WO1996033977A1 - Quinazoline derivatives - Google Patents
Quinazoline derivatives Download PDFInfo
- Publication number
- WO1996033977A1 WO1996033977A1 PCT/GB1996/000958 GB9600958W WO9633977A1 WO 1996033977 A1 WO1996033977 A1 WO 1996033977A1 GB 9600958 W GB9600958 W GB 9600958W WO 9633977 A1 WO9633977 A1 WO 9633977A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- pharmaceutically
- alkoxy
- quinazoline
- quinazoline derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/930,041 US5932574A (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
JP8532249A JPH11507329A (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
AU53430/96A AU5343096A (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
EP96910131A EP0824525B1 (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
DE69613367T DE69613367T2 (en) | 1995-04-27 | 1996-04-23 | CHINAZOLIN DERIVATIVES |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9508566.8A GB9508566D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivative |
GB9508568.4 | 1995-04-27 | ||
GBGB9508568.4A GB9508568D0 (en) | 1995-04-27 | 1995-04-27 | Quinazoline derivative |
GB9508566.8 | 1995-04-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996033977A1 true WO1996033977A1 (en) | 1996-10-31 |
Family
ID=26306937
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1996/000958 WO1996033977A1 (en) | 1995-04-27 | 1996-04-23 | Quinazoline derivatives |
Country Status (6)
Country | Link |
---|---|
US (1) | US5932574A (en) |
EP (1) | EP0824525B1 (en) |
JP (1) | JPH11507329A (en) |
AU (1) | AU5343096A (en) |
DE (1) | DE69613367T2 (en) |
WO (1) | WO1996033977A1 (en) |
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997032856A1 (en) * | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
US5770599A (en) * | 1995-04-27 | 1998-06-23 | Zeneca Limited | Quinazoline derivatives |
US5770603A (en) * | 1996-04-13 | 1998-06-23 | Zeneca Limited | Quinazoline derivatives |
US5814630A (en) * | 1996-02-14 | 1998-09-29 | Zeneca Limited | Quinazoline compounds |
US5821246A (en) * | 1994-11-12 | 1998-10-13 | Zeneca Limited | Aniline derivatives |
US5866572A (en) * | 1996-02-14 | 1999-02-02 | Zeneca Limited | Quinazoline derivatives |
US5932574A (en) * | 1995-04-27 | 1999-08-03 | Zeneca Limited | Quinazoline derivatives |
US5942514A (en) * | 1995-04-27 | 1999-08-24 | Zeneca Limited | Quinazoline derivatives |
US5952333A (en) * | 1995-04-27 | 1999-09-14 | Zeneca Limited | Quinazoline derivative |
US5955464A (en) * | 1994-11-30 | 1999-09-21 | Zeneca Limited | 4-anilinoquinazoline derivatives bearing a heteroaryl substituted at the 6-position and possessing anti-cell-proliferation properties |
US5962458A (en) * | 1995-12-18 | 1999-10-05 | Zeneca Limited | Substituted quinazolines |
US6015814A (en) * | 1995-04-27 | 2000-01-18 | Zeneca Limited | Quinazoline derivative |
US6184225B1 (en) | 1996-02-13 | 2001-02-06 | Zeneca Limited | Quinazoline derivatives as VEGF inhibitors |
US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
US6344459B1 (en) | 1996-04-12 | 2002-02-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
WO2003082831A1 (en) * | 2002-03-28 | 2003-10-09 | Astrazeneca Ab | 4-anilino quinazoline derivatives as antiproliferative agents |
US6673803B2 (en) | 1996-09-25 | 2004-01-06 | Zeneca Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
US7148230B2 (en) | 2003-07-29 | 2006-12-12 | Astrazeneca Ab | Quinazoline derivatives |
US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
EP1950201A1 (en) | 1998-09-29 | 2008-07-30 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
EP1970058A1 (en) | 1998-08-18 | 2008-09-17 | The Regents of the University of California Office of Technology Transfer | Epidermal growth factor receptor antagonists for treating hypersecretion of mucus in the lungs |
