100 mg, of valsartan or a pharmaceutically acceptable salt thereof; and a unit dose between about 6 and 60 mg, especially between about 10 and 30 mg, of hydrochlorothiazide
  • An especially preferred embodiment of the invention is a solid oral dosage form, which contain as the active agent a) a unit dose of about 80 mg or 160 mg of valsartan or a pharmaceutically acceptable salt thereof, and a unit dose of about 12 5 mg hydrochlorothiazide
  • valsartan The preparation of valsartan is described in the U.S. patent specification no. 5 399 578 which is incorporated herein by reference.
  • a pharmaceutically acceptable salt of valsartan can be prepared in a manner known per se Thus for example, acid addition salts are obtained by treatment with an acid or a suitable ion exchange agent Such salts can be converted to free acid in a conventional manner by treatment with a suitable basic agent
  • Valsartan is preferably in its free form, that is, not in one of its salt forms
  • Hydrochlorothiazide is a known therapeutic agent which is useful in the treatment of hypertension
  • a solid oral dosage form according to the invention comprises additives conventional in the dosage form in question Tabletting aids, commonly used in tablet formulation can be used and reference is made to the extensive literature on the subject, see in particular Fiedler's "Lexicon der Hilfstoffe", 4th Edition, ECV Aulendorf 1996 which is incorporated herein by reference These include but are not limited to disintegrants, binders, lubricants, ghdants, stabilising agents, fillers or diluents, surfactants and the like
  • CMC-Ca CMC-Na
  • crosslinked PVP Crosslinked Polyplasdone of Kollidon XL
  • Alginic acid sodium alginate and guar gum
  • crosslinked PVP Crospovidone
  • crosslinked CMC Ac-Di-
  • binders one can particularly mention starches, e.g. potato starch, wheat starch, corn starch, microcrystalline cellulose, e.g. products known under the registered trade marks Avicel, Filtrak, Heweten or Pharmacel, hydroxypropyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, e.g. hydroxypropyl cellulose having a hydroxypropyl content of 5 to 16 % by weight and a Mw of from 80000 to 1 150 000, more particularly 140 000 to 850000.
  • starches e.g. potato starch, wheat starch, corn starch, microcrystalline cellulose, e.g. products known under the registered trade marks Avicel, Filtrak, Heweten or Pharmacel, hydroxypropyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, e.g. hydroxypropyl cellulose having a hydroxypropyl content of 5 to 16 % by weight and a Mw of from 80000 to 1 150
  • colloidal silica e.g. Aerosil , magnesium trisilicate, powdered cellulose, starch, talc and tribasic calcium phosphate.
  • fillers or diluents one can mention confectioner's sugar, compressible sugar, dextrates, dextrin, dextrose, lactose, mannitol, microcellulose, in particular having a density of about 0.45g/cm 3 , e.g. Avicel, powdered cellulose, sorbitol, sucrose and talc.
  • lubricants one can mention in particular Mg, Al or Ca stearate, PEG 4000 - 8000 and talc.
  • additives can be selected and used by the skilled artisan having regard to the particular desired properties of the solid oral dosage form by routine experimentation and without any undue burden.
  • the amount of each type of additive employed may vary within ranges conventional in the art.
  • the amount of glidant may vary within a range of from 0.1 to 10% by weight, in particular 0.1 to 5% by weight, e.g. 0.1 to 0.5% by weight
  • the amount of binder may vary within a range of from about 10 to 45% by weight, e.g. 20 to 30% by weight
  • the amount of disintegrant may vary within a range of from 2 to 20% by weight, e.g.
  • the amount of filler or diluent may vary within a range of from 15 to 40% by weight; whereas the amount of lubricant may vary within a range of from 0.1 to 5.0% by weight. It is a characteristic of the present solid oral dosage forms that they contain only a relatively small amount of additives given the high content of active agent. This enables the production of physically small unit dosage forms.
  • the total amount of additives in a given unit dosage may be about 65 % or less by weight based on the total weight of the solid oral dosage form, more particularly about 50 % or less.
  • the additive content is in the range of about 35 to 55 % by weight, more particularly 45 to 55 % by weight, e.g. 38 to 43 % by weight
  • each additive and the amounts relative to other additives is similarly dependent on the desired properties of the solid oral dosage form and may also be chosen by the skilled artisan by routine experimentation without undue burden
  • the solid oral dosage form may be chosen to exhibit accelerated and/or delayed release of the active agent with or without quantitative control of the release of active agent.
  • a disintegrant such as crosslinked polyvinyl pyrrolidone, for example those products known under the registered trade marks Polyplasdone ⁇ XL or Koll ⁇ don a 'CL, in particular having a molecular weight in excess of 1 000 000, more particularly having a particle size distribution of less than 400 microns or less than 74 microns, or reactive additives (effervescent mixtures) that effect rapid disintegration of the tablet in the presence of water, for example so-called effervescent tablets that contain an acid in solid form, typically citric acid, which acts in water on a base containing chemically combined carbon dioxide, for example sodium hydrogencarbonate or sodium carbonate, and releases carbon dioxide
  • preferred additives are microcrystalline cellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC) or CMC-Ca, Mg, Ca or Al stearate, anhydrous colloidal silica and talc
  • CMC carboxymethylcellulose
  • Mg carboxymethylcellulose
  • Ca or Al stearate anhydrous colloidal silica and talc
  • stearate e.g Mg stearate is preferably employed in amounts of 1.0 to 5 0% by weight, e g 1 5% to 3 0 % by weight
  • the silica is preferably employed in an amount of from 0 5 to 10% by weight
  • the active agent consists of a combination of both valsartan or a pharmaceutically acceptable salt thereof and HCTZ it is preferred to employ additives selected from any of those additives recited in the previous paragraph and crosslinked polyvinylpyrolhdone.
  • the stearate is preferably employed in an amount of from 1 to 5% by weight, e.g.
  • the cellulose material e.g microcrystalline cellulose is preferably present in an amount of 10 to 30%, e g 21 %
  • the silica is preferably present in an amount of from 0 5 to 10%, e.g 1 % by weight
  • the crosslinked polyvinylpyrohdone is preferably present in an amount of from 10 to 20%, e g about 13% by weight.
