WO1996032400A1 - Dihalogenated ferrocenes and processes for the preparation thereof - Google Patents
Dihalogenated ferrocenes and processes for the preparation thereof Download PDFInfo
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- WO1996032400A1 WO1996032400A1 PCT/EP1996/001439 EP9601439W WO9632400A1 WO 1996032400 A1 WO1996032400 A1 WO 1996032400A1 EP 9601439 W EP9601439 W EP 9601439W WO 9632400 A1 WO9632400 A1 WO 9632400A1
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- 0 **C(C=C1)=CC1C1=CC=CC1 Chemical compound **C(C=C1)=CC1C1=CC=CC1 0.000 description 5
- OZDZHQJWJQHHMD-UHFFFAOYSA-N BrC1=CC=CC1 Chemical compound BrC1=CC=CC1 OZDZHQJWJQHHMD-UHFFFAOYSA-N 0.000 description 1
- NFWSQSCIDYBUOU-UHFFFAOYSA-N CC1=CC=CC1 Chemical compound CC1=CC=CC1 NFWSQSCIDYBUOU-UHFFFAOYSA-N 0.000 description 1
- MMTHHHLQVDLNMK-UHFFFAOYSA-N CC1C(P)=CC=C1 Chemical compound CC1C(P)=CC=C1 MMTHHHLQVDLNMK-UHFFFAOYSA-N 0.000 description 1
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- B01J31/24—Phosphines, i.e. phosphorus bonded to only carbon atoms, or to both carbon and hydrogen atoms, including e.g. sp2-hybridised phosphorus compounds such as phosphabenzene, phosphole or anionic phospholide ligands
- B01J31/2404—Cyclic ligands, including e.g. non-condensed polycyclic ligands, the phosphine-P atom being a ring member or a substituent on the ring
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Definitions
- the invention relates to ferrocenes substituted in the 1 ,2- and 1 '-positions and to processes for the preparation thereof.
- Ferrocenyldiphosphine ligands having a silylene group are important intermediates for ferrocenyldiphosphines, and their metal complexes with transition metals such as rhodium or iridium, bonded via that silylene group to inorganic or polymeric organic carriers.
- Those complexes are used widely in the hydrogenation of organic double or triple bonds, espe ⁇ cially olefinic double bonds and carbon-hetero atom double bonds.
- the complexes are suitable especially for enantioselective hydrogenation using chiral ferrocenyldiphosphines and corresponding prochiral unsaturated compounds.
- EP-A-0-496 699 and EP-A-0496700 disclose silane-group-containing dioxolan- and pyrrolidine-diphosphines and their rhodium or iridium complexes that are fixed to an inorganic carrier such as, for example, a silicate. In that manner there is obtained in the hydrogenation a heterogeneous reaction mixture from which the inorganically fixed catalyst can readily be separated when the reaction is complete.
- silylated ferrocenyldiphosphines in such a manner that they are copolymerisable, for example, via an olefinically unsaturated bond.
- Such procedures are described, for example, in J. Org. Chem. 1981 , 46, 2960-2965.
- the reaction to be catalysed can be carried out heterogeneously or homogeneously depending upon the polymer chosen.
- the polymer may be so selected and also subsequently so modified in a targeted manner that the catalyst can readily be separated off and re-used after the reaction.
- the catalysts may be re-used several times.
- Ferrocenyldiphosphines that contain an organic radical bonded via a silylene group to a cyclopentadienyl ring can be immobilised in a simple manner both on inorganic and on poly ⁇ meric organic carriers or, after the introduction of a polymerisable group, can be immobilised also by copolymerisation.
- the immobilised ferrocenyl ⁇ diphosphine ligands form complexes that can be used as highly active catalysts in the enantioselective hydrogenation of carbon-carbon, carbon-nitrogen or carbon-oxygen double bonds.
- the selectivity and the total yield are surprisingly high for immobilised systems.
- the iridium catalysts are especially well suited to imine hydrogenation since they have clearly the highest activity and the highest catalyst productivity in comparison with other immobilised systems. Their selectivity is likewise very good. The catalysts can readily be separated from the reaction solution and used again. There are virtually no losses of metal and ligand. The use of those immobilised catalysts therefore enables hydrogenation to be carried out economically, especially on an industrial scale.
- Ferrocenes that are substituted by two phosphine groups at a cyclopentadienyl ring are known, and their preparation and use as ligands in metal complexes for stereoselective hydrogenation is described, for example, in EP-A-564 406.
- ferrocenes having a halogen atom bonded to both cyclopentadienyl groups in the 1- and 1 '-positions are known, for example, from R. F. Kovar et al., Organometal. Chem. Syn., 1 (1970/1971) 173-181. Their preparation by means of lithiation and subsequent halogenation is likewise diclosed therein.
