WO1996035785A3 - Transgenic animals having a defective thyroid hormone receptor beta gene - Google Patents

Transgenic animals having a defective thyroid hormone receptor beta gene Download PDF

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Publication number
WO1996035785A3
WO1996035785A3 PCT/EP1996/001983 EP9601983W WO9635785A3 WO 1996035785 A3 WO1996035785 A3 WO 1996035785A3 EP 9601983 W EP9601983 W EP 9601983W WO 9635785 A3 WO9635785 A3 WO 9635785A3
Authority
WO
WIPO (PCT)
Prior art keywords
defective
hormone receptor
thyroid hormone
transgenic animals
receptor beta
Prior art date
Application number
PCT/EP1996/001983
Other languages
French (fr)
Other versions
WO1996035785A2 (en
WO1996035785A9 (en
Inventor
Douglas Forrest
Thomas Curran
Original Assignee
Karobio Ab
Douglas Forrest
Thomas Curran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Karobio Ab, Douglas Forrest, Thomas Curran filed Critical Karobio Ab
Priority to AU59981/96A priority Critical patent/AU5998196A/en
Publication of WO1996035785A2 publication Critical patent/WO1996035785A2/en
Publication of WO1996035785A3 publication Critical patent/WO1996035785A3/en
Publication of WO1996035785A9 publication Critical patent/WO1996035785A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Environmental Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides a transgenic mammal which is heterozygous or homozygous for an at least partially defective thyroid hormone receptor β gene, cells derived from the mammal and methods for the use of the mammal and the cells.
PCT/EP1996/001983 1995-05-11 1996-05-10 Transgenic animals having a defective thyroid hormone receptor beta gene WO1996035785A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59981/96A AU5998196A (en) 1995-05-11 1996-05-10 Transgenic animals having a defective thyroid hormone recept or beta gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43739095A 1995-05-11 1995-05-11
US08/437,390 1995-05-11

Publications (3)

Publication Number Publication Date
WO1996035785A2 WO1996035785A2 (en) 1996-11-14
WO1996035785A3 true WO1996035785A3 (en) 1996-12-12
WO1996035785A9 WO1996035785A9 (en) 1997-02-06

Family

ID=23736226

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/001983 WO1996035785A2 (en) 1995-05-11 1996-05-10 Transgenic animals having a defective thyroid hormone receptor beta gene

Country Status (2)

Country Link
AU (1) AU5998196A (en)
WO (1) WO1996035785A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001095711A2 (en) * 2000-06-14 2001-12-20 Deltagen, Inc. Transgenic mice containing nuclear hormone receptor gene disruptions
WO2005085865A2 (en) * 2004-03-09 2005-09-15 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with thyroid hormone receptor beta (thrb)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024282A1 (en) * 1993-04-09 1994-10-27 Pfizer Inc. A human t-cell receptor of the g-protein coupled receptor family

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994024282A1 (en) * 1993-04-09 1994-10-27 Pfizer Inc. A human t-cell receptor of the g-protein coupled receptor family

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHATTERJEE, V.K.K.: "Resistance to thyroid hormone - an uncommon cause of thyroxine excess and inappropriate TSH secretion", ACTA MEDICA AUSTRIACA, vol. 21, no. 2, 1994, pages 56 - 60, XP002015494 *
FORREST, D. ET AL.: "Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function", THE EMBO JOURNAL, vol. 15, no. 12, 17 June 1996 (1996-06-17), pages 3006 - 3015, XP000604851 *
HAYASHI, Y. ET AL.: "A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor", MOLECULAR ENDOCRINOLOGY, vol. 10, no. 1, 1996, pages 100 - 106, XP000603520 *
O'DONNELL, A. AND KOENIG, R.: "Mutational analysis identifies a new functional domain of the thyroid hormone receptor", MOLECULAR ENDOCRINOLOGY, vol. 4, no. 5, May 1990 (1990-05-01), pages 715 - 720, XP000603789 *
PARILLA, R. ET AL.: "Characterization of seven novel mutations of the c-erbAbeta gene in unrelated kindreds with generalized thyroid hormone resistance", JOURNAL OF CLINICAL INVESTIGATION, vol. 88, December 1991 (1991-12-01), pages 2123 - 2130, XP000574480 *
WONG, R. ET AL.: "A transgenic model of resistance to thyroid hormone (RTH): correlation of mutant thyroid hormone beta (TRbeta1) levels with the phenotype of fat loss and hyperactivity", JOURNAL OF INVESTIGATIVE MEDECINE, vol. 43, no. Suppl.2, April 1995 (1995-04-01), pages 223A *
WONG, R. ET AL.: "A transgenic model of resistance to thyroid hormone (RTH): Correlation of mutant thyroid hormone beta receptor (TRbeta1) levels with the phenotype of fat loss and hyperactivity", CLINICAL RESEARCH MEETING, SAN DIEGO, CALIFORNIA, MAY 5-8, 1995, XP002015493 *
WONG, R. ET AL.: "Cell type-dependent modulation of the dominant negative action of human mutant thyroid hormone beta1 receptors", MOLECULAR MEDICINE, vol. 1, no. 3, March 1995 (1995-03-01), pages 309 - 319, XP000603622 *
WOOD, W.M. ET AL.: "Structural and functional characterization of the genomic locus encoding the murine beta2 thyroid hormone receptor", MOLECULAR ENDOCRINOLOGY, vol. 8, no. 12, December 1994 (1994-12-01), pages 1605 - 1617, XP000603682 *

Also Published As

Publication number Publication date
AU5998196A (en) 1996-11-29
WO1996035785A2 (en) 1996-11-14

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