WO1997010849A1 - Copolymeric micelle drug composition and method for the preparation thereof - Google Patents
Copolymeric micelle drug composition and method for the preparation thereof Download PDFInfo
- Publication number
- WO1997010849A1 WO1997010849A1 PCT/KR1996/000163 KR9600163W WO9710849A1 WO 1997010849 A1 WO1997010849 A1 WO 1997010849A1 KR 9600163 W KR9600163 W KR 9600163W WO 9710849 A1 WO9710849 A1 WO 9710849A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydrophobic
- drug
- block copolymer
- micelle
- poly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96932066A EP0854731B1 (en) | 1995-09-21 | 1996-09-21 | Copolymeric micelle drug composition and method for the preparation thereof |
DE69625921T DE69625921T2 (en) | 1995-09-21 | 1996-09-21 | MEDICINES BASED ON COPOLYMER MICLES AND METHOD FOR THE PRODUCTION THEREOF |
CA002231886A CA2231886C (en) | 1995-09-21 | 1996-09-21 | Copolymeric micelle drug composition and method for the preparation thereof |
AU70980/96A AU699988B2 (en) | 1995-09-21 | 1996-09-21 | Biodegradable polymeric micelle-type drug composition and method for the preparation thereof |
JP51260897A JP3634377B2 (en) | 1995-09-21 | 1996-09-21 | Biodegradable polymeric micelle-type drug composition and method for producing the same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019950030981A KR0180334B1 (en) | 1995-09-21 | 1995-09-21 | Drug messenger using el-2l-2 micelle and method for sealing drug to it |
KR1995/30981 | 1995-09-21 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/547,545 Continuation-In-Part US6322805B1 (en) | 1995-09-21 | 2000-04-12 | Biodegradable polymeric micelle-type drug composition and method for the preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997010849A1 true WO1997010849A1 (en) | 1997-03-27 |
Family
ID=19427413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR1996/000163 WO1997010849A1 (en) | 1995-09-21 | 1996-09-21 | Copolymeric micelle drug composition and method for the preparation thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US6322805B1 (en) |
EP (1) | EP0854731B1 (en) |
JP (1) | JP3634377B2 (en) |
KR (1) | KR0180334B1 (en) |
CN (1) | CN1214818C (en) |
AU (1) | AU699988B2 (en) |
CA (1) | CA2231886C (en) |
DE (1) | DE69625921T2 (en) |
ES (1) | ES2188787T3 (en) |
MX (1) | MX9802156A (en) |
WO (1) | WO1997010849A1 (en) |
Cited By (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999018998A2 (en) * | 1997-10-09 | 1999-04-22 | Theryte Limited | Delivery system |
JPH11343250A (en) * | 1998-04-02 | 1999-12-14 | Basf Ag | Use of graft copolymer as solubilizing agent, and pharmaceutical preparation, cosmetic preparation and food containing the same |
EP1002546A2 (en) * | 1998-11-10 | 2000-05-24 | Basf Aktiengesellschaft | Use of esters or amides of hydroxylated carboxylic acid as solubilizers |
EP1024790A1 (en) * | 1997-08-08 | 2000-08-09 | University Of Utah Research Foundation | Injectable biodegradable block copolymer gels for use in drug delivery |
EP1034207A1 (en) * | 1997-10-03 | 2000-09-13 | Macromed Inc. | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
WO2001021174A1 (en) * | 1999-09-23 | 2001-03-29 | Dabur Research Foundation | Formulations of paclitaxel entrapped into nanoparticles of polymeric micelles |
WO2001052826A2 (en) * | 2000-01-20 | 2001-07-26 | Supratek Pharma Inc. | Novel podophyllotoxin compositions |
EP1127570A2 (en) * | 2000-02-09 | 2001-08-29 | NanoCarrier Co., Ltd. | Production process for polymeric micelle composition charged therein with drug |
EP1141079A1 (en) * | 1998-10-01 | 2001-10-10 | Macromed Inc. | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
WO2002000194A2 (en) * | 2000-06-29 | 2002-01-03 | Labopharm, Inc. | Polymeric micelle compositions |
US6365191B1 (en) | 1999-02-17 | 2002-04-02 | Dabur Research Foundation | Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
KR100360827B1 (en) * | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof |
EP1267946A2 (en) * | 2000-02-28 | 2003-01-02 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
WO2003000778A1 (en) * | 2001-06-25 | 2003-01-03 | Samyang Corporation | Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug |
WO2003008480A1 (en) * | 2001-07-14 | 2003-01-30 | Samyang Corporation | Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug |
EP1280557A1 (en) * | 2000-05-12 | 2003-02-05 | Samyang Corporation | Method for the preparation of polymeric micelle via phase separation of block copolymer |
EP1282447A1 (en) * | 2000-05-17 | 2003-02-12 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
WO2003017972A2 (en) * | 2001-08-27 | 2003-03-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) |
