WO1997031327A1 - Carte personnelle du genome humain et procedes et systemes de fabrication de celle-ci - Google Patents

Carte personnelle du genome humain et procedes et systemes de fabrication de celle-ci Download PDF

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Publication number
WO1997031327A1
WO1997031327A1 PCT/US1996/019690 US9619690W WO9731327A1 WO 1997031327 A1 WO1997031327 A1 WO 1997031327A1 US 9619690 W US9619690 W US 9619690W WO 9731327 A1 WO9731327 A1 WO 9731327A1
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WO
WIPO (PCT)
Prior art keywords
card
individual
genome
sequence
machine
Prior art date
Application number
PCT/US1996/019690
Other languages
English (en)
Inventor
William L. Reber
Cary D. Perttunen
Original Assignee
Motorola Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Motorola Inc. filed Critical Motorola Inc.
Priority to AU14141/97A priority Critical patent/AU1414197A/en
Publication of WO1997031327A1 publication Critical patent/WO1997031327A1/fr

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Classifications

    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06K—GRAPHICAL DATA READING; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
    • G06K19/00—Record carriers for use with machines and with at least a part designed to carry digital markings
    • G06K19/06—Record carriers for use with machines and with at least a part designed to carry digital markings characterised by the kind of the digital marking, e.g. shape, nature, code
    • G06K19/067—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components
    • G06K19/07—Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards also with resonating or responding marks without active components with integrated circuit chips
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q20/00—Payment architectures, schemes or protocols
    • G06Q20/30—Payment architectures, schemes or protocols characterised by the use of specific devices or networks
    • G06Q20/34—Payment architectures, schemes or protocols characterised by the use of specific devices or networks using cards, e.g. integrated circuit [IC] cards or magnetic cards
    • G06Q20/341—Active cards, i.e. cards including their own processing means, e.g. including an IC or chip
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q20/00—Payment architectures, schemes or protocols
    • G06Q20/30—Payment architectures, schemes or protocols characterised by the use of specific devices or networks
    • G06Q20/34—Payment architectures, schemes or protocols characterised by the use of specific devices or networks using cards, e.g. integrated circuit [IC] cards or magnetic cards
    • G06Q20/357—Cards having a plurality of specified features
    • G06Q20/3576—Multiple memory zones on card
    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07F—COIN-FREED OR LIKE APPARATUS
    • G07F7/00—Mechanisms actuated by objects other than coins to free or to actuate vending, hiring, coin or paper currency dispensing or refunding apparatus
    • G07F7/08—Mechanisms actuated by objects other than coins to free or to actuate vending, hiring, coin or paper currency dispensing or refunding apparatus by coded identity card or credit card or other personal identification means
    • G07F7/10—Mechanisms actuated by objects other than coins to free or to actuate vending, hiring, coin or paper currency dispensing or refunding apparatus by coded identity card or credit card or other personal identification means together with a coded signal, e.g. in the form of personal identification information, like personal identification number [PIN] or biometric data
    • G07F7/1008—Active credit-cards provided with means to personalise their use, e.g. with PIN-introduction/comparison system
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • G16H10/65—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records stored on portable record carriers, e.g. on smartcards, RFID tags or CD

