WO1997022694A3 - Diagnostic reagents relating to diabetes - Google Patents

Diagnostic reagents relating to diabetes Download PDF

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Publication number
WO1997022694A3
WO1997022694A3 PCT/CA1996/000867 CA9600867W WO9722694A3 WO 1997022694 A3 WO1997022694 A3 WO 1997022694A3 CA 9600867 W CA9600867 W CA 9600867W WO 9722694 A3 WO9722694 A3 WO 9722694A3
Authority
WO
WIPO (PCT)
Prior art keywords
sequence
nucleic acid
diabetes
diagnostic reagents
relates
Prior art date
Application number
PCT/CA1996/000867
Other languages
French (fr)
Other versions
WO1997022694A2 (en
Inventor
Catherine Jane Pallen
Lin Cui
Wei-Ping Yu
Original Assignee
Univ Singapore
Catherine Jane Pallen
Lin Cui
Yu Wei Ping
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9526036.0A external-priority patent/GB9526036D0/en
Priority claimed from GBGB9605710.4A external-priority patent/GB9605710D0/en
Priority claimed from GBGB9620265.0A external-priority patent/GB9620265D0/en
Application filed by Univ Singapore, Catherine Jane Pallen, Lin Cui, Yu Wei Ping filed Critical Univ Singapore
Priority to EP96941561A priority Critical patent/EP0874901A2/en
Priority to AU10909/97A priority patent/AU1090997A/en
Publication of WO1997022694A2 publication Critical patent/WO1997022694A2/en
Publication of WO1997022694A3 publication Critical patent/WO1997022694A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Rehabilitation Therapy (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to a nucleic acid encoding a polypeptide that has the properties of an Insulin-dependent diabetes mellitus (IDDM)-associated autoantigen, which nucleic acid comprises: (a) the coding sequence of SEQ. ID. No. 1, 10 or 11, and/or the sequence complementary thereto; (b) a sequence which hybridises to a sequence defined in (a); (c) a sequence that is degenerate as a result of the genetic code to a nucleic acid sequence defined in (a) or (b); (d) a sequence having at least 80 % homology to a sequence defined in (a), (b) or (c). It also relates to the polypeptides encoded by such nucleic acids, and to diagnostic methods which employ such polypeptides.
PCT/CA1996/000867 1995-12-20 1996-12-20 Diagnostic reagents relating to diabetes WO1997022694A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP96941561A EP0874901A2 (en) 1995-12-20 1996-12-20 Diagnostic reagents relating to diabetes
AU10909/97A AU1090997A (en) 1995-12-20 1996-12-20 Diagnostic reagents relating to diabetes

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9526036.0A GB9526036D0 (en) 1995-12-20 1995-12-20 Diagnostic reagents relating to diabetes
GB9526036.0 1995-12-20
GB9605710.4 1996-03-19
GBGB9605710.4A GB9605710D0 (en) 1996-03-19 1996-03-19 Diagnostic reagents relating to diabetes
GB9620265.0 1996-09-27
GBGB9620265.0A GB9620265D0 (en) 1996-09-27 1996-09-27 Diagnostic reagents relating to diabetes

Publications (2)

Publication Number Publication Date
WO1997022694A2 WO1997022694A2 (en) 1997-06-26
WO1997022694A3 true WO1997022694A3 (en) 1997-08-14

Family

ID=27268040

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1996/000867 WO1997022694A2 (en) 1995-12-20 1996-12-20 Diagnostic reagents relating to diabetes

Country Status (3)

Country Link
EP (1) EP0874901A2 (en)
AU (1) AU1090997A (en)
WO (1) WO1997022694A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0893691A1 (en) * 1997-07-23 1999-01-27 Mach, Bernard François, Prof. Methods for diagnosis and therapy of autoimmunedisease, such as insulin dependent diabetes mellitus, involving retroviral superantigens
AU9160398A (en) * 1997-07-22 1999-02-16 Novimmune Sa Methods for diagnosis and therapy of autoimmune disease, such as insulin dependent diabetes mellitus, involving retroviral superantigens
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
JP4594588B2 (en) * 2001-04-10 2010-12-08 ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニヴァーシティ Therapeutic and diagnostic uses of antibody-specific profiles
CN1961074A (en) 2003-12-24 2007-05-09 三星电子株式会社 Polynucleotide associated with a type II diabetes comprising single nucleotide polymorphism, microarray and diagnostic kit comprising the same and method for analyzing polynucleotide using the same
KR100695147B1 (en) 2005-02-15 2007-03-14 삼성전자주식회사 2 2 A method for diagnosing type II diabetes mellitus using multilocus marker polynucleotide comprising a marker associeated with type II diabetes mellitus and microarray having immobilized the polynucleotide set
DE202006010878U1 (en) 2006-07-11 2006-09-21 Takata-Petri Ag Airbag arrangement for vehicle occupant restraint system has chamber section that extends forward when airbag inflated to protect occupant including for forward occupant movements at angle by catching associated occupant body regions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017186A1 (en) * 1990-05-04 1991-11-14 Rijksuniversiteit Te Leiden Beta cell antigen
WO1997007211A1 (en) * 1995-08-11 1997-02-27 THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES Materials and methods for detection and treatment of insulin-dependent diabetes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017186A1 (en) * 1990-05-04 1991-11-14 Rijksuniversiteit Te Leiden Beta cell antigen
WO1997007211A1 (en) * 1995-08-11 1997-02-27 THE GOVERNMENT OF THE UNITED STATES, represented by THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES Materials and methods for detection and treatment of insulin-dependent diabetes

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ADAMS M.D. ET AL.: "3400 new expressed sequence tags identify diversity of transcripts in human brain.", NATURE GENETICS, vol. 4, no. 3, July 1993 (1993-07-01), pages 256 - 267, XP000674622 *
CUI L. ET AL.: "Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 40, 4 October 1996 (1996-10-04), pages 24817 - 24823, XP002032721 *
KAWASAKI E. ET AL.: "Molecular cloning and characterization of the human transmembrane protein tyrosine phosphatase homologue, phogrin, an autoantigen of type 1 diabetes.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 227, no. 2, 14 October 1996 (1996-10-14), pages 440 - 447, XP002032722 *
LAN M S ET AL: "MOLECULAR CLONING AND IDENTIFICATION OF A RECEPTOR-TYPE PROTEIN TYROSINE PHOSPHATASE, IA-2, FROM HUMAN INSULINOMA", DNA AND CELL BIOLOGY, vol. 13, no. 5, May 1994 (1994-05-01), pages 505 - 514, XP000612611 *
PAYTON M.A. ET AL.: "Relationship of the 37.000 and 40.000 Mw tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).", JOURNAL OF CLINICAL INVESTIGATION, vol. 96, September 1995 (1995-09-01), pages 1506 - 1511, XP000612574 *
SEISSLIER J. ET AL.: "Autoantibodies to tyrosine phosphatases IA-2 and IA-2 beta in insulin-dependent diabetes mellitus.", 32ND ANNUAL MEETING OF THE EUROPEAN ASSOCIATIONN FOR THE STUDY OF DIABETES, DIABETOLOGIA, vol. 39, no. SUPPL.1, 1 September 1996 (1996-09-01) - 5 September 1996 (1996-09-05), VIENNA, AUSTRIA, pages a85, XP000612637 *

Also Published As

Publication number Publication date
AU1090997A (en) 1997-07-14
WO1997022694A2 (en) 1997-06-26
EP0874901A2 (en) 1998-11-04

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