WO2003028700A2 (en) * | 2001-09-28 | 2003-04-10 | Solubest Ltd. | Water soluble nanoparticles of hydrophilic and hydrophobic active materials |
WO2003099260A1 (en) * | 2002-05-24 | 2003-12-04 | Nanocarrier Co., Ltd. | Method for preparing polymer micelle pharmaceutical preparation containing drug for injection |
EP1465598A1 (en) * | 2001-12-21 | 2004-10-13 | SOANE, David S. | Use of oligomers and polymers for drug solublization, stabilization, and delivery |
US6878693B2 (en) | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
WO2005040247A1 (en) * | 2003-10-24 | 2005-05-06 | Samyang Corporation | Polymeric composition for drug delivery |
US6998134B2 (en) | 1998-09-11 | 2006-02-14 | Gerhard Schmidmaier | Biologically active implants |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
US7141643B2 (en) | 2000-12-06 | 2006-11-28 | Cognis Performance Chemicals Uk Ltd. | Alkylene oxide-lactone copolymers |
AU2002240755B2 (en) * | 2001-03-13 | 2007-07-05 | Angiotech International Ag | Micellar drug delivery vehicles and uses thereof |
US7510731B2 (en) | 2001-06-08 | 2009-03-31 | Labopharm Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
JP2010208955A (en) * | 2009-03-06 | 2010-09-24 | Makoto Yuasa | Disease treatment drug |
US7875677B2 (en) | 2001-04-20 | 2011-01-25 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
WO2011110694A2 (en) | 2010-03-12 | 2011-09-15 | Dsm Ip Assets B.V. | Micelle compositions and process for the preparation thereof |
EP2612656A1 (en) * | 2010-09-02 | 2013-07-10 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug block-copolymer composite and pharmaceutical product containing same |
US8524783B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
WO2014001904A1 (en) * | 2012-06-27 | 2014-01-03 | Medincell | Biodegradable drug delivery for hydrophobic compositions |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
WO2016020547A1 (en) | 2014-08-08 | 2016-02-11 | Dsm Ip Assets B.V. | Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides |
WO2018031850A1 (en) * | 2016-08-12 | 2018-02-15 | Purdue Research Foundation | Polymer lung surfactants |
WO2018227293A1 (en) * | 2017-06-13 | 2018-12-20 | The University Of British Columbia | Polymeric paste compositions for drug delivery |
US11253598B2 (en) | 2015-09-15 | 2022-02-22 | Samyang Holdings Corporation | Pharmaceutical composition containing anionic drug, and preparation method therefor |
US11865205B2 (en) | 2015-11-16 | 2024-01-09 | Medincell S.A. | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI9810945B8 (en) * | 1997-06-27 | 2021-05-25 | Abraxis Bioscience Inc | formulations of pharmacological agents, methods for their preparation and methods for using them |
SE9801288D0 (en) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and method of production |
KR100391487B1 (en) * | 2000-11-08 | 2003-07-16 | 주식회사 한국코러스제약 | biphenyl dimethyl dicarboxylate composition for injections |
MXPA03004112A (en) * | 2000-11-09 | 2003-08-19 | Astrazeneca Ab | Oral pharmaceutical composition containing a block copolymer. |
US20030157170A1 (en) * | 2001-03-13 | 2003-08-21 | Richard Liggins | Micellar drug delivery vehicles and precursors thereto and uses thereof |
AU2002258649A1 (en) * | 2001-03-30 | 2002-10-28 | Rhodia Inc. | Aqeuous suspension of nanoparticles comprising an agrochemical active ingredient |
KR100773078B1 (en) * | 2001-06-21 | 2007-11-02 | 주식회사 삼양사 | Polymeric micelle-type drug composition comprising poorly water soluble crystalline drugs |
WO2003000156A1 (en) | 2001-06-22 | 2003-01-03 | Southern Biosystems, Inc. | Zero-order prolonged release coaxial implants |
US6623729B2 (en) * | 2001-07-09 | 2003-09-23 | Korea Advanced Institute Of Science And Technology | Process for preparing sustained release micelle employing conjugate of anticancer drug and biodegradable polymer |
GB0116920D0 (en) * | 2001-07-11 | 2001-09-05 | Sulzer Vascutek Ltd | Delivery system |
JP4063510B2 (en) * | 2001-07-13 | 2008-03-19 | ナノキャリア株式会社 | Composition for freeze-drying of drug-containing polymer micelle and freeze-dried preparation thereof |
KR100492805B1 (en) * | 2001-10-18 | 2005-06-07 | 주식회사 삼양사 | Polymeric micelle composition with improved stability |
KR20030065831A (en) * | 2002-02-01 | 2003-08-09 | 주식회사 태평양 | cyclosporin-containing sustained release pharmaceutical composition |
US7018655B2 (en) | 2002-03-18 | 2006-03-28 | Labopharm, Inc. | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions |
US6780324B2 (en) * | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
AU2003230761A1 (en) * | 2002-03-29 | 2003-10-13 | Abbott Laboratories | Polymeric micelle formulations of hydrophobic compounds and methods |
CN1290893C (en) * | 2002-05-03 | 2006-12-20 | 詹森药业有限公司 | Polymeric microemulsions |
