WO1996033206A1 - Peptides de conotoxine - Google Patents

Peptides de conotoxine Download PDF

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Publication number
WO1996033206A1
WO1996033206A1 PCT/US1996/005262 US9605262W WO9633206A1 WO 1996033206 A1 WO1996033206 A1 WO 1996033206A1 US 9605262 W US9605262 W US 9605262W WO 9633206 A1 WO9633206 A1 WO 9633206A1
Authority
WO
WIPO (PCT)
Prior art keywords
cys
conotoxin
peptide
xaa
gly
Prior art date
Application number
PCT/US1996/005262
Other languages
English (en)
Inventor
Ki-Joon Shon
Michelle M. Grilley
Baldomero M. Olivera
Doju Yoshikami
Maren Marsh
Lourdes J. Cruz
David R. Hillyard
Original Assignee
University Of Utah Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/599,556 external-priority patent/US5670622A/en
Priority claimed from US08/624,123 external-priority patent/US5739276A/en
Application filed by University Of Utah Research Foundation filed Critical University Of Utah Research Foundation
Priority to AU55502/96A priority Critical patent/AU700592B2/en
Priority to JP8531855A priority patent/JPH11503909A/ja
Priority to EP96912813A priority patent/EP0821694A4/fr
Publication of WO1996033206A1 publication Critical patent/WO1996033206A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Peptides de conotoxine, en particulier de δ-conotoxine PVIA et de ν-conotoxine PIIIA. La δ-conotoxine PVIA se trouve dans une espèce de mollusque conidé vivant dans le Pacifique est, chassant le poisson, appelée Conus purpurascens. Cette substance est composée de 29 restes d'acides aminés de la séquence Glu-Ala-Cys-Tyr-Ala-Xaa1-Gly-Thr-Phe-Cys-Gly-Ile-Lys-Xaa2-Gly-Leu-Cys-Cys-Ser-Glu-Phe-Cys-Leu-Pro-Gly-Val-Cys-Pro-Gly (SEQ ID No. 1), où Xaa1 ou Xaa2 sont Pro ou 4-trans-hydroxyproline. La terminaison C peut être libre ou munie d'un amide. La δ-conotoxine PVIA est spécifique aux vertégrés et cible des canaux Na+ sensibles à la tension. La ν-conotoxine PIIIA se trouve également dans le Conus purpurascens. Elle consiste en 22 restes d'acides aminés de la séquence Xaa¿1?-Arg-Leu-Cys-Cys-Gly-Phe-Xaa2-Lys-Ser-Cys-Arg-Ser-Arg-Gln-Cys-Lys-Xaa2-His-Arg-Cys-Cys (SEQ ID No. 2) où Xaa1 représente pyroglutamate ou glutamine et Xaa2 représente 4-trans-hydroxyproline ou proline. Ce dernier peptide cible les canaux de sodium.
PCT/US1996/005262 1995-04-17 1996-04-17 Peptides de conotoxine WO1996033206A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU55502/96A AU700592B2 (en) 1995-04-17 1996-04-17 Conotoxin peptides
JP8531855A JPH11503909A (ja) 1995-04-17 1996-04-17 コノトキシンペプチド
EP96912813A EP0821694A4 (fr) 1995-04-17 1996-04-17 Peptides de conotoxine

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US42356195A 1995-04-17 1995-04-17
US08/423,561 1995-04-17
US08/599,556 1996-02-15
US08/599,556 US5670622A (en) 1996-02-15 1996-02-15 Conotoxin peptide PIIIA
US08/624,123 US5739276A (en) 1994-10-07 1996-03-29 Conotoxin peptides
US08/624,123 1996-03-29

Publications (1)

Publication Number Publication Date
WO1996033206A1 true WO1996033206A1 (fr) 1996-10-24

Family

ID=27411407

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/005262 WO1996033206A1 (fr) 1995-04-17 1996-04-17 Peptides de conotoxine

Country Status (5)

Country Link
EP (1) EP0821694A4 (fr)
JP (1) JPH11503909A (fr)
AU (1) AU700592B2 (fr)
CA (1) CA2216751A1 (fr)
WO (1) WO1996033206A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948526A1 (fr) * 1996-11-08 1999-10-13 University Of Utah Research Foundation Peptides contryphanes
EP1129106A1 (fr) * 1998-09-14 2001-09-05 The University Of Queensland Peptides de conotoxines cyclises
WO2004066990A2 (fr) * 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Methodes destinees a traiter les troubles du tractus urinaire inferieur au moyen de modulateurs du canal sodique
US7084116B2 (en) 2003-03-10 2006-08-01 Dynogen Pharmaceuticals, Inc. Methods for treating lower urinary tract disorders and the related disorders vulvodynia and vulvar vestibulitis using Cav2.2 subunit calcium channel modulators
US7125848B2 (en) 2003-06-13 2006-10-24 Dynogen Pharmaceuticals, Inc. Methods of treating non-inflammatory gastrointestinal tract disorders using Cav2.2 subunit calcium channel modulators
US7223754B2 (en) 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
US8226537B2 (en) 2008-09-12 2012-07-24 Terumo Bct, Inc. Blood processing apparatus with cell separation chamber with baffles
US8722859B2 (en) 2000-04-11 2014-05-13 Genentech, Inc. Multivalent antibodies and uses therefor

