WO1997008933A3 - Hollow fiber oxygenator - Google Patents

Hollow fiber oxygenator Download PDF

Info

Publication number
WO1997008933A3
WO1997008933A3 PCT/US1996/014148 US9614148W WO9708933A3 WO 1997008933 A3 WO1997008933 A3 WO 1997008933A3 US 9614148 W US9614148 W US 9614148W WO 9708933 A3 WO9708933 A3 WO 9708933A3
Authority
WO
WIPO (PCT)
Prior art keywords
chamber
blood
fibers
caps
hollow fiber
Prior art date
Application number
PCT/US1996/014148
Other languages
French (fr)
Other versions
WO1997008933A2 (en
Inventor
Jose Biscegli
Original Assignee
Baxter Int
Jose Biscegli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Jose Biscegli filed Critical Baxter Int
Priority to JP51134197A priority Critical patent/JP3878675B2/en
Priority to BR9610126-1A priority patent/BR9610126A/en
Priority to AU69646/96A priority patent/AU714100B2/en
Priority to US09/029,646 priority patent/US6004511A/en
Priority to EP96930684A priority patent/EP0847285A2/en
Publication of WO1997008933A2 publication Critical patent/WO1997008933A2/en
Publication of WO1997008933A3 publication Critical patent/WO1997008933A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1698—Blood oxygenators with or without heat-exchangers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1623—Disposition or location of membranes relative to fluids
    • A61M1/1625—Dialyser of the outside perfusion type, i.e. blood flow outside hollow membrane fibres or tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1621—Constructional aspects thereof
    • A61M1/1629—Constructional aspects thereof with integral heat exchanger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3623—Means for actively controlling temperature of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0231—Manufacturing thereof using supporting structures, e.g. filaments for weaving mats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/033—Specific distribution of fibres within one potting or tube-sheet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/04—Hollow fibre modules comprising multiple hollow fibre assemblies
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/22—Cooling or heating elements
    • B01D2313/221—Heat exchangers

Abstract

The present invention relates to a hollow fiber oxygenerator, comprising a housing, comprising a core wall and an outer wall spaced from the core wall thus forming a chamber between the walls, at least one blood inlet to and at least one blood outlet from said chamber, first and second caps closing the chamber at a first and, respectively, a second end thereof, one of the caps having at least one gas inlet, the other having at least one gas outlet associated therewith, selectively permeable continuous hollow fiber filaments extending inside the chamber between the first cap and the second cap, wherein the ends of the fibers are sealed between the core wall and the outer wall at the ends of the chamber spaced from the caps, thus leaving a header space between the sealings and the caps, the ends of the fibers being open, wherein the circumferential angle difference for the fibers between the two sealings is between 0° and 180° and to a method for oxygenating blood, comprising passing a free oxygen containing gas through a plurality of hollow fiber filaments extending principally axially through an oxygenerator chamber and passing blood through the oxygenator chamber, wherein the blood flows primarily axially through the chamber along the plurality of fibers, characterized in that the fibers are arranged in such a way that they cause integrally a helical flow of the blood around the axis of the chamber.
PCT/US1996/014148 1995-09-01 1996-08-29 Hollow fiber oxygenator WO1997008933A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP51134197A JP3878675B2 (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator
BR9610126-1A BR9610126A (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator and blood oxygenation process
AU69646/96A AU714100B2 (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator
US09/029,646 US6004511A (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator
EP96930684A EP0847285A2 (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19532365A DE19532365C2 (en) 1995-09-01 1995-09-01 Hollow fiber oxygenator
DE19532365.3 1995-09-01

Publications (2)

Publication Number Publication Date
WO1997008933A2 WO1997008933A2 (en) 1997-03-13
WO1997008933A3 true WO1997008933A3 (en) 1997-06-05

Family

ID=7771069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/014148 WO1997008933A2 (en) 1995-09-01 1996-08-29 Hollow fiber oxygenator

Country Status (7)

Country Link
EP (1) EP0847285A2 (en)
JP (1) JP3878675B2 (en)
AU (1) AU714100B2 (en)
BR (1) BR9610126A (en)
DE (1) DE19532365C2 (en)
WO (1) WO1997008933A2 (en)
ZA (1) ZA967361B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9910313B1 (en) * 1998-05-08 2008-11-18 combined blood reservoir / heat exchanger.
JP4041254B2 (en) 1999-12-15 2008-01-30 テルモ株式会社 Hollow fiber membrane oxygenator
JP5418275B2 (en) * 2010-02-15 2014-02-19 ニプロ株式会社 Heat exchanger and oxygenator with integrated heat exchanger
JP5418274B2 (en) * 2010-02-15 2014-02-19 ニプロ株式会社 Heat exchanger and oxygenator with integrated heat exchanger
EP2537542B1 (en) * 2010-02-15 2021-04-21 Nipro Corporation Heat exchanger and heat exchanger-integrated in an artificial lung
JP5477034B2 (en) * 2010-02-15 2014-04-23 ニプロ株式会社 Heat exchanger integrated oxygenator
JP5844585B2 (en) * 2011-09-15 2016-01-20 ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ Blood processing unit having a modified flow path
DE102016006013A1 (en) * 2016-05-18 2017-11-23 Xenios Ag System for extracorporeal membrane oxygenation with a blood pump and an oxygenator
DE102016010398A1 (en) * 2016-06-10 2017-12-14 Hemovent Gmbh Gas exchange unit, method for manufacturing a gas exchange unit and set with a gas exchange unit and a humidifying and heating device