US7649023B2 (en) | 2002-06-11 | 2010-01-19 | Novartis Ag | Biodegradable block copolymeric compositions for drug delivery |
KR100502840B1 (en) * | 2002-09-04 | 2005-07-21 | 학교법인 포항공과대학교 | A block copolymer micelle composition having an improved drug loading capacity |
FR2845930B1 (en) * | 2002-10-21 | 2006-05-26 | Oreal | PROCESS FOR SOLUBILIZING LIPOPHILIC COMPOUNDS IN AQUEOUS SOLUTION BY AMPHIPHILIC BLOCK COPOLYMERS AND COSMETIC COMPOSITION |
DE60319727T2 (en) * | 2002-10-21 | 2009-03-12 | L'oreal | METHOD OF RESOLVING LIPOPHILER COMPOUNDS, AND COSMETIC COMPOSITION. |
KR20040047056A (en) * | 2002-11-29 | 2004-06-05 | 한미약품 주식회사 | Oral micro-emulsion composition comprising biphenyldimethyldicarboxylate |
US8685428B2 (en) * | 2002-12-10 | 2014-04-01 | Advanced Cardiovascular Systems, Inc. | Therapeutic composition and a method of coating implantable medical devices |
US20040197408A1 (en) * | 2002-12-30 | 2004-10-07 | Angiotech International Ag | Amino acids in micelle preparation |
US7279181B2 (en) * | 2003-06-03 | 2007-10-09 | Ferro Corporation | Method for preparation of particles from solution-in-supercritical fluid or compressed gas emulsions |
TWI248947B (en) * | 2003-07-21 | 2006-02-11 | Ind Tech Res Inst | Biodegradable copolymer, and polymeric micelle composition containing the copolymer |
US7311901B2 (en) * | 2003-10-10 | 2007-12-25 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
CN100471886C (en) * | 2003-10-10 | 2009-03-25 | 株式会社三养社 | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
KR100577514B1 (en) * | 2003-10-21 | 2006-05-10 | 한미약품 주식회사 | Oral micro-emulsion composition comprising biphenyldimethyldicarboxylate, and carduus marianus extract or silybin isolated therefrom |
US20050101605A1 (en) * | 2003-11-07 | 2005-05-12 | Ahmed Salah U. | Oral liquid formulations of methotrexate |
US8313765B2 (en) | 2003-12-04 | 2012-11-20 | Industrial Technology Research Institute | Biodegradable hyaluronic acid derivative, biodegradable polymeric micelle composition and pharmaceutical or bioactive composition |
GB2408741B (en) * | 2003-12-04 | 2008-06-18 | Ind Tech Res Inst | Hyaluronic acid derivative with urethane linkage |
KR20050054129A (en) | 2003-12-04 | 2005-06-10 | 주식회사 삼양사 | Biodegradable branched polylactide derivatives capable of forming polymeric micelles, and their preparation method and use |
KR100967114B1 (en) * | 2003-12-16 | 2010-07-05 | (주)아모레퍼시픽 | Skin application compositions of emulsion type using amphiphilic polymers based on polyepsilon-caprolactone |
ATE340815T1 (en) * | 2003-12-22 | 2006-10-15 | Ind Tech Res Inst | BIODEGRADABLE COPOLYMERS AND POLYMER MICELLER COMPOSITION CONTAINING THESE COPOLYMERS |
US20050214379A1 (en) * | 2004-01-02 | 2005-09-29 | Sandro Mecozzi | Encapsulation of chemical compounds in fluorous-core and fluorous-inner-shell micelles formed from semifluorinated-block or fluorinated-block copolymers |
US20050226932A1 (en) * | 2004-04-09 | 2005-10-13 | Samyang Corporation | Pharmaceutical formulations for itraconazole |
AU2005239948B9 (en) * | 2004-05-06 | 2009-04-23 | Samyang Biopharmaceuticals Corporation | Delivery system for bioactive agents on the basis of a polymeric drug carrier comprising an amphiphilic block polymer and a polylacticacid derivative |
CA2580305A1 (en) * | 2004-06-02 | 2005-12-15 | The Governors Of The University Of Alberta | Polymer based nano-carriers for the solubilization and delivery of hydrophobic drugs |
US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
CN1320927C (en) * | 2005-01-27 | 2007-06-13 | 浙江大学 | Cytomembrane imitated polymer micella as medicine carrying system |
US20060257493A1 (en) * | 2005-04-28 | 2006-11-16 | Amiji Mansoor M | Nanoparticulate delivery systems for treating multi-drug resistance |
US8124128B2 (en) * | 2005-11-08 | 2012-02-28 | Industrial Technology Research Institute | Amphiphilic block copolymers and nano particles comprising the same |
JP5027157B2 (en) | 2006-01-19 | 2012-09-19 | オールエクセル,インコーポレイティド | Solubilization and targeted introduction of drugs with self-assembling amphiphilic polymers |
AR054215A1 (en) | 2006-01-20 | 2007-06-13 | Eriochem Sa | A PHARMACEUTICAL FORMULATION OF A TAXANE, A SOLID COMPOSITION OF A LIOFILIZED TAXAN FROM AN ACETIC ACID SOLUTION, A PROCEDURE FOR THE PREPARATION OF A SOLID COMPOSITION OF A TAXANE, A SOLUBILIZING COMPOSITION OF A LIOFILIZED TAXANE AND AN ELEMENTARY KIT |
JP5933889B2 (en) * | 2006-03-21 | 2016-06-15 | ザ・ガバナーズ・オブ・ザ・ユニバーシティー・オブ・アルバータ | Novel poly (ethylene oxide) -block-poly (ester) block copolymer |
JPWO2007136134A1 (en) * | 2006-05-23 | 2009-10-01 | ナノキャリア株式会社 | Method for producing hydrophobic drug-encapsulating polymer micelle |
JP2010504318A (en) * | 2006-09-22 | 2010-02-12 | ラボファーム インコーポレイテッド | Compositions and methods for pH targeted drug delivery |