  • Particularly preferred solid oral dosage forms contain as additives microcrystalline cellulose and crosslinked polyvinylpyrrolidone ( PVP)
  • the solid oral dosage forms according to the present invention may be in the form of dragees in which case the solid oral dosage form is provided with a coating typically a sugar, shellac or other film coating entirely conventional in the art
  • a coating typically a sugar, shellac or other film coating entirely conventional in the art
  • the additives commonly used in confectioning are employed in such methods.
  • the solid oral dosage forms of the present invention are useful for lowering the blood pressure, either systolic or diastolic or both.
  • the conditions for which the instant invention is useful include, without limitation, hypertension (whether of the malignant, essential, reno-vascular, diabetic, isolated systolic, or other secondary type), congestive heart failure, angina (whether stable or unstable), myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction (such as Alzheimer's) and stroke.
  • the exact dose of active agent and the particular formulation to be adminstered depend on a number of factors, e.g. the condition to be treated, the desired duration of the treatment and the rate of release of the active agent.
  • the amount of the active agent required and the release rate thereof may be determined on the basis of known in vitro or in vivo techniques, determining how long a particular active agent concentration in the blood plasma remains at an acceptable level for a therapeutic effect.
  • the invention provides in another of its aspects a process of making a solid oral dosage form as hereinabove described.
  • Such solid oral dosage form may be produced by working up components a) and b) defined hereinabove in appropriate amounts, to form unit dosage forms.
  • the process is carried out in the absence of water, i.e it is a dry compression method
  • the process may be carried out under ambient conditions of temperature and humidity, it is not necessary to ensure that the process is carried out in a dry atmosphere
  • the initial grinding step 1) may be carried out according to conventional milling methods or micronisation methods
  • the active agent and the additives can be milled either individually or together to particle sizes from about 0 1 ⁇ to about 200 ⁇ , preferably 1 0 ⁇ to 100 ⁇ At least 90 % of the crystals of both the active agent and the additives are present in these ranges Particles of this size are obtained by conventional comminution methods, e g grinding in an air jet mill, hammer and screen mill, fine impact mill, ball mill or vibrator mill
  • Micronisation is preferably effected by known methods using an ultrasonic disin ⁇ tegrator, e.g of the BRANSON Sonifier type, or by stirring a suspension with a high speed agitator, for example with a stirrer of the HOMOREX type.
  • an ultrasonic disin ⁇ tegrator e.g of the BRANSON Sonifier type
  • stirring a suspension with a high speed agitator for example with a stirrer of the HOMOREX type.
  • the ground particles may optionally at this stage be sieved and mixed according to known methods Compression to form a cop ⁇ mate requires the compaction of the dry ground components Compaction may be carried out using a slugging technique or preferably, roller compaction Roller compaction apparatus is conventional and essentially utilises two rollers which roll towards each other A hydraulic ram forces one of the rollers against the other to exert a compacting force against the ground particles fed into the roller compactor via a screw conveyor system
  • a compaction force of between 25 and 65 kN is preferably used within this range of compaction forces it has surprisingly been found that for each particular formulation a minimum compaction force should be used in order to obtain a solid oral dosage form wherein the granulate disintegrates into discrete primary particles at a desirable rate, e g disintegration occurs approximately six times faster for a solid oral dosage form compressed above a minimum compaction force Such a rapind disintegration rate is unusual for tablets and is similar to the disintegration rate of a capsule formulation
  • the particular minimum compaction force is dependent on the active agent content in any given formulation and therefore also depends on the amount and nature of the additives present
  • a solid oral dosage form containing an active agent consisting of 80 mg valsartan and 12 5 mg HCTZ, and approp ⁇ ate additives in appropriate quantities is preferably made by a process wherein the compaction force used to produce the cop ⁇ mate is at least 30 kN Approp ⁇ ate additives in appropriate quantities for this active agent may be 31 5 mg microcrystalline cellulose, 1 5 mg anhydrous colloidal silica 4 5 mg magnesium stearate and 20 mg crosslinked PVP
  • a solid oral dosage form comprising a unit dose of 160 mg valsartan and 12 5 mg HCTZ, and appropriate additives in appropriate quantities is preferably made by a process wherein the compaction force used to produce the cop ⁇ mate is at least 25 kN
  • Appropriate additives in approp ⁇ ate quantities for this active agent may be 75 5 mg microcrystalline cellulose, 3 0 mg anhydrous colloidal silica, 9 0 mg magnesium stearate and 40 m° crosslinked PVP Given this information, the skilled addressee would clearly be able to determine the minimum compaction force for other formulations using routine experimentation and without undue burden.
  • the roller speed is set at between 1 and 15 rpm and is preferably 1.3 to 7.5 rpm. After passing through the rollers the compacted mass (the coprimate) resembles a thin ribbon in segments.
  • the coprimate may be screened and or milled to produce the granulate. Screening in its simplest form involves the passing of the coprimate emerging from the rollers through a seive under mechanical pressure. More preferably, the coprimate is screened using an oscillating mill, e.g. a MGI 624 Frewitt (Key International Inc.).
  • the granulate thus formed has a rather wide particle size distribution e.g. from 9 to 340 microns.
  • it is conventional to sort the under-sized and over-sized particles and remove them from the granulate for recycling or recirculation.
  • the over- and under-sized particles are typically compacted an additional one or more times in order to obtain the desired particle size distribution of the granulate.
  • Such a process is time consuming and therefore increases the cost of manufacture of solid oral dosage forms.
  • the additional passes through the roller compactor under such high compaction forces can have deleterious effects on the active agent and also render the granulate less suitable for compression into the solid oral dosage form.
  • the compression of the granulates to tablet cores can be carried out in a conventional tabletting machine, e.g in an EK-0 Korsch eccentric tabletting machine or a rotary compression machine, preferably at a compression greater than 2 kN.
  • the tablet cores may vary in shape and be, for example, round, oval, oblong, cylindrical or any other suitable shape, and may also vary in size depending on the concentration of the therapeutic agents.
  • a characteristic of tablets according to the invention is their small size having regard to the amount of active agent contained therein
  • a solid oral dosage form is compressed in the form of a tablet having an oblong shape in which the ratio of dimensions length:w ⁇ dth:he ⁇ ght is 2.5 - 5.0. 0 9 - 2.0- 1 0 and preferably in which the base and top face of the tablet independently of one another are planar or convexly curved about the longitudinal axis; the side faces are planar, the end faces can be of any shape and the edges are optionally bevelled or rounded
  • a solid oral dosage form is compressed, from the granulate, in the form of a tablet of oblong shape in which the length is approximately 10.0 to 1 1 0 mm, the width approximately 5 0 to 6 0 mm and the height approximately 3 0 to 4 0 mm
  • a solid oral dosage form is compressed from granulates in the form of a tablet of oblong shape in which the length is approximately 15.0 to 16.0 mm. the width approximately 6.0 to 7.0 mm and the height approximately 3 5 to 5 0 mm
  • a tablet which is essentially disc-shaped with the upper and lower faces having a slightly convex sui face
  • the tablet has a diameter of about 8 to 8 5 mm and a depth of about 3 to 3.5 mm, or a diameter of about 16 mm and a depth of about 6 mm
  • the tablets may occupy a volume from about 0.1 cm 3 to about 0.45cm , more particularly 0.2 to 0.3 cm 3 , e g about 0 125 cm 3 or 0.25 cm 3 .
  • Dyes suitable for use in pharmacy typically include carotinoids, iron oxides or chlorophyll
  • valsartan 80 0 mg(53 3 %) hydrochlorothiazide 12 5 mg( 8 3 %) colloidal anhydrous silica AEROSLL 1 5 mg( 1 0 %) microcrystalline cellulose AVICEL 31.5 mg(21.0 %) polyvmylpyrrolidone CROSPOVIDONE 20 0 mg( 13.3 %) magnesium stearate 4 5 mg( 3.0 %)
  • the components except for a portion of the magnesium stearate are blended in a container mixer
  • the blended material is sieved and pre-blended for an additional period of time in a container mixer.
  • the blended material is compacted using a roller compactor (Bepex Pharmapaktor L 200/50 P, Hosokawa Micron Group) by applying a compaction force of 25-65 kN and a roller speed of 1 3-7 5 rpm
  • the compacted mate ⁇ al is sieved again and the remaining portion of the magnesium stearate is added and final blended in a container mixer
  • 150 mg of the homogenous mixture is compressed into tablets using ovaloid punches (10 x 5.2 mm)
  • the tablets obtained have a length of 100-10 2 mm, a width of 5 2-5 4 mm and a height of 3 3-3 9 mm
  • a solid oral dosage form prepared according to Example 1 is coated with a film coating formulation
  • a spray coater apparatus (D ⁇ a- coater DRC-500, Powrex Ltd) is charged with the solid oral dosage form of Example 1 The coating formulation is sprayed into the solid oral dosage form rotating in the apparatus at 6-12 rpm. Spray pressure is 1.9 - 2.2 Kg/cm 2 and the spray rate is 5 9 -
  • the coated solid oral dosage form is dried in the coater apparatus at a temperature of 40°C until a moisture content in the coated solid oral dosage form is less than 2 5% by weight
  • the tablets obtained have a length of 10 1-10 3 mm, a width of 5.3-5 5 mm and a height of 3 4-4 0 mm
  • a 300 0 mg tablet is formed according to the method described in Example 1
  • the tablets obtained have a length of 15.0-15.2 mm, a width of 6.0-6.2 mm and a height of 3 9-4 7 mm
  • a solid oral dosage form according to Example 2 is coated with a composition (see formulation below) according to the methodology of Example la.
  • the tablets obtained have a length of 15 1 -15.3 mm, a width of 6.1 -6.3 mm and a height of 4 0-4 8 mm.
  • the components (above the line) are blended in a container mixer
  • the blended material is sieved and pre-blended for an additional period of time in a container mixer
  • the blended material is compacted using a roller compactor (Bepex Pharmapaktor L 200/50 P, Hosokawa Micron Group) by applying a compaction force of 25-65 kN and a roller speed of 1.3-7.5 ⁇ m
  • the compacted material is sieved again and the components below the line are added and final blended in a container mixer
  • 200 mg of the homogenous mixture is compressed into tablets using ovaloid punches ( 10 x 5 2 mm)
  • the tablets obtained have a diameter of 8 5 mm and a thickness of 3 9 mm
  • the film coating is applied to the solid oral dosage form of Example 3 according to the methodology of Example 1A
  • the coated tablet has a diameter of 8.6 mm and a thickness of 4.0 mm.

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Abstract

The present invention is concerned with solid oral dosage forms comprising of a) an active agent selected from valsartan and optionally HCTZ, and b) pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods.

Description

SOLIDORAL DOSAGE FORMS OFVALSARTAN
The invention relates to solid oral dosage forms containing valsartan, in particular solid oral dosage forms containing valsartan and hydrochlorothiazide (HCTZ) and a process of forming the same.
The angiotensin II receptor antagonist - Valsartan - is known to be effective in the treatment of congestive heart failure and reducing blood pressure irrespective of age, sex or race and is also well tolerated. Its combination with HCTZ is also known for the treatment of hypertension.
The oral administration of such pharmaceutical agents as tablets or capsules has certain advantages over parenteral administration such as l.v. or ι.m.: Diseases requiring treatment with painful injectable formulations are considered to be more serious than those conditions which can be treated with oral dosage forms. However, the major advantage with oral formulations is held to be their suitability for self administration whereas parenteral formulations have to be administered in most cases by a physician or paramedical personnel.
However, valsartan is difficult to formulate and heretofore it has not been possible to make oral formulations in the form of tablets in a reliable and robust way.
