WO1996037163A1 - Process and device for the computer-assisted restoration of teeth - Google Patents

Process and device for the computer-assisted restoration of teeth

Info

Publication number
WO1996037163A1
WO1996037163A1 PCT/DE1996/000840 DE9600840W WO9637163A1 WO 1996037163 A1 WO1996037163 A1 WO 1996037163A1 DE 9600840 W DE9600840 W DE 9600840W WO 9637163 A1 WO9637163 A1 WO 9637163A1
Authority
WO
Grant status
Application
Patent type
Prior art keywords
computer
device
machine
grinding
data
Prior art date
Application number
PCT/DE1996/000840
Other languages
German (de)
French (fr)
Inventor
Manfred Franetzki
Original Assignee
Siemens Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00Dental prostheses; Making same
    • A61C13/0003Making bridge-work, inlays, implants or the like
    • A61C13/0004Computer-assisted sizing or machining of dental prostheses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C5/00Filling or capping teeth
    • A61C5/70Tooth crowns; Making thereof
    • A61C5/77Methods or devices for making crowns
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61CDENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C9/00Impression cups, i.e. impression trays; Impression methods
    • A61C9/004Means or methods for taking digitized impressions
    • A61C9/0046Data acquisition means or methods

Abstract

The proposal is for a process and device for the computer-assisted restoration of teeth. In a first stage of the process the geometry of the tooth to be restored is measured with the aid of a measuring device and electronically stored. In a second stage the tooth image is interpreted, in a third stage the restoring element is constructed using CAD and in a fourth stage the restoring element is ground from a block of suitable material with the aid of a numerically controlled grinder (CAM). According to the invention, the CAD/CAM operation, i.e. stages 2, 3 and part of 4, is transferred to a powerful central computer (13) having the appropriate tools. The computer operates automatically to the greatest possible extent; where necessary it is run by an experienced operator and is connected via a data line (12) to the 3D measuring device (2 and 15, 20) and the grinder (17).

Description

description

Method and apparatus for computer-assisted restoration of teeth

The restoration of teeth is nowadays increasingly with industrial ceramic or other sanded or millable Materi¬ al, with the restoration following procedure deliegt zugrun¬:

First (scanning with optical or mechanical sensors or 3D camera) is using a measuring the geometry of the tooth to be restored and its surroundings (and possibly the counter teeth) recorded and stored electronically.

In a second step, the image is interpreted. Here, ground lines, cavity margins, equatorial lines, bumps, etc. must be identified and located. This is usually done manually by the experienced dentist.

In the third step, the Restaurat is (inlay, onlay, crown, veneer, etc.) were constructed. This task requires a corresponding computer and professional CAD (Computer Aided Design) work by the operator on the machine to dreidimensiona¬ lem imagination and the ability to construct the screen with computer resources.

The quality of restaurats depends essentially on these skills and the training level of the staff.

In the fourth step, the result of this construction is translated into a program for a numerically controlled grinding / milling machine. In the fifth step, the Restaurat in an NC machine (CAM) is finally made from a block of material.

In the final step, the Restaurat will be integrated into the patient's jaw.

The features specified in claim 1 invention has for its object to find a technical solution that allows without special skills and training of the see zahnmedizini- staff such a process and an after-working unit dental in Computer Aided Design (CAD) yet in the use practice while also Investi¬ tion costs lower for the dentist.

The invention described in detail below is essentially based on two main ideas:

I.

The user-intensive steps two and three, that is, the interpretation of the 3D image (s) and the construction of the Restaurates (CAD activity) can be taken from the dental office personnel. These processes are shifted to a center that has appropriate facilities, namely a powerful computer-ons, called in the following central computer, and an experienced operator.

II.

The powerful computer (host) can be equipped with aufwen¬ more vibrant programs and tools, such as with an optimized graphical image processing, a better pattern recognition and image manipulation with dentists and Restauratbibliotheken that allow a largely automatic image interpretation and CAD activities of the computer. The calculator can be designed, for example, according to the principle of neural networks. This computer is connected via a data network module and data cables to the device in the dental practice ver¬.

A Restauraterstellung can therefore fen flow-off as follows:

The dentist made as required 3D images from präpa¬ to centering the tooth, to possibly also from the neighboring and counter-teeth or the equivalent of dental impressions. Color shots may, in addition to a video camera provides er¬ be. Then the tooth is riert präpa¬ in the usual way. are from the prepared tooth 3D then and possibly create video images.

The images are first stored in an existing 3D measuring device to the dentist. These activities are simple and quick to learn from the practice staff. The 3D measuring device consists essentially of a measuring camera with the corresponding camera electronics, a power supply and a screen.