Definitions

  • the present invention relates to personal medical information cards.
  • the set of instructions for making an organism is called its genome.
  • the genome for a human consists of coiled threads of deoxyribonucleic acid (DNA) and associated protein molecules found in every cell nucleus of the human.
  • the components of these threads of DNA encode all of the information needed for building and maintaining life in the human.
  • Each DNA molecule contains a number of genes, which are the basic physical and functional units of heredity.
  • a gene is a specific sequence of nucleotide bases within the human genome.
  • the human genome is estimated to ⁇ uiprise approximately 50,000 tc 100,000 g ⁇ n ⁇ .
  • a number of these genes, estimated at 4000, are involved in an individual's predisposition to disease.
  • the Human Genome Project was initiated in 1990 with a goal of characterizing the entire human genome in order to devise improved strategies for disease identification, treatment, and prevention.
  • the prospect of determining an individual's predisposition to disease based on his/her genome has led some to warn of the potential for genetic-based discrimination in health insurance coverage.
  • genetic information could be used to exclude high-risk individuals from health care by either denying coverage or by charging prohibitive rates.
  • the fear of discrimination may act to inhibit an individual from divulging his/her genetic status, even in light cf the benefits of preventative measures and treatments which can be prescribed based on an early diagnosis of genetic predisposition to disease.
  • FIG. 1 is a block diagram of a system for producing a personal genome card in accordance with the present invention
  • FIG. 2 is a flow chart of an embodiment of a method of producing a personal genome card for an individual
  • FIG. 3 is a block diagram illustrating a system for storing information in a personal genome card
  • FIG. 4 is an illustration of a PCMCIA embodiment of a personal genome card
  • FIG. 5 is a block diagram of a smart card embodiment of a personal genome card
  • FIG. 6 is a block diagram illustrating a system for accessing a personal genome card.
  • Embodiments of the present invention advantageously provide a personal genome card containing a stored representation of an individual's genome.
  • the personal genome card is sized to be carried by the individual for use in both medical and personal identification applications.
  • Embodiments of the personal genome card limit external access to at least a portion of the representation of the individual's genome in order to avoid instances of genetic-based discrimination.
  • FIG. 1 is a block diagram of a system for producing a personal genome card 10 in accordance with the present invention.
  • the personal genome card 10 includes a card member 12 which, preferably, is sized for carrying on an individual 14.
  • the card member 12 can be the size of a credit card for carrying within a wallet, a purse, or a pocket of the individual 14.
  • a machine-readable storage medium 16 is integrated in the card member 12.
  • the machine-readable storage medium 16 is utilized to store personal genome information for the individual 14.
  • the machine-readable storage medium 16 can be in the form of an electronic memory device, a magnetic memory device, or an optical memory device, for example.
  • the machine- readable storage medium 16 is non-volatile so that a powering signal need not be applied to maintain the personal genome information therein. Further, it is preferred that the machine-readable storage medium 16 be rewriteable so that the information contained therein can be updated.
  • the interface 18 is utilized to communicate the personal genome information between the machine-readable storage medium 16 and an exterior read/write device such as a computer.
  • a genetic screening apparatus 20 is utilized to screen at least a portion of a personal human genome 22 of the individual 14.
  • the genetic screening apparatus 20 is utilized to screen at least a portion of a personal human genome 22 of the individual 14.
  • the 20 forms the personal genome information to be stored in the personal genome card 10.
  • the personal genome information is communicated to a data storing device 24 which performs a step of storing a representation thereof in the machine-readable storage medium 16.
  • the data storing device 24 can be embodied a computer, for example, which communicates the personal genome information to the machine-readable storage medium 16 via the interface 18.
  • the personal genome card 10 includes a PC card, such as a PCMCIA card, having an internal memory for storing the personal genome information.
  • the interface 18 includes a PC card interface which is received by a mating PC card interface in the computer.
  • the personal genome information produced by the genetic screening apparatus 20 can be in any of a variety of forms.
  • the genetic screening apparatus 20 determines a sequence of nucleotide bases for at least a portion of the personal human genome 22 of the individual 14.
  • the sequence of nucleotide bases can be determined from either a DNA sample or an RNA sample of the individual 1 .
  • the DNA or RNA sample can be sequenced to determine either a partial nucleotide sequence or an entire nucleotide sequence cf the personal human genome 22 of the individual 14.
  • a sequence of nucleotide bases can be determined from a messenger RNA (mRNA) sample from the individual 14, or equivalently from copy DNA (cDNA) synthesized from the mRNA sample.
  • the sequence of nucleotide bases in mRNA or cDNA is indicative of a protein-coding portion of the DNA, i.e. a gene of the individual 14.
  • the existence of mRNA provides evidence of an active or expressed gene within the individual 14.
  • the data storing device 24 stores a representation of the sequence of nucleotide bases, determined from any of the above-described approaches, in the machine-readable storage medium 16.
  • the nucleotide bases within the sequence are selected from adenine (A) , cytosine (C) , guanine (G) , and thymine (T) .
  • the nucleotide bases within the sequence are selected from adenine (A) , cytosine (C) , guanine (G) , and uracil (U) .
