WO1996023760A1 - 2-aminoindans as selective dopamine d3 ligands - Google Patents
2-aminoindans as selective dopamine d3 ligands Download PDFInfo
- Publication number
- WO1996023760A1 WO1996023760A1 PCT/US1996/000020 US9600020W WO9623760A1 WO 1996023760 A1 WO1996023760 A1 WO 1996023760A1 US 9600020 W US9600020 W US 9600020W WO 9623760 A1 WO9623760 A1 WO 9623760A1
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- WO
- WIPO (PCT)
- Prior art keywords
- compound
- solid
- added
- water
- under vacuum
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C311/05—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/41—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems
- C07C211/42—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/46—Y being a hydrogen or a carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Abstract
Description
Claims
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ301492A NZ301492A (en) | 1995-02-01 | 1996-01-16 | Substituted 2-aminoindane derivatives and medicaments |
SI9630319T SI0807101T1 (en) | 1995-02-01 | 1996-01-16 | 2-aminoindans as selective dopamine d3 ligands |
DE69613349T DE69613349T2 (en) | 1995-02-01 | 1996-01-16 | 2-AMINOINDANE AS SELECTIVE DOPAMINE D3 LIGANDS |
AT96902582T ATE202072T1 (en) | 1995-02-01 | 1996-01-16 | 2-AMINOINDANES AS SELECTIVE DOPAMINE D3 LIGANDS |
AU46930/96A AU707091B2 (en) | 1995-02-01 | 1996-01-16 | 2-aminoindans as selective dopamine D3 ligands |
JP52353396A JP3878210B2 (en) | 1995-02-01 | 1996-01-16 | 2-Aminoindanes as selective dopamine D3 ligands |
HU9702241A HU224354B1 (en) | 1995-02-01 | 1996-01-16 | Use of 2-aminoindan derivatives and pharmaceutical compositions containing them |
EP96902582A EP0807101B1 (en) | 1995-02-01 | 1996-01-16 | 2-aminoindans as selective dopamine d3 ligands |
US08/860,532 US5936000A (en) | 1995-02-01 | 1996-01-16 | 2-aminoindans as selective dopamine D3 ligands |
DK96902582T DK0807101T3 (en) | 1995-02-01 | 1996-01-16 | 2-Aminoindanes as selective dopamine D3 ligands |
FI973176A FI973176A0 (en) | 1995-02-01 | 1997-07-31 | 2-aminoindanes as selective dopamine D3 ligands |
NO19973532A NO317732B1 (en) | 1995-02-01 | 1997-07-31 | New 2-aminoindan compounds and their use in the manufacture of drugs for the treatment of central nervous system diseases associated with dopamine D3 receptor activity. |
MXPA/A/1997/005883A MXPA97005883A (en) | 1995-02-01 | 1997-08-01 | 2-aminoindanos as selective ligands of dopamine |
HK98109663A HK1008897A1 (en) | 1995-02-01 | 1998-08-04 | 2-Aminoindans as selective dopamine d3 ligands. |
GR20010401377T GR3036517T3 (en) | 1995-02-01 | 2001-09-04 | 2-aminoindans as selective dopamine d3 ligands |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US38223995A | 1995-02-01 | 1995-02-01 | |
US08/382,239 | 1995-02-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996023760A1 true WO1996023760A1 (en) | 1996-08-08 |
Family
ID=23508092
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/000020 WO1996023760A1 (en) | 1995-02-01 | 1996-01-16 | 2-aminoindans as selective dopamine d3 ligands |
Country Status (22)
Country | Link |
---|---|
US (1) | US5936000A (en) |
EP (1) | EP0807101B1 (en) |
JP (1) | JP3878210B2 (en) |
KR (1) | KR100427962B1 (en) |
CN (1) | CN1166622C (en) |
AT (1) | ATE202072T1 (en) |
AU (1) | AU707091B2 (en) |
CA (1) | CA2208600A1 (en) |
CZ (1) | CZ285850B6 (en) |
DE (1) | DE69613349T2 (en) |
DK (1) | DK0807101T3 (en) |
ES (1) | ES2159017T3 (en) |
FI (1) | FI973176A0 (en) |
GR (1) | GR3036517T3 (en) |
HK (1) | HK1008897A1 (en) |
HU (1) | HU224354B1 (en) |
NO (1) | NO317732B1 (en) |
NZ (1) | NZ301492A (en) |
PL (1) | PL321634A1 (en) |
PT (1) | PT807101E (en) |
RU (1) | RU2161601C2 (en) |
WO (1) | WO1996023760A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6084130A (en) * | 1996-05-31 | 2000-07-04 | Pharmacia & Upjohn Company | Aryl substituted bicyclic amines as selective dopamine D3 ligands |
US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
WO2006040177A1 (en) | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co.Kg | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 recptor |
WO2006040180A1 (en) * | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co. Kg | Aminomethyl substituted bicyclic aromatic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
WO2006040182A1 (en) | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
WO2010025235A1 (en) * | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
US7750051B2 (en) | 2006-12-14 | 2010-07-06 | Teva Pharmaceutical Industries, Ltd. | Crystalline solid rasagiline base |
US7834048B2 (en) | 2004-10-14 | 2010-11-16 | Abbott Gmbh & Co. Kg | Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
EP2305659A1 (en) | 2004-11-29 | 2011-04-06 | Novartis AG | 5-hydroxy-benzothiazole derivatives having beta-2-adrenoreceptor agonist activity |
EP2332915A1 (en) | 1999-06-04 | 2011-06-15 | Novartis AG | Beta2-adrenoceptor agonists |
US8497273B2 (en) | 2006-04-19 | 2013-07-30 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
US8642642B2 (en) | 2006-04-19 | 2014-02-04 | Abbott Laboratories | Heterocyclic arylsulphones suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6162930A (en) * | 1998-03-06 | 2000-12-19 | Baylor University | Anti-mitotic agents which inhibit tubulin polymerization |
WO2001053260A1 (en) * | 2000-01-18 | 2001-07-26 | Novartis Ag | Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion |
ATE272617T1 (en) | 2000-06-13 | 2004-08-15 | Lilly Co Eli | SULFONAMIDE DERIVATIVES |
EP1260221A3 (en) * | 2001-05-23 | 2002-12-18 | Pfizer Products Inc. | Combination treatment for depression and anxiety |
JP2008531546A (en) * | 2005-02-22 | 2008-08-14 | テバ ファーマシューティカル インダストリーズ リミティド | An improved process for the synthesis of enantiomeric indanylamine derivatives |
US7652053B2 (en) * | 2006-11-30 | 2010-01-26 | Hoffmann-La Roche Inc. | Diaminocycloalkane MCH receptor antagonists |
CA2774071A1 (en) * | 2009-09-15 | 2011-03-24 | Ube Industries, Ltd. | Nonaqueous electrolyte solution and electrochemical element using same |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0286277A1 (en) * | 1987-03-25 | 1988-10-12 | Pfizer Limited | Antiarrythmic agents |
WO1995004713A1 (en) * | 1993-08-06 | 1995-02-16 | The Upjohn Company | 2-aminoindans as selective dopamine d3 ligands |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4132737A (en) * | 1978-02-27 | 1979-01-02 | Eli Lilly And Company | Trifluoromethyl substituted 1-aminoindanes |
US5225596A (en) * | 1989-01-09 | 1993-07-06 | The Upjohn Company | Halo substituted aminotetralins |
ATE113271T1 (en) * | 1989-01-09 | 1994-11-15 | Upjohn Co | HALOGEN-SUBSTITUTED AMINOTETRALINES. |
-
1996
- 1996-01-16 CN CNB961917415A patent/CN1166622C/en not_active Expired - Fee Related
- 1996-01-16 WO PCT/US1996/000020 patent/WO1996023760A1/en active IP Right Grant
- 1996-01-16 EP EP96902582A patent/EP0807101B1/en not_active Expired - Lifetime
- 1996-01-16 CZ CZ972313A patent/CZ285850B6/en not_active IP Right Cessation
- 1996-01-16 KR KR1019970705233A patent/KR100427962B1/en not_active IP Right Cessation
- 1996-01-16 US US08/860,532 patent/US5936000A/en not_active Expired - Fee Related
- 1996-01-16 AU AU46930/96A patent/AU707091B2/en not_active Ceased
- 1996-01-16 JP JP52353396A patent/JP3878210B2/en not_active Expired - Fee Related
- 1996-01-16 PT PT96902582T patent/PT807101E/en unknown
- 1996-01-16 NZ NZ301492A patent/NZ301492A/en unknown
- 1996-01-16 AT AT96902582T patent/ATE202072T1/en not_active IP Right Cessation
- 1996-01-16 DE DE69613349T patent/DE69613349T2/en not_active Expired - Fee Related
- 1996-01-16 DK DK96902582T patent/DK0807101T3/en active
- 1996-01-16 CA CA002208600A patent/CA2208600A1/en not_active Abandoned
- 1996-01-16 HU HU9702241A patent/HU224354B1/en not_active IP Right Cessation
- 1996-01-16 ES ES96902582T patent/ES2159017T3/en not_active Expired - Lifetime
- 1996-01-16 PL PL96321634A patent/PL321634A1/en unknown
- 1996-01-16 RU RU97114793/04A patent/RU2161601C2/en not_active IP Right Cessation
-
1997
- 1997-07-31 NO NO19973532A patent/NO317732B1/en unknown
- 1997-07-31 FI FI973176A patent/FI973176A0/en not_active IP Right Cessation
-
1998
- 1998-08-04 HK HK98109663A patent/HK1008897A1/en not_active IP Right Cessation
-
2001
- 2001-09-04 GR GR20010401377T patent/GR3036517T3/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0286277A1 (en) * | 1987-03-25 | 1988-10-12 | Pfizer Limited | Antiarrythmic agents |
WO1995004713A1 (en) * | 1993-08-06 | 1995-02-16 | The Upjohn Company | 2-aminoindans as selective dopamine d3 ligands |
Non-Patent Citations (1)
Title |
---|
U. HACKELL ET AL: "Monophenolic 2-(dipropylamino)indans and related compounds: Central dopamine-receptor stimulating activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 24, no. 4, 1981, WASHINGTON US, pages 429 - 434, XP002003221 * |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6084130A (en) * | 1996-05-31 | 2000-07-04 | Pharmacia & Upjohn Company | Aryl substituted bicyclic amines as selective dopamine D3 ligands |
US6197798B1 (en) | 1998-07-21 | 2001-03-06 | Novartis Ag | Amino-benzocycloalkane derivatives |
EP2332915A1 (en) | 1999-06-04 | 2011-06-15 | Novartis AG | Beta2-adrenoceptor agonists |
US7834048B2 (en) | 2004-10-14 | 2010-11-16 | Abbott Gmbh & Co. Kg | Azabicycloheptyl compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
WO2006040180A1 (en) * | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co. Kg | Aminomethyl substituted bicyclic aromatic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
KR101300046B1 (en) * | 2004-10-14 | 2013-08-30 | 애보트 게엠베하 운트 콤파니 카게 | 6-Amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
US8486984B2 (en) | 2004-10-14 | 2013-07-16 | Abbott Gmbh & Co., Kg | Aminomethyl substituted bicyclic aromatic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
US7759397B2 (en) | 2004-10-14 | 2010-07-20 | Abbott Gmbh & Co. Kg | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
US8470810B2 (en) | 2004-10-14 | 2013-06-25 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
US7851463B2 (en) | 2004-10-14 | 2010-12-14 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
WO2006040182A1 (en) | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
EP2311803A1 (en) | 2004-10-14 | 2011-04-20 | Abbott GmbH & Co. KG | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
EP2311801A1 (en) | 2004-10-14 | 2011-04-20 | Abbott GmbH & Co. KG | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
EP2311802A1 (en) | 2004-10-14 | 2011-04-20 | Abbott GmbH & Co. KG | Heterocyclic compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
WO2006040177A1 (en) | 2004-10-14 | 2006-04-20 | Abbott Gmbh & Co.Kg | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine d3 recptor |
AU2005293693B2 (en) * | 2004-10-14 | 2011-11-17 | AbbVie Deutschland GmbH & Co. KG | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor |
TWI382013B (en) * | 2004-10-14 | 2013-01-11 | Abbott Gmbh & Co Kg | Aminoindane dopamine d3 receptor antagonists |
EP2305659A1 (en) | 2004-11-29 | 2011-04-06 | Novartis AG | 5-hydroxy-benzothiazole derivatives having beta-2-adrenoreceptor agonist activity |
US8497273B2 (en) | 2006-04-19 | 2013-07-30 | Abbott Gmbh & Co. Kg | Heterocyclic compounds suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
US8642642B2 (en) | 2006-04-19 | 2014-02-04 | Abbott Laboratories | Heterocyclic arylsulphones suitable for treating disorders that respond to modulation of the serotonin 5HT6 receptor |
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WO2010025235A1 (en) * | 2008-08-29 | 2010-03-04 | Regents Of The University Of Michigan | Selective ligands for the dopamine 3 (d3) receptor and methods of using the same |
Also Published As
Publication number | Publication date |
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PL321634A1 (en) | 1997-12-08 |
CZ285850B6 (en) | 1999-11-17 |
RU2161601C2 (en) | 2001-01-10 |
CN1172469A (en) | 1998-02-04 |
CZ231397A3 (en) | 1998-03-18 |
HK1008897A1 (en) | 1999-07-23 |
DE69613349T2 (en) | 2001-10-31 |
HUP9702241A2 (en) | 1998-07-28 |
ES2159017T3 (en) | 2001-09-16 |
NZ301492A (en) | 1999-01-28 |
US5936000A (en) | 1999-08-10 |
EP0807101B1 (en) | 2001-06-13 |
FI973176A (en) | 1997-07-31 |
CN1166622C (en) | 2004-09-15 |
KR100427962B1 (en) | 2004-11-16 |
ATE202072T1 (en) | 2001-06-15 |
NO317732B1 (en) | 2004-12-13 |
CA2208600A1 (en) | 1996-08-08 |
NO973532L (en) | 1997-10-01 |
AU4693096A (en) | 1996-08-21 |
GR3036517T3 (en) | 2001-12-31 |
PT807101E (en) | 2001-12-28 |
MX9705883A (en) | 1997-10-31 |
DK0807101T3 (en) | 2001-09-10 |
JPH10513180A (en) | 1998-12-15 |
AU707091B2 (en) | 1999-07-01 |
HUP9702241A3 (en) | 1999-05-28 |
KR19980701836A (en) | 1998-06-25 |
JP3878210B2 (en) | 2007-02-07 |
EP0807101A1 (en) | 1997-11-19 |
FI973176A0 (en) | 1997-07-31 |
DE69613349D1 (en) | 2001-07-19 |
HU224354B1 (en) | 2005-08-29 |
NO973532D0 (en) | 1997-07-31 |
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