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000076532A1 (fr) * 1999-06-10 2000-12-21 University Of Utah Research Foundation νO-CONOPEPTIDES ET LEUR UTILISATION COMME ANESTHESIQUES LOCAUX

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432155A (en) * 1993-06-29 1995-07-11 The Salk Institute For Biological Studies Conotoxins I

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5432155A (en) * 1993-06-29 1995-07-11 The Salk Institute For Biological Studies Conotoxins I

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHEMISTRY, 18 April 1995, Volume 34, Number 15, SHON et al., "Purification, Characterization, Synthesis and Cloning of the Lockjaw Peptide from Conus Purpurascens Venom", pages 4913-4918. *
BIOCHEMISTRY, 1994, Volume 33, Number 38, SHON et al., "Delta-Conotoxin GmVIA, a Novel Peptide from the Venom of Conus Gloriamaris", pages 11420-11425. *
CHEMICAL REVIEWS, 1993, Volume 93, Number 5, MYERS et al., "Conus Peptides as Chemical Probes for Receptors and Ion Channels", pages 1923-1936. *
See also references of EP0821694A4 *
THE JOURNAL OF BIOLOGICAL CHEMISTRY, 20 January 1995, Volume 270, Number 3, FAINZILBER et al., "A New Conotoxin Affecting Sodium Current Inactivation Interacts with the delta-Conotoxin Receptor Site", pages 1123-1129. *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0948526A4 (fr) * 1996-11-08 2003-01-02 Univ Utah Res Found Peptides contryphanes
EP0948526A1 (fr) * 1996-11-08 1999-10-13 University Of Utah Research Foundation Peptides contryphanes
US7001883B1 (en) 1998-09-14 2006-02-21 The University Of Queensland Cyclized conotoxin peptides
EP1129106A4 (fr) * 1998-09-14 2002-07-03 Univ Queensland Peptides de conotoxines cyclises
EP1129106A1 (fr) * 1998-09-14 2001-09-05 The University Of Queensland Peptides de conotoxines cyclises
US7312195B2 (en) 1998-09-14 2007-12-25 The University Of Queensland Cyclised conotoxin peptides
US8722859B2 (en) 2000-04-11 2014-05-13 Genentech, Inc. Multivalent antibodies and uses therefor
US9493579B2 (en) 2000-04-11 2016-11-15 Genentech, Inc. Multivalent antibodies and uses therefor
WO2004066990A2 (fr) * 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Methodes destinees a traiter les troubles du tractus urinaire inferieur au moyen de modulateurs du canal sodique
WO2004066990A3 (fr) * 2003-01-30 2004-11-04 Dynogen Pharmaceuticals Inc Methodes destinees a traiter les troubles du tractus urinaire inferieur au moyen de modulateurs du canal sodique
US7084116B2 (en) 2003-03-10 2006-08-01 Dynogen Pharmaceuticals, Inc. Methods for treating lower urinary tract disorders and the related disorders vulvodynia and vulvar vestibulitis using Cav2.2 subunit calcium channel modulators
US7223754B2 (en) 2003-03-10 2007-05-29 Dynogen Pharmaceuticals, Inc. Thiazolidinone, oxazolidinone, and imidazolone derivatives for treating lower urinary tract and related disorders
US7459430B2 (en) 2003-03-10 2008-12-02 Dynogen Pharmaceuticals, Inc. Methods of using ziconotide to treat overactive bladder
US7125848B2 (en) 2003-06-13 2006-10-24 Dynogen Pharmaceuticals, Inc. Methods of treating non-inflammatory gastrointestinal tract disorders using Cav2.2 subunit calcium channel modulators
US8226537B2 (en) 2008-09-12 2012-07-24 Terumo Bct, Inc. Blood processing apparatus with cell separation chamber with baffles

Also Published As

Publication number Publication date
CA2216751A1 (fr) 1996-10-24
JPH11503909A (ja) 1999-04-06
EP0821694A4 (fr) 1999-04-14
AU5550296A (en) 1996-11-07
EP0821694A1 (fr) 1998-02-04
AU700592B2 (en) 1999-01-07

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