The images are then via a data line - the most einfach¬ case may invest a ange¬ on a telephone line connected modem use - transmit action räumes to an externally of the loading befindliches data center. There, the images are interpreted and Restaurat is constructed with the help of the central computer with or without operator guidance. The central computer then provides the restoration data on the same data line in the dental office back, in a form which stet gewährlei¬ that the grinding machine can grind out the Restaurat located there. The dentist then only needs to use the patient's Restaurat. This all happens - as before - quickly th at a meeting of patient sequentially The grinding machine need not necessarily Behand¬ the room where the dentist are;. it may be elsewhere, for example in a dental laboratory or in a service center that offers both the computational power as well as the mechanical production of Restaurate. In this case, however, no visit treatment will be possible because of the necessary transport of the restaurats generally.

The invention is described below with reference to examples of three Ausführungs¬.

1 shows a first embodiment in which in a room A, which is to the treatment room of a dentist, which normally is the workplace for patient treatment represent, a compact device 1 (CAD / CAM device) is located. Such a compact device is spielsweise described in DE-4030176. It includes a 3D camera 2 with the necessary care and Bilderzeu- supply electronics; an integrated, here only indicated symbolically microprocessor 3 of the image processing, Kon¬ constructive tion and control grinding machine; a screen 4, various control elements 5 (trackball, buttons, input Fu߬ switch), a floppy disk drive 6 for storing the original 3D images and the restorations and, disposed in a grinding chamber 7 grinding machine 8. In a stage of the machine can also a video camera with corresponding electrical supply contained. The Video¬ images can be saved with the help of an external printer and printed. The 3D video images can only alter¬ natively, are not displayed simultaneously on the screen.

In the inventive modification of the CAD / CAM functions of the compact unit 1 are not used; it is rather the original 3D images, if necessary, the

, Transmit video images of corresponding data network modules 10, 11 and a data line 12 to a central computer. 13 This central computer is provided in comparison to the aforementioned, located in the compact unit 1 microprocessor 3 with more complex programs and tools, and is located outside the treatment chamber A, for example in a dental laboratory or in a specially created central data center (space B). There, the previously mentioned image interpretation and construction durchge leads. The result will be transmitted back via the same data line 12 and the two data network modules 11, 10 and in

stored in the memory of the microprocessor 3 of the grinding machine in the space A. Thereafter, the milling or grinding of the restaurats with the machine's own means (Universal computer and grinding) is carried out. In this variant, the user does have no investment cost advantage in the CAD / CAM machine, but it saves processing learning and performing the Bildbear¬ and construction. So it is a gain in time for labor costs and quality.

2 shows a variant is when used in room A, ie at the dental practice, a PC 15th This PC is completed by a 3D camera 16 which corresponds to Pos. 2 in Fig. 1, and optionally a (not presented darge) video camera, with the necessary electronics. The electronics may be arranged in the external PC in their own housings and / or of a plug (s).

The PC 15 also has the necessary interfaces steering species to pair it with the zen externally shown here, data networks, eg via modem.

The images produced by the cameras are cached on PC-own store and can be checked by the practitioner on the screen for suitability. The useful images can then be transferred as in Description 1 to the central computer 13 in the room B, where it is processed and the result is then transferred back 6 again, either in the above-mentioned PC or - (directly into the grinding machine 17 which - with appropriate equipment is executed in this case without monitor). After that, the production of restaurats follows etc.

The control of the grinding machine can be carried directly by the PC or a built-in processor of the grinding machine; in the latter case it would be a CNC machine.

3 shows a further variant which differs from that shown in Figure 2 essentially by the fact that one or more cameras are arranged at a location directly on the dental treatment station DV box 20th The DV-Box 20 is advantageously designed as a 3D measuring device and ent holds in the simplest version, the previously mentioned SD measuring camera with corresponding electronics, a screen and a power supply. In various stages of either a 3D camera 21 with corresponding electronics, a monitor 22 and controls 23 and a (here only symbolically, indicated) integrated computer 24 (PC) or additionally one or more video cameras in / on this DV-Box be 25 and / or X-ray cameras mounted 26th The computer 24 is connected to the grinding machine 17 via a data transmission line 27th

The advantages of the variants 2 and 3 compared to those of Option 1 are that one for purposes other existing PC (th with all storage and Peripheriekomponen-) can be used, which stems the cost of CAD / CAM Sy¬ reduced and makes it possible to use each increased performance of a new generation of pCs.

