WO1996017865A3 - Genes and gene products for use in the diagnosis of degenerative nerve damage - Google Patents

Genes and gene products for use in the diagnosis of degenerative nerve damage Download PDF

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Publication number
WO1996017865A3
WO1996017865A3 PCT/EP1995/004777 EP9504777W WO9617865A3 WO 1996017865 A3 WO1996017865 A3 WO 1996017865A3 EP 9504777 W EP9504777 W EP 9504777W WO 9617865 A3 WO9617865 A3 WO 9617865A3
Authority
WO
WIPO (PCT)
Prior art keywords
genes
gene products
diagnosis
nerve damage
degenerative nerve
Prior art date
Application number
PCT/EP1995/004777
Other languages
German (de)
French (fr)
Other versions
WO1996017865A2 (en
Inventor
Hans-Werner Mueller
Clemens Gillen
Marc Gleichmann
Original Assignee
Boehringer Mannheim Gmbh
Mueller Hans Werner
Clemens Gillen
Marc Gleichmann
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19502525A external-priority patent/DE19502525A1/en
Application filed by Boehringer Mannheim Gmbh, Mueller Hans Werner, Clemens Gillen, Marc Gleichmann filed Critical Boehringer Mannheim Gmbh
Priority to AU43023/96A priority Critical patent/AU693982B2/en
Priority to JP8517317A priority patent/JPH10511544A/en
Priority to EP95941669A priority patent/EP0796275A2/en
Publication of WO1996017865A2 publication Critical patent/WO1996017865A2/en
Publication of WO1996017865A3 publication Critical patent/WO1996017865A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention concerns novel genes and gene products expressed in degenerating and/or regenerating peripheral nerves, and the use of such genes and gene products in diagnosis and/or therapy. The nucleic acids shown in SEQ ID NO:1 to 30 hybridise with the nucleic acids which are the subject matter of the invention.
PCT/EP1995/004777 1994-12-05 1995-12-05 Genes and gene products for use in the diagnosis of degenerative nerve damage WO1996017865A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU43023/96A AU693982B2 (en) 1994-12-05 1995-12-05 Genes and gene products for use in the diagnosis of degenerative nerve damage
JP8517317A JPH10511544A (en) 1994-12-05 1995-12-05 Novel genes and gene products for diagnosis and regeneration of degenerative nerve injury
EP95941669A EP0796275A2 (en) 1994-12-05 1995-12-05 Genes and gene products for use in the diagnosis of degenerative nerve damage

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE4443159 1994-12-05
DEP4443159.7 1994-12-05
DE19502525.3 1995-01-27
DE19502525A DE19502525A1 (en) 1994-12-05 1995-01-27 New genes and gene products for the diagnosis and regeneration of degenerative nerve damage

Publications (2)

Publication Number Publication Date
WO1996017865A2 WO1996017865A2 (en) 1996-06-13
WO1996017865A3 true WO1996017865A3 (en) 1996-09-19

Family

ID=25942564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004777 WO1996017865A2 (en) 1994-12-05 1995-12-05 Genes and gene products for use in the diagnosis of degenerative nerve damage

Country Status (5)

Country Link
EP (1) EP0796275A2 (en)
JP (1) JPH10511544A (en)
AU (1) AU693982B2 (en)
CA (1) CA2206994A1 (en)
WO (1) WO1996017865A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003569A1 (en) * 1989-08-30 1991-03-21 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
WO1992020797A1 (en) * 1991-05-20 1992-11-26 Case Western Reserve University Neurotrophic factor, preparation and uses thereof
WO1994021670A1 (en) * 1993-03-15 1994-09-29 The Scripps Research Institute Human serotonin receptors, dna encoding the receptors, and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003569A1 (en) * 1989-08-30 1991-03-21 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Neurotrophin-3, a novel neurotrophic factor related to nerve growth factor and brain derived neurotrophic factor
WO1992020797A1 (en) * 1991-05-20 1992-11-26 Case Western Reserve University Neurotrophic factor, preparation and uses thereof
WO1994021670A1 (en) * 1993-03-15 1994-09-29 The Scripps Research Institute Human serotonin receptors, dna encoding the receptors, and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A.E.FEUCHTER ET AL.: "Strategy for detecting cellular transcripts promoted by human endogenous long terminal repeats : identific<tion of a novel gene (cdc4l) with homology to yeast CDC4", GENOMICS, vol. 13, pages 1237 - 46, XP000568626 *
DE LEON M ET AL: "IDENTIFICATION OF TRANSCRIPTIONALLY REGULATED GENES AFTER SCIATIC NERVE INJURY", JOURNAL OF NEUROSCIENCE RESEARCH, 29 (4). 1991. 437-448. *
FISCHER I. ET AL.: "Moelcular cloning of plasmolipin", THE JOURNAL OF BIOCHEMICAL CHEMISTRY, vol. 269, no. 40, pages 24912 - 24919 *
GILLEN C ET AL: "Differentially expressed genes after peripheral nerve injury", JOURNAL OF NEUROSCIENCE RESEARCH, 42 (2). 1995. 159-171., XP000568934 *
K.HAYASAKA ET AL.: "Mutation of the myelin Po gene in Charcot-Marie-Tooth neuropathy type 1B", HUMAN MOLECULAR GENETICS, vol. 2, no. 9, pages 1369 - 1372, XP000566482 *
N.H.LEE ET AL.: "Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growt factor treatment", PNAS, vol. 92, pages 8303 - 8307 *
RAUTENSRAUSS B. ET AL.: "Identification of a de novo insertional mutation in P0 in a patient with Dejerine-Sottas syndrome (DSS) phenotype", HUMAN MOLECULAR GENETICS, vol. 3, no. 9, pages 1701 - 1702, XP000266483 *

Also Published As

Publication number Publication date
AU693982B2 (en) 1998-07-09
CA2206994A1 (en) 1996-06-13
JPH10511544A (en) 1998-11-10
EP0796275A2 (en) 1997-09-24
WO1996017865A2 (en) 1996-06-13
AU4302396A (en) 1996-06-26

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