US9000048B2 (en) * | 2006-11-28 | 2015-04-07 | Wisconsin Alumni Research Foundation | Fluoropolymer-based emulsions for the intravenous delivery of fluorinated volatile anesthetics |
US7662883B2 (en) * | 2006-12-28 | 2010-02-16 | The Goodyear Tire & Rubber Company | Rubbery block polymers containing polylactone and rubber compounds including the same |
US8900562B2 (en) * | 2007-01-12 | 2014-12-02 | Wisconsin Alumni Research Foundation | Semi-fluorinated block copolymers for delivery of therapeutic agents |
US7537532B2 (en) * | 2007-05-16 | 2009-05-26 | Young Carl D | Handle for implement and method |
JP5171146B2 (en) * | 2007-07-27 | 2013-03-27 | 学校法人 関西大学 | Biodegradable polymer having temperature responsiveness and method for producing the same |
EP2200613B1 (en) | 2007-09-21 | 2018-09-05 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
AR063111A1 (en) | 2007-10-03 | 2008-12-30 | Eriochem Sa | A PHARMACEUTICAL FORMULATION OF TAXANO |
DE112008002914A5 (en) * | 2007-11-06 | 2010-09-30 | B. Braun Melsungen Ag | A hydrophobic drug containing aqueous emulsions |
US9801818B2 (en) * | 2007-12-31 | 2017-10-31 | Samyang Biopharmaceuticals Corporation | Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug |
KR101024742B1 (en) * | 2007-12-31 | 2011-03-24 | 주식회사 삼양사 | Amphiphilic Block Copolymer Micelle Composition Containing Taxane and Manufacturing Process of The Same |
KR101005562B1 (en) * | 2008-05-01 | 2011-01-05 | 한국생명공학연구원 | Preparation method of homogeneous sized polymer nanoparticles containing water-insoluble drugs |
US8603532B2 (en) | 2008-10-20 | 2013-12-10 | Massachusetts Institute Of Technology | Nanostructures for drug delivery |
CN102292109A (en) * | 2008-11-21 | 2011-12-21 | 株式会社三奍社 | Polymer micelle composition for treatment of resistant cancer cells |
CA2748520C (en) | 2008-12-26 | 2013-12-17 | Se-Ho Kim | Pharmaceutical composition containing an anionic drug, and a production method therefor |
EP2201935B1 (en) * | 2008-12-26 | 2020-07-08 | Samyang Biopharmaceuticals Corporation | Polymeric micelle composition containing a poorly soluble drug and preparation method of the same |
US20100203150A1 (en) * | 2009-02-06 | 2010-08-12 | National Tsing Hua University | Novel amphiphilic copolymers and fabrication method thereof |
CN101810560B (en) * | 2009-02-20 | 2013-07-10 | 北京大学 | Cyclosporine A polymeric micelles composition |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
CA2756072A1 (en) * | 2009-03-30 | 2010-10-14 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
WO2011038278A2 (en) | 2009-09-25 | 2011-03-31 | Wisconsin Alumni Research Foundation | Micelle encapsulation of therapeutic agents |
EP2485768A1 (en) | 2009-10-07 | 2012-08-15 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
EP2512522A4 (en) * | 2009-12-16 | 2013-09-25 | Brigham & Womens Hospital | Particles for multiple agent delivery |
KR101267813B1 (en) | 2009-12-30 | 2013-06-04 | 주식회사 삼양바이오팜 | An injectable composition comprising polymeric nanoparticles containing rapamycin with an improved water solubility and a method for preparing the same, and an anticancer composition comprising the same for a combination therapy with radiation |
CN101732723B (en) * | 2009-12-30 | 2012-07-25 | 上海市肿瘤研究所 | Polyethylene glycol-poly(lactic-co-glycolic acid)-polylysine nano-delivery system, preparation method and application thereof |
CN102198083B (en) * | 2010-05-27 | 2012-07-18 | 四川大学 | Micelles and freeze-dried preparations of diblock polymer-supported taxane medicines and preparation and use thereof |
CN101880265A (en) * | 2010-06-09 | 2010-11-10 | 江南大学 | Acid-sensitive polymeric micelle pharmaceutical composition and preparation method thereof |
US8834861B2 (en) | 2011-03-10 | 2014-09-16 | International Business Machines Corporation | Polycarbonates for delivery of drugs and methods of preparation thereof |
US8945627B2 (en) | 2011-05-05 | 2015-02-03 | Wisconsin Alumni Research Foundation | Micelles for the solubilization of gossypol |
GB201111439D0 (en) * | 2011-07-04 | 2011-08-17 | Syngenta Ltd | Formulation |
KR101286854B1 (en) * | 2011-09-29 | 2013-07-17 | 중앙대학교 산학협력단 | BAB tri-block copolymer containing poly(L-lactide) (A) and poly(ethylene glycol) (B), preparation method thereof and drug delivery system using the same |
PT2833869T (en) | 2012-04-04 | 2020-11-25 | Samyang Biopharmaceuticals | Method of preparing composition for delivering an anionic drug |
ES2782507T3 (en) * | 2012-04-23 | 2020-09-15 | Nanoproteagen Ltd | Polymeric nanoparticles and a process for their preparation |
EP2841486B1 (en) | 2012-04-23 | 2020-01-15 | NanoProteagen Ltd. | Polymeric nanoparticles and a process of preparation thereof |