- Ri is C ⁇ -C ⁇ alkyl, phenyl or phenyl substituted by from 1 to 3 CrC alkyl or d-C 4 alkoxy substituents;
- R 2 and R 3 are each independently of the other hydrogen or C ⁇ -C ⁇ 2 alkyl
- Hal is F, Cl, Br or I.
- Ri as alkyl is preferably linear. It preferably contains from 1 to 4 carbon atoms. Examples of such alkyl are methyl, ethyl, n- and iso-propyl, n-, iso- and tert-butyl, pentyl, hexyl, heptyl and octyl. Preference is given to methyl and ethyl, and methyl is especially preferred.
- Ri as substituted phenyl preferably contains 1 or 2 substituents.
- Alkyl substituents may be, for example, methyl, ethyl, n- and iso-propyl, n-, iso- and tert-butyl; methyl and ethyl are preferred.
- Alkoxy substituents may be, for example, methoxy, ethoxy, n- and iso-propoxy, n- iso- and tert-butoxy; methoxy and ethoxy are preferred.
- Ri is preferably phenyl or phenyl substituted by 1 or 2 CrC alkyl or C- ⁇ -C alkoxy substituents.
- R 2 and R 3 as alkyl may be linear or branched.
- Examples of Ci- to C 8 -alkyl are mentioned above and include in addition the various isomers of nonyl, decyl, undecyl and dodecyl.
- R 2 and R 3 may also be bonded to one another and form a cyclic alkyl group. Resulting examples are pyrrolidine and piperidine.
- R 2 and R 3 are each independently of the other hydrogen, methyl or ethyl, and are especially both hydrogen or methyl.
- Hal is preferably CI, Br or I.
- the compounds of formula I can be prepared in accordance with analogous processes in a manner known perse, as described, for example, by R. F. Kovar et al., Organometal. Chem. Syn., 1 (1970/1971 ) 173-181 for the reaction of di-lithiated compounds with halogen ⁇ ating agents or by T. Hayashi et al., Bull Chem. Soc. Jpn., 53 (1980) 1138-1151 for stereo- selective lithiation.
- the invention relates also to a process for the preparation of compounds of formula I wherein a compound of formula II
- Ri, R 2 and R 3 are as defined above, is reacted in an inert organic solvent first with an equivalent of alkyllithium and then, in the presence of an amine complexing agent for Li, with a second equivalent of alkyllithium and the product is then reacted with a halogenating agent.
- Alkyllithium is to be understood in the context of this invention as being preferably tert- butyl-, sec-butyl- or n-butyl-lithium.
- Halogenating agents are known in the general prior art for many reactions. Some are also mentioned, for example, in Gmelin, Handbuch der Anorganischen Chemie, Eisen- Organischetechnischschriften Mol A Ferrocen 7, Eighth Edition, Springer Veriag 1980, pages 128-136.
- a halogenating agent selected from the group consisting of Cl 2 , hexa- chloroethane, 1 ,2-dichlorotetrafluoroethane, toluene-4-sulfonyl chloride, Br 2 , 1 ,2-dibromo- tetrachloroethane, 1 ,2-dibromotetrafluoroethane, toluene-4-sulfonyl bromide, 2,3-dimethyl- 2,3-dibromobutane, l 2 , 1 ,2-diiodotetrafluoroethane, perfluoropropyl iodide, perfluoroethyl iodide, toluene-4-sulfonyl iodide and perf luorom ethyl iodide.
- the compounds of formula I act as starting materials for the preparation of compounds of formula III which are likewise novel and a subject of this invention.
- the invention relates also to compounds of formula III
- Rio and R are identical or different and are C ⁇ -C ⁇ 2 alkyl, Cs-Ci 2 Cycloalkyl, phenyl,
- R4, R 5 and R 6 are each independently of the others Ci-Ctalkyl or phenyl;
- R 7 and R ⁇ are H, C ⁇ -Ci2alkyl or phenyl or
- R 7 and R 8 together are tetramethylene, pentamethylene or 3-oxa-1 ,5-pentylene;
- R 9 is H or d-C 4 alkyl; is H or an alkali metal;
- X ' is the anion of a monobasic acid.
- R10 and Rn as alkyl may be linear or branched and they contain preferably from 1 to 8 and especially from 1 to 4 carbon atoms.
- alkyl examples include methyl, ethyl, n- and iso- propyl, n-, iso- and tert-butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl and dodecyl.
- Methyl, ethyl, n- and iso-propyl, n-, iso- and tert-butyl are preferred.
- R 10 and Rn are identical, as alkyl they are especially isopropyl or tert-butyl.
- cycloalkyl contains preferably from 5 to 8 and especially 5 or 6 ring carbon atoms.
- examples of cycloalkyl are cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclo- decyl and cyclododecyl. Preference is given to cyclopentyl and cyclohexyl, and cyclohexyl is especially preferred.
