WO1997029745B1 - Procedes et compositions zwitterioniques utilisees comme modificateurs de reponse biologique - Google Patents
Procedes et compositions zwitterioniques utilisees comme modificateurs de reponse biologiqueInfo
- Publication number
- WO1997029745B1 WO1997029745B1 PCT/US1997/002270 US9702270W WO9729745B1 WO 1997029745 B1 WO1997029745 B1 WO 1997029745B1 US 9702270 W US9702270 W US 9702270W WO 9729745 B1 WO9729745 B1 WO 9729745B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- group
- zwitterion
- mammal
- compound
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract 11
- 239000000367 immunologic factor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 13
- 241000124008 Mammalia Species 0.000 claims abstract 9
- 201000010099 disease Diseases 0.000 claims abstract 9
- 239000004480 active ingredient Substances 0.000 claims abstract 4
- 230000001225 therapeutic Effects 0.000 claims abstract 3
- 239000002253 acid Substances 0.000 claims 5
- JKMHFZQWWAIEOD-UHFFFAOYSA-N HEPES Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 4
- 239000007995 HEPES buffer Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 239000007991 ACES buffer Substances 0.000 claims 2
- 206010003816 Autoimmune disease Diseases 0.000 claims 2
- 239000007987 MES buffer Substances 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000007990 PIPES buffer Substances 0.000 claims 2
- 210000002966 Serum Anatomy 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000002260 anti-inflammatory agent Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 229940116904 ANTIINFLAMMATORY THERAPEUTIC RADIOPHARMACEUTICALS Drugs 0.000 claims 1
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- 229940064005 Antibiotic throat preparations Drugs 0.000 claims 1
- 229940083879 Antibiotics FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Drugs 0.000 claims 1
- 229940042052 Antibiotics for systemic use Drugs 0.000 claims 1
- 229940042786 Antitubercular Antibiotics Drugs 0.000 claims 1
- 210000001772 Blood Platelets Anatomy 0.000 claims 1
- 229950003499 FIBRIN Drugs 0.000 claims 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 1
- 102000009123 Fibrin Human genes 0.000 claims 1
- 108010073385 Fibrin Proteins 0.000 claims 1
- 229940012952 Fibrinogen Drugs 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 229940019698 Fibrinogen containing hemostatics Drugs 0.000 claims 1
- 229940093922 Gynecological Antibiotics Drugs 0.000 claims 1
- 208000006454 Hepatitis Diseases 0.000 claims 1
- 210000002540 Macrophages Anatomy 0.000 claims 1
- 229940074726 OPHTHALMOLOGIC ANTIINFLAMMATORY AGENTS Drugs 0.000 claims 1
- 208000004880 Polyuria Diseases 0.000 claims 1
- 229940024982 Topical Antifungal Antibiotics Drugs 0.000 claims 1
- 229940029983 VITAMINS Drugs 0.000 claims 1
- 229940021016 Vitamin IV solution additives Drugs 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agents Drugs 0.000 claims 1
- 230000000259 anti-tumor Effects 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 230000003115 biocidal Effects 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001419 dependent Effects 0.000 claims 1
- 230000035619 diuresis Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 229940079866 intestinal antibiotics Drugs 0.000 claims 1
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 1
- 229940005935 ophthalmologic Antibiotics Drugs 0.000 claims 1
- 230000025627 positive regulation of urine volume Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000000542 sulfonic acid group Chemical group 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Abstract
L'invention concerne un procédé de traitement d'une maladie affectant un animal, ce procédé consistant à administrer un composé zwitterion amphotère comme ingrédient actif. L'invention concerne également une composition pharmaceutique comprenant un composé zwitterion utilisé comme ingrédient actif en combinaison avec un excipient et autres agents pharmaceutiques adjoints.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EA199800717A EA001929B1 (ru) | 1996-02-13 | 1997-02-13 | Способ лечения заболеваний млекопитающих и цвиттерионная композиция |
US08/983,269 US6071919A (en) | 1996-02-13 | 1997-02-13 | Zwitterionic compositions and methods as biological response modifiers |
EP97907616A EP0904073A4 (fr) | 1996-02-13 | 1997-02-13 | Procedes et compositions zwitterioniques utilisees comme modificateurs de reponse biologique |
JP52947997A JP3309990B2 (ja) | 1996-02-13 | 1997-02-13 | 生物学的応答調節剤としての双性イオンの組成物及び方法 |
IL12577597A IL125775A (en) | 1996-02-13 | 1997-02-13 | Use of a zwitterion composition in the preparation of pharmaceutical compositions |
AU19577/97A AU700502B2 (en) | 1996-02-13 | 1997-02-13 | Zwitterionic compositions and methods as biological response modifiers |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/600,901 US5716959A (en) | 1996-02-13 | 1996-02-13 | Method of treating disease with piperazine zwitterion compounds |
