WO1997009430A3 - A human metalloproteinase, variants thereof and dna sequences codding therefor - Google Patents

A human metalloproteinase, variants thereof and dna sequences codding therefor Download PDF

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Publication number
WO1997009430A3
WO1997009430A3 PCT/GB1996/002181 GB9602181W WO9709430A3 WO 1997009430 A3 WO1997009430 A3 WO 1997009430A3 GB 9602181 W GB9602181 W GB 9602181W WO 9709430 A3 WO9709430 A3 WO 9709430A3
Authority
WO
WIPO (PCT)
Prior art keywords
therefor
codding
variants
dna sequences
metalloproteinase
Prior art date
Application number
PCT/GB1996/002181
Other languages
French (fr)
Other versions
WO1997009430A2 (en
Inventor
Andrew James Penrose Docherty
Patrick Marcel Slocombe
Original Assignee
Celltech Therapeutics Ltd
Andrew James Penrose Docherty
Patrick Marcel Slocombe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9518023.8A external-priority patent/GB9518023D0/en
Priority claimed from GBGB9521495.3A external-priority patent/GB9521495D0/en
Priority claimed from GBGB9521498.7A external-priority patent/GB9521498D0/en
Priority claimed from GBGB9526229.1A external-priority patent/GB9526229D0/en
Priority claimed from GBGB9612150.4A external-priority patent/GB9612150D0/en
Application filed by Celltech Therapeutics Ltd, Andrew James Penrose Docherty, Patrick Marcel Slocombe filed Critical Celltech Therapeutics Ltd
Priority to AU68833/96A priority Critical patent/AU6883396A/en
Priority to EP96929420A priority patent/EP0789769A2/en
Priority to US08/836,442 priority patent/US5990293A/en
Publication of WO1997009430A2 publication Critical patent/WO1997009430A2/en
Publication of WO1997009430A3 publication Critical patent/WO1997009430A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

A human metalloproteinase is described together with nucleic acids coding therefor and corresponding antisense DNA and RNA. The metalloproteinase may be used to generate antibodies therefor and to obtain other compounds capable of regulating the action of the metalloproteinase in vivo.
PCT/GB1996/002181 1995-09-05 1996-09-05 A human metalloproteinase, variants thereof and dna sequences codding therefor WO1997009430A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU68833/96A AU6883396A (en) 1995-09-05 1996-09-05 A human metalloproteinase, variants thereof and dna sequences codding therefor
EP96929420A EP0789769A2 (en) 1995-09-05 1996-09-05 A human metalloproteinase, variants thereof and dna sequences codding therefor
US08/836,442 US5990293A (en) 1996-09-05 1996-09-05 Human metalloproteinase, variants thereof and DNA sequence coding therefor

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB9518023.8 1995-09-05
GBGB9518023.8A GB9518023D0 (en) 1995-09-05 1995-09-05 Biological compounds
GBGB9521495.3A GB9521495D0 (en) 1995-10-20 1995-10-20 Biological compounds
GB9521498.7 1995-10-20
GBGB9521498.7A GB9521498D0 (en) 1995-10-20 1995-10-20 Biological compounds
GB9521495.3 1995-10-20
GBGB9526229.1A GB9526229D0 (en) 1995-12-21 1995-12-21 Biological compounds
GB9526229.1 1995-12-21
GBGB9612150.4A GB9612150D0 (en) 1996-06-11 1996-06-11 Biological compounds
GB9612150.4 1996-06-11

Publications (2)

Publication Number Publication Date
WO1997009430A2 WO1997009430A2 (en) 1997-03-13
WO1997009430A3 true WO1997009430A3 (en) 1997-05-01

Family

ID=27517310

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/002181 WO1997009430A2 (en) 1995-09-05 1996-09-05 A human metalloproteinase, variants thereof and dna sequences codding therefor

Country Status (3)

Country Link
EP (1) EP0789769A2 (en)
AU (1) AU6883396A (en)
WO (1) WO1997009430A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2341327A1 (en) 1998-09-03 2000-03-16 Takeda Chemical Industries, Ltd. Novel protein and dna thereof
DE10238298A1 (en) * 2002-08-21 2004-03-04 Beiersdorf Ag Use of antisense oligonucleotides for the treatment of degenerative skin symptoms
WO2008119882A2 (en) * 2007-03-30 2008-10-09 Wallac Oy Screening methods based on human adam12 polypeptide and binding agents thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DOCHERTY, A.J.P. AND MURPHY, G.: "The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins", ANNALS OF THE RHEUMATIC DISEASES, vol. 49, no. 1, June 1990 (1990-06-01), pages 469 - 479, XP000651440 *
DOCHERTY, A.J.P. ET AL.: "The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases", TRENDS IN BIOTECHNOLOGY, vol. 10, no. 6, June 1992 (1992-06-01), pages 200 - 207, XP002027325 *
FREIJE, J.M.P. ET AL.: "Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas", J.BIOL.CHEM., vol. 269, no. 24, June 1994 (1994-06-01), pages 16766 - 16773, XP002027323 *
HITE, L.A. ET AL.: "Sequence of a cDNA clone encoding the zinc metalloproteinase hemorrhagic toxin e from Crotalus atrox: Evidence for signal, zymogen, and disintegrin-like structures", BIOCHEMISTRY, vol. 31, 1992, pages 6203 - 6211, XP000651508 *
PAINE, M.J.I. ET AL.: "Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, Jararhagin, from Bothrops jararaca Venom", J.BIOL.CHEM., vol. 267, no. 32, November 1992 (1992-11-01), pages 22869 - 22876, XP002027322 *
PEI, D. AND WEISS, S.J.: "Furin-dependent intracellular activation of the human stromelysin-3 zymogen", NATURE, vol. 375, May 1995 (1995-05-01), pages 244 - 247, XP002027324 *
SATO, H. ET AL.: "A matrix metalloproteinase expressed on the surface of invasive tumor cells", NATURE, vol. 370, July 1994 (1994-07-01), pages 61 - 65, XP000578393 *

Also Published As

Publication number Publication date
WO1997009430A2 (en) 1997-03-13
AU6883396A (en) 1997-03-27
EP0789769A2 (en) 1997-08-20

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