- the cycloalkyl may be substituted, for example by from 1 to 3 alkyl or alkoxy substituents. Examples of such substituents have been given above. Methyl and ethyl and methoxy and ethoxy are preferred. Examples of substituted cycloalkyl are methyl- and methoxy-cyclo- pentyl and -cyclohexyl.
- Rio and Rn as substituted phenyl preferably contain 1 or 2 substituents. When phenyl contains 2 or 3 substituents, those substituents may be identical or different.
- alkyl and alkoxy substituents examples include methyl, ethyl and methoxy and ethoxy.
- the phenyl substituent is halogen, it is preferably -F, -Cl or -Br.
- the phenyl substituent is C ⁇ -C 5 fluoroalkyl
- it is fully or partially fluorinated CrC alkyl.
- Examples thereof are the position isomers of mono- to deca-fluoropentyl, mono- to octa- fluorobutyl, mono- to hexa-fluoropropyl, mono- to tetra-fluoroethyl and mono- and di-fluoro- methyl.
- the partially fluorinated alkyl radicals those of the formulae -CF 2 H and -CF 2 (C ⁇ -C 4 alkyl) are especially preferred. Special preference is given to perfluorinated alkyl.
- R 4 , R 5 and R 6 may be linear or branched alkyl that contains preferably from 1 to 8 and espe ⁇ cially from 1 to 4 carbon atoms. Examples of alkyl have been given above. Preferred alkyl is methyl, ethyl, n-propyl, n-butyl or tert-butyl.
- the substituent -SiR 4 R 5 R e is preferably tri- methylsilyl.
- M is preferably H, Li, Na or K.
- R 7 and R ⁇ as alkyl contain preferably from 1 to 6 and especially from 1 to 4 carbon atoms.
- the alkyl is preferably linear. Preferred examples are methyl, ethyl, n-propyl and n-butyl.
- R 9 as alkyl is preferably methyl.
- X * as an anion of a monobasic acid is preferably Cl " , Br " or the anion of a carboxylic acid, for example formate, acetate, trichloroacetate or trifluoroacetate.
- R1 0 and R as substituted phenyl are 2-methyl-, 3-methyl-, 4-methyl-, 2- or 4-ethyl-, 2- or 4-isopropyl-, 2- or 4-tert-butyl-, 2-methoxy-, 3-methoxy-, 4-methoxy-, 2- or4-ethoxy-, 4-trimethylsilyl-, 2- or4-fluoro-, 2,4-difluoro-, 2- or4-chloro-, 2,4-dichloro-, 2,4- dimethyl-, 3,5-dimethyl-, 2-methoxy-4-methyl-, 3,5-dimethyl-4-methoxy-, 3,5-dimethyl-4- (dimethylamino)-, 2- or 4-amino-, 2- or 4-methylamino-, 2- or 4-(dimethylamino)-, 2- or 4- SO 3 H-, 2- or 4-S0 3 Na-, 2- or 4-pNH 3 C ⁇ -, 3,4,5-trimethylphen-1 -yl, 2,4,
- R 10 and Rn are especially preferably cyclohexyl, tert-butyl, phenyl, 2- or 4-methylphen-l-yl, 2- or 4-methoxyphen-1-yl, 2- or4-(dimethylamino)phen-1-yl, 3,5-dimethyl-4-(dimethylamino)- ph ⁇ n-1-yl or 3,5-dimethyl-4-methoxyphen-1-yl, but especially cyclohexyl, phenyl, 4- methylphen-1-yl or tert-butyl.
- the process is preferably carried out by adding alkyllithium at a temperature of from -90 to +20°C.
- the compound of formula V is added preferably at a temperature of from -90 to +20°C.
- the invention relates also to ferrocenyldiphosphines of formula VI that are obtained using compounds of formula III as starting materials,
- R12 and R 13 are each independently of the other C ⁇ -C ⁇ 2 alkyl, Cs-C ⁇ 2 cycloalkyl, phenyl, C5-Ci2cyclo ⁇ alkyl substituted by C ⁇ -C 4 alkyl or by CrC 4 alkoxy, or phenyl mono- or poly-substituted by from one to three d-dalkyl, C ⁇ -C 4 alkoxy, -SiF RsRe, halogen, -S0 3 M, -CCfeM, -PO3M, -NR 7 R 8 , -rNR 7 R 8 R 9 ]X " or C ⁇ -C 5 fluoroalkyl substituents; or the group -PR1 2 R13 is a radical of formula IV, IVa, IVb or IVc
- Rs, Re, R 7 , Re, R 9 , M and X ' have the definitions and preferred meanings given above.
- Examples of alkyl, cycloalkyl, substituted phenyl and fluoroalkyl have already been given above and apply also to the definitions of R12 and R13.
- R 12 and R1 3 are preferably CrC 8 alkyl. Examples of C ⁇ -C 8 alkyl have already been mentioned.
- R1 2 and R 13 preferably are identical and are isopropyl or tert-butyl.