US8633296B1 (en) * | 2012-09-12 | 2014-01-21 | International Business Machines Corporation | Composite hydrogels for delivery of biologically active materials |
US20150174254A1 (en) * | 2013-12-23 | 2015-06-25 | Mcneil-Ppc, Inc. | Topical gel compositions including polycaprolactone polymer and methods for enhancing the topical application of a benefit agent |
CN107072963B (en) | 2014-09-03 | 2020-07-07 | 吉倪塞思公司 | Therapeutic nanoparticles and related compositions, methods and systems |
CN104887627A (en) * | 2015-05-15 | 2015-09-09 | 海南圣欣医药科技有限公司 | Application of copolymer in antitumor drugs |
US20160346219A1 (en) | 2015-06-01 | 2016-12-01 | Autotelic Llc | Phospholipid-coated therapeutic agent nanoparticles and related methods |
KR101726728B1 (en) | 2015-07-28 | 2017-04-14 | 주식회사 삼양바이오팜 | Method for analyzing related substances of a pharmaceutical composition containing a polymeric carrier |
KR101748191B1 (en) | 2015-07-28 | 2017-06-19 | 주식회사 삼양바이오팜 | Pharmaceutical composition with improved storage stability and method for preparing the same |
US20170027866A1 (en) * | 2015-07-29 | 2017-02-02 | Samyang Biopharmaceuticals Corporation | Pharmaceutical composition with improved storage stability and method for preparing the same |
US20170028067A1 (en) * | 2015-07-29 | 2017-02-02 | Samyang Biopharmaceuticals Corporation | Pharmaceutical composition with improved storage stability and method for preparing the same |
US20170028068A1 (en) * | 2015-07-29 | 2017-02-02 | Samyang Biopharmaceuticals Corporation | Pharmaceutical composition with improved storage stability and method for preparing the same |
CN106928461A (en) * | 2015-12-28 | 2017-07-07 | 上海鑫淼医药科技有限公司 | A kind of preparation method and applications of PLA-PEG-PLA dendritics |
CA3017690C (en) | 2016-03-14 | 2024-02-20 | Wisconsin Alumni Research Foundation | Oligolactic acid conjugates and micelles with enhanced anticancer efficacy |
CA3031691A1 (en) | 2016-09-13 | 2018-03-22 | Rasna Research Inc. | Dactinomycin compositions and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
CN107137350A (en) * | 2017-05-02 | 2017-09-08 | 辽宁大学 | A kind of taxol polymer micelle and preparation method thereof |
CN112105390A (en) | 2018-04-02 | 2020-12-18 | 威斯康星校友研究基金会 | Stereocomplex of oligolactic acid conjugates in micelles for improved physical stability and enhanced antitumor efficacy |
CN110917149A (en) * | 2018-12-26 | 2020-03-27 | 银谷制药有限责任公司 | Polymer micelle freeze-drying preparation for encapsulating insoluble antitumor drug |
CN110652595B (en) * | 2019-10-21 | 2022-11-29 | 南通大学附属医院 | Poly leucine-poly aspartic acid segmented copolymer stereo composite drug-loaded micelle and preparation method thereof |
KR102172987B1 (en) | 2019-10-23 | 2020-11-02 | 가톨릭대학교 산학협력단 | folic acid-poly(ε-caprolactone)-folic acid which has folate receptor targeting and endosomolytic activity, and use thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0092918A2 (en) * | 1982-04-22 | 1983-11-02 | Imperial Chemical Industries Plc | Continuous release formulations |
EP0166596A2 (en) * | 1984-06-26 | 1986-01-02 | Imperial Chemical Industries Plc | Biodegradable amphipathic copolymers |
EP0552802A2 (en) * | 1992-01-23 | 1993-07-28 | Eastman Kodak Company | Chemically fixed micelles comprising copolymer |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
WO1995003357A1 (en) * | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Biodegradable particles |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2517760B2 (en) | 1989-05-11 | 1996-07-24 | 新技術事業団 | Water-soluble polymerized pharmaceutical preparation |
FR2678168B1 (en) | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | NANOPARTICLES HAVING CAPTURE TIME BY THE EXTENDED RETICULO ENDOTHELIAL DYSTEM. |
US5518730A (en) * | 1992-06-03 | 1996-05-21 | Fuisz Technologies Ltd. | Biodegradable controlled release flash flow melt-spun delivery system |
KR940003548U (en) | 1992-08-14 | 1994-02-21 | 김형술 | Laundry dryer |
WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
DE69524398T2 (en) | 1994-04-08 | 2002-07-18 | Atrix Lab Inc | LIQUID DELIVERY AGENTS |
US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
-
1995
- 1995-09-21 KR KR1019950030981A patent/KR0180334B1/en active IP Right Grant
-
1996
- 1996-09-21 JP JP51260897A patent/JP3634377B2/en not_active Expired - Lifetime
- 1996-09-21 EP EP96932066A patent/EP0854731B1/en not_active Expired - Lifetime
- 1996-09-21 AU AU70980/96A patent/AU699988B2/en not_active Expired
- 1996-09-21 CA CA002231886A patent/CA2231886C/en not_active Expired - Lifetime
- 1996-09-21 WO PCT/KR1996/000163 patent/WO1997010849A1/en active IP Right Grant
- 1996-09-21 DE DE69625921T patent/DE69625921T2/en not_active Expired - Lifetime
