WO1997031111A3 - A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them - Google Patents

A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them Download PDF

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Publication number
WO1997031111A3
WO1997031111A3 PCT/NL1997/000079 NL9700079W WO9731111A3 WO 1997031111 A3 WO1997031111 A3 WO 1997031111A3 NL 9700079 W NL9700079 W NL 9700079W WO 9731111 A3 WO9731111 A3 WO 9731111A3
Authority
WO
WIPO (PCT)
Prior art keywords
organic anion
family
nucleic acids
cells
methods
Prior art date
Application number
PCT/NL1997/000079
Other languages
French (fr)
Other versions
WO1997031111A2 (en
Inventor
Elferink Ronald Petrus Jo Oude
Coenraad Cornelis Paulusma
Piter Jabik Bosma
Piet Borst
Raymond Evers
Marcel Kool
Original Assignee
Introgene Bv
Amc Amsterdam
Kanker Inst Nl
Elferink Ronald Petrus Jo Oude
Coenraad Cornelis Paulusma
Piter Jabik Bosma
Piet Borst
Raymond Evers
Marcel Kool
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Introgene Bv, Amc Amsterdam, Kanker Inst Nl, Elferink Ronald Petrus Jo Oude, Coenraad Cornelis Paulusma, Piter Jabik Bosma, Piet Borst, Raymond Evers, Marcel Kool filed Critical Introgene Bv
Priority to EP97904656A priority Critical patent/EP0900273A2/en
Priority to AU17366/97A priority patent/AU1736697A/en
Publication of WO1997031111A2 publication Critical patent/WO1997031111A2/en
Publication of WO1997031111A3 publication Critical patent/WO1997031111A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention provides a novel family of organic anion transporters of which until now only one member was known. The family includes multispecific organic anion transporters related to the canalicular multispecific organic anion transporter. The cDNA encoding the latter is also provided. The rat and human cDNA are exemplified. Uses of nucleic acids based on this gene family and of cells comprising such nucleic acids as well as vectors comprising sequences thereof are also disclosed especially in the area of gene therapy.
PCT/NL1997/000079 1996-02-22 1997-02-21 A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them WO1997031111A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP97904656A EP0900273A2 (en) 1996-02-22 1997-02-21 A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them
AU17366/97A AU1736697A (en) 1996-02-22 1997-02-21 A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96200460 1996-02-22
EP96200460.2 1996-02-22

Publications (2)

Publication Number Publication Date
WO1997031111A2 WO1997031111A2 (en) 1997-08-28
WO1997031111A3 true WO1997031111A3 (en) 1997-11-27

Family

ID=8223703

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1997/000079 WO1997031111A2 (en) 1996-02-22 1997-02-21 A family of organic anion transporters, nucleic acids encoding them, cells comprising them and methods for using them

Country Status (3)

Country Link
EP (1) EP0900273A2 (en)
AU (1) AU1736697A (en)
WO (1) WO1997031111A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105463086A (en) * 2015-12-11 2016-04-06 上海新培晶医学检验所有限公司 Kit for detecting ABCC2 gene of Dubin-Johnson syndrome and detection method of kit

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759515B1 (en) 1997-02-25 2004-07-06 Corixa Corporation Compositions and methods for the therapy and diagnosis of prostate cancer
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
ATE374211T1 (en) 1998-06-11 2007-10-15 Gilead Sciences Inc GENE CODING ORGANIC ANION TRANSPORTER
AU5340699A (en) * 1998-08-07 2000-02-28 Axys Pharmaceuticals, Inc. Human anion transporter genes atnov
EP1173457A4 (en) * 1999-03-04 2005-08-03 Smithkline Beecham Corp Polynucleotide and polypeptide sequences encoding human organic anion transporter 6(hoatp6) and screening methods thereof
US7601494B2 (en) * 1999-03-17 2009-10-13 The University Of North Carolina At Chapel Hill Method of screening candidate compounds for susceptibility to biliary excretion
US6759238B1 (en) * 1999-03-31 2004-07-06 St. Jude Children's Research Hospital Multidrug resistance associated proteins and uses thereof
AU769361B2 (en) * 1999-05-20 2004-01-22 Bristol-Myers Squibb Company Novel organic anion transport proteins
US6692934B1 (en) 1999-05-20 2004-02-17 Bristol-Myers Squibb Co. Organic anion transport proteins
US20040091964A1 (en) * 2000-08-31 2004-05-13 Phillip Board Modified proteins, isolated novel peptides,and uses thereof
US8835608B2 (en) 2006-12-01 2014-09-16 Duke University Anti-MRP3 antibodies and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012987A1 (en) * 1991-01-10 1992-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The genetic locus ugt1 and a mutation therein
WO1994010303A1 (en) * 1992-10-27 1994-05-11 Queen's University At Kingston Multidrug resistance gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992012987A1 (en) * 1991-01-10 1992-08-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services The genetic locus ugt1 and a mutation therein
WO1994010303A1 (en) * 1992-10-27 1994-05-11 Queen's University At Kingston Multidrug resistance gene

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
BUCHLER M ET AL: "cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.", J BIOL CHEM, JUN 21 1996, 271 (25) P15091-8, UNITED STATES, XP002017517 *
COLE SP ET AL: "Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line [see comments]", SCIENCE, DEC 4 1992, 258 (5088) P1650-4, UNITED STATES, XP002017513 *
KITAMURA T ET AL: "Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.", PROC NATL ACAD SCI U S A, MAY 1990, 87 (9) P3557-61, UNITED STATES, XP002017515 *
MAYER R ET AL: "Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes.", J CELL BIOL, OCT 1995, 131 (1) P137-50, UNITED STATES, XP000608636 *
PAULUSMA CC ET AL: "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene.", SCIENCE, FEB 23 1996, 271 (5252) P1126-8, UNITED STATES, XP002017518 *
YI J-R ET AL: "Expression cloning of the cDNA for a polypeptide associated with rat hepatic sinusoidal reduced glutathione transport: Characteristics and comparison with the canalicular transporter", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 92 (5). 1995. 1495-1499., XP002017516 *
ZAMAN GJ ET AL: "The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.", PROC NATL ACAD SCI U S A, SEP 13 1994, 91 (19) P8822-6, UNITED STATES, XP002017514 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105463086A (en) * 2015-12-11 2016-04-06 上海新培晶医学检验所有限公司 Kit for detecting ABCC2 gene of Dubin-Johnson syndrome and detection method of kit

Also Published As

Publication number Publication date
WO1997031111A2 (en) 1997-08-28
EP0900273A2 (en) 1999-03-10
AU1736697A (en) 1997-09-10

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