- R 12 and R ⁇ 3 as cycloalkyl preferably contain from 5 to 8 carbon atoms.
- R ⁇ 2 and R ⁇ 3 are unsubstituted phenyl or phenyl substituted by 1 or 2 substituents.
- R12 and R13 as substituted phenyl are especially preferably 2-methyl-, 3-methyl-, 4-methyl-, 2- or 4-ethyh 2- or 4-isopropyl-, 2- or 4-tert-butyl-, 2-methoxy-, 3-methoxy-, 4-methoxy-, 2- or 4-ethoxy-, 4-trimethylsilyl-, 2- or 4-fluoro-, 2,4-difluoro-, 2- or 4-chloro-, 2,4-dichloro-, 2,4- dimethyl-, 3,5-dimethyl-, 2-methoxy-4-methyl-, 3,5-dimethyl-4-methoxy-, 3,5-dimethyl-4- (dimethylamino)-, 2- or 4-amino-, 2- or 4-methylamino-, 2- or 4-(dimethylamino)-, 2- or 4- S0 3 H-, 2- or 4-S03Na-, 2- or 4-fNH 3 CI , 3,4,5-trimethylphen-l-yl, 2,4,6-trimethylphen
- R 12 and R 13 are identical and are phenyl, cyclohexyl, 2- or 4-methylphen-1-yl, 2- or 4-methoxyphen-1-yl, 2- or 4-(dimethylamino)phen-1-yl, 3,5-dimethyl-4-(dimethylamino)phen-1-yl or 3,5-dimethyl-4- methoxyphen-1-yl;
- R ⁇ 2 and R ⁇ 3 are more especially identical radicals and are cyclohexyl or phenyl.
- R12 and R13 are each cyclohexyl or phenyl and Rio and Rn are phenyl, cyclohexyl or tert-butyl are especially preferred.
- the process for the preparation of compounds of formula VI comprises reacting a compound of formula III with a compound of formula H-P(R 12 Ri3) in acetic acid, with R 12 and R ⁇ 3 having the definitions and preferred meanings given above.
- the compounds of formulae I, III and VI may be obtained in the form of racemates, pure enantiomers or mixtures of enantiomers. If the synthesis is carried out using enantiomeric- ally pure compounds of formula II as starting materials, there is formed very preferentially only one of the two possible diastereoisomers of the compounds of formula I and conseq ⁇ uently also of the compounds of formula III and VI.
- racemates or optically active mixtures are used as starting materials, they can be separa ⁇ ted into the stereoisomers by means of known methods, with chromatographic methods generally being preferred.
- the optical isomers of compounds of formula VI especially are valuable starting materials for the preparation of immobilised hydrogenation catalysts.
- the isolation and purification of the compounds is carried out in accordance with methods known perse, for example distillation, extraction, crystallisation and/or chromatographic methods.
- the compounds of formula VI can in a first step be lithiated with alkyllithium in known manner, as described, for example, in J. Chem. Soc. Chem. Commun., 1994, 2347-2348.
- a compound of formula VII CISi(R ⁇ 4 ) -(Ri5)-CI (VII) is then added and reacted to form compounds of formula VIII,
- radicals R 14 are each independently of the other Ci-C t alkyl, C 3 -C ⁇ cycloalkyl, benzyl or phenyl or are together C -Ci2alkylene and R ⁇ 5 is Ci-Ci ⁇ alkylene or phenylene.
- R ⁇ 4 is methyl and R 15 is propyl.
- Ri to R 13 have been defined above.
- the compounds of formula VIII can also be obtained by in a first step lithiating compounds of formula III in accordance with known procedures and then in a second step reacting with compounds of formula VII to form compounds of formula IX the definitions an d preferred meanings of the radicals Ri to R 15 have been given above.
- Compounds of formula IX may also be used as hydrogenation and hydrosilylation catalysts analogously to the amine-group-containing diphosphines described by Cullen et al. in Can. J. Chem. Vol. 60, 1982, pages 1793 to 1799.
- the compounds of formula IX can likewise be immobilised on polymers and used as immobilised ligands in enantioselective catalytic reactions.
- Ra is CrC 4 alkyl or OR17
- A is NH or N(C ⁇ -C ⁇ 2 )alkyl
- R ⁇ 6 is d-C ⁇ alkylene
- R 7 is C ⁇ -C ⁇ 2 alkyl.
- reaction steps are analogy processes that are described, for example, in EP-A-612 758 and in EP-A-496699.
- the step of amination to form the compounds of formula Villa is known to the person skilled in the art from current reference books on organic chemistry.
- Q is a bridge group formed by a diisocyanate
- PM is the radical of a polymer-forming monomer that contains as functional group, bonded directly or in a side chain, a hydroxy group or a primary or secondary amine group which is bonded to the diphosphine via a bridge group Q formed by a diisocyanate.
