WO1997027745B1 - Procede de diagnostic et de traitement, compositions et appareils connexes - Google Patents
Procede de diagnostic et de traitement, compositions et appareils connexesInfo
- Publication number
- WO1997027745B1 WO1997027745B1 PCT/US1997/001576 US9701576W WO9727745B1 WO 1997027745 B1 WO1997027745 B1 WO 1997027745B1 US 9701576 W US9701576 W US 9701576W WO 9727745 B1 WO9727745 B1 WO 9727745B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vasospasm
- treatment
- dosage
- vasodilator
- group
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims 5
- 238000003745 diagnosis Methods 0.000 title 1
- 206010047163 Vasospasm Diseases 0.000 claims abstract 17
- 230000000261 vasodilator Effects 0.000 claims abstract 9
- 239000003071 vasodilator agent Substances 0.000 claims abstract 9
- 201000010099 disease Diseases 0.000 claims abstract 8
- SNIOPGDIGTZGOP-UHFFFAOYSA-N 1,2,3-propanetrioltrinitrate Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims abstract 6
- 229960003711 glyceryl trinitrate Drugs 0.000 claims abstract 6
- 230000004703 negative regulation of smooth muscle contraction Effects 0.000 claims abstract 4
- 230000004648 relaxation of smooth muscle Effects 0.000 claims abstract 4
- 239000007921 spray Substances 0.000 claims abstract 3
- 230000017531 blood circulation Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 229940014995 Nitroglycerin Drugs 0.000 claims 5
- 239000000006 Nitroglycerin Substances 0.000 claims 5
- HMJIYCCIJYRONP-UHFFFAOYSA-N (+-)-Isradipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)C)C1C1=CC=CC2=NON=C12 HMJIYCCIJYRONP-UHFFFAOYSA-N 0.000 claims 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- -1 patch Substances 0.000 claims 4
- 206010003736 Attention deficit/hyperactivity disease Diseases 0.000 claims 3
- 210000001736 Capillaries Anatomy 0.000 claims 3
- 201000006287 attention deficit hyperactivity disease Diseases 0.000 claims 3
- 230000001684 chronic Effects 0.000 claims 3
- 230000002685 pulmonary Effects 0.000 claims 3
- GJSURZIOUXUGAL-UHFFFAOYSA-N 2-((2,6-Dichlorophenyl)imino)imidazolidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 claims 2
- 206010010254 Concussion Diseases 0.000 claims 2
- 206010027599 Migraine Diseases 0.000 claims 2
- 208000008085 Migraine Disorders Diseases 0.000 claims 2
- 229960001597 Nifedipine Drugs 0.000 claims 2
- HYIMSNHJOBLJNT-UHFFFAOYSA-N Nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 claims 2
- 229940023488 Pill Drugs 0.000 claims 2
- 208000008348 Post-Concussion Syndrome Diseases 0.000 claims 2
- 206010061920 Psychotic disease Diseases 0.000 claims 2
- 206010044390 Transient ischaemic attack Diseases 0.000 claims 2
- 229960002896 clonidine Drugs 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- 230000003205 diastolic Effects 0.000 claims 2
- 229940079593 drugs Drugs 0.000 claims 2
- 229960004427 isradipine Drugs 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000002674 ointment Substances 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 201000010875 transient cerebral ischemia Diseases 0.000 claims 2
- 210000000481 Breast Anatomy 0.000 claims 1
- 206010007541 Cardiac disease Diseases 0.000 claims 1
- 208000006093 Closed Head Injury Diseases 0.000 claims 1
- 206010070976 Craniocerebral injury Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010013932 Dyslexia Diseases 0.000 claims 1
- 208000001640 Fibromyalgia Diseases 0.000 claims 1
- 206010056819 Gastric disease Diseases 0.000 claims 1
- 206010021118 Hypotonia Diseases 0.000 claims 1
- 206010022114 Injury Diseases 0.000 claims 1
- 208000001286 Intracranial Vasospasm Diseases 0.000 claims 1
- 206010024855 Loss of consciousness Diseases 0.000 claims 1
- 206010027175 Memory impairment Diseases 0.000 claims 1
- 208000008433 Motor Disorders Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 206010037175 Psychiatric disease Diseases 0.000 claims 1
- 206010058895 Psychogenic seizure Diseases 0.000 claims 1
- 206010042772 Syncope Diseases 0.000 claims 1
- 206010044074 Torticollis Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 230000001154 acute Effects 0.000 claims 1
- 230000002490 cerebral Effects 0.000 claims 1
- 230000003788 cerebral perfusion Effects 0.000 claims 1
- 201000009541 complex regional pain syndrome Diseases 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 201000010238 heart disease Diseases 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 238000007917 intracranial administration Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 201000008895 mood disease Diseases 0.000 claims 1
- 230000036640 muscle relaxation Effects 0.000 claims 1
- 201000001947 reflex sympathetic dystrophy Diseases 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 230000001953 sensory Effects 0.000 claims 1
- 230000035939 shock Effects 0.000 claims 1
- 230000002889 sympathetic Effects 0.000 claims 1
- 230000001052 transient Effects 0.000 claims 1
Abstract
L'invention concerne un procédé de traitement d'un malade présentant un vasospasme ou d'autres symptômes qui peuvent être soulagés par l'administration d'un relaxant des muscles lisses ou d'un vasodilatateur. La figure représente un examen Doppler intracrânien, effectué en continu, de l'artère cérébrale moyenne après une vaporisation de nitroglycérine.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/101,934 US6258032B1 (en) | 1997-01-29 | 1997-01-29 | Method of diagnosis and treatment and related compositions and apparatus |
| AU22522/97A AU2252297A (en) | 1996-01-31 | 1997-01-29 | Method of diagnosis and treatment and related compositions and apparatus |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1088196P | 1996-01-31 | 1996-01-31 | |
| US60/010,881 | 1996-01-31 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| WO1997027745A1 WO1997027745A1 (fr) | 1997-08-07 |
| WO1997027745B1 true WO1997027745B1 (fr) | 1997-10-30 |
| WO1997027745A9 WO1997027745A9 (fr) | 1997-11-27 |
Family
ID=21747861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1997/001576 WO1997027745A1 (fr) | 1996-01-31 | 1997-01-29 | Procede de diagnostic et de traitement, compositions et appareils connexes |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2252297A (fr) |
| WO (1) | WO1997027745A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9903028D0 (sv) * | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| IL149106A0 (en) * | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4163790A (en) * | 1977-05-11 | 1979-08-07 | A. H. Robins Company, Inc. | Method for increasing coronary blood flow in mammals |
| US5278192A (en) * | 1992-07-02 | 1994-01-11 | The Research Foundation Of State University Of New York | Method of vasodilator therapy for treating a patient with a condition |
-
1997
- 1997-01-29 WO PCT/US1997/001576 patent/WO1997027745A1/fr active Application Filing
- 1997-01-29 AU AU22522/97A patent/AU2252297A/en not_active Abandoned
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