WO1997008309A3 - Ribozyme therapy for hepatitis b infections - Google Patents

Ribozyme therapy for hepatitis b infections Download PDF

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Publication number
WO1997008309A3
WO1997008309A3 PCT/US1996/013975 US9613975W WO9708309A3 WO 1997008309 A3 WO1997008309 A3 WO 1997008309A3 US 9613975 W US9613975 W US 9613975W WO 9708309 A3 WO9708309 A3 WO 9708309A3
Authority
WO
WIPO (PCT)
Prior art keywords
hepatitis
infections
hbv
infection
methods
Prior art date
Application number
PCT/US1996/013975
Other languages
French (fr)
Other versions
WO1997008309A2 (en
WO1997008309A9 (en
Inventor
Tsvi Goldenberg
Mang Yu
Peter J Welch
Jack R Barber
Original Assignee
Immusol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immusol Inc filed Critical Immusol Inc
Publication of WO1997008309A2 publication Critical patent/WO1997008309A2/en
Publication of WO1997008309A3 publication Critical patent/WO1997008309A3/en
Publication of WO1997008309A9 publication Critical patent/WO1997008309A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/122—Hairpin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention provides ribozymes useful to treat or prevent Hepatitis B Virus ('HBV') infection in an organism or subject, as well as methods of treating an HBV infection. Reagents such as vectors, host cells, DNA molecules coding for these ribozymes useful in methods of treatment and prevention of HBV infection also are provided.
PCT/US1996/013975 1995-08-29 1996-08-29 Ribozyme therapy for hepatitis b infections WO1997008309A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52125595A 1995-08-29 1995-08-29
US08/521,255 1995-08-29

Publications (3)

Publication Number Publication Date
WO1997008309A2 WO1997008309A2 (en) 1997-03-06
WO1997008309A3 true WO1997008309A3 (en) 1997-07-10
WO1997008309A9 WO1997008309A9 (en) 1997-08-14

Family

ID=24076029

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/013975 WO1997008309A2 (en) 1995-08-29 1996-08-29 Ribozyme therapy for hepatitis b infections

Country Status (1)

Country Link
WO (1) WO1997008309A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0522578D0 (en) * 2005-11-04 2005-12-14 King S College London Ribozymal nucleic acid

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304578A1 (en) * 1987-06-22 1989-03-01 Medeva Holdings B.V. Peptide comprising hepatitis B surface antigen
WO1995022600A1 (en) * 1994-02-22 1995-08-24 Immusol, Inc. Ribozyme therapy for hepatitis b infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0304578A1 (en) * 1987-06-22 1989-03-01 Medeva Holdings B.V. Peptide comprising hepatitis B surface antigen
WO1995022600A1 (en) * 1994-02-22 1995-08-24 Immusol, Inc. Ribozyme therapy for hepatitis b infection

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BECK, J. AND NASSAL, M.: "Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells", NUCLEIC ACIDS RESEARCH, vol. 23, no. 24, 1995, pages 4954 - 4962, XP002029174 *
GEORG, S.T. ET AL.: "Ribozyme-mediated cleavage of hepatitis B virus surface antigen mRNA", ANTIVIRAL RESEARCH, vol. 20, no. supp.1, 1993, pages 165, XP000652951 *
KIJIMA, H. ET AL.: "Therapeutic applications of ribozymes", PHARMACEUTICAL THER., vol. 68, no. 2, 1995, pages 247 - 267, XP000612090 *
WANG, P. ET AL.: "Effects of ribozyme on HBV in vitro and in HepG2 cell", FASEB JOURNAL, vol. 7, no. 7, 1993, pages a1301, XP002029175 *
YU, M. ET AL.: "In vitro and in vivo characterization of a second functional hairpin ribozyme against HIV-1", VIROLOGY, vol. 206, 1995, pages 381-386, XP000652043 *

Also Published As

Publication number Publication date
WO1997008309A2 (en) 1997-03-06

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