US7569577B2 (en) | 2003-09-16 | 2009-08-04 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
US7625908B2 (en) | 2003-11-13 | 2009-12-01 | Astrazeneca Ab | Quinazoline derivatives |
US7632840B2 (en) | 2004-02-03 | 2009-12-15 | Astrazeneca Ab | Quinazoline compounds for the treatment of hyperproliferative disorders |
US7659279B2 (en) | 2003-04-30 | 2010-02-09 | Astrazeneca Ab | Quinazoline derivatives and their use in the treatment of cancer |
US7820683B2 (en) | 2005-09-20 | 2010-10-26 | Astrazeneca Ab | 4-(1H-indazol-5-yl-amino)-quinazoline compounds as erbB receptor tyrosine kinase inhibitors for the treatment of cancer |
US7838530B2 (en) | 2003-09-25 | 2010-11-23 | Astrazeneca Ab | Quinazoline derivatives as antiproliferative agents |
CN1882570B (en) * | 2003-09-19 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | Quinazoline derivatives |
US7910731B2 (en) | 2002-03-30 | 2011-03-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
WO2011035540A1 (en) | 2009-09-28 | 2011-03-31 | 齐鲁制药有限公司 | 4-(substituted anilino)quinazoline derivatives as tyrosine kinase inhibitors |
US7947676B2 (en) | 2004-12-14 | 2011-05-24 | Astrazeneca Ab | Pyrazolo[3,4-d]pyrimidine compounds as antitumor agents |
US7998949B2 (en) | 2007-02-06 | 2011-08-16 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
US8080558B2 (en) | 2007-10-29 | 2011-12-20 | Natco Pharma Limited | 4-(tetrazol-5-yl)-quinazoline derivatives as anti-cancer agent |
US8088782B2 (en) | 2008-05-13 | 2012-01-03 | Astrazeneca Ab | Crystalline 4-(3-chloro-2-fluoroanilino)-7 methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline difumarate form A |
EP2423331A2 (en) | 2004-03-31 | 2012-02-29 | The General Hospital Corporation | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments |
US8399461B2 (en) | 2006-11-10 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same |
EP2615183A1 (en) | 2008-05-14 | 2013-07-17 | Genomic Health, Inc. | Predictors of patient response to treatment with EGF receptor inhibitors |
US8497369B2 (en) | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
WO2013143057A1 (en) | 2012-03-26 | 2013-10-03 | 中国科学院福建物质结构研究所 | Quinazoline derivative and application thereof |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
US8735410B2 (en) | 2005-02-26 | 2014-05-27 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
US9040548B2 (en) | 1999-11-05 | 2015-05-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
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DE69838172T2 (en) | 1997-08-22 | 2008-04-10 | Astrazeneca Ab | OXINDOLYLCHINAZOLE DERIVATIVES AS ANGIOGENESEHEMMER |
AU5003200A (en) | 1999-05-14 | 2000-12-05 | United States Of America As Represented By The Department Of Veterans Affairs, The | Isolation and characterization of epidermal growth factor related protein |
US7049410B2 (en) * | 1999-05-14 | 2006-05-23 | Majumdar Adhip P N | Antibodies to a novel EGF-receptor related protein (ERRP) |
AU2003250701A1 (en) * | 2002-07-31 | 2004-02-16 | Wayne R. Danter | Protein tyrosine kinase inhibitors |
ES2298563T3 (en) * | 2002-10-09 | 2008-05-16 | Critical Outcome Technologies, Inc. | INHIBITORS OF PROTEINS TIROSINA KINASAS. |
DE10326186A1 (en) * | 2003-06-06 | 2004-12-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
GEP20084551B (en) * | 2004-05-06 | 2008-11-25 | Warner Lambert Co | 4-phenylamino-quinazolin-6-yl-amides |
US20070231298A1 (en) * | 2006-03-31 | 2007-10-04 | Cell Genesys, Inc. | Cytokine-expressing cancer immunotherapy combinations |
US8034815B2 (en) | 2007-01-11 | 2011-10-11 | Critical Outcome Technologies, Inc. | Compounds and method for treatment of cancer |
EP2225226B1 (en) | 2007-12-26 | 2016-08-17 | Critical Outcome Technologies, Inc. | Compounds and their use in a method for treatment of cancer |