  • the representation can include an uncompressed sequence of two-bit codes, wherein each two-bit code indicates one of four different nucleotide bases which comprise the sequence.
  • the representation can include a lossless, compressed representation of the sequence. Various lossless data compression techniques can be utilized for this purpose.
  • Another form of personal genome information which can be determined by the genetic screening apparatus 20 is a genetic map for the individual 14.
  • the genetic map is representative of positions of predetermined molecular markers within the DNA or RNA of the individual 14.
  • the molecular markers can be determined using a restriction enzyme which cuts the DNA or the RNA into fragments about a predetermined nucleotide subsequence.
  • a restriction enzyme can be utilized to determine the position of a molecular marker in the form of a G-A-T-C subsequence.
  • the data storing device 24 stores a representation of the genetic map in the machine-readable storage medium 16.
  • the representation can include a sequence of codes representative of distances between adjacent molecular markers.
  • the representation can include a sequence of codes representative of absolute positions of the molecular markers.
  • a lossless data compression technique can be utilized to produce a lossless, compressed representation based on either approach for storing the genetic map.
  • the personal genome information stored in the machine-readable storage medium 16 either directly or indirectly indicates if the individual 14 has a genetically-inherited disease and/or a genetic predisposition to a disease. If so, an appropriate treatment strategy can be formulated by medical personnel.
  • FIG. 2 is a flow chart of an embodiment of a method of producing a personal genome card for an individual.
  • the method includes a step of providing the card member 12 having the machine-readable storage medium 16 integrated therein, as indicated by block 40.
  • a smart card or a PC card, such as a PCMCIA card, can be utilized to provide the card member 12.
  • a step of determining a first sequence of nucleotide bases for at least a portion of a genome of the individual 14 is performed.
  • the first sequence of nucleotide bases can be determined by a genetic sequencing apparatus in the genetic screening apparatus 20. If desired, the sequence of nucleotide bases can be determined for an entire exon, for an entire gene, for an entire chromosome, or for the entire genome of the individual 14.
  • a step of storing a representation of the first sequence in the machine-readable storage medium 16 is performed, as indicated by block 44.
  • the step of storing the representation of the first sequence can include compressing the first sequence to form lossless, compressed data, and storing the lossless, compressed data in the machine-readable storage medium.
  • the lossless, compressed data can include a code which identifies the predetermined sequence for the exon or the gene. For example, if the exon or the gene has a sequence observed in other individuals, a single code can be utilized to compress the representation of the sequence.
  • the lossless, compressed data can include a first code identifying the predetermined sequence and a second code indicating the corruption or the mutation.
  • the corruption or the mutation can be present at the birth of the individual 14 or can be incident-based, i.e. an aberration from the individual's genes at birth.
  • the method can include a step of storing, in the machine-readable storage medium 16, phenotype information for the individual 14.
  • the phenotype information is associated with genotype information encoded by the first sequence.
  • the method can further include a step of storing, in the machine-readable storage medium 16, a personal medical history for the individual 14, as indicated by block 48.
  • the method can include steps of storing genome information and medical information for one or more family members of the individual 14.
  • a step of determining a second sequence of nucleotide bases for at least a portion of a genome of a family member of the individual 14 is performed, as indicated by block 50.
  • a step of storing a representation of the second sequence of nucleotide bases in the machine-readable storage medium 16 is performed, as indicated by block 52.
  • a step of storing, in the machine-readable storage medium 16, phenotype information for the family member is performed.
  • a step of storing a personal medical history for the family member can be performed as indicated by block 56.
  • the steps indicated by blocks 50, 52, 54, and 56 can be repeated for a plurality of family members of the individual 14.
  • the plurality of family members include at least one ancestor of the individual 14, such as a mother and/or a father of the individual 14.
  • the genetic pedigree information is useful for predicting diseases whose onset are probabilistic for individuals having a predetermined disease gene. For example, if a disease gene is identified in the genome of the individual 14, the genetic pedigree information can be referred to determine if ancestors of the individual 14 having the same disease gene expressed a corresponding disease.
  • FIG. 3 is a block diagram illustrating a system for storing information in a personal genome card 60.
  • a computer 62 or like programmable apparatus receives or determines a first sequence of nucleotide bases 64 for the individual 14, phenotype information 66 for the individual 14, a personal medical history 68 for the individual 14, a second sequence of nucleotide bases 70 for at least one family member of the individual 14, phenotype information 72 for the family member, a personal medical history 74 for the family member, and identification information 76 (such as name, social security number, or insurance number) for the individual 14.
  • the computer 62 stores this information in a storage medium 78 interfaced to the computer 62 via an interface 80.
  • the system described is amenable to a PCMCIA embodiment of the personal genome card 60, wherein the interface 80 is a PCMCIA interface.