Capsules are undesirable since large capsules must be used to accommodate effective amounts of active agent, which in the case of valsartan, is of low density and is therefore rather bulky
We have now found a solid oral dosage form containing valsartan or a pharmaceutically acceptable salt thereof optionally in combination with HCTZ which can be produced according to a reliable and robust process, which solid oral dosage form is small relative to the amount of active agent used. Said solid oral dosage forms are smaller, for a given amount of active agent, than any known formulations of this active substance According to the invention there is provided a solid oral dosage form compπsing
a) an active agent containing an effective amount of valsartan or a pharmaceutically acceptable salt thereof and
b) pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods
preferably wherein the active agent is present in an amount of more than 35 % by weight, preferably more than 50 % by weight based on the total weight of the solid oral dosage form. In particular, the amount of active agent may be present in an amount of from 45 to 65 % by weight, e.g. 57 to 62 % by weight
Solid oral dosage forms according to the invention provide for the administration of the active substance in a smaller oral form than was heretofore possible for a given unit dose of active agent. Furthermore, the oral dosage forms obtained are stable both to the production process and during storage, e.g for 2 years in conventional packaging, e.g. sealed aluminium blister packs.
By "effective amount" is meant the amount of active agent which halts or reduces the progress of the condition being treated or which otherwise completely or partly cures or acts palliatively on the condition. Such an amount can be easily determined by a person skilled in the art by routine experimentation and with no undue burden
In a solid oral dosage form according to the invention wherein the active agent consists entirely of valsartan or a pharmaceutically acceptable salt thereof, it is preferred if the active agent is present in an amount of from 10 to 250 mg, more preferable 40 to 160 mg, most preferably 40 to 80 mg, e.g 40, 80 or 160 mg The active agent valsartan is particularly suitable for combination with other active agents, e g HCTZ
Accordingly, in an further embodiment of the invention there is provided a solid oral dosage form as heremabove described additionally containing HCTZ as a component of the active agent
It has been found that valsartan, or a pharmaceutically acceptable salt thereof, combined in a dose range from about 10 to 250 mg with hydrochlorothiazide in a dose range from about 6 to 60 mg, is suitable for more efficient treatment of hypertension With these dose ranges of the combined active agents, valsartan is found to have a greater efficacy in reducing elevated blood pressure to normal levels than it would have if used at the same dose range in monotherapy. Moreover, when hydrochlorothiazide is being administered in combination with valsartan, the diuretic agent is more effective as compared to monotherapy at the dose range indicated Particularly suitable is a dose range from about 50 and 100 mg valsartan or a pharmaceutically acceptable salt thereof and from about 10 to 30 mg hydrochlorothiazide More preferred is a unit dose of about 80 mg valsartan and 12 5 mg or 25 mg of hydrochlorothiazide and 160 mg valsartan and 12 5 mg or 25 mg of hydrochlorothiazide. The weight ratio of valsartan or a pharmaceutically acceptable salt thereof to hydrochlorothiazide is from about 1 :6 to about 42 1 , more preferably 2 1 to 13 1 , most preferably 2 1 to 10: 1.
The present invention particularly relates to a solid oral dosage form, which contain as the active agent a) a unit dose between about 10 and 250 mg, especially between about 50 and 100 mg, of valsartan or a pharmaceutically acceptable salt thereof; and a unit dose between about 6 and 60 mg, especially between about 10 and 30 mg, of hydrochlorothiazide An especially preferred embodiment of the invention is a solid oral dosage form, which contain as the active agent a) a unit dose of about 80 mg or 160 mg of valsartan or a pharmaceutically acceptable salt thereof, and a unit dose of about 12 5 mg hydrochlorothiazide
The preparation of valsartan is described in the U.S. patent specification no. 5 399 578 which is incorporated herein by reference. A pharmaceutically acceptable salt of valsartan can be prepared in a manner known per se Thus for example, acid addition salts are obtained by treatment with an acid or a suitable ion exchange agent Such salts can be converted to free acid in a conventional manner by treatment with a suitable basic agent
Valsartan is preferably in its free form, that is, not in one of its salt forms
Hydrochlorothiazide is a known therapeutic agent which is useful in the treatment of hypertension
A solid oral dosage form according to the invention comprises additives conventional in the dosage form in question Tabletting aids, commonly used in tablet formulation can be used and reference is made to the extensive literature on the subject, see in particular Fiedler's "Lexicon der Hilfstoffe", 4th Edition, ECV Aulendorf 1996 which is incorporated herein by reference These include but are not limited to disintegrants, binders, lubricants, ghdants, stabilising agents, fillers or diluents, surfactants and the like
As disintegrants one can particularly mention CMC-Ca, CMC-Na, crosslinked PVP (Crospovidone, Polyplasdone of Kollidon XL), Alginic acid, sodium alginate and guar gum, most preferably crosslinked PVP, Crospovidone, crosslinked CMC and Ac-Di-
Sol O 97/49394 PC17EP97/03172
5
As binders one can particularly mention starches, e.g. potato starch, wheat starch, corn starch, microcrystalline cellulose, e.g. products known under the registered trade marks Avicel, Filtrak, Heweten or Pharmacel, hydroxypropyl cellulose, hydroxyethyl cellulose and hydroxypropylmethyl cellulose, e.g. hydroxypropyl cellulose having a hydroxypropyl content of 5 to 16 % by weight and a Mw of from 80000 to 1 150 000, more particularly 140 000 to 850000.
As glidants one can mention in particular colloidal silica, e.g. Aerosil , magnesium trisilicate, powdered cellulose, starch, talc and tribasic calcium phosphate.
As fillers or diluents one can mention confectioner's sugar, compressible sugar, dextrates, dextrin, dextrose, lactose, mannitol, microcellulose, in particular having a density of about 0.45g/cm3, e.g. Avicel, powdered cellulose, sorbitol, sucrose and talc.
As lubricants one can mention in particular Mg, Al or Ca stearate, PEG 4000 - 8000 and talc.
One or more of these additives can be selected and used by the skilled artisan having regard to the particular desired properties of the solid oral dosage form by routine experimentation and without any undue burden.