Claims

claims
1. Method and apparatus for computer-aided Restaura¬ tion von_Zähnen wherein detected in a first step by means of a measuring device, the geometry of the restored tooth and the tooth image so obtained is stored electronically in which interprets the tooth image in a second step and in a third step, the Restaurat is constructed with the help of CAD, and in which finally the Restaurat with the aid of a numerically controlled grinding device milled out of a suitable dental restorative material in a fourth step of a block, is characterized in that the image acquisition (step 1) with a 3D measuring device however, takes place at the treatment center, the CAD / CAM tasks
(Steps 2 and 3) to a non-lung space on dental Behand¬ located central computer (13) to be outsourced, in which the central computer thus at least partly has programs and tools, the identifier for Musterer-, the image processing, the CAD design and production control programs for NC-controlled machines (17) are suitable, and that these steps are carried out at least partially automatically by the central computer.
2. The method / device according to claim 1, characterized in that the 3D measuring device and the grinding machine via data lines are connected, for example via modem and telephone line with the central computer (13).
3. The method / device according to claim 1, characterized in that the CAD work is performed at the central computer (13) by an experienced operator in the method.
8 4. The method / device according to claim 1, characterized in that the steps one and four in a compact unit (1) are carried out together.
5. The method / device according to claim 1, characterized in that the 3D measuring device from the 3D camera, a PC and one or more PC boards with the hardware and software is be¬ for operating the 3D camera and that the grinding machine it is set up separately.
6. The method / device according to claim 1 or 5, since ¬ by in that the 3D measuring device is designed as a portable device.
7. The method / device according to claim 5, characterized in that the 3D measuring device additionally contains at least one video camera, an X-ray camera or programs practice administration.
PCT/DE1996/000840 1995-05-22 1996-05-13 Process and device for the computer-assisted restoration of teeth WO1996037163A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1995118702 DE19518702C2 (en) 1995-05-22 1995-05-22 Method and apparatus for computer-assisted restoration of teeth
DE19518702.4 1995-05-22

Publications (1)

Publication Number Publication Date
WO1996037163A1 true true WO1996037163A1 (en) 1996-11-28

Family

ID=7762538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/000840 WO1996037163A1 (en) 1995-05-22 1996-05-13 Process and device for the computer-assisted restoration of teeth

Country Status (2)

Country Link
DE (1) DE19518702C2 (en)
WO (1) WO1996037163A1 (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998044865A1 (en) * 1997-04-10 1998-10-15 Nobel Biocare Ab (Publ) Arrangement and system for production of dental products and transmission of information
DE19724724A1 (en) * 1997-06-12 1998-12-24 Matthias Dr Weiler Bone augmentation piece manufacture for adding to or replacing bone material
WO1999013796A1 (en) * 1997-09-17 1999-03-25 Decim Ab Method and blank for the production of a dental body
WO2001035854A1 (en) 1999-11-17 2001-05-25 3M Innovative Properties Company Mill blank for dental prosthesis
WO2001085054A1 (en) 2000-05-09 2001-11-15 3M Innovative Properties Company Dental models and methods of fixturing the same
WO2002017815A1 (en) 2000-08-31 2002-03-07 3M Innovative Properties Company Dental mill blank and support stub assembly
GB2374016A (en) * 2001-01-31 2002-10-09 Gc Kk Process for preparing dental prosthesis
WO2003057068A1 (en) 2001-12-21 2003-07-17 3M Innovative Properties Company Removable dental models
US6821123B2 (en) 1997-04-10 2004-11-23 Nobel Biocare Ab Arrangement and system for production of dental products and transmission of information
WO2005055856A1 (en) * 2003-12-10 2005-06-23 Nobel Biocare Ab (Publ) System and arrangement for production and insertion of a dental bridge structure
US6913666B1 (en) 1997-03-21 2005-07-05 Woodwelding Ag Process for anchoring connecting elements in a material with pores or cavities and connecting elements therefor
US7079914B2 (en) 2001-12-28 2006-07-18 Nobel Biocare Ab System and method for producing a three-dimensional body comprising bone or tissue-compatible material
US7160405B2 (en) 1999-06-18 2007-01-09 Woodwelding Ag Integral joining
US7708560B2 (en) 2004-11-22 2010-05-04 3M Innovative Properties Company System and method for manufacturing dental prostheses
US7950924B2 (en) 2001-12-28 2011-05-31 Nobel Biocare Services Ag Arrangement and device for using a template to form holes for implants in bone, preferably jaw bone
USRE43584E1 (en) 2000-12-29 2012-08-14 Nobel Biocare Services Ag Method, arrangement and program for a prosthetic installation
US8540510B2 (en) 2006-05-04 2013-09-24 Nobel Biocare Services Ag Device for securing a dental implant in bone tissue, a method for making a surgical template and a method of securing a dental implant in bone tissue
US8932337B2 (en) 2001-03-02 2015-01-13 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
US9348973B2 (en) 2009-05-18 2016-05-24 Nobel Biocare Services Ag Method and system providing improved data matching for virtual planning
CN107126273A (en) * 2017-05-23 2017-09-05 高艳云 Multifunctional dental filling system