- 1996-09-21 CN CNB961971347A patent/CN1214818C/en not_active Expired - Lifetime
- 1996-09-21 ES ES96932066T patent/ES2188787T3/en not_active Expired - Lifetime
-
1998
- 1998-03-19 MX MX9802156A patent/MX9802156A/en unknown
-
2000
- 2000-04-12 US US09/547,545 patent/US6322805B1/en not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0092918A2 (en) * | 1982-04-22 | 1983-11-02 | Imperial Chemical Industries Plc | Continuous release formulations |
EP0166596A2 (en) * | 1984-06-26 | 1986-01-02 | Imperial Chemical Industries Plc | Biodegradable amphipathic copolymers |
EP0552802A2 (en) * | 1992-01-23 | 1993-07-28 | Eastman Kodak Company | Chemically fixed micelles comprising copolymer |
US5384333A (en) * | 1992-03-17 | 1995-01-24 | University Of Miami | Biodegradable injectable drug delivery polymer |
WO1995003357A1 (en) * | 1993-07-23 | 1995-02-02 | Massachusetts Institute Of Technology | Biodegradable particles |
Cited By (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667048B1 (en) | 1997-01-07 | 2003-12-23 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6982282B2 (en) | 1997-01-07 | 2006-01-03 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6660286B1 (en) | 1997-01-07 | 2003-12-09 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US8853260B2 (en) | 1997-06-27 | 2014-10-07 | Abraxis Bioscience, Llc | Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
EP1024790A1 (en) * | 1997-08-08 | 2000-08-09 | University Of Utah Research Foundation | Injectable biodegradable block copolymer gels for use in drug delivery |
EP1024790A4 (en) * | 1997-08-08 | 2000-10-25 | Univ Utah Res Found | Injectable biodegradable block copolymer gels for use in drug delivery |
EP1034207A1 (en) * | 1997-10-03 | 2000-09-13 | Macromed Inc. | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
JP2002516910A (en) * | 1997-10-03 | 2002-06-11 | マクロメド・インコーポレーテッド | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) -polyethylene glycol copolymer with inverse thermal gelling properties |
JP4656725B2 (en) * | 1997-10-03 | 2011-03-23 | プロセリックス・ソルト・レイク・シティ,インコーポレーテッド | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) -polyethylene glycol copolymer with inverse thermal gelation properties |
JP2010144178A (en) * | 1997-10-03 | 2010-07-01 | Macromed Inc | Biodegradable low molecular weight triblock poly(lactide-co-glycolide)-polyethylene glycol copolymer having reverse thermal gelation property |
EP1034207A4 (en) * | 1997-10-03 | 2002-04-17 | Macromed Inc | BIODEGRADABLE LOW MOLECULAR WEIGHT TRIBLOCK POLY(LACTIDE-co-GLYCOLIDE) POLYETHYLENE GLYCOL COPOLYMERS HAVING REVERSE THERMAL GELATION PROPERTIES |
US6702995B1 (en) | 1997-10-09 | 2004-03-09 | Theryte, Ltd. | Delivery system |
WO1999018998A3 (en) * | 1997-10-09 | 1999-07-22 | Univ Liverpool | Delivery system |
WO1999018998A2 (en) * | 1997-10-09 | 1999-04-22 | Theryte Limited | Delivery system |
JPH11343250A (en) * | 1998-04-02 | 1999-12-14 | Basf Ag | Use of graft copolymer as solubilizing agent, and pharmaceutical preparation, cosmetic preparation and food containing the same |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US10646622B2 (en) | 1998-09-11 | 2020-05-12 | Gerhard Schmidmaier | Biologically active implants |
US6998134B2 (en) | 1998-09-11 | 2006-02-14 | Gerhard Schmidmaier | Biologically active implants |
EP1141079A4 (en) * | 1998-10-01 | 2004-03-24 | Macromed Inc | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
EP1141079A1 (en) * | 1998-10-01 | 2001-10-10 | Macromed Inc. | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
EP1002546A3 (en) * | 1998-11-10 | 2003-07-09 | Basf Aktiengesellschaft | Use of esters or amides of hydroxylated carboxylic acid as solubilizers |
EP1002546A2 (en) * | 1998-11-10 | 2000-05-24 | Basf Aktiengesellschaft | Use of esters or amides of hydroxylated carboxylic acid as solubilizers |
US6365191B1 (en) | 1999-02-17 | 2002-04-02 | Dabur Research Foundation | Formulations of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles, process for preparing same and the use thereof |
KR100360827B1 (en) * | 1999-08-14 | 2002-11-18 | 주식회사 삼양사 | Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof |
WO2001021174A1 (en) * | 1999-09-23 | 2001-03-29 | Dabur Research Foundation | Formulations of paclitaxel entrapped into nanoparticles of polymeric micelles |
WO2001052826A2 (en) * | 2000-01-20 | 2001-07-26 | Supratek Pharma Inc. | Novel podophyllotoxin compositions |
WO2001052826A3 (en) * | 2000-01-20 | 2002-03-14 | Supratek Pharma Inc | Novel podophyllotoxin compositions |
EP1127570A3 (en) * | 2000-02-09 | 2001-09-12 | NanoCarrier Co., Ltd. | Production process for polymeric micelle composition charged therein with drug |
