WO1996029115A1 - Procede de chirurgie laser corneenne - Google Patents

Procede de chirurgie laser corneenne Download PDF

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Publication number
WO1996029115A1
WO1996029115A1 PCT/US1996/003582 US9603582W WO9629115A1 WO 1996029115 A1 WO1996029115 A1 WO 1996029115A1 US 9603582 W US9603582 W US 9603582W WO 9629115 A1 WO9629115 A1 WO 9629115A1
Authority
WO
WIPO (PCT)
Prior art keywords
recited
lentoid
stroma
tissue
posterior surface
Prior art date
Application number
PCT/US1996/003582
Other languages
English (en)
Inventor
Mark Speaker
Vicenzo Marchi
Tibor Juhasz
Heinz Gisel
Original Assignee
Escalon Medical Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Escalon Medical Corp. filed Critical Escalon Medical Corp.
Publication of WO1996029115A1 publication Critical patent/WO1996029115A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F9/00825—Methods or devices for eye surgery using laser for photodisruption
    • A61F9/00827—Refractive correction, e.g. lenticle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
    • A61F2009/00872—Cornea

Definitions

  • the present invention pertains generally to ophthalmic surgery which is useful for correcting vision deficiencies. More particularly, the present invention pertains to methods which surgically correct the vision of a patient by removing portions of the stroma to reshape the cornea.
  • the present invention is particularly, but not exclusively useful as a method for using a laser beam to photodisrupt a surface surrounding and containing the predetermined volume of stromal tissue which needs to be removed to correct the vision of the patient.
  • Vision impairment can occur for many reasons, and be the result of many causes.
  • One, all too common, cause for vision impairment results from a defective condition of the eye which occurs when the refractive characteristics of the cornea do not cause parallel rays of light to focus on the retina.
  • myopia i.e. near-sightedness
  • hypermetropia i.e. far-sightedness
  • Both myopic and hyperopic conditions result in varying degrees of vision impairment and, as is well known, in most cases the conditions are correctable.
  • the previously removed anterior portion of the cornea is then repositioned on the cornea to cover the photodisruption.
  • This procedure like the procedure disclosed in Bille et al. •586, has as its objective the removal of only stromal tissue with the consequent preservation of anterior corneal tissue.
  • the surgical procedure employed must be capable of removing corneal tissue having a thickness which is accurate to within less than ten microns. Furthermore, this degree of accuracy applies for any refractive correction regardless of the total amount of correction required.
  • an object of the present invention to provide a method for corneal laser surgery which corrects the refractive characteristics of the cornea by removing only stromal tissue with minimal photodisruption of the tissue.
  • Another object of the present invention is to provide a method for corneal laser surgery which essentially maintains the structural integrity of corneal tissue.
  • Still another object of the present invention is to provide a method for corneal laser surgery which can be accomplished with a high level of precision when cutting corneal tissue by photodisruption.
  • Yet another object of the present invention is to provide a method for corneal laser surgery which is relatively easy to practice and comparatively cost effective.
  • a method for corneal laser surgery includes the step of first determining a volume of stromal tissue which needs to be removed in order to correct the vision of the patient.
  • This volume of stromal tissue which is to be removed is formed as a lentoid that is defined by an anterior surface and a posterior surface. Accordingly, these surfaces are situated relative to each other so that the lentoid shaped volume of tissue to be removed is positioned therebetween.
  • a pulsed laser beam is focused to position its focal point at a preselected start point on the posterior surface of the lentoid.
  • the focal point is then moved over the posterior surface to photodisrupt tissue on this surface and separate the lentoid from surrounding tissue.
  • the same process is repeated for the anterior surface and the result is that the lentoid of stromal tissue to be removed is completely surrounded by photodisrupted tissue and thereby free of attachments to surrounding tissue.
  • the posterior surface is shaped as a concave plate and the anterior surface is shaped as a convex plate. The removal of the resultant lens shaped tissue lentoid or disc is specifically intended to correct myopia.
  • the anterior surface or the posterior surface, or both can be substantially flat.
  • the concave posterior surface could be modified to be a convex surface and thus have a curved surface which is similar to the anterior surface.
  • the posterior surface is shaped as a concave annular surface and the anterior surface is shaped as a convex annular surface.
  • the stromal tissue to be removed is a ring shaped or doughnut shaped volume which is specifically intended to correct hyperopia.
  • the method of the present invention also contemplates the creation of a channel through the stroma which provides for extracorporeal access to the encapsulated portion of the stroma.
  • the encapsulated portion of the stroma can then be accessed, gripped, and removed or retrieved from the stroma through the channel.
  • the cornea is appropriately reshaped to correct the particular vision defect of the patient.
  • the laser system to be used for accomplishing the methods will incorporate a beam of sequential laser pulses. Further, it is contemplated that the duration of laser pulses in the beam will be in the nanosecond, picosecond or femtosecond ranges.
  • Figure 1 is a perspective view of a patient being treated with the method of the present invention
  • Figure 2 is a perspective view of an eye
  • Figure 3 is a cross sectional view of the cornea of the eye as seen along the line 3-3 in Figure 2 showing a representative portion of stromal tissue to be removed for the correction of myopia;
  • Figure 3A is a cross-sectional view of a lentoid having a convex anterior surface and a concave posterior surface;
  • Figure 3B is a cross-sectional view of a lentoid having a convex anterior surface and a concave posterior surface which are separated by a contiguous flat annular surface therebetween;
  • Figure 3C is a cross-sectional view of a lentoid having a flat anterior surface and a flat posterior surface which are separated by a contiguous flat annular surface therebetween;
  • Figure 4 is a plan view of the cornea of the eye as seen in the direction of the line 4-4 in Figure 2 showing a representative path for movement of the laser beam focal point to prepare the portion of stromal tissue shown in Figure 3 for removal from the cornea;
  • Figure 5 is a cross sectional view of the cornea of the eye as seen along the line 3-3 in Figure 2 showing a representative portion of stromal tissue to be removed for the correction of hyperopia