- Preferred diisocyanates are 1 ,6-bis[isocyanato]hexane, 5-isocyanato-3-(isocyanatomethyl)- 1 ,1 ,3-trimethylcyclohexane, 1 ,3-bis[5-isocyanato-1 ,3,3-trimethyl-phenyl]-2,4-dioxo-1 ,3- diazetidine, 3,6-bis[9-isocyanato-nonyl]-4,5-di(1 -heptenyl)cyclohexene, bis[4-isocyanato- cyclohexyljmethane, trans-1 ,4-bispsocyanatojcyclohexane, 1 ,3-bispsocyanatomethyl]- benzene, 1 ,3-bis[1-isocyanato-1-methyl-ethyl]benzene, 1 ,4-bis[2-isocyanato-ethy
- diisocyanates are 1 ,6-bis[isocyanato]hexane, 5-isocyanato-3-(iso- cyanatomethyl)-1 ,1 ,3-trimethylcyclohexane, 2,4-bis[isocyanato]toluene, 2,6-bis[isocyanato]- toluene, 2,4-/2,6-bispsocyanato]toluene and bis[4-isocyanato-phenyl]methane.
- the polymers according to the invention may be uncrosslinked thermoplastic, crosslinked or structurally crosslinked polymers.
- the polymers can be either polymerisates of olefinically unsaturated monomers, for example polyolefins, polyacrylates, polyisoprenes, polybutadiene, polystyrene, poly- phenylene, polyvinyl chloride, polyvinylidene chloride or polyallyl compounds. They may also be polyaddition compounds, for example polyurethanes or polyethers. Polycondensed products which may be mentioned are polyesters or polyamides
- Another preferred group of polymers is formed by monomers derived from ⁇ , ⁇ -unsaturated acids and their esters and amides, the structural units of which contain a hydroxy group or a primary or secondary amine group bonded as functional group.
- the monomers from the group of the acrylates and the C ⁇ -C 4 alkyl esters thereof, methacrylates and the C ⁇ -C 4 alkyl esters thereof, acrylamide and acrylonitrile, the structural units of which contain a hydroxy group or a primary or secondary amine group bonded as functional group in the ester or amide group.
- the hydroxy-functional or primary or secondary amine-functional monomers form from 1 to 100 mole %, preferably from 5 to 100 mole % and especially from 10 to 100 mole %, of the polymer structure in the case of soluble or swellable polymers in which the functional group is already present.
- crosslinked polymers that are functional ised subsequently, preferably from 1 to 50 mole %, especially from 1 to 20 mole %, hydroxy-functional or primary or secondary amine-functional groups are present, the molar percentages being based on the monomer forming the majority of the polymer.
- the loading of the polymer with ferrocenyldiphosphines according to the invention is preferably from 5 to 100 mole %, especially from 5 to 50 mole %, based on the available hydroxy group or primary or secondary amine group of the polymer.
- the polymeric carriers can be prepared as follows: polymers having structural repeating units of at least one monomer that contains a hydroxy group or a primary or secondary amine group bonded as functional group directly in the polymer spine or in a side chain
- A) in a first step are fully or partially reacted, in an inert organic solvent, with a diisocyanate that forms a bridge group Q and in a second step the product is reacted with a diphosphine that contains tertiary phosphine groups bonded in the 1 ,2-positions of one cyclopentadienyl ring, one of which tertiary phosphine groups is bonded directly and the other of which is bonded via a group CHRi to the cyclopentadienyl ring, and that contains a silylene group -Si(R ⁇ 4 ) 2 -Ri 5 -A- bonded to the other cyclopentadienyl radical; or
- any free isocyanate groups that remain are crosslinked with a C 2 -C 24 diol or d-C 2 di- amine or removed by reaction with a C 2 -C ⁇ 2 alcohol or d-C ⁇ amine.
- the diisocyanates forming a bridge group Q can be reacted with the amine or hydroxy groups of the polymer and of the diphosphine at room temperature or elevated temperature, for example from 30° to 100°C in accordance with methods known in the literature.
- the compounds of formula VI I Id can be reacted to form ferrocenyldiphosphines fixed on inorganic carriers by means of an analogous reaction procedure - as disclosed in EP-A- 0496699.
- the solid carrier T can be a silicate or a semi-metal oxide or metal oxide or a glass, which are preferably present in the form of powders having average particle diameters of from 10 nm to 2000 ⁇ m, preferably from 10 nm to 1000 ⁇ m and especially from 10 nm to 500 ⁇ m. They may be either compact or porous particles. Porous particles preferably have large internal surface areas, for example from 1 to 1200 m 2 , preferably from 30 to 600 m 2 . Examples of oxides and silicates are SiO 2> Ti0 2 , ZrO 2 , MgO, NiO, W0 3 , Al 2 0 3 , La 2 0 3 , silica gels, clays and zeolites. Preferred carriers are silica gels, aluminium oxide, titanium oxide or glass and mixtures thereof. An example of a glass as carrier is "controlled pore glass" which is commercially available.
