WO1997004756A3 - Methacrylate backbone surfactants in nanoparticulate formulations - Google Patents

Methacrylate backbone surfactants in nanoparticulate formulations Download PDF

Info

Publication number
WO1997004756A3
WO1997004756A3 PCT/US1996/011777 US9611777W WO9704756A3 WO 1997004756 A3 WO1997004756 A3 WO 1997004756A3 US 9611777 W US9611777 W US 9611777W WO 9704756 A3 WO9704756 A3 WO 9704756A3
Authority
WO
WIPO (PCT)
Prior art keywords
surfactants
nanoparticulate formulations
methacrylate backbone
methacrylate
drug substance
Prior art date
Application number
PCT/US1996/011777
Other languages
French (fr)
Other versions
WO1997004756A2 (en
Inventor
Sui-Ming Wong
Original Assignee
Nanosystems Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanosystems Llc filed Critical Nanosystems Llc
Priority to AU65464/96A priority Critical patent/AU6546496A/en
Publication of WO1997004756A2 publication Critical patent/WO1997004756A2/en
Publication of WO1997004756A3 publication Critical patent/WO1997004756A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A61K49/049—Surface-modified nanoparticles, e.g. immune-nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Nanoparticles having an effective average particle size diameter of less than 100 nm comprising a crystalline organic drug substance and a copolymer of methoxypolyethyleneglycol-methacrylate-methoxymethacrylate adsorbed on the surface of the crystalline organic drug substance.
PCT/US1996/011777 1995-07-26 1996-07-16 Methacrylate backbone surfactants in nanoparticulate formulations WO1997004756A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU65464/96A AU6546496A (en) 1995-07-26 1996-07-16 Methacrylate backbone surfactants in nanoparticulate formulations

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
USNOTFURNISHED 1989-09-22
US198595P 1995-07-26 1995-07-26
US60/001,985 1995-07-26

Publications (2)

Publication Number Publication Date
WO1997004756A2 WO1997004756A2 (en) 1997-02-13
WO1997004756A3 true WO1997004756A3 (en) 1997-03-27

Family

ID=21698707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/011777 WO1997004756A2 (en) 1995-07-26 1996-07-16 Methacrylate backbone surfactants in nanoparticulate formulations

Country Status (2)

Country Link
AU (1) AU6546496A (en)
WO (1) WO1997004756A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19911041A1 (en) * 1999-03-12 2000-09-14 Henkel Kgaa Flexible and absorbent carriers for treating the skin equipped with nanoparticle dispersions
US6878693B2 (en) 2001-09-28 2005-04-12 Solubest Ltd. Hydrophilic complexes of lipophilic materials and an apparatus and method for their production
JP2005507393A (en) * 2001-09-28 2005-03-17 ソルベスト リミテッド Water-soluble nanoparticles of hydrophilic and hydrophobic active substances
GB0216700D0 (en) 2002-07-18 2002-08-28 Astrazeneca Ab Process
GB0302673D0 (en) 2003-02-06 2003-03-12 Astrazeneca Ab Pharmaceutical formulations
US7217759B2 (en) * 2003-05-20 2007-05-15 Arch Uk Biocides Limited Composition and use
US7226968B2 (en) * 2003-05-20 2007-06-05 Arch Uk Biocides Limited Composition and use
WO2005030257A2 (en) * 2003-09-30 2005-04-07 Solubest Ltd. Water soluble nanoparticles inclusion complexes
US7846412B2 (en) * 2003-12-22 2010-12-07 Emory University Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof
GB0516549D0 (en) 2005-08-12 2005-09-21 Sulaiman Brian Milling system
US8236913B2 (en) 2006-12-07 2012-08-07 Toyo Boseki Kabushiki Kaisha (Meth)acrylate copolymer, a method for producing the same and a medical device
WO2024104274A1 (en) * 2022-11-14 2024-05-23 浙江省化工研究院有限公司 Surfactant, preparation method therefor and use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
EP0577215A1 (en) * 1992-07-01 1994-01-05 NanoSystems L.L.C. Surface modified anticancer nanoparticles
EP0601619A2 (en) * 1992-12-04 1994-06-15 NanoSystems L.L.C. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
EP0577215A1 (en) * 1992-07-01 1994-01-05 NanoSystems L.L.C. Surface modified anticancer nanoparticles
EP0601619A2 (en) * 1992-12-04 1994-06-15 NanoSystems L.L.C. Use of non-ionic cloud point modifiers to minimize nanoparticle aggregation during sterilization

Also Published As

Publication number Publication date
AU6546496A (en) 1997-02-26
WO1997004756A2 (en) 1997-02-13

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