EP1127570A2 (en) * | 2000-02-09 | 2001-08-29 | NanoCarrier Co., Ltd. | Production process for polymeric micelle composition charged therein with drug |
EP1267946A4 (en) * | 2000-02-28 | 2008-07-02 | Genesegues Inc | Nanocapsule encapsulation system and method |
EP1267946A2 (en) * | 2000-02-28 | 2003-01-02 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
EP1280557A4 (en) * | 2000-05-12 | 2009-07-22 | Samyang Corp | Method for the preparation of polymeric micelle via phase separation of block copolymer |
EP1280557A1 (en) * | 2000-05-12 | 2003-02-05 | Samyang Corporation | Method for the preparation of polymeric micelle via phase separation of block copolymer |
EP1282447A4 (en) * | 2000-05-17 | 2005-08-10 | Samyang Corp | Stable polymeric micelle-type drug composition and method for the preparation thereof |
EP1282447A1 (en) * | 2000-05-17 | 2003-02-12 | Samyang Corporation | Stable polymeric micelle-type drug composition and method for the preparation thereof |
CZ302369B6 (en) * | 2000-06-29 | 2011-04-13 | Labopharm, Inc. | Micelle-forming composition |
WO2002000194A2 (en) * | 2000-06-29 | 2002-01-03 | Labopharm, Inc. | Polymeric micelle compositions |
WO2002000194A3 (en) * | 2000-06-29 | 2002-08-08 | Labopharm Inc | Polymeric micelle compositions |
US7141643B2 (en) | 2000-12-06 | 2006-11-28 | Cognis Performance Chemicals Uk Ltd. | Alkylene oxide-lactone copolymers |
AU2002240755B2 (en) * | 2001-03-13 | 2007-07-05 | Angiotech International Ag | Micellar drug delivery vehicles and uses thereof |
US7875677B2 (en) | 2001-04-20 | 2011-01-25 | The University Of British Columbia | Micellar drug delivery systems for hydrophobic drugs |
US7510731B2 (en) | 2001-06-08 | 2009-03-31 | Labopharm Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
WO2003000778A1 (en) * | 2001-06-25 | 2003-01-03 | Samyang Corporation | Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug |
WO2003008480A1 (en) * | 2001-07-14 | 2003-01-30 | Samyang Corporation | Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug |
US7226616B2 (en) | 2001-07-14 | 2007-06-05 | Samyang Corporation | Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug |
AU2002319922B2 (en) * | 2001-07-14 | 2004-12-16 | Samyang Biopharmaceuticals Corporation | Positively charged amphiphilic block copolymer as drug carrier and complex thereof with negatively charged drug |
WO2003017972A2 (en) * | 2001-08-27 | 2003-03-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) |
WO2003017972A3 (en) * | 2001-08-27 | 2003-10-02 | Yissum Res Dev Co | Multi-component polymeric systems with reverse thermal gelation behaviour (e.g. peo-ppo copolymers) |
WO2003028700A3 (en) * | 2001-09-28 | 2004-06-17 | Solubest Ltd | Water soluble nanoparticles of hydrophilic and hydrophobic active materials |
AU2002362475B2 (en) * | 2001-09-28 | 2008-07-10 | Solubest Ltd. | Water soluble nanoparticles of hydrophilic and hydrophobic active materials |
WO2003028700A2 (en) * | 2001-09-28 | 2003-04-10 | Solubest Ltd. | Water soluble nanoparticles of hydrophilic and hydrophobic active materials |
US6878693B2 (en) | 2001-09-28 | 2005-04-12 | Solubest Ltd. | Hydrophilic complexes of lipophilic materials and an apparatus and method for their production |
US7081450B2 (en) | 2001-09-28 | 2006-07-25 | Solubest Ltd. | Water soluble nanoparticles of hydrophilic and hydrophobic active materials and an apparatus and method for their production |
US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
US7897563B2 (en) | 2001-12-21 | 2011-03-01 | Soane Family Trust | Use of oligomers and polymers for drug solubilization, stabilization, and delivery |
EP1465598A1 (en) * | 2001-12-21 | 2004-10-13 | SOANE, David S. | Use of oligomers and polymers for drug solublization, stabilization, and delivery |
EP1465598A4 (en) * | 2001-12-21 | 2006-12-20 | David S Soane | Use of oligomers and polymers for drug solublization, stabilization, and delivery |
WO2003099260A1 (en) * | 2002-05-24 | 2003-12-04 | Nanocarrier Co., Ltd. | Method for preparing polymer micelle pharmaceutical preparation containing drug for injection |
WO2005040247A1 (en) * | 2003-10-24 | 2005-05-06 | Samyang Corporation | Polymeric composition for drug delivery |
JP2010208955A (en) * | 2009-03-06 | 2010-09-24 | Makoto Yuasa | Disease treatment drug |
US8524784B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
US8629186B2 (en) | 2009-04-30 | 2014-01-14 | Intezyne Technologies, Inc. | Polymer micelles containing anthracyclines for the treatment of cancer |
US8524783B2 (en) | 2009-04-30 | 2013-09-03 | Intezyne Technologies, Incorporated | Polymer micelles containing anthracylines for the treatment of cancer |
EP2382966A1 (en) | 2010-03-12 | 2011-11-02 | DSM IP Assets B.V. | Micelle compositions and process for the preparation thereof |