  • FIG. 4 is an illustration of a PCMCIA embodiment of a personal genome card 90.
  • the personal genome card 90 includes a card member 92 having a PCMCIA interface 94.
  • a storage medium such as a memory is integrated within the card member 92.
  • the personal genome card 90 can be received in a PCMCIA port on the computer 62 for storing personal genome information, personal medical history, and pedigree information in the memory.
  • FIG. 5 is a block diagram of a smart card embodiment of a personal genome card 100. Similar to the embodiment of FIG. 1, the personal genome card 100 includes a machine-readable storage medium 102 and an interface 104 integrated within a card member 106.
  • a processor 108 is integrated in the card member 106.
  • the processor 108 is operative to limit external access to predetermined information stored in the machine-readable storage medium 102. The access is allowed or denied based upon whether a predetermined access code is provided to the processor 108.
  • the predetermined access code can be a secret code known only by the individual 14.
  • the processor 108 receives the predetermined access code via the interface 104 or via a user interface 109 incorporated in the card member 106. Having the user interface 109 (such as a series of buttons) incorporated in the card member 106 allows the individual 14 to enter the predetermined access code without having to divulge the predetermined access code to others.
  • the processor 108 does not limit external access to personal medical information which would be vital in an emergency medical situation where communication with the individual 14 is either impaired or impossible.
  • the processor 108 does limit external access to at least a portion of the personal genome information. This access is limited to avoid a possibility of discrimination in obtaining health insurance or discrimination in hiring based on having a genetic predisposition to a disease.
  • the processor 108 can also be operative to decompress the lossless, compressed data stored on the machine-readable storage medium 102. As a result, decompressed data is communicated via the interface 104.
  • FIG. 6 is a block diagram illustrating a system for accessing a personal genome card 110.
  • the personal genome card 110 communicates with an on-line system 112.
  • the on-line system 112 accesses the information stored in a machine-readable storage medium 111 for analysis and/or display.
  • the on-line system 112 can be located remotely from the personal genome card 110, as illustrated in FIG. 6, or can be co-located with the personal genome card 110.
  • the personal genome card 110 is received by an interface 114.
  • the interface 114 mates with an interface 116 within the personal genome card 110.
  • a modem 118 is coupled to the interface 114 to communicate data with a remote modem 120.
  • the modem 118 can communicate with the remote modem 120 using either a wireline link or a wireless link.
  • the remote modem 120 communicates the data to a computer system having a computer 122, a user interface 124 (e.g. a keyboard and/or a mouse) , and a display device 126 (e.g. a computer monitor) . If the personal genome card 110 is co-located with the on-line system 112, the modem
  • the on-line system 112 can be utilized by medical personnel to diagnose the individual's genetic condition.
  • the medical personnel can navigate the information stored the personal genome card 110 by entering navigation instructions into the user interface 124.
  • the navigation instructions are communicated to the personal genome card 110 by the remote modem 120, the modem 118, and the interface 114.
  • the personal genome card 110 communicates either compressed data or uncompressed data to the computer 122 by the interface 114, the modem 118, and the remote modem 120.
  • the computer 122 includes decompression software to decompress the personal genome information.
  • a predetermined amount of the data can be transmitted to the computer 122.
  • the computer 122 is utilized for analysis and/or display of the personal genome information, the personal medical history, and the pedigree information.
  • Medical personnel can use the analysis of the personal genome information to determine if the individual 14 has a genetically-inherited disease or a genetic predisposition to a disease. Further, a doctor can compare the personal genome information in the personal genome card 110 to more-recently screened information to determine if any mutations have occurred since a previous screening.
  • the personal medical history can be utilized to determine if the individual 14 has previously exhibited any symptoms of the disease.
  • the pedigree information can be utilized to gauge the likelihood of an onset of the disease based on the genome and medical history of the individual's ancestors.
  • the personal genome information is also useful in prescribing drugs which will not adversely affect the individual 14.
  • the on-line system 112 can also be utilized for remote identification purposes.
  • the on-line system 112 contains a database 130 of personal genome information for a plurality of individuals, and compares the personal genome information received from the personal genome card 110 thereto.
  • the on-line system 112 can also be utilized to store updates of an individual's genome over his/her lifetime.
  • the various embodiments of the present invention store personal genome information in a card which can be carried by an individual, they provide a significant improvement in that the card can be used by medical personnel to determine if the individual has a genetic predisposition to disease. As more disease genes are identified in scientific research, the personal genome information in the personal genome card can be reviewed as a preventative diagnostic procedure. As a result of the preventative diagnostic, medical personnel may prescribe preventative measures for the individual to reduce a likelihood of acquiring a disease.
  • the various embodiments of the present invention as herein-described limit external access to at least a portion of the personal genome information in order to avoid genetic-based discrimination.

