WO1996040262A3 - Process for preparing encapsulated water soluble beta-carotene - Google Patents

Process for preparing encapsulated water soluble beta-carotene Download PDF

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Publication number
WO1996040262A3
WO1996040262A3 PCT/US1996/006981 US9606981W WO9640262A3 WO 1996040262 A3 WO1996040262 A3 WO 1996040262A3 US 9606981 W US9606981 W US 9606981W WO 9640262 A3 WO9640262 A3 WO 9640262A3
Authority
WO
WIPO (PCT)
Prior art keywords
carotene
beta
solution
water soluble
soluble beta
Prior art date
Application number
PCT/US1996/006981
Other languages
French (fr)
Other versions
WO1996040262A2 (en
Inventor
Nancy Elaine Fortier
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of WO1996040262A2 publication Critical patent/WO1996040262A2/en
Publication of WO1996040262A3 publication Critical patent/WO1996040262A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/035—Halogenated hydrocarbons having aliphatic unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for preparing a powdered water soluble beta-carotene is disclosed. The carotenoid composition is prepared by combining an aqueous solution of cyclodextrin or derivatized cyclodextrins, and a solution of beta-carotene, beta-carotene derivatives or mixtures thereof, dissolved in an organic solvent. The beta-carotene solution is added to the cyclodextrin solution with stirring for a time sufficient to remove the organic solvent. Excess beta-carotene is removed and the remaining solution is evaporated to dryness.
PCT/US1996/006981 1995-06-07 1996-05-16 Process for preparing encapsulated water soluble beta-carotene WO1996040262A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48532895A 1995-06-07 1995-06-07
US08/485,328 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040262A2 WO1996040262A2 (en) 1996-12-19
WO1996040262A3 true WO1996040262A3 (en) 1997-05-22

Family

ID=23927734

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/006981 WO1996040262A2 (en) 1995-06-07 1996-05-16 Process for preparing encapsulated water soluble beta-carotene

Country Status (1)

Country Link
WO (1) WO1996040262A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007856A (en) * 1997-08-08 1999-12-28 The Procter & Gamble Company Oil-in-water dispersions of β-carotene and other carotenoids stable against oxidation prepared from water-dispersible beadlets having high concentrations of carotenoid
CN1232539C (en) * 2002-05-10 2005-12-21 刘云清 Match of organic medicine and beta-cyclodextrin derivative and its preparing process
WO2004005353A1 (en) * 2002-07-04 2004-01-15 Poltec As Complexes of cyclodextrins and carotenoids
US7781572B2 (en) 2005-10-05 2010-08-24 Nse Products, Inc. Nanosized carotenoid cyclodextrin complexes
CN111973484A (en) 2013-03-12 2020-11-24 普莱玛疗法公司 Dental compositions comprising chelating agents and bases

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073931A (en) * 1974-03-27 1978-02-14 Teijin Limited Nitroglycerine inclusion compounds with cyclodextrin and composition containing same
DE2746087A1 (en) * 1977-10-13 1979-04-26 Chinoin Gyogyszer Es Vegyeszet CYCLODEXTRIN INCLUSION COMPLEX WITH INDOMETHACIN, METHOD FOR THEIR MANUFACTURING AND PHARMACEUTICAL AGENTS
US4826963A (en) * 1985-09-10 1989-05-02 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara, R.T. Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredient
FR2681868A1 (en) * 1991-09-30 1993-04-02 Sederma Sa New amphiphilic substances derived from cyclodextrins and their use in cosmetic compositions
WO1996039870A1 (en) * 1995-06-07 1996-12-19 The Procter & Gamble Company Fat substitutes containing water soluble beta-caroten

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073931A (en) * 1974-03-27 1978-02-14 Teijin Limited Nitroglycerine inclusion compounds with cyclodextrin and composition containing same
DE2746087A1 (en) * 1977-10-13 1979-04-26 Chinoin Gyogyszer Es Vegyeszet CYCLODEXTRIN INCLUSION COMPLEX WITH INDOMETHACIN, METHOD FOR THEIR MANUFACTURING AND PHARMACEUTICAL AGENTS
US4826963A (en) * 1985-09-10 1989-05-02 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara, R.T. Inclusion complex of 7-isopropoxy-isoflavon formed with cyclodextrin, the preparation thereof and pharmaceutical compositions containing these compounds as active ingredient
FR2681868A1 (en) * 1991-09-30 1993-04-02 Sederma Sa New amphiphilic substances derived from cyclodextrins and their use in cosmetic compositions
WO1996039870A1 (en) * 1995-06-07 1996-12-19 The Procter & Gamble Company Fat substitutes containing water soluble beta-caroten

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHUEV, V. P. ET AL: "Use of mechanochemical activation to modify properties of bioactive compounds", SIB. KHIM. ZH., NO. 5, PAGE(S) 156-7, 1991, XP002028417 *
SELVA, ANTONIO ET AL: "Detection of the inclusion complexes of ß-carotene with cyclodextrins by electrospray mass spectrometry", EUR. MASS SPECTROM., VOL. 1, NO. 2, PAGE(S) 215-16, 1995, XP000646347 *
SZENTE, L. ET AL: "Solubilization of fatty acids and similar lipids by methylated cyclodextrins", MINUTES INT. SYMP. CYCLODEXTRINS, 6TH,, 1992, pages 340 - 344, XP000646349 *
YAKUSHINA L M ET AL: "Study of bioavailability and pharmacodynamics of various forms of artificial ß-carotene in volunteers.", VOPROSY MEDITSINSKOI KHIMII, VOL. 41, NO. 4, PUBL. 1995, PAGE(S) 36-41., XP000647663 *

Also Published As

Publication number Publication date
WO1996040262A2 (en) 1996-12-19

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