The amount of each type of additive employed, e.g. glidant, binder, disintegrant, filler or diluent and lubricant may vary within ranges conventional in the art. Thus for example, the amount of glidant may vary within a range of from 0.1 to 10% by weight, in particular 0.1 to 5% by weight, e.g. 0.1 to 0.5% by weight; the amount of binder may vary within a range of from about 10 to 45% by weight, e.g. 20 to 30% by weight; the amount of disintegrant may vary within a range of from 2 to 20% by weight, e.g. 15% by weight; the amount of filler or diluent may vary within a range of from 15 to 40% by weight; whereas the amount of lubricant may vary within a range of from 0.1 to 5.0% by weight. It is a characteristic of the present solid oral dosage forms that they contain only a relatively small amount of additives given the high content of active agent. This enables the production of physically small unit dosage forms. The total amount of additives in a given unit dosage may be about 65 % or less by weight based on the total weight of the solid oral dosage form, more particularly about 50 % or less. Preferably the additive content is in the range of about 35 to 55 % by weight, more particularly 45 to 55 % by weight, e.g. 38 to 43 % by weight
The absolute amounts of each additive and the amounts relative to other additives is similarly dependent on the desired properties of the solid oral dosage form and may also be chosen by the skilled artisan by routine experimentation without undue burden For example, the solid oral dosage form may be chosen to exhibit accelerated and/or delayed release of the active agent with or without quantitative control of the release of active agent.
Thus, where accelerated release is desired, e.g about 90% release within a ten minute, more particularly a five minute period, a disintegrant such as crosslinked polyvinyl pyrrolidone, for example those products known under the registered trade marks Polyplasdone^XL or Kollιdona'CL, in particular having a molecular weight in excess of 1 000 000, more particularly having a particle size distribution of less than 400 microns or less than 74 microns, or reactive additives (effervescent mixtures) that effect rapid disintegration of the tablet in the presence of water, for example so-called effervescent tablets that contain an acid in solid form, typically citric acid, which acts in water on a base containing chemically combined carbon dioxide, for example sodium hydrogencarbonate or sodium carbonate, and releases carbon dioxide
Whereas if delayed release is desired one can employ pellet coating technology, wax matrix systems, polymer matrix tablets or polymer coatings conventional in the art Quantitative control of the release of the active agent can be achieved by conventional techniques known in the art. Such dosage forms are known as oral osmotic systems (OROS), coated tablets, matrix tablets, press-coated tablets, multilayer tablets and the
In a solid oral dosage form wherein the active agent consist entirely of valsartan or a pharmaceutically acceptable salt thereof, preferred additives are microcrystalline cellulose, hydroxypropylcellulose, carboxymethylcellulose (CMC) or CMC-Ca, Mg, Ca or Al stearate, anhydrous colloidal silica and talc The amounts of additive employed will depend upon how much active agent is to be used The stearate, e.g Mg stearate is preferably employed in amounts of 1.0 to 5 0% by weight, e g 1 5% to 3 0 % by weight Whereas the silica is preferably employed in an amount of from 0 5 to 10% by weight
In a solid oral dosage form wherein the active agent consists of a combination of both valsartan or a pharmaceutically acceptable salt thereof and HCTZ it is preferred to employ additives selected from any of those additives recited in the previous paragraph and crosslinked polyvinylpyrolhdone. The stearate is preferably employed in an amount of from 1 to 5% by weight, e.g. 3% The cellulose material, e.g microcrystalline cellulose is preferably present in an amount of 10 to 30%, e g 21 % The silica is preferably present in an amount of from 0 5 to 10%, e.g 1 % by weight The crosslinked polyvinylpyrohdone is preferably present in an amount of from 10 to 20%, e g about 13% by weight. Particularly preferred solid oral dosage forms contain as additives microcrystalline cellulose and crosslinked polyvinylpyrrolidone ( PVP)
The solid oral dosage forms according to the present invention may be in the form of dragees in which case the solid oral dosage form is provided with a coating typically a sugar, shellac or other film coating entirely conventional in the art Attention is drawn to the numerous known methods of coating employed in the art, e g spray coating in a fluidized bed, e g by the known methods using apparatus available from Aeromatic, Glatt, Wurster or Hutthn, in a perforated pan by the Accela Cota method, or to the submerged sword coating method. The additives commonly used in confectioning are employed in such methods.
The solid oral dosage forms of the present invention are useful for lowering the blood pressure, either systolic or diastolic or both. The conditions for which the instant invention is useful include, without limitation, hypertension (whether of the malignant, essential, reno-vascular, diabetic, isolated systolic, or other secondary type), congestive heart failure, angina (whether stable or unstable), myocardial infarction, artherosclerosis, diabetic nephropathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction (such as Alzheimer's) and stroke.
The exact dose of active agent and the particular formulation to be adminstered depend on a number of factors, e.g. the condition to be treated, the desired duration of the treatment and the rate of release of the active agent. For example, the amount of the active agent required and the release rate thereof may be determined on the basis of known in vitro or in vivo techniques, determining how long a particular active agent concentration in the blood plasma remains at an acceptable level for a therapeutic effect.
The invention provides in another of its aspects a process of making a solid oral dosage form as hereinabove described. Such solid oral dosage form may be produced by working up components a) and b) defined hereinabove in appropriate amounts, to form unit dosage forms.
In a preferred embodiment there is provided a process of making the solid oral dosage forms as hereinabove described comprising the steps of
1) grinding the active agent and pharmaceutically acceptable additives, n) subjecting a mixture of the ground active agent and additives to compression to form a copπmate
in) converting the copπmate to form a granulate and
ιv) compressing the granulate to form the solid oral dosage form
The process is carried out in the absence of water, i.e it is a dry compression method The process may be carried out under ambient conditions of temperature and humidity, it is not necessary to ensure that the process is carried out in a dry atmosphere
The initial grinding step 1) may be carried out according to conventional milling methods or micronisation methods
The active agent and the additives can be milled either individually or together to particle sizes from about 0 1 μ to about 200 μ, preferably 1 0 μ to 100 μ At least 90 % of the crystals of both the active agent and the additives are present in these ranges Particles of this size are obtained by conventional comminution methods, e g grinding in an air jet mill, hammer and screen mill, fine impact mill, ball mill or vibrator mill
Micronisation is preferably effected by known methods using an ultrasonic disin¬ tegrator, e.g of the BRANSON Sonifier type, or by stirring a suspension with a high speed agitator, for example with a stirrer of the HOMOREX type.
