WO1996039487A1 - Chemically defined medium for human mesenchymal stem cells - Google Patents
Chemically defined medium for human mesenchymal stem cells Download PDFInfo
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- WO1996039487A1 WO1996039487A1 PCT/US1996/008405 US9608405W WO9639487A1 WO 1996039487 A1 WO1996039487 A1 WO 1996039487A1 US 9608405 W US9608405 W US 9608405W WO 9639487 A1 WO9639487 A1 WO 9639487A1
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- insulin
- composition
- serum
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- growth factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/36—Lipids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/105—Insulin-like growth factors [IGF]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/135—Platelet-derived growth factor [PDGF]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/80—Neurotransmitters; Neurohormones
- C12N2501/825—Serotonine (5-HT); Melatonine
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- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU59692/96A AU5969296A (en) | 1995-06-05 | 1996-06-03 | Chemically defined medium for human mesenchymal stem cells |
EP96916987A EP0832188A4 (en) | 1995-06-05 | 1996-06-03 | Chemically defined medium for human mesenchymal stem cells |
JP9501017A JPH11506610A (en) | 1995-06-05 | 1996-06-03 | Synthetic medium for human mesenchymal stem cells |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/464,599 US5908782A (en) | 1995-06-05 | 1995-06-05 | Chemically defined medium for human mesenchymal stem cells |
US08/464,599 | 1995-06-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996039487A1 true WO1996039487A1 (en) | 1996-12-12 |
Family
ID=23844553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/008405 WO1996039487A1 (en) | 1995-06-05 | 1996-06-03 | Chemically defined medium for human mesenchymal stem cells |
Country Status (6)
Country | Link |
---|---|
US (1) | US5908782A (en) |
EP (1) | EP0832188A4 (en) |
JP (1) | JPH11506610A (en) |
AU (1) | AU5969296A (en) |
CA (1) | CA2223582A1 (en) |
WO (1) | WO1996039487A1 (en) |
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EP0948255A1 (en) * | 1996-12-06 | 1999-10-13 | Osiris Therapeutics, Inc. | Improved chondrogenic differentiation of human mesenchymal stem cells |
WO2000027996A1 (en) * | 1998-11-09 | 2000-05-18 | Consorzio Per La Gestione Del Centro Di Biotecnologie Avanzate | Serum free medium for chondrocyte-like cells |
US6733746B2 (en) | 1996-03-12 | 2004-05-11 | Invitrogen Corporation | Hematopoietic cell culture nutrient supplement |
WO2004052177A2 (en) | 2002-12-05 | 2004-06-24 | Case Western Reserve University | Cell-based therapies for ischemia |
EP1478734A2 (en) * | 2002-01-25 | 2004-11-24 | Genzyme Corporation | Serum-free media for chondrocytes and methods of use thereof |
EP1629089A1 (en) * | 2003-06-03 | 2006-03-01 | Organ Recovery Systems, Inc. | Selection and propagation of progenitor cells |
WO2008002914A3 (en) * | 2006-06-26 | 2008-04-10 | Gambro Bct Inc | Method of culturing mesenchymal stem cells |
WO2009084662A1 (en) * | 2007-12-28 | 2009-07-09 | Fujirebio Inc. | Medium for mammalian somatic cells and additive therefor |
WO2011069091A1 (en) | 2009-12-04 | 2011-06-09 | Boston Biomedical Research Institute, Inc. | Method for cloning pluripotent stem cells |
WO2011159797A2 (en) | 2010-06-15 | 2011-12-22 | Cellular Dynamics International, Inc. | A compendium of ready-built stem cell models for interrogation of biological response |
WO2012006440A2 (en) | 2010-07-07 | 2012-01-12 | Cellular Dynamics International, Inc. | Endothelial cell production by programming |
US8198084B2 (en) | 1996-08-30 | 2012-06-12 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
WO2012109208A2 (en) | 2011-02-08 | 2012-08-16 | Cellular Dynamics International, Inc. | Hematopoietic precursor cell production by programming |
WO2014130770A1 (en) | 2013-02-22 | 2014-08-28 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
WO2014132137A2 (en) | 2013-03-01 | 2014-09-04 | Université De Genève | Transgenic cell selection |
WO2015164228A1 (en) | 2014-04-21 | 2015-10-29 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
