WO1997035967A3 - Transgenic organisms with altered telomerase activity - Google Patents

Transgenic organisms with altered telomerase activity Download PDF

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Publication number
WO1997035967A3
WO1997035967A3 PCT/US1997/005070 US9705070W WO9735967A3 WO 1997035967 A3 WO1997035967 A3 WO 1997035967A3 US 9705070 W US9705070 W US 9705070W WO 9735967 A3 WO9735967 A3 WO 9735967A3
Authority
WO
WIPO (PCT)
Prior art keywords
telomerase activity
transgenic organisms
altered telomerase
altered
organisms
Prior art date
Application number
PCT/US1997/005070
Other languages
French (fr)
Other versions
WO1997035967A2 (en
Inventor
Carol Greider
Maria Antonia Blasco Marhuenda
Ronald A Depinho
Han-Woong Lee
Original Assignee
Cold Spring Harbor Lab
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cold Spring Harbor Lab, Einstein Coll Med filed Critical Cold Spring Harbor Lab
Priority to AU25936/97A priority Critical patent/AU2593697A/en
Publication of WO1997035967A2 publication Critical patent/WO1997035967A2/en
Publication of WO1997035967A3 publication Critical patent/WO1997035967A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Transgenic nonhuman organisms, such as transgenic mice, with altered expression of telomerase are provided. Methods of using these organisms, including methods of detecting compounds that affect the expression of telomerase are also disclosed.
PCT/US1997/005070 1996-03-28 1997-03-21 Transgenic organisms with altered telomerase activity WO1997035967A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU25936/97A AU2593697A (en) 1996-03-28 1997-03-21 Transgenic organisms with altered telomerase activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62316696A 1996-03-28 1996-03-28
US08/623,166 1996-03-28

Publications (2)

Publication Number Publication Date
WO1997035967A2 WO1997035967A2 (en) 1997-10-02
WO1997035967A3 true WO1997035967A3 (en) 1997-12-11

Family

ID=24497038

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/005070 WO1997035967A2 (en) 1996-03-28 1997-03-21 Transgenic organisms with altered telomerase activity

Country Status (2)

Country Link
AU (1) AU2593697A (en)
WO (1) WO1997035967A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6767719B1 (en) 1997-11-26 2004-07-27 Geron Corporation Mouse telomerase reverse transcriptase
US7390891B1 (en) 1996-11-15 2008-06-24 Amgen Inc. Polynucleotides encoding a telomerase component TP2
WO1999027113A1 (en) * 1997-11-26 1999-06-03 Geron Corporation Mouse telomerase reverse transcriptase
JP2003503071A (en) 1999-06-30 2003-01-28 アドバンスド セル テクノロジー、インコーポレイテッド Cytoplasmic transfer to dedifferentiated recipient cells
AU2002313817A1 (en) 2001-08-27 2003-03-10 Advanced Cell Technology, Inc. Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US20100167404A1 (en) 2005-08-03 2010-07-01 Advanced Cell Technology, Inc. Methods of Reprogramming Animal Somatic Cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
KR102249987B1 (en) * 2018-06-29 2021-05-11 서울대학교 산학협력단 Pancreatic Organoid Derived from Mutant Mouse and Use thereof and Standardized Method for Identifying Drug Efficacy
EP3816277A4 (en) * 2018-06-29 2022-03-23 Seoul National University R & DB Foundation Mutant mouse-derived pancreatic organoid and method for evaluating standardized drug for efficacy

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996001614A2 (en) * 1994-07-07 1996-01-25 Cold Spring Harbor Laboratory Rna component of telomerase
WO1996019580A2 (en) * 1994-12-19 1996-06-27 Cold Spring Harbor Laboratory Telomerase protein component

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996001835A1 (en) * 1994-07-07 1996-01-25 Geron Corporation Mammalian telomerase
WO1996001614A2 (en) * 1994-07-07 1996-01-25 Cold Spring Harbor Laboratory Rna component of telomerase
WO1996019580A2 (en) * 1994-12-19 1996-06-27 Cold Spring Harbor Laboratory Telomerase protein component

Also Published As

Publication number Publication date
WO1997035967A2 (en) 1997-10-02
AU2593697A (en) 1997-10-17

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