The ground particles may optionally at this stage be sieved and mixed according to known methods Compression to form a copπmate requires the compaction of the dry ground components Compaction may be carried out using a slugging technique or preferably, roller compaction Roller compaction apparatus is conventional and essentially utilises two rollers which roll towards each other A hydraulic ram forces one of the rollers against the other to exert a compacting force against the ground particles fed into the roller compactor via a screw conveyor system
A compaction force of between 25 and 65 kN is preferably used Within this range of compaction forces it has surprisingly been found that for each particular formulation a minimum compaction force should be used in order to obtain a solid oral dosage form wherein the granulate disintegrates into discrete primary particles at a desirable rate, e g disintegration occurs approximately six times faster for a solid oral dosage form compressed above a minimum compaction force Such a rapind disintegration rate is unusual for tablets and is similar to the disintegration rate of a capsule formulation The particular minimum compaction force is dependent on the active agent content in any given formulation and therefore also depends on the amount and nature of the additives present
A solid oral dosage form containing an active agent consisting of 80 mg valsartan and 12 5 mg HCTZ, and appropπate additives in appropriate quantities is preferably made by a process wherein the compaction force used to produce the copπmate is at least 30 kN Appropπate additives in appropriate quantities for this active agent may be 31 5 mg microcrystalline cellulose, 1 5 mg anhydrous colloidal silica 4 5 mg magnesium stearate and 20 mg crosslinked PVP
A solid oral dosage form comprising a unit dose of 160 mg valsartan and 12 5 mg HCTZ, and appropriate additives in appropriate quantities is preferably made by a process wherein the compaction force used to produce the copπmate is at least 25 kN Appropriate additives in appropπate quantities for this active agent may be 75 5 mg microcrystalline cellulose, 3 0 mg anhydrous colloidal silica, 9 0 mg magnesium stearate and 40 m° crosslinked PVP Given this information, the skilled addressee would clearly be able to determine the minimum compaction force for other formulations using routine experimentation and without undue burden.
The roller speed is set at between 1 and 15 rpm and is preferably 1.3 to 7.5 rpm. After passing through the rollers the compacted mass (the coprimate) resembles a thin ribbon in segments.
The coprimate may be screened and or milled to produce the granulate. Screening in its simplest form involves the passing of the coprimate emerging from the rollers through a seive under mechanical pressure. More preferably, the coprimate is screened using an oscillating mill, e.g. a MGI 624 Frewitt (Key International Inc.).
The granulate thus formed has a rather wide particle size distribution e.g. from 9 to 340 microns. At this stage of the roller compaction process it is conventional to sort the under-sized and over-sized particles and remove them from the granulate for recycling or recirculation. Thus removed the over- and under-sized particles are typically compacted an additional one or more times in order to obtain the desired particle size distribution of the granulate. Such a process is time consuming and therefore increases the cost of manufacture of solid oral dosage forms. Furthermore, the additional passes through the roller compactor under such high compaction forces can have deleterious effects on the active agent and also render the granulate less suitable for compression into the solid oral dosage form.
It has been found however, that the granulate first emerging from the roller compactor after screening or milling and containing both over- and under-sized particles can in fact be compressed to form solid oral dosage forms without affecting the properties of the solid oral dosage form. 12
The compression of the granulates to tablet cores can be carried out in a conventional tabletting machine, e.g in an EK-0 Korsch eccentric tabletting machine or a rotary compression machine, preferably at a compression greater than 2 kN. The tablet cores may vary in shape and be, for example, round, oval, oblong, cylindrical or any other suitable shape, and may also vary in size depending on the concentration of the therapeutic agents. A characteristic of tablets according to the invention is their small size having regard to the amount of active agent contained therein
In a preferred embodiment of the invention tablets obtained by the compression method described above are slightly oval The edges of the tablets may be bevelled or rounded
In a particularly preferred embodiment of the invention a solid oral dosage form is compressed in the form of a tablet having an oblong shape in which the ratio of dimensions length:wιdth:heιght is 2.5 - 5.0. 0 9 - 2.0- 1 0 and preferably in which the base and top face of the tablet independently of one another are planar or convexly curved about the longitudinal axis; the side faces are planar, the end faces can be of any shape and the edges are optionally bevelled or rounded
In a particularly preferred embodiment of the invention a solid oral dosage form is compressed, from the granulate, in the form of a tablet of oblong shape in which the length is approximately 10.0 to 1 1 0 mm, the width approximately 5 0 to 6 0 mm and the height approximately 3 0 to 4 0 mm
In another particularly preferred embodiment of the invention a solid oral dosage form is compressed from granulates in the form of a tablet of oblong shape in which the length is approximately 15.0 to 16.0 mm. the width approximately 6.0 to 7.0 mm and the height approximately 3 5 to 5 0 mm
In yet another preferred embodiment of the invention there is provided a tablet which is essentially disc-shaped with the upper and lower faces having a slightly convex sui face Preferably the tablet has a diameter of about 8 to 8 5 mm and a depth of about 3 to 3.5 mm, or a diameter of about 16 mm and a depth of about 6 mm The tablets may occupy a volume from about 0.1 cm3 to about 0.45cm , more particularly 0.2 to 0.3 cm3, e g about 0 125 cm3 or 0.25 cm3.