CA2730890C (en) | 2008-07-17 | 2018-05-15 | Critical Outcome Technologies Inc. | Thiosemicarbazone inhibitor compounds and cancer treatment methods |
EP3235818A3 (en) | 2010-04-01 | 2018-03-14 | Critical Outcome Technologies, Inc. | Compounds for the treatment of hiv |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0566226A1 (en) * | 1992-01-20 | 1993-10-20 | Zeneca Limited | Quinazoline derivatives |
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
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US3266990A (en) * | 1963-09-24 | 1966-08-16 | Warner Lambert Pharmaceutical | Derivatives of quinazoline |
JPS5538325A (en) * | 1978-09-11 | 1980-03-17 | Sankyo Co Ltd | 4-anilinoquinazoline derivative and its preparation |
US4343940A (en) * | 1979-02-13 | 1982-08-10 | Mead Johnson & Company | Anti-tumor quinazoline compounds |
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ATE110071T1 (en) * | 1988-01-23 | 1994-09-15 | Kyowa Hakko Kogyo Kk | PYRIDAZINONE DERIVATIVES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM. |
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GB9314884D0 (en) * | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Tricyclic derivatives |
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-
1996
- 1996-04-23 EP EP96910131A patent/EP0824525B1/en not_active Expired - Lifetime
- 1996-04-23 JP JP8532249A patent/JPH11507329A/en active Pending
- 1996-04-23 US US08/930,041 patent/US5932574A/en not_active Expired - Fee Related
- 1996-04-23 WO PCT/GB1996/000958 patent/WO1996033977A1/en active IP Right Grant
- 1996-04-23 AU AU53430/96A patent/AU5343096A/en not_active Abandoned
- 1996-04-23 DE DE69613367T patent/DE69613367T2/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0566226A1 (en) * | 1992-01-20 | 1993-10-20 | Zeneca Limited | Quinazoline derivatives |
EP0635498A1 (en) * | 1993-07-19 | 1995-01-25 | Zeneca Limited | Quinazoline derivatives and their use as anti-cancer agents |
Cited By (66)
Publication number | Priority date | Publication date | Assignee | Title |
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US5821246A (en) * | 1994-11-12 | 1998-10-13 | Zeneca Limited | Aniline derivatives |
US5955464A (en) * | 1994-11-30 | 1999-09-21 | Zeneca Limited | 4-anilinoquinazoline derivatives bearing a heteroaryl substituted at the 6-position and possessing anti-cell-proliferation properties |
US5942514A (en) * | 1995-04-27 | 1999-08-24 | Zeneca Limited | Quinazoline derivatives |
US5770599A (en) * | 1995-04-27 | 1998-06-23 | Zeneca Limited | Quinazoline derivatives |
US6015814A (en) * | 1995-04-27 | 2000-01-18 | Zeneca Limited | Quinazoline derivative |
US5952333A (en) * | 1995-04-27 | 1999-09-14 | Zeneca Limited | Quinazoline derivative |
US5932574A (en) * | 1995-04-27 | 1999-08-03 | Zeneca Limited | Quinazoline derivatives |
US6258951B1 (en) | 1995-12-18 | 2001-07-10 | Zeneca Limited | Chemical compounds |
US5962458A (en) * | 1995-12-18 | 1999-10-05 | Zeneca Limited | Substituted quinazolines |
US6071921A (en) * | 1995-12-18 | 2000-06-06 | Zeneca Limited | Chemical compounds |
US6362336B1 (en) | 1995-12-18 | 2002-03-26 | Zeneca Limited | Chemical compounds |
US6184225B1 (en) | 1996-02-13 | 2001-02-06 | Zeneca Limited | Quinazoline derivatives as VEGF inhibitors |
US5866572A (en) * | 1996-02-14 | 1999-02-02 | Zeneca Limited | Quinazoline derivatives |
US5814630A (en) * | 1996-02-14 | 1998-09-29 | Zeneca Limited | Quinazoline compounds |
US6897214B2 (en) | 1996-02-14 | 2005-05-24 | Zeneca Limited | Quinazoline derivatives |
WO1997032856A1 (en) * | 1996-03-05 | 1997-09-12 | Zeneca Limited | 4-anilinoquinazoline derivatives |
US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
US6344459B1 (en) | 1996-04-12 | 2002-02-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