  • Figure 6 is a plan view of the cornea of the eye as seen in the direction of the line 4-4 in Figure 2 showing a representative path for movement of the laser beam focal point to prepare the portion of stromal tissue shown in Figure 5 for removal from the cornea;
  • Figure 7 is a cross sectional view of the cornea of the eye as seen along the line 3-3 in Figure 2 showing the gripping of the portion of stromal tissue to be removed;
  • Figure 8 is a cross sectional view of the cornea of the eye as seen along the line 3-3 in Figure 2 showing the retrieval of the portion of stromal tissue to be removed.
  • an apparatus 10 for generating a laser beam 12 is shown. Specifically, the laser beam 12 is shown being directed onto an eye 14 of a patient 16.
  • the apparatus 10 is capable of generating a pulsed laser beam 12 having physical characteristics similar to those of the laser beams generated by a laser system as disclosed and claimed in U.S. Patent No.4, 76 , 930, which is also assigned to the assignee of the present invention.
  • the present invention contemplates the use of a pulsed laser beam 12 which has pulses with durations as long as a few nanoseconds or as short as only a few femptoseconds.
  • Figure 2 shows the anatomical structure of eye 14 and, specifically, that the cornea 18 is anterior to the pupil 20, the iris 22, and the sclera 24. Additionally, Figure 2 indicates that the optical axis 26 of eye 14 passes through the cornea 18. Consequently, the tissue of cornea 18 is transparent to visible light.
  • the cornea 18 includes five anatomically definable layers of tissue. Going in a direction from anterior to posterior in Figure 3, the tissue layers of the cornea are: epithelium 26, Bowman's membrane 28, stroma 30, Decemet 's membrane 32 and endothelium 34. Of these, the stroma 30 is of most importance for the present invention as it contains the only tissue which is to be removed for correction of the patient's vision.
  • the correction of a myopic condition can be accomplished by the removal of a predetermined volume of stromal tissue.
  • the particular volume of stromal tissue to be removed for the correction of myopia will depend on the amount of correction required and will be a lens or lentoid shaped volume.
  • a lentoid volume 36 is shown in cross section in Figures 3 and 3A.
  • the lentoid volume 36 will be defined by an anterior surface 38 and a posterior surface 40. Together, the anterior surface 38 and the posterior surface 40 will completely enclose or encapsulate the lentoid volume 36 of stromal tissue 30 which is to be removed.
  • the anterior surface 38 may be convex in shape and the posterior surface 40 may be concave in its shape.
  • the actual shape for lentoid 36 may vary according to the needs and desires of the physician.
  • several possible shapes for lentoid 36 are shown in Figures 3A, 3B and 3C.
  • the lentoid 36 shown in Figure 3A is as suggested above where the anterior surface 38 is convex and the posterior surface 40 is concave.
  • Figure 3B shows a variation from this shape wherein the anterior concave surface 38' is separated from the posterior concave surface 40' by a substantially flat annular surface 41.
  • the flat annular surface 41 is contiguous with both the anterior surface 38' and the posterior surface 40'.
  • Figure 3C shows yet another variation for lentoid 36 wherein both the anterior surface 38" and the posterior surface 40" are flat. Again, the anterior surface 38" and the posterior surface 40" are separated by the contiguous flat annular surface 41.
  • a predetermined start point 42 is shown, which is preferably on the posterior surface 40.
  • the laser beam 12 is then focused initially on the predetermined start point 42 and, subsequently, the focal point of the laser beam 12 is moved according to computer programmed instructions along the spiral path 44.
  • the spiral projection of the laser beam's focal point continues along spiral path 44 to create the concave posterior surface 40 until it reaches a point 46.
  • the laser beam 12 is focused at a start point 42' on the anterior surface 38 of lentoid volume 36.
  • the focal point of the laser beam 12 is then moved, again according to computer programmed instructions along a spiral path 42' to create the convex anterior surface 38 until the focal point again arrives at the point 46.
  • the lentoid volume 36 is encapsulated and surrounded by photodisrupted tissue in the surfaces 38 and 40.
  • the maximum distance 47 between the surfaces 38 and 40 will not exceed two hundred and fifty microns.
  • a channel 48 is next formed into the cornea 18 to provide for extracorporeal access to the lentoid volume 36.
  • the channel 48 will be created by the photodisruption of stromal tissue 30 in a manner similar to that used for the creation of anterior surface 38 and posterior surface 40.
  • a complete or a partial, or interrupted, spiral path 50 is followed by the focal point of laser beam 12.
  • the activation of laser beam 12 can be interrupted and turned off during the excursion of its focal point through an arc of predetermined magnitude.
  • the arc in which the laser beam 12 is inactivated is shown as the space 52 and is estimated to be approximated two hundred and seventy degrees.
  • the laser beam 12 is activated and the channel 48 is created over the remaining approximately ninety degrees of travel for the laser beam 12 focal point.
  • annular tissue volume 54 to be removed from stroma 30 in this procedure has a slightly different shape than is required for the treatment of myopia.
  • the annular tissue volume 54 is annular shaped.
  • One way to create this annular tissue volume 54 is to initially focus the laser beam 12 to a predetermined start point 56 on annular tissue volume 54.
  • the posterior surface 58 of annular tissue volume 54 is then created by moving the focal point of laser beam 12 along a depth variable spiral path 60 until it reaches a point 62 to create a concave posterior surface 58.
  • a channel 48 can be created in substantially the same manner as disclosed above for the procedure to create a myopic condition.
  • the procedure for creating the annular tissue volume 54 of stromal tissue 30 also requires that the annular tissue volume 54 be severed on a plane 66 which is between and generally perpendicular to the anterior surface 64 and the posterior surface 58.
  • this severance of annular tissue volume 54 along plane 66 allows for removal of the annular tissue volume 54 through the channel 48.
  • the annular tissue volume 54 can also be severed along a plane 68 which is generally diametrically opposite from the plane 66 and which, like plane 66, is between and generally perpendicular to the surfaces 58 and 64.
  • a device 70 can be inserted through channel 48, as shown in Figure 7, to grip and then remove the particular volume from stroma 30, as shown in Figure 8.
  • the device 70 can be any instrument known in the pertinent art, such as a tweezers or a suction probe.

