WO1997028684A1 - Hypertensive transgenic rat - Google Patents

Hypertensive transgenic rat Download PDF

Info

Publication number
WO1997028684A1
WO1997028684A1 PCT/JP1997/000289 JP9700289W WO9728684A1 WO 1997028684 A1 WO1997028684 A1 WO 1997028684A1 JP 9700289 W JP9700289 W JP 9700289W WO 9728684 A1 WO9728684 A1 WO 9728684A1
Authority
WO
WIPO (PCT)
Prior art keywords
rats
human
dna coding
hypertensive
transgenic rat
Prior art date
Application number
PCT/JP1997/000289
Other languages
French (fr)
Japanese (ja)
Inventor
Hisaaki Ishikawa
Sueo Mukumoto
Susumu Satoh
Masakazu Kobayashi
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of WO1997028684A1 publication Critical patent/WO1997028684A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A hypertensive transgenic rat having a DNA coding for the human renin bound to a promoter capable of highly expressing a DNA coding for human renins in rats and another DNA coding for the human angiotensinogen bound to a promoter capable of highly expressing a DNA coding for human angiotensinogens in rats; a process for producing the rats; and a method of screening hypertension preventives and remedies by using the rats. These rats can serve as model animals for hypertension and accompanying diseases, thus being useful as means for research and development of preventives and remedies therefor.
PCT/JP1997/000289 1996-02-07 1997-02-06 Hypertensive transgenic rat WO1997028684A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8/21034 1996-02-07
JP2103496 1996-02-07

Publications (1)

Publication Number Publication Date
WO1997028684A1 true WO1997028684A1 (en) 1997-08-14

Family

ID=12043690

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/000289 WO1997028684A1 (en) 1996-02-07 1997-02-06 Hypertensive transgenic rat

Country Status (1)

Country Link
WO (1) WO1997028684A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071751A1 (en) * 1999-05-21 2000-11-30 Myriad Genetics, Inc. Diabetes gene
EP1252894A1 (en) * 2001-04-26 2002-10-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of agt and its derivatives for manufacturing anti-angiogenesis pharmaceutical compositions
US6902888B1 (en) 1999-05-21 2005-06-07 Myriad Genetics, Inc. Diabetes gene
JP2021122186A (en) * 2020-01-31 2021-08-30 株式会社島津製作所 Pathogen detection method and kit

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J. BIOL. CHEM., Vol. 266, FUKAMIZU A. et al., pages 11617-11621, (1993). *
KAZUYA MATSUMOTO, Protein-Nucleic Acid-Enzyme, Vol. 40, pages 2223-2233, (1995). *
MOL. CELL BIOCHEM., Vol. 131, HATAE T. et al., pages 43-47, (1994). *
PROC. NATL. ACAD. SCI. U.S.A., Vol. 87, OHKUBO H. et al., pages 5153-5157, (1990). *
PROC. NATL. ACAD. SCI. U.S.A., Vol. 89, GATEN D. et al., pages 7806-7810, (1992). *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000071751A1 (en) * 1999-05-21 2000-11-30 Myriad Genetics, Inc. Diabetes gene
US6902888B1 (en) 1999-05-21 2005-06-07 Myriad Genetics, Inc. Diabetes gene
US7374884B2 (en) 1999-05-21 2008-05-20 Myriad Genetics, Inc. Diabetes gene
EP1252894A1 (en) * 2001-04-26 2002-10-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of agt and its derivatives for manufacturing anti-angiogenesis pharmaceutical compositions
WO2002087607A1 (en) * 2001-04-26 2002-11-07 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of agt and its derivatives for manufacturing anti-angiogenesis pharmaceutical compositions
JP2021122186A (en) * 2020-01-31 2021-08-30 株式会社島津製作所 Pathogen detection method and kit

Similar Documents

Publication Publication Date Title
DE69615090D1 (en) Composite clay material and process for its manufacture, compound material and composite clay rubber using it, and process for their manufacture
WO1999014330A8 (en) DcR3 POLYPEPTIDE, A TNFR HOMOLOG
AU2721797A (en) Artificial antibodies to corticosteroids prepared by molecular imprinting
ID17698A (en) PROCESS FOR PRODUCING L-GLUTAMIC ACID WITH FERMENTATION
ID19236A (en) CARBONILATION PROCESS USING IRIDIUM CATALYST TO PRODUCE ACETIC ACID
ID19222A (en) CARBONILATION PROCESS USING IRIDIUM CATALYST FOR THE MAKING OF ACETIC ACID
EP0712862A3 (en) Selective acylation of epsilon-amino groups
AU2003249119A8 (en) Catalyst based on a solid microporous crystalline material and method of improving diesel fraction quality using said catalyst
CA2281830A1 (en) Methods of commercial production and extraction of protein from seed
HK1097280A1 (en) Method for producing a peptide with a pl above 8 or below 5
ID21457A (en) CATALYST, PROCESS FOR PRODUCING CATALYST AND PROCESS FOR MAKING VINYL ACETATE USING CATALYST
WO1997028684A1 (en) Hypertensive transgenic rat
ID15998A (en) PROCESS FOR PRODUCING 2,6-DIMETYLNAFTALENA AND A PROCESS FOR PRODUCING 2,6-NAFTALENADICARBOSILATE ACID
DE69714943D1 (en) METHOD FOR PRODUCING FEED PELLETS
DE69604314D1 (en) Tetraphenol compounds, process for their preparation and their use as photosensitizers
EP0913473A4 (en) Process for producing icosapentaenoic acid by genetic recombination
EP1118669A9 (en) Production of camelid antibodies in plants
AU5168598A (en) Method for producing tagged genes, transcripts and proteins
EP0899268A3 (en) Process for the preparation of omeprazole and intermediate compounds
AU4535397A (en) A method to control plant fungal diseases
AU1887500A (en) A process for preparing activated carbon from urban waste
IL115979A0 (en) Method for producing ground reinforced by fibrous additives
AU3665400A (en) Method for producing a road joint, and joint obtained by said method
AU1621900A (en) Transgenic animals as urinary bioreactors for the production of protein in the urine, recombinant dna construct for kidney-specific expression, and method of using same
DE59900129D1 (en) Process for producing endo-nortropin using 8-benzyl-nortropan-3-one perchlorate as an intermediate, and the latter salt itself

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase