WO1996027008A3 - Mittel zur therapie von tumoren und anderen hyperplasien - Google Patents

Mittel zur therapie von tumoren und anderen hyperplasien Download PDF

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Publication number
WO1996027008A3
WO1996027008A3 PCT/DE1996/000351 DE9600351W WO9627008A3 WO 1996027008 A3 WO1996027008 A3 WO 1996027008A3 DE 9600351 W DE9600351 W DE 9600351W WO 9627008 A3 WO9627008 A3 WO 9627008A3
Authority
WO
WIPO (PCT)
Prior art keywords
agent
hyperplasia
treating tumours
tumour suppressor
tumours
Prior art date
Application number
PCT/DE1996/000351
Other languages
English (en)
French (fr)
Other versions
WO1996027008A2 (de
Inventor
Michael Strauss
Jiri Bartek
Jiri Lukas
Volker Sandig
Original Assignee
Max Planck Gesellschaft
Michael Strauss
Jiri Bartek
Jiri Lukas
Volker Sandig
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19539130A external-priority patent/DE19539130C2/de
Application filed by Max Planck Gesellschaft, Michael Strauss, Jiri Bartek, Jiri Lukas, Volker Sandig filed Critical Max Planck Gesellschaft
Priority to JP8525959A priority Critical patent/JPH10512155A/ja
Priority to EP96903923A priority patent/EP0812355A2/de
Publication of WO1996027008A2 publication Critical patent/WO1996027008A2/de
Publication of WO1996027008A3 publication Critical patent/WO1996027008A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it

Abstract

Die Erfindung betrifft ein Mittel zur Therapie von Tumoren und anderen Hyperplasien. Anwendungsgebiete der Erfindung sind die Medizin und die pharmazeutische Industrie. Das erfindungsgemäße Mittel ist dadurch gekennzeichnet, daß es ein mit dem Tumorsuppressor Rb kooperierendes Tumorsuppressorgen, eine antisense- oder Ribozym-Sequenz gegen antagonistische Kinasen bzw. Cycline oder eine andere die Phosphorylierung des Rb-Proteins hemmende Substanz enthält.
PCT/DE1996/000351 1995-02-28 1996-02-26 Mittel zur therapie von tumoren und anderen hyperplasien WO1996027008A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP8525959A JPH10512155A (ja) 1995-02-28 1996-02-26 癌およびその他の過形成を治療する薬剤
EP96903923A EP0812355A2 (de) 1995-02-28 1996-02-26 Mittel zur therapie von tumoren und anderen hyperplasien

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19508734 1995-02-28
DE19508734.8 1995-02-28
DE19539130A DE19539130C2 (de) 1995-02-28 1995-10-20 Mittel zur Therapie von Tumoren und anderen Hyperplasien
DE19539130.6 1995-10-20

Publications (2)

Publication Number Publication Date
WO1996027008A2 WO1996027008A2 (de) 1996-09-06
WO1996027008A3 true WO1996027008A3 (de) 1996-11-14

Family

ID=26013265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1996/000351 WO1996027008A2 (de) 1995-02-28 1996-02-26 Mittel zur therapie von tumoren und anderen hyperplasien

Country Status (3)

Country Link
EP (1) EP0812355A2 (de)
JP (1) JPH10512155A (de)
WO (1) WO1996027008A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6994851B1 (en) 1997-07-10 2006-02-07 Mannkind Corporation Method of inducing a CTL response
US6977074B2 (en) 1997-07-10 2005-12-20 Mannkind Corporation Method of inducing a CTL response
ES2527412T3 (es) 2007-02-15 2015-01-23 Mannkind Corporation Método para aumentar la respuesta de los linfocitos T
AU2010310468A1 (en) 2009-10-23 2012-05-24 Mannkind Corporation Cancer immunotherapy and method of treatment

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020691A1 (en) * 1992-04-20 1993-10-28 Tykocinski Mark L Method for inducing tumor immunity
WO1995028483A1 (en) * 1994-04-14 1995-10-26 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
WO1996003875A1 (en) * 1994-07-29 1996-02-15 Emory University Compositions for targeting materials to cells containing androgen receptors
WO1996015245A1 (en) * 1994-11-11 1996-05-23 Arch Development Corporation A process of inhibiting non-neoplastic pathological cell proliferation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993020691A1 (en) * 1992-04-20 1993-10-28 Tykocinski Mark L Method for inducing tumor immunity
WO1995028483A1 (en) * 1994-04-14 1995-10-26 Cold Spring Harbor Laboratory Cell-cycle regulatory proteins, and uses related thereto
WO1996003875A1 (en) * 1994-07-29 1996-02-15 Emory University Compositions for targeting materials to cells containing androgen receptors
WO1996015245A1 (en) * 1994-11-11 1996-05-23 Arch Development Corporation A process of inhibiting non-neoplastic pathological cell proliferation

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BACCHETTI, S. & GRAHAM, F.: "Inhibition of cell proliferation by an adenovirus vector expressing human wild type p53 protein", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 3, no. 5, November 1993 (1993-11-01), pages 781 - 788, XP000576129 *
HANNON, G. & BEACH, D.: "p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest", NATURE, vol. 371, 15 September 1994 (1994-09-15), LONDON GB, pages 257 - 261, XP002008793 *
LUKAS, J. ET AL.: "Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16.", NATURE, (1995 JUN 8) 375 (6531) 503-6, XP002008796 *
PARRY, D. ET AL.: "Lack of cyclin D-Cdk complexes in Rb -negative cells correlates with high levels of p16INK4 / MTS1 tumour suppressor gene product.", EMBO JOURNAL, (1995 FEB 1) 14 (3) 503-11., XP002008797 *
SERRANO, M. ET AL.: "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4", NATURE, vol. 366, 16 December 1993 (1993-12-16), LONDON GB, pages 704 - 707, XP002008795 *
SHAPIRO, G. ET AL.: "Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.", CANCER RESEARCH, (1995 FEB 1) 55 (3) 505-9., XP002008798 *
SLEBOS, R. ET AL.: "p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, June 1994 (1994-06-01), WASHINGTON US, pages 5320 - 5324, XP002008794 *
SPILLARE, E. ET AL.: "Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16-INK4.", MOLECULAR CARCINOGENESIS 16 (1). 1996. 53-60, XP000576136 *

Also Published As

Publication number Publication date
JPH10512155A (ja) 1998-11-24
WO1996027008A2 (de) 1996-09-06
EP0812355A2 (de) 1997-12-17

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