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1007059C2 (en) * 1997-09-17 1998-10-09 Cordent Multi Media B V Technical dental imaging system.
DE19838238A1 (en) 1998-08-22 2000-03-02 Girrbach Dental Gmbh Method for computer-controlled production of dentures
DE19922279A1 (en) * 1999-05-11 2000-11-16 Friedrich Schiller Uni Jena Bu A process for generating patient-specific implants
DE19922870A1 (en) * 1999-05-19 2000-12-07 Paul Weigl Automatic adjustment of dental restoration work comprises submitting CAD data to iterative process comprising analyzing properties of natural tooth, calculating required values, applying material to produce these and correcting
FR2824254B1 (en) * 2001-05-07 2004-04-02 Medcom Method for taking an impression for making a dental prosthesis and architecture of equipment for its implementation
WO2005004742A1 (en) * 2003-07-14 2005-01-20 Degudent Gmbh Method for representing a dental object and for producing dentures
DE102005029454A1 (en) * 2005-06-24 2007-01-04 Implant & 3D Planungscenter GbR (vertretungsberechtigte Gesellschafter Dr. Jan Kielhorn, 74629 Pfedelbach, Gerhard Stachulla, 86444 Affing, Marcel Liedtke, 86447 Todtenweis) Method and system for inspecting an implant planning
DE102005056565B4 (en) * 2005-11-25 2013-05-29 Heiko Schafberg A process for preparing an enlarged model of the dental situation of a patient

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010935A1 (en) * 1992-11-09 1994-05-26 Ormco Corporation Custom orthodontic appliance forming method and apparatus
WO1995015731A1 (en) * 1993-12-06 1995-06-15 Nobelpharma Ab Method and arrangement for collecting data for production of artificial support members or replacement parts for the human body

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054785B1 (en) * 1980-12-24 1985-07-03 Werner H. Dr.med.dent. Mörmann Process for the manufacture of medical and dental, alloplastic, endoprosthetic and exoprosthetic fittings
DE4030176A1 (en) * 1990-09-24 1992-03-26 Siemens Ag Calibrating dental crown machining tool for start position - detecting start from change in sound generated from surface when touched by conversion to electrical signal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010935A1 (en) * 1992-11-09 1994-05-26 Ormco Corporation Custom orthodontic appliance forming method and apparatus
WO1995015731A1 (en) * 1993-12-06 1995-06-15 Nobelpharma Ab Method and arrangement for collecting data for production of artificial support members or replacement parts for the human body