- metal complexes of rhodium or iridium by reacting the organic or inorganic carriers to which the diphosphines are bonded with a metal compound of the formula [Me(Y)D] 2 or Me(Y) 2 + E " wherein Me is rhodium or iridium, Y represents two monoolefin ligands or one diene ligand; D is -Cl, -Br or -I and E " is the anion of an oxy acid or complex acid.
- Metal complexes in which Y is 1 ,5-hexadiene, 1 ,5-cyclooctadiene or norbornadiene are preferred.
- D is preferably -Cl, -Br or -I.
- E " is CIO 4 " , CF 3 SO 3 “ , CH 3 SO 3 , HS0 4 “ , BF 4 “ , B(phenyl) 4 ⁇ PF 6 ⁇ SbCI 6 “ , AsF 6 “ or SbF 6 " .
- the reaction is advantageously carried out under an inert gas atmosphere, for example argon, and expediently at temperatures of from 0 to 40°C, preferably at room temperature, in the case of soluble polymer-bonded diphosphines.
- a solvent or mixture of solvents is advantageously co-used, for example hydrocarbons (benzene, toluene, xylene), halogena- ted hydrocarbons (methylene chloride, chloroform, carbon tetrachloride, chlorobenzene), alkanols (methanol, ethanol, ethylene glycol monomethyl ether), and ethers (diethyl ether, dibutyl ether, ethylene glycol dimethyl ether) or mixtures thereof.
- hydrocarbons benzene, toluene, xylene
- halogena- ted hydrocarbons methylene chloride, chloroform, carbon tetrachloride, chlorobenzene
- alkanols methanol, ethanol,
- the metal complexes are used for the asymmetric hydrogenation of prochiral compounds having carbon-carbon or carbon-hetero atom double bonds, especially the Ir complexes for the hydrogenation of asymmetric ketimines.
- Such hydrogenations with soluble homogeneous ferrocenyldiphosphine metal complexes are disclosed, for example, in EP-A-612 758.
- the primary amine (8) is prepared by way of Gabriel synthesis (conversion of the chloride into the phthalimide and freeing of the amine with hydrazine hydrate) from compound (7)
- Example 7
- Example 7 in 3 ml of DMF and the mixture is stirred at 96°C for 1.5 hours. After cooling, the mixture is extracted by shaking in water/toluene and the organic phase is dried with sodium sulfate and concentrated in a rotary evaporator. After purification by chromatography
- the primary amine of formula 13 is prepared by way of Gabriel synthesis (conversion of the chloride into the phthalimide and freeing of the amine with hydrazine hydrate):
- Example B Ligands immobilised on silica ⁇ el or polystyrene
- Example A9 or of formula 14 from Example A14 in toluene is added and the mixture is stirred at 85-90°C for 20 hours. After cooling and settling, the supernatant solution is drawn off using a syringe. The mixture is then washed six times with MeOH (7 ml per g of carrier each time) and finally dried at 40-50°C under a high vacuum. The results are given in Table 1.
- TDI 2,4-toluylene diisocyanate
- the excess TDI is then removed by filtering off the solution and washing five times with 30 ml of methylene chloride.
- the carrier that has reacted with the TDI is then stirred in 30 ml of methylene chloride, and a solution of 100 mg (0.133 mmol) of the compound of formula (13) from Example A13 in 2 ml of methylene chloride is added dropwise thereto. The mixture is stirred overnight.
- 10 ml of ethyl alcohol containing 30 ⁇ l of triethylamine are added as catalyst and the mixture is stirred overnight at 40°C.
- the yellowish-orange carrier is then filtered off and washed five times using 20 ml of methylene chloride each time. Finally the carrier is dried under a high vacuum.
- the reaction mixture is then introduced under pressure into a 50 ml steel autoclave using a steel capillary against a current of inert gas and then hydrogenated at 25°C at a hydrogen pressure of 80 bar. After 16 hours the hydrogenation is discontinued, the hydrogen is depressurised and the catalyst is filtered off. The conversion is 68 % after that time and the optical yield is 71.1 % (S).
