WO1997024138A3 - Medical use of proteases - Google Patents

Medical use of proteases Download PDF

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Publication number
WO1997024138A3
WO1997024138A3 PCT/GB1996/003089 GB9603089W WO9724138A3 WO 1997024138 A3 WO1997024138 A3 WO 1997024138A3 GB 9603089 W GB9603089 W GB 9603089W WO 9724138 A3 WO9724138 A3 WO 9724138A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteases
medical use
pathways
modulators
intracellular signal
Prior art date
Application number
PCT/GB1996/003089
Other languages
French (fr)
Other versions
WO1997024138A2 (en
Inventor
Tracey Leahanne Mynott
Christian Engwerda
Original Assignee
Cortecs Ltd
Tracey Leahanne Mynott
Christian Engwerda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortecs Ltd, Tracey Leahanne Mynott, Christian Engwerda filed Critical Cortecs Ltd
Priority to EP96942449A priority Critical patent/EP0876153A2/en
Priority to JP9524091A priority patent/JP2000502697A/en
Priority to AU11818/97A priority patent/AU1181897A/en
Publication of WO1997024138A2 publication Critical patent/WO1997024138A2/en
Publication of WO1997024138A3 publication Critical patent/WO1997024138A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21004—Trypsin (3.4.21.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22002—Papain (3.4.22.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides

Abstract

Proteases have been found to be modulators of intracellular signal transduction, in particular modulators of pathways in which inositol phosphates play a role, and are therefore useful in the treatment of various diseases and conditions which are mediated by these intracellular signal pathways.
PCT/GB1996/003089 1995-12-29 1996-12-13 Medical use of proteases WO1997024138A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96942449A EP0876153A2 (en) 1995-12-29 1996-12-13 Medical use of proteases
JP9524091A JP2000502697A (en) 1995-12-29 1996-12-13 Use of proteases in medicine
AU11818/97A AU1181897A (en) 1995-12-29 1996-12-13 Medical use of proteases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9526691.2 1995-12-29
GBGB9526691.2A GB9526691D0 (en) 1995-12-29 1995-12-29 Medical use of proteases

Publications (2)

Publication Number Publication Date
WO1997024138A2 WO1997024138A2 (en) 1997-07-10
WO1997024138A3 true WO1997024138A3 (en) 1997-10-16

Family

ID=10786186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/003089 WO1997024138A2 (en) 1995-12-29 1996-12-13 Medical use of proteases

Country Status (6)

Country Link
EP (1) EP0876153A2 (en)
JP (1) JP2000502697A (en)
AU (1) AU1181897A (en)
GB (1) GB9526691D0 (en)
WO (1) WO1997024138A2 (en)
ZA (1) ZA9610433B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1012305A1 (en) 1997-02-25 2000-06-28 Cortecs (UK) Limited Component of bromelain
US20020102253A1 (en) 1997-02-25 2002-08-01 Mynott Tracey Lehanne Component of bromelain
DE19726255C2 (en) * 1997-06-20 2000-03-16 Mucos Pharma Gmbh & Co Influence of cytokines by proteolytic enzymes and rutoside
DE19726244C2 (en) * 1997-06-20 2000-03-02 Mucos Pharma Gmbh & Co Use of proteolytic enzymes and rutoside to prevent or treat graft rejection
DE19726254C2 (en) * 1997-06-20 1999-10-21 Mucos Pharma Gmbh & Co Tolerance induction through proteases
DE19957318A1 (en) * 1999-11-29 2001-06-21 Mucos Pharma Gmbh & Co Influence of TGF-beta by proteolytic enzymes
DE10018980A1 (en) * 2000-04-17 2001-11-08 Mucos Pharma Gmbh & Co Prophylaxis and therapy of diabetes mellitus I using proteolytic enzymes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Systematische Enzymtherapie: Grosse Zukunft zu erwarten", THERAPIEWOCHE ÖSTERREICH, vol. 7, no. 2, 1992, pages 65 - 72, XP000652911 *
A.GESCHER: "Modulators of signal transduction as cancer chemotherapeutic agents - novel mechanisms and toxicities", TOXICOLOGY LETTERS, vol. 82/83, December 1995 (1995-12-01), pages 159 - 163, XP000652605 *
DARIO C. ALTIERI: "Proteases and protease receptors in modulation of leukocyte effector functions", J. LEUKOC. BIOL., vol. 58, no. 2, 1995, pages 120 - 127, XP000652620 *
DENIS GODIN ET AL.: "Mode of action of thrombin in the rat aorta", BR. J. PHARMACOL., vol. 115, no. 6, July 1995 (1995-07-01), pages 903 - 908, XP000652621 *
ELENA GABRIELESCU: "An integrative approach to the proteolytic control of the cell-mediated cytotoxicity", ROUM. ARCH. MICROBIOL. IMMUNOL., vol. 51, no. 1-2, 1992, pages 33 - 51, XP000652932 *
G.STAUDER: "Pharmacological effects of oral enzyme combinations", CASOPIS LEKARU CESKYCH, vol. 134, no. 19, 1995, pages 620 - 624, XP000652595 *
M.T.ALONSO ET AL.: "Leupeptin does not affect the normal signal transduction mechanism in platelets", FEBS LETT., vol. 244, no. 2, 1989, pages 407 - 410, XP000652613 *

Also Published As

Publication number Publication date
WO1997024138A2 (en) 1997-07-10
JP2000502697A (en) 2000-03-07
AU1181897A (en) 1997-07-28
ZA9610433B (en) 1998-06-11
GB9526691D0 (en) 1996-02-28
EP0876153A2 (en) 1998-11-11

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