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167830A1 (en) * 1972-01-10 1973-08-24 Baxter Laboratories Inc
FR2231421A1 (en) * 1973-05-30 1974-12-27 Rhone Poulenc Sa
FR2266531A1 (en) * 1974-04-04 1975-10-31 Asahi Chemical Ind
FR2374932A1 (en) * 1976-12-24 1978-07-21 Rhone Poulenc Ind HOLLOW FIBER APPARATUS, USABLE IN PARTICULAR AS AN ARTIFICIAL KIDNEY
US4289623A (en) * 1975-11-05 1981-09-15 Extracorporeal Medical Specialties, Inc. Hollow fiber dialysis
EP0093677A1 (en) * 1982-04-27 1983-11-09 Hospal Industrie Hollow fibre apparatus
EP0285812A1 (en) * 1987-03-10 1988-10-12 Akzo Nobel N.V. Multiple layer hollow fibre assembly
JPH01281125A (en) * 1988-04-30 1989-11-13 Daikin Ind Ltd Membrane-type gas separation device
JPH0259016A (en) * 1988-08-25 1990-02-28 Ube Ind Ltd Gas separation membrane module
JPH02102660A (en) * 1988-10-07 1990-04-16 Kuraray Co Ltd Hollow yarn type fluid processor
EP0471921A1 (en) * 1990-08-24 1992-02-26 The Dow Chemical Company Hollow fiber membrane fluid separation device adapted for boreside feed which contains multiple concentric stages
EP0507722A1 (en) * 1991-04-03 1992-10-07 Polystan Holding A/S Hollow fiber blood oxygenator incorporating a heat exchanger
US5217689A (en) * 1989-10-26 1993-06-08 Baxter International Inc. Blood oxygenation system

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3422008A (en) * 1963-10-24 1969-01-14 Dow Chemical Co Wound hollow fiber permeability apparatus and process of making the same
GB1481064A (en) * 1973-08-30 1977-07-27 Teijin Ltd Membrane apparatus for treating fluids
US4031012A (en) * 1975-09-17 1977-06-21 Gics Pharmaceuticals, Inc. Separatory apparatus
DE2646358C2 (en) * 1976-10-14 1982-05-13 Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG Apparatebau KG, 6380 Bad Homburg Hollow fiber dialyzer
US4239729A (en) * 1978-06-06 1980-12-16 Terumo Corporation Oxygenator
AU565652B2 (en) * 1982-02-19 1987-09-24 Dow Chemical Company, The Hollow fibre oxygenator element
CA1267339A (en) * 1985-01-08 1990-04-03 Anthony Badolato Mass transfer device having a microporous, spirally wound hollow fiber membrane
US5217698A (en) * 1986-02-06 1993-06-08 Steris Corporation Office size instrument sterilization system

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2167830A1 (en) * 1972-01-10 1973-08-24 Baxter Laboratories Inc
FR2231421A1 (en) * 1973-05-30 1974-12-27 Rhone Poulenc Sa
FR2266531A1 (en) * 1974-04-04 1975-10-31 Asahi Chemical Ind
US4289623A (en) * 1975-11-05 1981-09-15 Extracorporeal Medical Specialties, Inc. Hollow fiber dialysis
FR2374932A1 (en) * 1976-12-24 1978-07-21 Rhone Poulenc Ind HOLLOW FIBER APPARATUS, USABLE IN PARTICULAR AS AN ARTIFICIAL KIDNEY
EP0093677A1 (en) * 1982-04-27 1983-11-09 Hospal Industrie Hollow fibre apparatus
EP0285812A1 (en) * 1987-03-10 1988-10-12 Akzo Nobel N.V. Multiple layer hollow fibre assembly
JPH01281125A (en) * 1988-04-30 1989-11-13 Daikin Ind Ltd Membrane-type gas separation device
JPH0259016A (en) * 1988-08-25 1990-02-28 Ube Ind Ltd Gas separation membrane module
JPH02102660A (en) * 1988-10-07 1990-04-16 Kuraray Co Ltd Hollow yarn type fluid processor
US5217689A (en) * 1989-10-26 1993-06-08 Baxter International Inc. Blood oxygenation system
EP0471921A1 (en) * 1990-08-24 1992-02-26 The Dow Chemical Company Hollow fiber membrane fluid separation device adapted for boreside feed which contains multiple concentric stages
EP0507722A1 (en) * 1991-04-03 1992-10-07 Polystan Holding A/S Hollow fiber blood oxygenator incorporating a heat exchanger

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8951, Derwent World Patents Index; Class E36, AN 89-374632 *
DATABASE WPI Section Ch Week 9015, Derwent World Patents Index; Class J01, AN 90-110178 *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 053 (C - 0683) 31 January 1990 (1990-01-31) *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 232 (C - 0719) 17 May 1990 (1990-05-17) *
PATENT ABSTRACTS OF JAPAN vol. 014, no. 306 (C - 0735) 3 July 1990 (1990-07-03) *

Also Published As

Publication number Publication date
JP2001507245A (en) 2001-06-05
AU714100B2 (en) 1999-12-16
ZA967361B (en) 1997-09-16
EP0847285A2 (en) 1998-06-17
DE19532365A1 (en) 1997-03-06
DE19532365C2 (en) 1998-12-17
BR9610126A (en) 1999-12-07
WO1997008933A2 (en) 1997-03-13
AU6964696A (en) 1997-03-27
JP3878675B2 (en) 2007-02-07

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