They may furthermore be transparent, colourless or coloured and also marked so as to impart to this product an individual appearance and to make them instantly recognizable. The use of dyes can serve to enhance the appearance as well as to identify the compositions. Dyes suitable for use in pharmacy typically include carotinoids, iron oxides or chlorophyll
There now follows a series of examples which serve to illustrate the invention
14
Example 1
Formula
valsartan 80 0 mg(53 3 %) hydrochlorothiazide 12 5 mg( 8 3 %) colloidal anhydrous silica AEROSLL 1 5 mg( 1 0 %) microcrystalline cellulose AVICEL 31.5 mg(21.0 %) polyvmylpyrrolidone CROSPOVIDONE 20 0 mg( 13.3 %) magnesium stearate 4 5 mg( 3.0 %)
150.0 mg
Method
The components except for a portion of the magnesium stearate are blended in a container mixer The blended material is sieved and pre-blended for an additional period of time in a container mixer.The blended material is compacted using a roller compactor (Bepex Pharmapaktor L 200/50 P, Hosokawa Micron Group) by applying a compaction force of 25-65 kN and a roller speed of 1 3-7 5 rpm The compacted mateπal is sieved again and the remaining portion of the magnesium stearate is added and final blended in a container mixer Then 150 mg of the homogenous mixture is compressed into tablets using ovaloid punches (10 x 5.2 mm) The tablets obtained have a length of 100-10 2 mm, a width of 5 2-5 4 mm and a height of 3 3-3 9 mm
Example la
A solid oral dosage form prepared according to Example 1 is coated with a film coating formulation
Cellulose H-P-M683 2 76 mg
Fe Oxide (Yellow) 17268 0 025
Fe Oxide (Red) 17266 0 025
PEG 8000 (flakes) 0 5
Talc PH 2 0
Titanium dioxide PH 0 7
Deionised water 2 5 Ethanol + 5% Isopropyl alcohol 20 0
Method
The PEG and cellulose are dissolved in the deionised water The remaining components are suspended in the resulting solution. A spray coater apparatus (Dπa- coater DRC-500, Powrex Ltd) is charged with the solid oral dosage form of Example 1 The coating formulation is sprayed into the solid oral dosage form rotating in the apparatus at 6-12 rpm. Spray pressure is 1.9 - 2.2 Kg/cm2 and the spray rate is 5 9 -
Thereafter the coated solid oral dosage form is dried in the coater apparatus at a temperature of 40°C until a moisture content in the coated solid oral dosage form is less than 2 5% by weight
The tablets obtained have a length of 10 1-10 3 mm, a width of 5.3-5 5 mm and a height of 3 4-4 0 mm
Example 2
Formula valsartan 160 0 mg(53 3 %) hydrochlorothiazide 12 5 mg( 8 3 %) colloidal anhydrous silica AEROSIL 3.0 mg( 1 0 %) microcrystalline cellulose AVICEL 75 5 mg(21 0 %) poly vinylpyrrohdone CROSPOVIDONE 400 mg( 13 3 %) magnesium stearate (FAC I) 9 0 mg( 3 0 %)
300.0 mg
A 300 0 mg tablet is formed according to the method described in Example 1 The tablets obtained have a length of 15.0-15.2 mm, a width of 6.0-6.2 mm and a height of 3 9-4 7 mm Example 2a
A solid oral dosage form according to Example 2 is coated with a composition (see formulation below) according to the methodology of Example la.
Formulation
Cellulose H-P-M683 5 51 mg
Fe Oxide (Red) 17266 0.75
PEG 8000 (flakes) 1.0
Talc PH 3.99
Titanium dioxide PH 0.75
Deionised water 5.0
Ethanol + 5% Isopropyl alcohol 40.0
The tablets obtained have a length of 15 1 -15.3 mm, a width of 6.1 -6.3 mm and a height of 4 0-4 8 mm.
Example 3 Formula valsartan 80.0 mg (40%)
AEROSIL 200 10.0 mg (5%)
L-HPC* L- 1 1 87.0 mg (43%) Magnesium Stearate 3.0 mg ( 1.5%)
AVICEL PH-301 10.0 mg (5%) L-HPC* L-21 5.0 mg (2.5%)
AEROSIL 200 1.0 mg (0.5%)
Talc 2.0 mg (1.0%)
Magnesium Stearate 2.0 mg ( 1 0%) 200.0 mg
* hydroxypropyl cellulose
Method
The components (above the line) are blended in a container mixer The blended material is sieved and pre-blended for an additional period of time in a container mixer The blended material is compacted using a roller compactor (Bepex Pharmapaktor L 200/50 P, Hosokawa Micron Group) by applying a compaction force of 25-65 kN and a roller speed of 1.3-7.5 φm The compacted material is sieved again and the components below the line are added and final blended in a container mixer Then 200 mg of the homogenous mixture is compressed into tablets using ovaloid punches ( 10 x 5 2 mm) The tablets obtained have a diameter of 8 5 mm and a thickness of 3 9 mm
Example 3A
Film Coating
Titanium dioxide l OO mg
TC-5R* 3 68 mg
PEG 6000 0 66 mg
Talc 2.66 mg
8 00 mg
* = hydroxypropylmethyl cellulose
Method
The film coating is applied to the solid oral dosage form of Example 3 according to the methodology of Example 1A The coated tablet has a diameter of 8.6 mm and a thickness of 4.0 mm.

Claims

Claims
1 A solid oral dosage form comprising
a) an active agent containing an effective amount of valsartan or a pharmaceutically acceptable salt thereof and
b) pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods
wherein the active agent is present m an amount of more than 35 % by weight based on the total weight of the solid oral dosage form
2 A solid oral dosage form according to claim 1 wherein the active agent is present in an amount of more than 50 % by weight.
3 A solid oral dosage form according to claim 1 or claim 2 wherein the active agent is present in an amount ranging from 57 to 62 % by weight
4 A solid oral dosage form according to any of the preceding claims wherein the active agent consists entirely of valsartan or a pharmaceutically acceptable salt thereof in a dosage of from between about 10 and 250 mg
5 A solid oral dosage form according to any of the preceding claims wherein the dosage range is from 40 to 160 mg
6 A solid oral dosage form according to any of the preceding claims wherein the dosage is 40 mg, 80 mg or 160 mg
7. A solid oral dosage form according to any of the claims 1 to 3 wherein the active agent consists of an effective amount of valsartan or a pharmaceutically acceptable salt thereof and an effective amount of hydrochlorothiazide (HCTZ).
8. A solid oral dosage form which comprises as therapeutic agents an effective amount of valsartan or a pharmaceutically acceptable salt thereof; an effective amount of HCTZ; and, pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods.
9. A solid oral dosage form according to claims 7 or 8 comprising a unit dose of about 10 to 250 mg of valsartan or a pharmaceutically acceptable salt thereof and a unit dose of about 6 to 60 mg of HCTZ.
