WO1997021095A3 - Process and device for carrying out highly accurate rapid chemical analyses - Google Patents

Process and device for carrying out highly accurate rapid chemical analyses Download PDF

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Publication number
WO1997021095A3
WO1997021095A3 PCT/DE1996/002351 DE9602351W WO9721095A3 WO 1997021095 A3 WO1997021095 A3 WO 1997021095A3 DE 9602351 W DE9602351 W DE 9602351W WO 9721095 A3 WO9721095 A3 WO 9721095A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
equivalent
titrator
concentration
carrying
Prior art date
Application number
PCT/DE1996/002351
Other languages
German (de)
French (fr)
Other versions
WO1997021095A2 (en
Inventor
Karl Cammann
Original Assignee
Karl Cammann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karl Cammann filed Critical Karl Cammann
Publication of WO1997021095A2 publication Critical patent/WO1997021095A2/en
Publication of WO1997021095A3 publication Critical patent/WO1997021095A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/29—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection
    • G01N21/293—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using visual detection with colour charts, graduated scales or turrets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method and a device for determining the concentration of an analyte, analyte mixture or biochemical analyte-equivalent substance (titrant) contained in a sample using at least one selective reagent (titrator). Instead of the concentration-proportional intensity measurement known from prior art, the invention uses an absolute equivalent quantity measurement which can be miniaturised and can be read off with considerably greater accuracy. Measurement of the titrator quantity equivalent to the analyte concentration, i.e. of the chemical titrator equivalent to be measured, is reduced to a simple and rapid procedure for determining a location or line. The reaction in the reaction series, i.e. the point on a titration line, at which equivalent quantities of analyte and titrator are present is determined. Other process steps such as biochemical analyte-identification reactions or chromatographic separations can also be included.
PCT/DE1996/002351 1995-12-04 1996-12-04 Process and device for carrying out highly accurate rapid chemical analyses WO1997021095A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995145130 DE19545130C2 (en) 1995-12-04 1995-12-04 Methods and devices for a modular microsystem for high-precision chemical rapid analyzes
DE19545130.9 1995-12-04

Publications (2)

Publication Number Publication Date
WO1997021095A2 WO1997021095A2 (en) 1997-06-12
WO1997021095A3 true WO1997021095A3 (en) 1997-07-10

Family

ID=7779111

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/002351 WO1997021095A2 (en) 1995-12-04 1996-12-04 Process and device for carrying out highly accurate rapid chemical analyses

Country Status (2)

Country Link
DE (1) DE19545130C2 (en)
WO (1) WO1997021095A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69808749D1 (en) * 1997-04-24 2002-11-21 Daikin Ind Ltd Comb-shaped sensor element with electrodes on the teeth and edge connections on the opposite side
GB9715101D0 (en) * 1997-07-18 1997-09-24 Environmental Sensors Ltd The production of microstructures for analysis of fluids
US6240790B1 (en) * 1998-11-09 2001-06-05 Agilent Technologies, Inc. Device for high throughout sample processing, analysis and collection, and methods of use thereof
DE19917398C2 (en) * 1999-04-16 2002-06-20 Accoris Gmbh Modular chemical microsystem
DE10030084A1 (en) * 2000-06-19 2002-01-10 Siemens Ag Multichamber covered container to accept, store, deliver and dispose of smallest quantities of e.g. blood, is made of flexible plastic elastomer in LIGA process
DE10059328C2 (en) * 2000-11-29 2003-08-14 Siemens Ag Process for creating a structured material library
DE10119036C1 (en) * 2001-04-18 2002-12-12 Disetronic Licensing Ag Immersion sensor for measuring the concentration of an analyte using an oxidase
DE10121960C1 (en) * 2001-05-05 2002-11-28 Schott Glas Device for continuously titrating used e.g. for monitoring food production comprises a titrating unit with an apparatus for inducing a sample stream
GB0127989D0 (en) * 2001-11-22 2002-01-16 Glaxo Group Ltd Medicament dispensing system
DE10164357B4 (en) * 2001-12-28 2005-11-10 Advalytix Ag titration
DE10344229A1 (en) 2003-09-24 2005-05-19 Steag Microparts Gmbh A microstructured device for removably storing small amounts of liquid and method for withdrawing the liquid stored in said device
DE10345029A1 (en) * 2003-09-25 2005-04-21 Microfluidic Chipshop Gmbh Device for contacting and connecting microfluidic systems comprises plugging plug made from rubber-like material directly into connections of systems so that electrical contact penetrates plug
DE102009028165B4 (en) * 2009-07-31 2017-03-30 Endress+Hauser Conducta Gmbh+Co. Kg Method and apparatus for the automated determination of the chemical oxygen demand of a liquid sample
DE102013006544B4 (en) 2013-04-16 2017-04-27 Dräger Safety AG & Co. KGaA Measuring device, reaction carrier and measuring method
DE102013006546B4 (en) 2013-04-16 2020-08-06 Dräger Safety AG & Co. KGaA Measuring device, reaction carrier and measuring method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3349937A (en) * 1961-08-31 1967-10-31 Cooke Engineering Company Titration apparatus
US3554705A (en) * 1967-06-13 1971-01-12 Xerox Corp Chemical package
US5011663A (en) * 1987-07-22 1991-04-30 S E A C S.R.L. Multitest-tube for clinical chemistry analysis for several simultaneous tests
DE4209064A1 (en) * 1992-03-20 1993-09-23 Vironos Diagnostika Gmbh Fluid sample feeding and removal appts. - comprises transparent test plate with test cells, upper plate with holes corresponding to test cells and feeding device with rows of nozzles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4735778A (en) * 1985-08-28 1988-04-05 Kureha Kagaku Kohyo Kabushiki Kaisha Microtiter plate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3349937A (en) * 1961-08-31 1967-10-31 Cooke Engineering Company Titration apparatus
US3554705A (en) * 1967-06-13 1971-01-12 Xerox Corp Chemical package
US5011663A (en) * 1987-07-22 1991-04-30 S E A C S.R.L. Multitest-tube for clinical chemistry analysis for several simultaneous tests
DE4209064A1 (en) * 1992-03-20 1993-09-23 Vironos Diagnostika Gmbh Fluid sample feeding and removal appts. - comprises transparent test plate with test cells, upper plate with holes corresponding to test cells and feeding device with rows of nozzles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. R. ROBINSON: "ACID-BASE MICROTITRATIONS BASED ON SERIAL DILUTION", ANALYTICAL CHEMISTRY, vol. 42, no. 4, April 1970 (1970-04-01), pages 495 - 498, XP002030655 *

Also Published As

Publication number Publication date
DE19545130A1 (en) 1997-06-05
DE19545130C2 (en) 2001-05-17
WO1997021095A2 (en) 1997-06-12

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