WO1997018308A3 - K-atp channel protein and methods relating to it - Google Patents

K-atp channel protein and methods relating to it Download PDF

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Publication number
WO1997018308A3
WO1997018308A3 PCT/GB1996/002831 GB9602831W WO9718308A3 WO 1997018308 A3 WO1997018308 A3 WO 1997018308A3 GB 9602831 W GB9602831 W GB 9602831W WO 9718308 A3 WO9718308 A3 WO 9718308A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods relating
atp channel
channel protein
atp
channel
Prior art date
Application number
PCT/GB1996/002831
Other languages
French (fr)
Other versions
WO1997018308A2 (en
Inventor
Frances Ashcroft
Hiroshi Sakura
Rebecca Ashfield
Stephen John Haslam Ashcroft
Original Assignee
Wellcome Trust Limited As Trus
Frances Ashcroft
Hiroshi Sakura
Rebecca Ashfield
Stephen John Haslam Ashcroft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Trust Limited As Trus, Frances Ashcroft, Hiroshi Sakura, Rebecca Ashfield, Stephen John Haslam Ashcroft filed Critical Wellcome Trust Limited As Trus
Priority to AU75832/96A priority Critical patent/AU7583296A/en
Publication of WO1997018308A2 publication Critical patent/WO1997018308A2/en
Publication of WO1997018308A3 publication Critical patent/WO1997018308A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention concerns materials and methods relating to an ATP-sensitive potassium ion channel (a K-ATP channel) molecule (and subunits thereof) which is implicated in a number of disease states associated with abnormal coupling of cellular metabolism to K+ fluxes and/or electrical activity.
PCT/GB1996/002831 1995-11-16 1996-11-18 K-atp channel protein and methods relating to it WO1997018308A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU75832/96A AU7583296A (en) 1995-11-16 1996-11-18 K-atp channel protein and methods relating to it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9523497.7A GB9523497D0 (en) 1995-11-16 1995-11-16 Cell membrane protein and application thereof
GB9523497.7 1995-11-16

Publications (2)

Publication Number Publication Date
WO1997018308A2 WO1997018308A2 (en) 1997-05-22
WO1997018308A3 true WO1997018308A3 (en) 1997-07-24

Family

ID=10784012

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/002831 WO1997018308A2 (en) 1995-11-16 1996-11-18 K-atp channel protein and methods relating to it

Country Status (3)

Country Link
AU (1) AU7583296A (en)
GB (1) GB9523497D0 (en)
WO (1) WO1997018308A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9701867D0 (en) * 1997-01-30 1997-03-19 Isis Innovation Materials and methods relating to cell membrane proteins
US7030096B1 (en) 1997-02-13 2006-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
JPH11346597A (en) 1998-06-10 1999-12-21 Susumu Kiyono Animal deficient in atp sensitive potassium channel gene
JP2002523380A (en) * 1998-08-18 2002-07-30 イェシバ・ユニバーシティ Gene therapy for regulating smooth muscle cell tone
EP1029929A1 (en) * 1999-02-19 2000-08-23 Institut Pasteur De Lille Method for determining the susceptibility of a NIDDM patient toward sulfonylurea therapy
EP1637612A1 (en) * 2004-09-10 2006-03-22 Sanofi-Aventis Deutschland GmbH Association of protein polymorphisms with coronary heart disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028131A1 (en) * 1993-05-21 1994-12-08 California Institute Of Technology Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof
WO1995028411A1 (en) * 1994-04-13 1995-10-26 Baylor College Of Medicine Sequence encoding mammalian sulfonylurea receptor and method of detecting persistent hyperinsulinemic hypoglycemia of infancy
EP0764721A1 (en) * 1995-09-18 1997-03-26 Susumu Seino Inohana Shukusha Chiba University ATP-sensitive potassium-channel proteins and genes for the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028131A1 (en) * 1993-05-21 1994-12-08 California Institute Of Technology Dna encoding inward rectifier, g-protein activated, mammalian, potassium kga channel and uses thereof
WO1995028411A1 (en) * 1994-04-13 1995-10-26 Baylor College Of Medicine Sequence encoding mammalian sulfonylurea receptor and method of detecting persistent hyperinsulinemic hypoglycemia of infancy
EP0764721A1 (en) * 1995-09-18 1997-03-26 Susumu Seino Inohana Shukusha Chiba University ATP-sensitive potassium-channel proteins and genes for the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HO, KEVIN ET AL: "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel", NATURE (LONDON) (1993), 362(6415), 31-8 CODEN: NATUAS;ISSN: 0028-0836, XP002030879 *
INAGAKI, NOBUYA ET AL: "Cloning and functional characterization of a novel ATP-sensitive potassium channel ubiquitously expressed in rat tissues, including pancreatic islets, pituitary, skeletal muscle, and heart", J. BIOL. CHEM. (1995), 270(11), 5691-4 CODEN: JBCHA3;ISSN: 0021-9258, XP002030880 *
INAGAKI, NOBUYA ET AL: "Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor", SCIENCE (WASHINGTON, D. C.) (17-11-1995), 270(5239), 1166-70 CODEN: SCIEAS;ISSN: 0036-8075, XP002030881 *
SAKURA, H. ET AL: "Cloning and functional expression of the cDNA encoding a novel ATP - sensitive potassium channel subunit expressed in pancreatic.beta.-cells, brain, heart and skeletal muscle", FEBS LETT. (1995), 377(3), 338-44 CODEN: FEBLAL;ISSN: 0014-5793, XP002030942 *

Also Published As

Publication number Publication date
AU7583296A (en) 1997-06-05
WO1997018308A2 (en) 1997-05-22
GB9523497D0 (en) 1996-01-17

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