WO1997048382A3 - Multiple-unit type prolonged action drug preparation - Google Patents
Multiple-unit type prolonged action drug preparation Download PDFInfo
- Publication number
- WO1997048382A3 WO1997048382A3 PCT/JP1997/001836 JP9701836W WO9748382A3 WO 1997048382 A3 WO1997048382 A3 WO 1997048382A3 JP 9701836 W JP9701836 W JP 9701836W WO 9748382 A3 WO9748382 A3 WO 9748382A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- drug preparation
- unit type
- cilostazol
- prolonged action
- action drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a multiple-unit type prolonged release action drug preparation which is characterized by containing at least 2 small tablets of sustained release type drug preparation obtained by formulating cilostazol with hydroxypropylmethylcellulose as the base material of the drug preparation. By formulating cilostazol as in the form of a multiple-unit type prolonged release action drug preparation of the present invention, side-effects, such as headache and other symptoms caused by high blood concentration of cilostazol due to the rapid absorption, can be reduced.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU29768/97A AU2976897A (en) | 1996-06-18 | 1997-05-29 | Multiple-unit type prolonged action drug preparation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15671896 | 1996-06-18 | ||
JP8/156718 | 1996-06-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997048382A2 WO1997048382A2 (en) | 1997-12-24 |
WO1997048382A3 true WO1997048382A3 (en) | 1998-02-19 |
Family
ID=15633827
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1997/001836 WO1997048382A2 (en) | 1996-06-18 | 1997-05-29 | Multiple-unit type prolonged action drug preparation |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2976897A (en) |
ID (1) | ID17125A (en) |
WO (1) | WO1997048382A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8865695B2 (en) | 2009-01-08 | 2014-10-21 | Lipocine Inc. | Steroidal compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA67802C2 (en) | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION |
EG23951A (en) * | 1999-03-25 | 2008-01-29 | Otsuka Pharma Co Ltd | Cilostazol preparation |
US20050186276A1 (en) * | 2003-07-17 | 2005-08-25 | Pfizer Inc | Pharmaceutical formulations |
WO2005023225A1 (en) * | 2003-09-05 | 2005-03-17 | Ranbaxy Laboratories Limited | Cilostazol adsorbate |
KR20080076440A (en) * | 2007-02-16 | 2008-08-20 | (주)아모레퍼시픽 | Controlled release preparation containing cilostazol and process for the preparation thereof |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
US20180147215A1 (en) | 2016-11-28 | 2018-05-31 | Lipocine Inc. | Oral testosterone undecanoate therapy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60228410A (en) * | 1984-04-26 | 1985-11-13 | Otsuka Pharmaceut Co Ltd | Long-acting drug preparation |
US4734285A (en) * | 1985-10-28 | 1988-03-29 | The Dow Chemical Company | Sustained release compositions |
EP0463173A1 (en) * | 1990-01-08 | 1992-01-02 | Otsuka Pharmaceutical Co., Ltd. | Hair tonic and dressing composition |
-
1997
- 1997-05-29 AU AU29768/97A patent/AU2976897A/en not_active Abandoned
- 1997-05-29 WO PCT/JP1997/001836 patent/WO1997048382A2/en active Application Filing
- 1997-06-16 ID IDP972047A patent/ID17125A/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60228410A (en) * | 1984-04-26 | 1985-11-13 | Otsuka Pharmaceut Co Ltd | Long-acting drug preparation |
US4734285A (en) * | 1985-10-28 | 1988-03-29 | The Dow Chemical Company | Sustained release compositions |
EP0463173A1 (en) * | 1990-01-08 | 1992-01-02 | Otsuka Pharmaceutical Co., Ltd. | Hair tonic and dressing composition |
Non-Patent Citations (3)
Title |
---|
DATABASE WPI Section Ch Week 9247, Derwent World Patents Index; Class A03, AN 86-003017 * |
PATENT ABSTRACTS OF JAPAN vol. 010, no. 098 (C - 339) 15 April 1986 (1986-04-15) * |
SUCKER H. ET AL: "Pharmazeutische Technologie", 1991, THIEME VERLAG, STUTTGART, XP002046215, 189560 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8865695B2 (en) | 2009-01-08 | 2014-10-21 | Lipocine Inc. | Steroidal compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9205057B2 (en) | 2010-11-30 | 2015-12-08 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9480690B2 (en) | 2010-11-30 | 2016-11-01 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
Also Published As
Publication number | Publication date |
---|---|
WO1997048382A2 (en) | 1997-12-24 |
AU2976897A (en) | 1998-01-07 |
ID17125A (en) | 1997-12-04 |
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