WO1997007209A3 - Receptor - Google Patents

Receptor Download PDF

Info

Publication number
WO1997007209A3
WO1997007209A3 PCT/GB1996/001980 GB9601980W WO9707209A3 WO 1997007209 A3 WO1997007209 A3 WO 1997007209A3 GB 9601980 W GB9601980 W GB 9601980W WO 9707209 A3 WO9707209 A3 WO 9707209A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
chemical
repeats
cadherin
screening
Prior art date
Application number
PCT/GB1996/001980
Other languages
French (fr)
Other versions
WO1997007209A2 (en
Inventor
Peter Little
Anna-Katerina Hadjantonakis
Original Assignee
Imperial College
Peter Little
Hadjantonakis Anna Katerina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial College, Peter Little, Hadjantonakis Anna Katerina filed Critical Imperial College
Priority to AU67481/96A priority Critical patent/AU6748196A/en
Publication of WO1997007209A2 publication Critical patent/WO1997007209A2/en
Publication of WO1997007209A3 publication Critical patent/WO1997007209A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

A method of screening a chemical for subsequent use as a pharmaceutical agent. The method comprises contacting the chemical with a receptor; and determining whether the chemical interacts with the receptor to form a chemical-receptor complex; wherein the receptor comprises EGF-like repeats and/or cadherin-like repeats.
PCT/GB1996/001980 1995-08-21 1996-08-14 Receptor WO1997007209A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU67481/96A AU6748196A (en) 1995-08-21 1996-08-14 Receptor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9517098.1A GB9517098D0 (en) 1995-08-21 1995-08-21 Receptor
GB9517098.1 1995-08-21

Publications (2)

Publication Number Publication Date
WO1997007209A2 WO1997007209A2 (en) 1997-02-27
WO1997007209A3 true WO1997007209A3 (en) 1997-05-15

Family

ID=10779538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1996/001980 WO1997007209A2 (en) 1995-08-21 1996-08-14 Receptor

Country Status (3)

Country Link
AU (1) AU6748196A (en)
GB (1) GB9517098D0 (en)
WO (1) WO1997007209A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7122623B2 (en) 1996-07-12 2006-10-17 Adherex Technologies, Inc. Compounds and methods for modulating cell adhesion
US6417325B1 (en) 1996-07-12 2002-07-09 Mcgill University Compounds and methods for cancer therapy
US6346512B1 (en) 1996-07-12 2002-02-12 Mcgill University Compounds and methods for modulating cell adhesion
US6207639B1 (en) 1996-07-12 2001-03-27 Mcgill University Compounds and methods for modulating neurite outgrowth
US6465427B1 (en) 1996-07-12 2002-10-15 Mcgill University Compounds and methods for modulating cell adhesion
ES2297861T3 (en) * 1996-07-12 2008-05-01 Mcgill University COMPOUNDS AND METHODS TO MODULATE CELL ADHESION.
US6333307B1 (en) 1996-07-12 2001-12-25 Mcgill University Compounds and method for modulating neurite outgrowth
US6562786B1 (en) 1996-07-12 2003-05-13 Mcgill University Compounds and methods for modulating apoptosis
US6169071B1 (en) 1996-07-12 2001-01-02 Mcgill University Compounds and methods for modulating cell adhesion
US6610821B1 (en) 1996-07-12 2003-08-26 Mcgill University Compounds and methods for modulating endothelial cell adhesion
US6203788B1 (en) 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
GB9725462D0 (en) * 1997-12-01 1998-01-28 Smithkline Beecham Plc Novel method
US6479256B1 (en) * 1998-03-04 2002-11-12 Icos Corporation Lectomedin materials and methods
US6277824B1 (en) 1998-07-10 2001-08-21 Adherex Technologies Compounds and methods for modulating adhesion molecule function

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013152A1 (en) * 1990-02-27 1991-09-05 Ludwig Institute For Cancer Research SUBSTANTIALLY PURE TRANSFORMING GROWTH FACTOR-β1-BINDING PROTEIN AND NUCLEOTIDE SEQUENCES EXPRESSING THE BINDING PROTEIN
WO1994000469A1 (en) * 1992-06-26 1994-01-06 Immunex Corporation Novel tyrosine kinase
WO1994010197A1 (en) * 1992-10-30 1994-05-11 Ludwig Institute For Cancer Research A novel protein tyrosine kinase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013152A1 (en) * 1990-02-27 1991-09-05 Ludwig Institute For Cancer Research SUBSTANTIALLY PURE TRANSFORMING GROWTH FACTOR-β1-BINDING PROTEIN AND NUCLEOTIDE SEQUENCES EXPRESSING THE BINDING PROTEIN
WO1994000469A1 (en) * 1992-06-26 1994-01-06 Immunex Corporation Novel tyrosine kinase
WO1994010197A1 (en) * 1992-10-30 1994-05-11 Ludwig Institute For Cancer Research A novel protein tyrosine kinase

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KATERINA HADJANTONAKIS ET AL.: "ME2: a novel receptor expressed in the mouse embryo", GENETICAL RESEARCH, vol. 68, no. 1, August 1996 (1996-08-01), pages 87 - 88, XP000610581 *
KEI-ICHI KUMA ET AL.: "Motifs of cadherin- and fibronectin type III-related sequences and evolution of the receptor-type protein tyrosine kinases: sequence similarity between proto-oncogene ret and cadherin family", MOLECULAR BIOLOGY AND EVOLUTION, vol. 10, no. 3, May 1993 (1993-05-01), pages 539 - 551, XP000610570 *

Also Published As

Publication number Publication date
WO1997007209A2 (en) 1997-02-27
AU6748196A (en) 1997-03-12
GB9517098D0 (en) 1995-10-25

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