US7786131B2 (en) | 1996-04-12 | 2010-08-31 | Warner-Lambert Company | Pyrimido[5,4-d]pyrimidines derivatives as irreversible inhibitors of tyrosine kinases |
US6602863B1 (en) | 1996-04-12 | 2003-08-05 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
US5770603A (en) * | 1996-04-13 | 1998-06-23 | Zeneca Limited | Quinazoline derivatives |
USRE42353E1 (en) | 1996-09-25 | 2011-05-10 | Astrazeneca Uk Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
US6673803B2 (en) | 1996-09-25 | 2004-01-06 | Zeneca Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
US6897210B2 (en) | 1996-09-25 | 2005-05-24 | Zeneca Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
EP1970058A1 (en) | 1998-08-18 | 2008-09-17 | The Regents of the University of California Office of Technology Transfer | Epidermal growth factor receptor antagonists for treating hypersecretion of mucus in the lungs |
US6288082B1 (en) | 1998-09-29 | 2001-09-11 | American Cyanamid Company | Substituted 3-cyanoquinolines |
USRE42376E1 (en) | 1998-09-29 | 2011-05-17 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines |
EP2253620A1 (en) | 1998-09-29 | 2010-11-24 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
US6297258B1 (en) | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
EP1950201A1 (en) | 1998-09-29 | 2008-07-30 | Wyeth Holdings Corporation | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
EP2896612A1 (en) | 1998-09-29 | 2015-07-22 | Wyeth Holdings LLC | Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors |
US6432979B1 (en) | 1999-08-12 | 2002-08-13 | American Cyanamid Company | Method of treating or inhibiting colonic polyps and colorectal cancer |
US10457664B2 (en) | 1999-11-05 | 2019-10-29 | Genzyme Corporation | Quinazoline derivatives as VEGF inhibitors |
US9040548B2 (en) | 1999-11-05 | 2015-05-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
AU2003214443B8 (en) * | 2002-03-28 | 2009-08-20 | Astrazeneca Ab | 4-anilino quinazoline derivatives as antiproliferative agents |
AU2003214443B2 (en) * | 2002-03-28 | 2009-07-16 | Astrazeneca Ab | 4-anilino quinazoline derivatives as antiproliferative agents |
WO2003082831A1 (en) * | 2002-03-28 | 2003-10-09 | Astrazeneca Ab | 4-anilino quinazoline derivatives as antiproliferative agents |
US8343982B2 (en) | 2002-03-30 | 2013-01-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds pharmaceutical compositions containing these compounds, their use and process for preparing the same |
US7910731B2 (en) | 2002-03-30 | 2011-03-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
US7659279B2 (en) | 2003-04-30 | 2010-02-09 | Astrazeneca Ab | Quinazoline derivatives and their use in the treatment of cancer |
US7148230B2 (en) | 2003-07-29 | 2006-12-12 | Astrazeneca Ab | Quinazoline derivatives |
US7569577B2 (en) | 2003-09-16 | 2009-08-04 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
CN1882570B (en) * | 2003-09-19 | 2010-12-08 | 阿斯利康(瑞典)有限公司 | Quinazoline derivatives |
US7838530B2 (en) | 2003-09-25 | 2010-11-23 | Astrazeneca Ab | Quinazoline derivatives as antiproliferative agents |
US7625908B2 (en) | 2003-11-13 | 2009-12-01 | Astrazeneca Ab | Quinazoline derivatives |
US7632840B2 (en) | 2004-02-03 | 2009-12-15 | Astrazeneca Ab | Quinazoline compounds for the treatment of hyperproliferative disorders |
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Also Published As
Publication number | Publication date |
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EP0824525A1 (en) | 1998-02-25 |
EP0824525B1 (en) | 2001-06-13 |
US5932574A (en) | 1999-08-03 |
AU5343096A (en) | 1996-11-18 |
DE69613367D1 (en) | 2001-07-19 |
JPH11507329A (en) | 1999-06-29 |
DE69613367T2 (en) | 2002-04-18 |
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