10. A solid oral dosage form according to any of the claims 7 to 9 comprising a unit dose of about 50 to 100 mg of valsartan or a pharmaceutically acceptable salt thereof and a unit dose of about 10 to 30 mg of HCTZ.
1 1. A solid oral dosage form according to any of the claims 7 to 9 comprising a unit dose of about 80 to 160 mg of valsartan or a pharmaceutically acceptable salt thereof and a unit dose of 12.5 mg or 25 mg of HCTZ.
12. A solid oral dosage form according to any of the preceding claims which comprises microcrystalline cellulose as a pharmaceutically acceptable additive.
13. A solid oral dosage form according to any of the preceding claims which comprises crosslinked polyvinylpyrrolidone (PVP) as a pharmaceutically acceptable additive.
14. A solid oral dosage form according to claim 12 wherein the microcrystalline cellulose is present in an amount of from 15 to 25 % by weight.
15. A solid oral dosage form according to claim 13 wherein the crosslinked PVP is present in an amount of from 10 to 30 % by weight.
16. A solid oral dosage form according to any of the preceding claims in the form of a tablet.
17. A solid oral dosage form according to any of the preceding claims in the form of a dragee.
18. A process of forming a solid oral dosage form as defined in any of the preceding claims comprising the steps of
i) grinding the active agent and pharmaceutically acceptable additives,
ii) subjecting a mixture of the ground active agent and additives to compression to form a coprimate
iii) converting the coprimate into granulate and
iv) compressing the granulate to form the solid oral dosage form.
19. A process according to claim 18 wherein the compression step ii) is carried out using roller compaction or slugging techniques.
20. A process accroding to claim 18 or 19 wherein step iii) is carried out by screening or milling the coprimate.
21. A process according to any of the claims 18 to 20 wherein the granulate is compressed without first being sized. 22 A process according to any of the claims 18 to 21 wherein the granulate is formed under a pressure of from 25 to 65 kN
23 Copπmates obtained by roller compaction or slugging according to claim 19
24 Granulate obtained according to the process according to claim 18
25 A solid oral dosage form produced according to a method as defined in any of the claims 18 to 22.
26 A solid oral dosage form substantially as hereinabove defined with reference to any of the Examples
27 Use of a solid oral dosage form as defined in any of the claims 1 to 17 in a method of treating hypertension (whether of the malignant, essential, reno-vascular, diabetic, isolated systolic, or other secondary type), congestive heart failure, angina (whether stable or unstable), myocardial infarction, artherosclerosis, diabetic nephro- pathy, diabetic cardiac myopathy, renal insufficiency, peripheral vascular disease, left ventricular hypertrophy, cognitive dysfunction, e g Alzheimer's, stroke, headache and chronic heart failure
PCT/EP1997/003172 1996-06-27 1997-06-18 Sold oral dosage forms of valsartan WO1997049394A2 (en)

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JP10502269A JP2000506540A (en) 1996-06-27 1997-06-18 Valsartan solid oral dosage form
AT97929209T ATE276750T1 (en) 1996-06-27 1997-06-18 METHOD FOR PREPARING SOLID ORAL DOSAGE FORMS OF VALSARTAN
IL12756497A IL127564A0 (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
EP97929209A EP0914119B1 (en) 1996-06-27 1997-06-18 Process for forming solid oral dosage forms of valsartan
SK1784-98A SK285902B6 (en) 1996-06-27 1997-06-18 Process for forming compressed solid oral dosage form of valsartan
AU33402/97A AU724998C (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
PL97363524A PL188271B1 (en) 1996-06-27 1997-06-18 Valsartan in a form of orally taken solid tablets
DK97929209T DK0914119T3 (en) 1996-06-27 1997-06-18 Process for the preparation of solid oral dosage forms of valsartan
US09/202,805 US6294197B1 (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
DK03027840T DK1410797T3 (en) 1996-06-27 1997-06-18 Solid oral dosage forms containing valsartan
BR9709956A BR9709956A (en) 1996-06-27 1997-06-18 Valsartan solid oral dosage forms
PL97330709A PL188233B1 (en) 1996-06-27 1997-06-18 Commercial from of valsartan fro oral administration
HU0203374A HU229134B1 (en) 1996-06-27 1997-06-18 Process of forming a compressed solid oral dosage form comprising valsartan
KR1020117011286A KR101208430B1 (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
KR1020097017936A KR101161283B1 (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
DE69730834T DE69730834T2 (en) 1996-06-27 1997-06-18 PROCESS FOR PREPARING SOLID ORAL DOSAGE FORMS OF VALSARTAN
NZ333385A NZ333385A (en) 1996-06-27 1997-06-18 Solid oral dosage forms containing 35% of valsartan
SI9730686T SI0914119T1 (en) 1996-06-27 1997-06-18 Process for forming solid oral dosage forms of valsartan
CA002259148A CA2259148C (en) 1996-06-27 1997-06-18 Solid oral dosage forms of valsartan
NO19986056A NO317181B1 (en) 1996-06-27 1998-12-22 Solid oral dosage forms of valsartan
HK99105148A HK1019858A1 (en) 1996-06-27 1999-11-09 Process for forming solid oral dosage forms of valsartan.
US09/920,159 US6485745B1 (en) 1996-06-27 2001-08-01 Solid oral dosage forms of valsartan
US10/251,009 US6858228B2 (en) 1996-06-27 2002-09-20 Solid oral dosage forms of valsartan
NO20041287A NO331739B1 (en) 1996-06-27 2004-03-26 Compressed solid oral dosage forms of valsartan and hydrochlorothiazide
IL195339A IL195339A0 (en) 1996-06-27 2008-11-17 Solid oral dosage forms of valsartan

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GBGB9613470.5A GB9613470D0 (en) 1996-06-27 1996-06-27 Small solid oral dosage form
GB9613470.5 1996-06-27

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US09202805 A-371-Of-International 1997-06-18
US09/920,159 Continuation US6485745B1 (en) 1996-06-27 2001-08-01 Solid oral dosage forms of valsartan
US10/251,009 Continuation US6858228B2 (en) 1996-06-27 2002-09-20 Solid oral dosage forms of valsartan

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