US9623048B2 (en) | 2013-02-08 | 2017-04-18 | Shanghai Institutes For Biological Sciences, Chinese Academy Of Sciences | Human hepatocyte-like cells and uses thereof |
WO2017070337A1 (en) | 2015-10-20 | 2017-04-27 | Cellular Dynamics International, Inc. | Methods for directed differentiation of pluripotent stem cells to immune cells |
WO2017070145A1 (en) | 2015-10-19 | 2017-04-27 | Cellular Dynamics International, Inc. | Production of virus-receptive pluripotent stem cell (psc)-derived hepatocytes |
WO2017079215A1 (en) | 2015-11-03 | 2017-05-11 | Glycomimetics, Inc. | Methods and compositions for the production of monoclonal antibodies, hematopoietic stem cells, and methods of using the same |
WO2018067836A1 (en) | 2016-10-05 | 2018-04-12 | Cellular Dynamics International, Inc. | Methods for directed differentiation of pluripotent stem cells to hla homozygous immune cells |
WO2018067826A1 (en) | 2016-10-05 | 2018-04-12 | Cellular Dynamics International, Inc. | Generating mature lineages from induced pluripotent stem cells with mecp2 disruption |
WO2018195175A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
WO2019186274A2 (en) | 2018-03-30 | 2019-10-03 | University Of Geneva | Micro rna expression constructs and uses thereof |
US10472605B2 (en) | 2014-02-14 | 2019-11-12 | National University Of Ireland, Galway | Serum-free medium |
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US20110091428A1 (en) * | 2000-07-31 | 2011-04-21 | New York Medical College | Compositions of adult organ stem cells and uses thereof |
US7862810B2 (en) * | 2000-07-31 | 2011-01-04 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
US20020098167A1 (en) * | 2000-07-31 | 2002-07-25 | Piero Anversa | Methods and compositions for the repair and/or regeneration of damaged myocardium |
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US20100028307A1 (en) * | 2008-07-31 | 2010-02-04 | O'neil John J | Pluripotent stem cell differentiation |
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Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444778A (en) * | 1981-08-27 | 1984-04-24 | Coughlin Shaun R | Method and composition for treating atherosclerosis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO162160C (en) * | 1987-01-09 | 1989-11-15 | Medi Cult As | SERUM-FREE GROWTH MEDIUM AND USE THEREOF. |
US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
-
1995
- 1995-06-05 US US08/464,599 patent/US5908782A/en not_active Expired - Lifetime
-
1996
- 1996-06-03 JP JP9501017A patent/JPH11506610A/en not_active Ceased
- 1996-06-03 CA CA002223582A patent/CA2223582A1/en not_active Abandoned
- 1996-06-03 AU AU59692/96A patent/AU5969296A/en not_active Abandoned
- 1996-06-03 WO PCT/US1996/008405 patent/WO1996039487A1/en not_active Application Discontinuation
- 1996-06-03 EP EP96916987A patent/EP0832188A4/en not_active Withdrawn
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4444778A (en) * | 1981-08-27 | 1984-04-24 | Coughlin Shaun R | Method and composition for treating atherosclerosis |
Non-Patent Citations (4)
Title |
---|
BROWER M, ET AL.: "GROWTH OF CELL LINES AND CLINICAL SPECIMENS OF HUMAN NON-SMALL CELL LUNG CANCER IN A SERUM-FREE DEFINED MEDIUM", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 46, no. 01, 1 February 1986 (1986-02-01), US, pages 798 - 806, XP002948928, ISSN: 0008-5472 * |
JESSOP H L, NOBLE B S, CRYER A: "THE DIFFERENTITATION OF A POTENTIAL MESENCHYMAL STEM CELL POPULATION WITHIN OVINE BONE MARROW", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 22, no. 03, 1 August 1994 (1994-08-01), GB, pages 248S, XP002948929, ISSN: 0300-5127 * |
MAURER H. R.: "TOWARDS CHEMICALLY-DEFINED, SERUM-FREE MEDIA FOR MAMMALIAN CELL CULTURE.", ANIMAL CELL CULTURE, XX, XX, 1 January 1986 (1986-01-01), XX, pages 13 - 31., XP002912242 * |
See also references of EP0832188A4 * |
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Also Published As
Publication number | Publication date |
---|---|
JPH11506610A (en) | 1999-06-15 |
CA2223582A1 (en) | 1996-12-12 |
AU5969296A (en) | 1996-12-24 |
EP0832188A1 (en) | 1998-04-01 |
EP0832188A4 (en) | 2001-07-25 |
US5908782A (en) | 1999-06-01 |
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