WO1997010258A3 - Antibodies against epitopes, exposed on surfaces of cancer cells outside desmosomes, of desmosomal cadherines - Google Patents

Antibodies against epitopes, exposed on surfaces of cancer cells outside desmosomes, of desmosomal cadherines Download PDF

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Publication number
WO1997010258A3
WO1997010258A3 PCT/DE1996/001567 DE9601567W WO9710258A3 WO 1997010258 A3 WO1997010258 A3 WO 1997010258A3 DE 9601567 W DE9601567 W DE 9601567W WO 9710258 A3 WO9710258 A3 WO 9710258A3
Authority
WO
WIPO (PCT)
Prior art keywords
cadherines
desmosomal
desmosomes
exposed
antibodies against
Prior art date
Application number
PCT/DE1996/001567
Other languages
German (de)
French (fr)
Other versions
WO1997010258A2 (en
Inventor
Werner Franke
Stephan Schaefer
Original Assignee
Progen Biotechnik Gmbh
Werner Franke
Stephan Schaefer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Progen Biotechnik Gmbh, Werner Franke, Stephan Schaefer filed Critical Progen Biotechnik Gmbh
Priority to EP96943842A priority Critical patent/EP0952987A2/en
Publication of WO1997010258A2 publication Critical patent/WO1997010258A2/en
Publication of WO1997010258A3 publication Critical patent/WO1997010258A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates to antibodies against parts of desmosomal cadherines, wherein the parts are also exposed on the surface of cells not connected by desmosomes. The invention also relates to processes for producing these antibodies and the use thereof.
PCT/DE1996/001567 1995-08-23 1996-08-23 Antibodies against epitopes, exposed on surfaces of cancer cells outside desmosomes, of desmosomal cadherines WO1997010258A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP96943842A EP0952987A2 (en) 1995-08-23 1996-08-23 Antibodies against epitopes, exposed on surfaces of cancer cells outside desmosomes, of desmosomal cadherines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE1995131033 DE19531033C2 (en) 1995-08-23 1995-08-23 Antibodies against epitopes of desmosomal cadherins exposed on surfaces of carcinoma cells outside of desmosomes
DE19531033.0 1995-08-23

Publications (2)

Publication Number Publication Date
WO1997010258A2 WO1997010258A2 (en) 1997-03-20
WO1997010258A3 true WO1997010258A3 (en) 1997-07-24

Family

ID=7770208

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/001567 WO1997010258A2 (en) 1995-08-23 1996-08-23 Antibodies against epitopes, exposed on surfaces of cancer cells outside desmosomes, of desmosomal cadherines

Country Status (3)

Country Link
EP (1) EP0952987A2 (en)
DE (1) DE19531033C2 (en)
WO (1) WO1997010258A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7481999B2 (en) 1998-05-05 2009-01-27 Adherex Technologies, Inc. Compounds and methods for modulating OB-cadherin-mediated function
AU2003298475A1 (en) 2002-11-14 2004-06-18 Adherex Technologies, Inc. Compounds and methods for modulating desmosomal and atypical cadherin-mediated cell adhesion

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
B. PETERS ET AL.: "Maintenance of cell-type-specific cytoskeletal character in epithelial cells out of epithelial context: Cytokeratins and other cytoskeletal proteins in the rests of Malassez of the periodontal ligament.", DIFFERENTIATION, vol. 59, no. 2, September 1995 (1995-09-01), LONDON, GROSSBRITANNIEN, pages 113 - 126, XP000674532 *
J. LORIMER ET AL.: "Cloning, sequence analysis and expression pattern of mouse desmocollin 2 (DSC2), a cadherin-like adhesion molecule.", MOLECULAR MEMBRANE BIOLOGY, vol. 11, no. 4, October 1994 (1994-10-01), WASHINGTON, DC, VSA, pages 229 - 236, XP000674534 *
S. NATSUGOE ET AL.: "Expression of desmoglein I in squamous cell carcinoma of the esophagus.", JOURNAL OF SURGICAL ONCOLOGY, vol. 57, no. 2, October 1994 (1994-10-01), SAN DIEGO, CA, VSA, pages 105 - 110, XP000674529 *
S. SCHÄFER ET AL.: "Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins.", EXPERIMENTAL CELL RESEARCH, vol. 211, no. 2, April 1994 (1994-04-01), NEW YORK, NY, VSA, pages 391 - 399, XP000674513 *
S. SCHÄFER ET AL.: "Immunological identification and characterization of the desmosomal cadherin Dsg2 in coupled and uncoupled epithelial cells and in human tissues.", DIFFERENTIATION, vol. 60, no. 2, May 1996 (1996-05-01), LONDON, GROSSBRITANNIEN, pages 99 - 108, XP000674533 *

Also Published As

Publication number Publication date
DE19531033C2 (en) 1998-01-29
EP0952987A2 (en) 1999-11-03
WO1997010258A2 (en) 1997-03-20
DE19531033A1 (en) 1997-02-27

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