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Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69603466T DE69603466T2 (en) | 1995-04-11 | 1996-04-02 | DIHALOGENIZED FERROCENES AND METHOD FOR THE PRODUCTION THEREOF |
CA002216153A CA2216153C (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof |
US08/930,171 US5925778A (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof |
AU54992/96A AU5499296A (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation hereof |
JP53068896A JP3854638B2 (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocene and process for producing the same |
EP96911992A EP0820460B1 (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof |
MX9707801A MX9707801A (en) | 1996-04-02 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof. |
BR9608128A BR9608128A (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and process for their preparation |
HU9801601A HU221611B (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof |
PL96322745A PL322745A1 (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and methods of obtaining them |
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CH106795 | 1995-04-11 | ||
CH1067/95-2 | 1995-04-11 |
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WO1996032400A1 true WO1996032400A1 (en) | 1996-10-17 |
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PCT/EP1996/001439 WO1996032400A1 (en) | 1995-04-11 | 1996-04-02 | Dihalogenated ferrocenes and processes for the preparation thereof |
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US (2) | US5925778A (en) |
EP (1) | EP0820460B1 (en) |
JP (1) | JP3854638B2 (en) |
KR (1) | KR100416359B1 (en) |
AT (1) | ATE182595T1 (en) |
AU (1) | AU5499296A (en) |
BR (1) | BR9608128A (en) |
CA (1) | CA2216153C (en) |
CZ (1) | CZ291280B6 (en) |
DE (1) | DE69603466T2 (en) |
ES (1) | ES2135894T3 (en) |
HU (1) | HU221611B (en) |
PL (1) | PL322745A1 (en) |
WO (1) | WO1996032400A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1998001457A1 (en) * | 1996-07-10 | 1998-01-15 | Novartis Ag | Functionalized ferrocenyldiphosphines, a process for their preparation and their use |
US6015919A (en) * | 1995-04-11 | 2000-01-18 | Novartis Ag | Dihalogenated ferrocenes and processes for the preparation thereof |
WO2000037478A1 (en) * | 1998-12-19 | 2000-06-29 | Degussa Aktiengesellschaft | Ligands and complexes for enantioselective hydrogenation |
US6133464A (en) * | 1996-10-07 | 2000-10-17 | Novartis Ag | Chiral ferrocenyls |
GB2423987A (en) * | 2005-03-09 | 2006-09-13 | E2V Tech | Metallocenes and their use as Raman spectroscopy labels |
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KR101464702B1 (en) * | 2006-12-02 | 2014-11-26 | 루사이트 인터내셔널 유케이 리미티드 | Novel carbonylation ligands and their use in the carbonylation of ethylenically unsaturated compounds |
GB0625518D0 (en) * | 2006-12-21 | 2007-01-31 | Lucite Int Uk Ltd | Carbonylation of conjugated dienes |
GB0812297D0 (en) * | 2008-07-04 | 2008-08-13 | Lucite Int Uk Ltd | Novel carbonylation ligand sand thier use of in the carbonylation of ethylenically unsaturated compounds |
JP5493346B2 (en) * | 2008-12-11 | 2014-05-14 | 東ソー株式会社 | Ferrocene derivatives and uses thereof |
GB0905995D0 (en) * | 2009-04-06 | 2009-05-20 | Univ Gent | Cyclic imidate ligands |
GB201000078D0 (en) | 2010-01-05 | 2010-02-17 | Lucite Int Uk Ltd | Process for the carbonylation of ethylenically unsaturated compounds, novel carbonylation ligands and catalyst systems incorporatng such ligands |
GB201211157D0 (en) | 2012-06-22 | 2012-08-08 | Atlas Genetics Ltd | Novel compounds and their use in analytical methods |
JP2023130917A (en) * | 2022-03-08 | 2023-09-21 | 国立大学法人 東京大学 | Core-shell type heterogeneous catalyst and manufacturing method for optically active compound employing the same |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0564406A1 (en) * | 1992-04-02 | 1993-10-06 | Ciba-Geigy Ag | Ferrocenyldiphosphine as ligands for homogeneous catalysts |
EP0612758A1 (en) * | 1993-02-26 | 1994-08-31 | Ciba-Geigy Ag | Ferrocenyl/diphosphines as ligands for homogeneous catalysts |
EP0646590A1 (en) * | 1993-10-01 | 1995-04-05 | Ciba-Geigy Ag | Ferrocenyldiphosphines substituted with fluoroalkyl groups as ligands for homogeneous catalysis |
WO1996016971A1 (en) * | 1994-11-29 | 1996-06-06 | Lonza Ag | Method of producing optically active metallocenyl phosphines |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0496700B1 (en) * | 1991-01-25 | 1996-03-06 | Ciba-Geigy Ag | Diphosphines containing silane groups, immobilized diphosphines and their use as hydrogenation catalysts |