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Abstract

Une carte personnelle du génome humain (10) comporte un élément de type carte (12) et un support d'information exploitable par ordinateur (16) intégré à l'élément de type carte. Des données exploitables par ordinateur, qui contiennent une représentation d'une séquence de bases nucléotidiques associé à au moins une partie du génome d'un individu (22), sont enregistrées sur ledit support d'information exploitable par ordinateur (16). Lesdites données exploitables par ordinateur peuvent en outre comporter des informations relatives au phénotype de l'individu, un historique médical personnel de l'individu et des informations relatives à son patrimoine génétique. Un microprocesseur peut également être intégré à l'élément de type carte. Ce microprocesseur sert à limiter l'accès à au moins une partie des informations enregistrées sur la carte personnelle du génome (10).
PCT/US1996/019690 1996-02-26 1996-12-11 Carte personnelle du genome humain et procedes et systemes de fabrication de celle-ci WO1997031327A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU14141/97A AU1414197A (en) 1996-02-26 1996-12-11 Personal human genome card and methods and systems for producing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60698596A 1996-02-26 1996-02-26
US08/606,985 1996-02-26

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Publication Number Publication Date
WO1997031327A1 true WO1997031327A1 (fr) 1997-08-28

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Cited By (10)

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WO1999001940A1 (fr) * 1997-07-01 1999-01-14 Hexagen Technology Limited Donnees biologiques
WO2000018960A2 (fr) * 1998-09-25 2000-04-06 Massachusetts Institute Of Technology Procedes et produits associes a la determination d'un genotype et a l'analyse de l'adn
WO2001031551A1 (fr) * 1999-10-22 2001-05-03 First Genetic Trust, Inc. Procede et systeme permettant de stocker des profils genetiques et d'acceder a ces profils genetiques
EP1313225A1 (fr) * 2000-04-19 2003-05-21 Satoshi Omori Informations relatives a des sequences nucleotidiques et procede et dispositif permettant d'enregistrer des informations relatives a la sequence d'un acide amine
EP1237327A3 (fr) * 2001-03-01 2003-07-02 NTT Data Technology Corporation Procédé et dispositif pour l'authentification individuelle et la signature numérique utilisant un dispositif comportant une marque d'identification basée sur un code ADN
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
WO2005088504A1 (fr) * 2004-03-17 2005-09-22 Fidelitygenetic Limited Transaction securisee de donnees d'adn
WO2005088503A1 (fr) * 2004-03-17 2005-09-22 Fidelitygenetic Limited Procedes pour traiter de l'information genomique et utilisations correspondantes
US7158892B2 (en) * 2002-06-28 2007-01-02 International Business Machines Corporation Genomic messaging system
US10437825B2 (en) 2014-01-29 2019-10-08 Relican Analytics, Inc. Optimized data condenser and method

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WO1999001940A1 (fr) * 1997-07-01 1999-01-14 Hexagen Technology Limited Donnees biologiques
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
WO2000018960A2 (fr) * 1998-09-25 2000-04-06 Massachusetts Institute Of Technology Procedes et produits associes a la determination d'un genotype et a l'analyse de l'adn
WO2000018960A3 (fr) * 1998-09-25 2000-09-08 Massachusetts Inst Technology Procedes et produits associes a la determination d'un genotype et a l'analyse de l'adn
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EP1313225A4 (fr) * 2000-04-19 2003-05-21 Satoshi Omori Informations relatives a des sequences nucleotidiques et procede et dispositif permettant d'enregistrer des informations relatives a la sequence d'un acide amine
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