WO1997041150A3 - Gene therapy for mitochondrial dna deffects using peptide nucleic acids - Google Patents
Gene therapy for mitochondrial dna deffects using peptide nucleic acids Download PDFInfo
- Publication number
- WO1997041150A3 WO1997041150A3 PCT/GB1997/001102 GB9701102W WO9741150A3 WO 1997041150 A3 WO1997041150 A3 WO 1997041150A3 GB 9701102 W GB9701102 W GB 9701102W WO 9741150 A3 WO9741150 A3 WO 9741150A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nucleic acids
- peptide nucleic
- mitochondrial dna
- deffects
- gene therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention concerns a method for selectively preventing the replication of mitochondrial DNA using complementary peptide nucleic acids; and the peptide nucleic acids for use in the method. Additionally novel targeting means are described for ensuring the targeting of the peptide nucleic acids into mitochondria.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9608803.4A GB9608803D0 (en) | 1996-04-27 | 1996-04-27 | Mitochondrial dna defects |
GB9608803.4 | 1996-04-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997041150A2 WO1997041150A2 (en) | 1997-11-06 |
WO1997041150A3 true WO1997041150A3 (en) | 1997-12-04 |
Family
ID=10792795
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1997/001102 WO1997041150A2 (en) | 1996-04-27 | 1997-04-22 | Gene therapy for mitochondrial dna deffects using peptide nucleic acids |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB9608803D0 (en) |
WO (1) | WO1997041150A2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6472209B1 (en) | 1997-10-17 | 2002-10-29 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6723560B2 (en) | 1998-10-08 | 2004-04-20 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
US6989270B1 (en) | 1997-10-17 | 2006-01-24 | Mayo Foundation For Medical Education And Research | Using polyamide nucleic acid oligomers to engender a biological response |
EP1574210B1 (en) | 1999-02-26 | 2016-04-06 | Novartis Vaccines and Diagnostics, Inc. | Microemulsions with adsorbed macromolecules |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020702A1 (en) * | 1991-05-24 | 1992-11-26 | Ole Buchardt | Peptide nucleic acids |
WO1995034665A2 (en) * | 1994-06-16 | 1995-12-21 | Peter Seibel | Chimerical peptide-nucleic acid fragment, process for producing the same and its use for appropriately introducing nucleic acids into cell organelles and cells |
WO1996004000A1 (en) * | 1994-08-05 | 1996-02-15 | The Regents Of The University Of California | PEPTIDE-BASED NUCLEIC ACID MIMICS (PENAMs) |
EP0700928A1 (en) * | 1994-08-08 | 1996-03-13 | Bayer Ag | Nucleic acid-binding oligomers for therapy and diagnostics |
-
1996
- 1996-04-27 GB GBGB9608803.4A patent/GB9608803D0/en active Pending
-
1997
- 1997-04-22 WO PCT/GB1997/001102 patent/WO1997041150A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992020702A1 (en) * | 1991-05-24 | 1992-11-26 | Ole Buchardt | Peptide nucleic acids |
WO1995034665A2 (en) * | 1994-06-16 | 1995-12-21 | Peter Seibel | Chimerical peptide-nucleic acid fragment, process for producing the same and its use for appropriately introducing nucleic acids into cell organelles and cells |
WO1996004000A1 (en) * | 1994-08-05 | 1996-02-15 | The Regents Of The University Of California | PEPTIDE-BASED NUCLEIC ACID MIMICS (PENAMs) |
EP0700928A1 (en) * | 1994-08-08 | 1996-03-13 | Bayer Ag | Nucleic acid-binding oligomers for therapy and diagnostics |
Also Published As
Publication number | Publication date |
---|---|
WO1997041150A2 (en) | 1997-11-06 |
GB9608803D0 (en) | 1996-07-03 |
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