EP0496699B1 (en) * | 1991-01-25 | 1995-04-26 | Ciba-Geigy Ag | Diphosphines containing silane groups, immobilized diphosphines and their use as hydrogenation catalysts |
DE59605736D1 (en) * | 1995-02-24 | 2000-09-21 | Novartis Ag | Silylated ferrocenyl diphosphines, silylated ferrocenyl diphosphines bound to inorganic or polymeric organic carriers, and metal complexes thereof, their preparation and use |
DE69603466T2 (en) * | 1995-04-11 | 1999-11-18 | Novartis Ag | DIHALOGENIZED FERROCENES AND METHOD FOR THE PRODUCTION THEREOF |
HRP960295A2 (en) * | 1995-07-06 | 1997-08-31 | Ciba Geigy Ag | Process for the hydrogenation of imines in the presence of immobilized iridium-diphosphine catalysts |
-
1996
- 1996-04-02 DE DE69603466T patent/DE69603466T2/en not_active Expired - Fee Related
- 1996-04-02 HU HU9801601A patent/HU221611B/en not_active IP Right Cessation
- 1996-04-02 CA CA002216153A patent/CA2216153C/en not_active Expired - Fee Related
- 1996-04-02 BR BR9608128A patent/BR9608128A/en not_active IP Right Cessation
- 1996-04-02 JP JP53068896A patent/JP3854638B2/en not_active Expired - Fee Related
- 1996-04-02 AT AT96911992T patent/ATE182595T1/en not_active IP Right Cessation
- 1996-04-02 KR KR1019970707184A patent/KR100416359B1/en not_active IP Right Cessation
- 1996-04-02 CZ CZ19973203A patent/CZ291280B6/en not_active IP Right Cessation
- 1996-04-02 WO PCT/EP1996/001439 patent/WO1996032400A1/en active IP Right Grant
- 1996-04-02 EP EP96911992A patent/EP0820460B1/en not_active Expired - Lifetime
- 1996-04-02 PL PL96322745A patent/PL322745A1/en unknown
- 1996-04-02 US US08/930,171 patent/US5925778A/en not_active Expired - Fee Related
- 1996-04-02 AU AU54992/96A patent/AU5499296A/en not_active Abandoned
- 1996-04-02 ES ES96911992T patent/ES2135894T3/en not_active Expired - Lifetime
-
1999
- 1999-02-08 US US09/246,203 patent/US6015919A/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0564406A1 (en) * | 1992-04-02 | 1993-10-06 | Ciba-Geigy Ag | Ferrocenyldiphosphine as ligands for homogeneous catalysts |
EP0612758A1 (en) * | 1993-02-26 | 1994-08-31 | Ciba-Geigy Ag | Ferrocenyl/diphosphines as ligands for homogeneous catalysts |
EP0646590A1 (en) * | 1993-10-01 | 1995-04-05 | Ciba-Geigy Ag | Ferrocenyldiphosphines substituted with fluoroalkyl groups as ligands for homogeneous catalysis |
WO1996016971A1 (en) * | 1994-11-29 | 1996-06-06 | Lonza Ag | Method of producing optically active metallocenyl phosphines |
Non-Patent Citations (1)
Title |
---|
KIM, T.-J. ET AL.: "FUNCTIONALIZED ORGANOMETALLIC LIGAND (1) SYNTHESIS OF SOME FERROCENE DERIVATIVES OF CYCLOHEXYL- AND CYCLOPENTADIENYL-PHOSPHINES", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 13, no. 6, 1992, pages 588 - 592, XP000565474 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6015919A (en) * | 1995-04-11 | 2000-01-18 | Novartis Ag | Dihalogenated ferrocenes and processes for the preparation thereof |
WO1998001457A1 (en) * | 1996-07-10 | 1998-01-15 | Novartis Ag | Functionalized ferrocenyldiphosphines, a process for their preparation and their use |
US6169192B1 (en) | 1996-07-10 | 2001-01-02 | Novartis Ag | Functionalized ferrocenyldiphosphines, a process for their preparation and their use |
US6133464A (en) * | 1996-10-07 | 2000-10-17 | Novartis Ag | Chiral ferrocenyls |
WO2000037478A1 (en) * | 1998-12-19 | 2000-06-29 | Degussa Aktiengesellschaft | Ligands and complexes for enantioselective hydrogenation |
GB2423987A (en) * | 2005-03-09 | 2006-09-13 | E2V Tech | Metallocenes and their use as Raman spectroscopy labels |
Also Published As
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JPH11503439A (en) | 1999-03-26 |
KR100416359B1 (en) | 2004-04-21 |
CZ291280B6 (en) | 2003-01-15 |
EP0820460B1 (en) | 1999-07-28 |
EP0820460A1 (en) | 1998-01-28 |
DE69603466D1 (en) | 1999-09-02 |
JP3854638B2 (en) | 2006-12-06 |
US5925778A (en) | 1999-07-20 |
CA2216153A1 (en) | 1996-10-17 |
ES2135894T3 (en) | 1999-11-01 |
DE69603466T2 (en) | 1999-11-18 |
PL322745A1 (en) | 1998-02-16 |
AU5499296A (en) | 1996-10-30 |
CA2216153C (en) | 2008-02-05 |
BR9608128A (en) | 1999-02-09 |
CZ320397A3 (en) | 1998-02-18 |
HU221611B (en) | 2002-11-28 |
HUP9801601A2 (en) | 1998-10-28 |
HUP9801601A3 (en) | 1999-03-29 |
KR19980703784A (en) | 1998-12-05 |
ATE182595T1 (en) | 1999-08-15 |
US6015919A (en) | 2000-01-18 |
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