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913666B1 (en) 1997-03-21 2005-07-05 Woodwelding Ag Process for anchoring connecting elements in a material with pores or cavities and connecting elements therefor
US6821123B2 (en) 1997-04-10 2004-11-23 Nobel Biocare Ab Arrangement and system for production of dental products and transmission of information
WO1998044865A1 (en) * 1997-04-10 1998-10-15 Nobel Biocare Ab (Publ) Arrangement and system for production of dental products and transmission of information
DE19724724A1 (en) * 1997-06-12 1998-12-24 Matthias Dr Weiler Bone augmentation piece manufacture for adding to or replacing bone material
WO1999013796A1 (en) * 1997-09-17 1999-03-25 Decim Ab Method and blank for the production of a dental body
US7815409B2 (en) 1999-06-18 2010-10-19 Woodwelding Ag Integral joining
US7160405B2 (en) 1999-06-18 2007-01-09 Woodwelding Ag Integral joining
WO2001035854A1 (en) 1999-11-17 2001-05-25 3M Innovative Properties Company Mill blank for dental prosthesis
WO2001085054A1 (en) 2000-05-09 2001-11-15 3M Innovative Properties Company Dental models and methods of fixturing the same
US6482284B1 (en) 2000-08-31 2002-11-19 3M Innovative Properties Company Method of making a dental mill blank and support stub assembly
WO2002017815A1 (en) 2000-08-31 2002-03-07 3M Innovative Properties Company Dental mill blank and support stub assembly
US6627327B2 (en) 2000-08-31 2003-09-30 3M Innovative Properties Company Dental mill blank and support stub assembly
USRE43584E1 (en) 2000-12-29 2012-08-14 Nobel Biocare Services Ag Method, arrangement and program for a prosthetic installation
GB2374016A (en) * 2001-01-31 2002-10-09 Gc Kk Process for preparing dental prosthesis
US6835066B2 (en) 2001-01-31 2004-12-28 Gc Corporation Process for preparing dental prosthesis
US9615872B2 (en) 2001-03-02 2017-04-11 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
US8945192B2 (en) 2001-03-02 2015-02-03 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
US8932337B2 (en) 2001-03-02 2015-01-13 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
US9216083B2 (en) 2001-03-02 2015-12-22 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
US9924988B2 (en) 2001-03-02 2018-03-27 Woodwelding Ag Implants for creating connections to tissue parts, in particular to skeletal parts, as well as device and method for implantation thereof
WO2003057068A1 (en) 2001-12-21 2003-07-17 3M Innovative Properties Company Removable dental models
US8142189B2 (en) 2001-12-28 2012-03-27 Noble Biocare Services AG Arrangement and device for using a template to form holes for implants in bone, preferably jaw bone
US7079914B2 (en) 2001-12-28 2006-07-18 Nobel Biocare Ab System and method for producing a three-dimensional body comprising bone or tissue-compatible material
US7950924B2 (en) 2001-12-28 2011-05-31 Nobel Biocare Services Ag Arrangement and device for using a template to form holes for implants in bone, preferably jaw bone
US8186999B2 (en) 2003-12-10 2012-05-29 Nobel Biocare Services Ag System and arrangement for production and insertion of a dental bridge structure
KR101156077B1 (en) * 2003-12-10 2012-06-28 노벨 바이오케어 서비시스 아게 System and arrangement for production and insertion of a dental bridge structure
WO2005055856A1 (en) * 2003-12-10 2005-06-23 Nobel Biocare Ab (Publ) System and arrangement for production and insertion of a dental bridge structure
US7708560B2 (en) 2004-11-22 2010-05-04 3M Innovative Properties Company System and method for manufacturing dental prostheses
US8540510B2 (en) 2006-05-04 2013-09-24 Nobel Biocare Services Ag Device for securing a dental implant in bone tissue, a method for making a surgical template and a method of securing a dental implant in bone tissue
US9348973B2 (en) 2009-05-18 2016-05-24 Nobel Biocare Services Ag Method and system providing improved data matching for virtual planning
CN107126273A (en) * 2017-05-23 2017-09-05 高艳云 Multifunctional dental filling system

Also Published As

Publication number Publication date Type
DE19518702C2 (en) 1999-03-11 grant
DE19518702A1 (en) 1996-11-28 application

Similar Documents

Publication Publication Date Title
US6454162B1 (en) Process for controlling the misuse of disposable medical products
US5733126A (en) Process and device for production of three-dimensional bodies
US7661956B2 (en) Methods for manufacturing dental implant components
EP0376873A2 (en) Apparatus for digitizing the contour of a dental surface, particularly useful for preparing a dental crown
US7220124B2 (en) Method for preparing a physical plaster model
EP0490848B1 (en) A procedure and apparatus for producing individually designed, three-dimensional bodies usable as tooth replacements, prostheses, etc.
US6846179B2 (en) Custom orthodontic appliance forming method and apparatus
US6915178B2 (en) Dental prosthesis manufacturing process, dental prosthesis pattern & dental prosthesis made thereby
US20040073417A1 (en) Orthodontic treatment planning with user-specified simulation of tooth movement
US5257184A (en) Method and apparatus with multiple data input stylii for collecting curvilinear contour data
US20080300716A1 (en) Method for manipulating a dental virtual model, method for creating physical entities based on a dental virtual model thus manipulated, and dental models thus created
US6905293B1 (en) Machine tool for the production of base structures for false teeth
US6386867B1 (en) Method and system for imaging and modeling dental structures
US7035702B2 (en) Methods for dental restoration
Ciocca et al. CAD-CAM generated ear cast by means of a laser scanner and rapid prototyping machine
US5131844A (en) Contact digitizer, particularly for dental applications
US20020081554A1 (en) Mating parts scanning and registration methods
US20080144777A1 (en) Portable digital radiographic devices
Strub et al. Computer-aided design and fabrication of dental restorations: current systems and future possibilities
US20070211081A1 (en) Augmented reality system for a dental laboratory
Williams et al. A technique for fabricating patterns for removable partial denture frameworks using digitized casts and electronic surveying
US20080015727A1 (en) Local enforcement of accuracy in fabricated models
US20040204787A1 (en) Method and system for fabricating a dental coping, and a coping fabricated thereby
Duret et al. CAD-CAM in dentistry
WO1998032394A1 (en) Dental scanning method and apparatus

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase