WO1996024581A3 - Derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds - Google Patents

Derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds Download PDF

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Publication number
WO1996024581A3
WO1996024581A3 PCT/EP1996/000524 EP9600524W WO9624581A3 WO 1996024581 A3 WO1996024581 A3 WO 1996024581A3 EP 9600524 W EP9600524 W EP 9600524W WO 9624581 A3 WO9624581 A3 WO 9624581A3
Authority
WO
WIPO (PCT)
Prior art keywords
stands
compounds
hydrogen
group
possibly substituted
Prior art date
Application number
PCT/EP1996/000524
Other languages
German (de)
French (fr)
Other versions
WO1996024581A2 (en
Inventor
Christos Tsaklakidis
Alfred Mertens
Gerd Zimmermann
Wolfgang Schaefer
Liesel Doerge
Original Assignee
Boehringer Mannheim Gmbh
Christos Tsaklakidis
Alfred Mertens
Gerd Zimmermann
Wolfgang Schaefer
Liesel Doerge
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh, Christos Tsaklakidis, Alfred Mertens, Gerd Zimmermann, Wolfgang Schaefer, Liesel Doerge filed Critical Boehringer Mannheim Gmbh
Priority to EP96901794A priority Critical patent/EP0808311A2/en
Priority to AU46229/96A priority patent/AU4622996A/en
Priority to JP8523994A priority patent/JPH10513465A/en
Publication of WO1996024581A2 publication Critical patent/WO1996024581A2/en
Publication of WO1996024581A3 publication Critical patent/WO1996024581A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of formula (I), in which R1 stands for hydrogen, lower alkyl, lower alkenyl, cycloalkyl, cycloalkenyl, a possibly substituted mono-or bi-cyclic aryl, a possibly substituted hetaryl, a possibly substituted aryl alkyl or one of the groups -OR?2, -NR3R4¿, W stands for nitrogen or -CR5, X, Z independently of each other stands for nitrogen or -CH, and where W stands for a nitrogen atom, X must be the group -CH, A stands for a valency bond or the carbonyl group, B stands for a valency bond or a C¿1?-C6 alkyl chain possibly substituted once or several times by lower alkyl or an OR?2¿ group, D stands for a valency bond, and, where X is a nitrogen atom, can also be the carbonyl group, A, B and D being unable to represent the valency bond simultaneously, R2 stands for hydrogen, lower alkyl or aryl alkyl, R3, R4 independently of each other stand for hydrogen or lower alkyl, or form a five- or six-membered heterocyclic ring together with the nitrogen atom to which they are linked, R5 stands for hydrogen or a group OR2. The invention also relates to a process for the production of these compounds, and medicaments containing them for the treatment of diseases which are attributable to thromboembolic conditions.
PCT/EP1996/000524 1995-02-10 1996-02-08 Derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds WO1996024581A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP96901794A EP0808311A2 (en) 1995-02-10 1996-02-08 New derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds
AU46229/96A AU4622996A (en) 1995-02-10 1996-02-08 New derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds
JP8523994A JPH10513465A (en) 1995-02-10 1996-02-08 Novel pyridyl and pyridazinyl-piperazine derivatives, methods for their preparation and preparations containing these compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19504329.4 1995-02-10
DE19504329A DE19504329A1 (en) 1995-02-10 1995-02-10 New pyridyl or pyridazinyl-piperazine derivatives, processes for their preparation and medicaments containing these compounds

Publications (2)

Publication Number Publication Date
WO1996024581A2 WO1996024581A2 (en) 1996-08-15
WO1996024581A3 true WO1996024581A3 (en) 1996-11-28

Family

ID=7753583

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/000524 WO1996024581A2 (en) 1995-02-10 1996-02-08 Derivatives of pyridil piperazine or pyridazinyl piperazyl, process for production thereof and medicaments containing these compounds

Country Status (9)

Country Link
EP (1) EP0808311A2 (en)
JP (1) JPH10513465A (en)
AU (1) AU4622996A (en)
CA (1) CA2212227A1 (en)
DE (1) DE19504329A1 (en)
IL (1) IL117082A (en)
TW (1) TW408121B (en)
WO (1) WO1996024581A2 (en)
ZA (1) ZA961045B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
EP0718287A2 (en) * 1994-12-23 1996-06-26 Dr. Karl Thomae GmbH Piperazine derivatives, medicaments containing them, their use, and processes for their preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994022835A2 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
EP0718287A2 (en) * 1994-12-23 1996-06-26 Dr. Karl Thomae GmbH Piperazine derivatives, medicaments containing them, their use, and processes for their preparation

Also Published As

Publication number Publication date
CA2212227A1 (en) 1996-08-15
TW408121B (en) 2000-10-11
ZA961045B (en) 1997-08-11
JPH10513465A (en) 1998-12-22
WO1996024581A2 (en) 1996-08-15
IL117082A (en) 2000-12-06
EP0808311A2 (en) 1997-11-26
IL117082A0 (en) 1996-06-18
AU4622996A (en) 1996-08-27
DE19504329A1 (en) 1996-08-14

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