WO2011110694A2 (en) | 2010-03-12 | 2011-09-15 | Dsm Ip Assets B.V. | Micelle compositions and process for the preparation thereof |
WO2011110407A2 (en) | 2010-03-12 | 2011-09-15 | Dsm Ip Assets B.V. | Micelle compositions and process for the preparation thereof |
EP2612656A4 (en) * | 2010-09-02 | 2014-03-12 | Nippon Kayaku Kk | Process for producing drug block-copolymer composite and pharmaceutical product containing same |
EP2612656A1 (en) * | 2010-09-02 | 2013-07-10 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug block-copolymer composite and pharmaceutical product containing same |
US9675521B2 (en) | 2010-09-02 | 2017-06-13 | Nippon Kayaku Kabushiki Kaisha | Process for producing drug-block copolymer composite and pharmaceutical preparation containing same |
EA031522B1 (en) * | 2012-06-27 | 2019-01-31 | Мединселл | Biodegradable drug delivery composition (variants) and method for preparing the biodegradable composition (variants) |
WO2014001904A1 (en) * | 2012-06-27 | 2014-01-03 | Medincell | Biodegradable drug delivery for hydrophobic compositions |
WO2016020547A1 (en) | 2014-08-08 | 2016-02-11 | Dsm Ip Assets B.V. | Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides |
US11253598B2 (en) | 2015-09-15 | 2022-02-22 | Samyang Holdings Corporation | Pharmaceutical composition containing anionic drug, and preparation method therefor |
US11865205B2 (en) | 2015-11-16 | 2024-01-09 | Medincell S.A. | Method for morselizing and/or targeting pharmaceutically active principles to synovial tissue |
WO2018031850A1 (en) * | 2016-08-12 | 2018-02-15 | Purdue Research Foundation | Polymer lung surfactants |
US11497764B2 (en) | 2016-08-12 | 2022-11-15 | Purdue Research Foundation | Polymer lung surfactants |
WO2018227293A1 (en) * | 2017-06-13 | 2018-12-20 | The University Of British Columbia | Polymeric paste compositions for drug delivery |
US11167034B2 (en) | 2017-06-13 | 2021-11-09 | The University Of British Columbia | Polymeric paste compositions for drug delivery |
Also Published As
Publication number | Publication date |
---|---|
US6322805B1 (en) | 2001-11-27 |
CA2231886C (en) | 2002-03-19 |
DE69625921T2 (en) | 2003-08-07 |
AU7098096A (en) | 1997-04-09 |
CA2231886A1 (en) | 1997-03-27 |
JPH10512287A (en) | 1998-11-24 |
CN1214818C (en) | 2005-08-17 |
KR0180334B1 (en) | 1999-03-20 |
JP3634377B2 (en) | 2005-03-30 |
KR970014759A (en) | 1997-04-28 |
AU699988B2 (en) | 1998-12-17 |
CN1197396A (en) | 1998-10-28 |
MX9802156A (en) | 1998-11-30 |
ES2188787T3 (en) | 2003-07-01 |
EP0854731A1 (en) | 1998-07-29 |
DE69625921D1 (en) | 2003-02-27 |
EP0854731B1 (en) | 2003-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0854731B1 (en) | Copolymeric micelle drug composition and method for the preparation thereof | |
KR100360827B1 (en) | Polymeric composition for solubilizing poorly water soluble drugs and process for the preparation thereof | |
AU2001262756B2 (en) | Stable polymeric micelle-type drug composition and method for the preparation thereof | |
JP5981514B2 (en) | Taxane-containing amphiphilic block copolymer micelle composition and production method thereof | |
Kwon | Polymeric micelles for delivery of poorly water-soluble compounds | |
EP1280557B1 (en) | Method for the preparation of polymeric micelle via phase separation of block copolymer | |
WO2009084801A1 (en) | Amphiphilic block copolymer micelle composition containing taxane and manufacturing process of the same | |
EP1539109B1 (en) | Block copolymer micelle composition having an enhanced drug-loading capacity and sustained release | |
EP1633797B1 (en) | Biodegradable branched polylactide derivativescapable of forming polymeric micelles, and their preparation method and use | |
KR100289074B1 (en) | Drug delivery systems as hydrophobic drug carriers | |
WO2005035606A1 (en) | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery | |
Qiu et al. | Constructing doxorubicin-loaded polymeric micelles through amphiphilic graft polyphosphazenes containing ethyl tryptophan and PEG segments | |
Zhao et al. | Star-shaped polycaprolactone-polyethyleneglycol copolymer micelle-like nanoparticles for picropodophyllin delivery |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 96197134.7 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU CA CN JP KP MX NO US VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2231886 Country of ref document: CA Ref document number: 2231886 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1996932066 Country of ref document: EP Ref document number: PA/A/1998/002156 Country of ref document: MX |
|
WWP | Wipo information: published in national office |
Ref document number: 1996932066 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1996932066 Country of ref document: EP |