WO1997003700A3 - Agent modulateur de l'activite de l'interferon-gamma - Google Patents
Agent modulateur de l'activite de l'interferon-gamma Download PDFInfo
- Publication number
- WO1997003700A3 WO1997003700A3 PCT/FR1996/001141 FR9601141W WO9703700A3 WO 1997003700 A3 WO1997003700 A3 WO 1997003700A3 FR 9601141 W FR9601141 W FR 9601141W WO 9703700 A3 WO9703700 A3 WO 9703700A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- interferon
- modulating agent
- gamma
- formula
- interferon activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Utilisation, dans la préparation d'un médicament modulateur de l'activité de l'interféron-η, d'un agent modulateur comprenant un groupement de formule A-X-B, dans laquelle A et B représentent indépendamment un groupe oligosaccharidique portant une charge anionique suffisante pour conférer audit groupe oligosaccharidique une affinité pour une partie de l'extrémité C-terminale de l'interféron-η humain contenant la séquence peptidique 125-131, et X est un bras espaceur de longueur suffisante pour permettre aux groupes A et B de se lier chacun à l'une desdites séquences peptidiques des extrémités C-terminales d'un homodimère d'interféron-η. Cet agent modulateur permet notamment de retarder la dégradation de l'interféron-η, de favoriser son activation, de permettre son action par voie générale et non simplement locale. Il permet également de modifier ou d'inhiber l'action locale de l'interféron-η endogène.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9508723A FR2736832B1 (fr) | 1995-07-19 | 1995-07-19 | Agent potentialisateur de l'interferon-gamma |
FR95/08723 | 1995-07-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1997003700A2 WO1997003700A2 (fr) | 1997-02-06 |
WO1997003700A3 true WO1997003700A3 (fr) | 1997-03-20 |
WO1997003700B1 WO1997003700B1 (fr) | 1997-05-09 |
Family
ID=9481130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1996/001141 WO1997003700A2 (fr) | 1995-07-19 | 1996-07-19 | Agent modulateur de l'activite de l'interferon-gamma |
Country Status (2)
Country | Link |
---|---|
FR (1) | FR2736832B1 (fr) |
WO (1) | WO1997003700A2 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2841250B1 (fr) * | 2002-06-19 | 2004-07-23 | Commissariat Energie Atomique | Composes se liant a l'interferon-gamma, leur procede de preparation, et medicaments les contenant |
-
1995
- 1995-07-19 FR FR9508723A patent/FR2736832B1/fr not_active Expired - Fee Related
-
1996
- 1996-07-19 WO PCT/FR1996/001141 patent/WO1997003700A2/fr active Application Filing
Non-Patent Citations (12)
Also Published As
Publication number | Publication date |
---|---|
FR2736832B1 (fr) | 1997-09-19 |
FR2736832A1 (fr) | 1997-01-24 |
WO1997003700A2 (fr) | 1997-02-06 |
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DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
122 | Ep: pct application non-entry in european phase |