US08/600,901 | 1996-02-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997029745A1 WO1997029745A1 (fr) | 1997-08-21 |
WO1997029745B1 true WO1997029745B1 (fr) | 1997-09-25 |
Family
ID=24405525
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/002270 WO1997029745A1 (fr) | 1996-02-13 | 1997-02-13 | Procedes et compositions zwitterioniques utilisees comme modificateurs de reponse biologique |
Country Status (8)
Country | Link |
---|---|
US (2) | US5716959A (fr) |
EP (1) | EP0904073A4 (fr) |
JP (1) | JP3309990B2 (fr) |
AU (1) | AU700502B2 (fr) |
CA (1) | CA2230639A1 (fr) |
EA (1) | EA001929B1 (fr) |
IL (1) | IL125775A (fr) |
WO (1) | WO1997029745A1 (fr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6114337A (en) * | 1998-11-27 | 2000-09-05 | Pugliese; Peter T. | Zwitteronic-fatty acid compounds having anti-inflammatory properties |
US6448251B1 (en) * | 1997-11-28 | 2002-09-10 | Peter T. Pugliese | Zwitterionic-fatty acid compounds having anti-inflammatory properties |
EP1033913A1 (fr) | 1997-11-28 | 2000-09-13 | Peter T. Pugliese | Composes a base d'acide zwitterionique a proprietes anti-inflammatoires |
DE69924146D1 (de) * | 1998-12-21 | 2005-04-14 | Inkeysa Sa | Etherlysophospholipide zur behandlung von chronischen entzündlichen erkrankungen |
JP4698843B2 (ja) * | 1999-05-17 | 2011-06-08 | エーザイ インコーポレイテッド | 生体活性剤の改良された細胞取り込み |
AUPR626001A0 (en) * | 2001-07-10 | 2001-08-02 | Mcgregor, Neil | A method of treatment and/or prophylaxis |
WO2004012662A2 (fr) * | 2002-08-01 | 2004-02-12 | Aesgen, Inc. | Traitement ameliore du cancer avec la glutamine |
US7592154B2 (en) * | 2005-08-05 | 2009-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Modulating SOS response induction by antimicrobial agents |
SI22466A (sl) * | 2007-03-14 | 2008-10-31 | Romina Znoj | Kombinacija, ki vsebuje rastlinske ekstrakte, in njena uporaba za zdravljenje različnih oblik raka |
EP2440198B1 (fr) * | 2009-06-09 | 2016-01-06 | Cimas Limited | Acides carboxyliques aliphatiques halogénés, oligomères et/ou polymères de ceux-ci et leur utilisation dans la dévitalisation de néoplasmes externes et internes |
MX360190B (es) * | 2009-09-17 | 2018-10-24 | Bespoke Bioscience Llc | Papel del acido n-2-hidroxi-etil-piperazina-n' -2-etano sulfonico (hepes) en el tratamiento de sintomas de abstinencia, efectos colaterales o ambos despues del tratamiento con anti-depresivos o inhibidores de serotonina selectiva (ssri). |
AU2016228315B2 (en) * | 2009-09-17 | 2018-01-04 | Bespoke Bioscience, Llc | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
AU2014206220B2 (en) * | 2009-09-17 | 2016-09-29 | Bespoke Bioscience, Llc | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
US20140377814A1 (en) * | 2012-02-07 | 2014-12-25 | Industry-Academic Cooperation Foundation, Yonsei University | Method For The Fixation Or Conversion Of High-Pressure Carbon Dioxide Using Barophilic Sulfur-Oxidizing Chemolithoautotrophs |
JP6612004B1 (ja) * | 2018-07-31 | 2019-11-27 | 株式会社親広産業 | グルコース消費促進剤および解糖系促進剤 |
WO2020026471A1 (fr) * | 2018-07-31 | 2020-02-06 | 株式会社親広産業 | Promoteur de la consommation de glucose et promoteur de glycolyse |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK227083D0 (da) * | 1982-08-17 | 1983-05-20 | Sullivan Donncha O | Farmaceutisk komposition og fremgangsmade til dens fremstilling |
US4696917A (en) * | 1985-08-01 | 1987-09-29 | Lindstrom Richard L | Irrigation solution |
IE853206L (en) * | 1985-12-18 | 1987-06-18 | Sullivan Donncha O | Use of aminosulfonic acids in treatment of inflammatory¹conditions |
GB8713091D0 (en) * | 1987-06-04 | 1987-07-08 | Millrine W P | Pharmaceutical compositions |
AU641529B2 (en) * | 1990-07-30 | 1993-09-23 | Bloomfield D.A. | Zwitterionic compounds and their N-halo derivatives for use in the treatment of clinical conditions |
AU9805998A (en) * | 1997-10-15 | 1999-05-03 | T. Ronald Theodore | Zwitterionic compositions and methods as biological response modifiers |
EP1033913A1 (fr) * | 1997-11-28 | 2000-09-13 | Peter T. Pugliese | Composes a base d'acide zwitterionique a proprietes anti-inflammatoires |
-
1996
- 1996-02-13 US US08/600,901 patent/US5716959A/en not_active Expired - Fee Related
-
1997
- 1997-02-13 CA CA002230639A patent/CA2230639A1/fr not_active Abandoned
- 1997-02-13 US US08/983,269 patent/US6071919A/en not_active Expired - Fee Related
- 1997-02-13 IL IL12577597A patent/IL125775A/en not_active IP Right Cessation
- 1997-02-13 EP EP97907616A patent/EP0904073A4/fr not_active Withdrawn
- 1997-02-13 JP JP52947997A patent/JP3309990B2/ja not_active Expired - Fee Related
- 1997-02-13 EA EA199800717A patent/EA001929B1/ru not_active IP Right Cessation
- 1997-02-13 AU AU19577/97A patent/AU700502B2/en not_active Ceased
- 1997-02-13 WO PCT/US1997/002270 patent/WO1997029745A1/fr not_active Application Discontinuation
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