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  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Optics & Photonics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Laser Surgery Devices (AREA)

Abstract

Cette invention concerne un procédé de chirurgie laser cornéenne, lequel consiste à orienter le pinceau lumineux d'un laser focalisé vers un point de départ dans le stroma. Le foyer est ensuite déplacé le long d'un chemin prédéterminé (42)(42') dans le stroma afin que le laser puisse découper le tissu sur la surface avant (42) et sur la surface arrière (42') d'un élément lenticulaire de tissu (36). Un canal est ainsi créé dans le stroma (48) qui fournira un accès extra-corporel à l'élément lenticulaire, lequel sera ensuite retiré ou extrait à travers ledit canal. Le tissu de stroma ainsi réduit va reformer la cornée de telle sorte que la vue du patient en sera améliorée.
PCT/US1996/003582 1995-03-20 1996-03-15 Procede de chirurgie laser corneenne WO1996029115A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40750895A 1995-03-20 1995-03-20
US08/407,508 1995-03-20

Publications (1)

Publication Number Publication Date
WO1996029115A1 true WO1996029115A1 (fr) 1996-09-26

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PCT/US1996/003582 WO1996029115A1 (fr) 1995-03-20 1996-03-15 Procede de chirurgie laser corneenne

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021048114A1 (fr) * 2019-09-10 2021-03-18 Carl Zeiss Meditec Ag Appareil de traitement chirurgical ophtalmique

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4907586A (en) * 1988-03-31 1990-03-13 Intelligent Surgical Lasers Method for reshaping the eye

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4907586A (en) * 1988-03-31 1990-03-13 Intelligent Surgical Lasers Method for reshaping the eye

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
LAMELLAR CORNEAL STROMECTOMY, For the Operative Treatment of Myopia, (TADEUSZ KRWAWICA), Lublin, Poland, From the Eye Clinic, THE ACADEMY OF MEDICINE, pp. 828-833. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021048114A1 (fr) * 2019-09-10 2021-03-18 Carl Zeiss Meditec Ag Appareil de traitement chirurgical ophtalmique

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