WO1996017843A3 - Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives - Google Patents

Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives Download PDF

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Publication number
WO1996017843A3
WO1996017843A3 PCT/EP1995/004795 EP9504795W WO9617843A3 WO 1996017843 A3 WO1996017843 A3 WO 1996017843A3 EP 9504795 W EP9504795 W EP 9504795W WO 9617843 A3 WO9617843 A3 WO 9617843A3
Authority
WO
WIPO (PCT)
Prior art keywords
4alkyl
4alkoxy
aryl
pyrimidinylamino
pyrimidinyloxy
Prior art date
Application number
PCT/EP1995/004795
Other languages
French (fr)
Other versions
WO1996017843A2 (en
Inventor
Clemens Lamberth
Fritz Schaub
Original Assignee
Sandoz Ltd
Sandoz Ag
Clemens Lamberth
Fritz Schaub
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd, Sandoz Ag, Clemens Lamberth, Fritz Schaub filed Critical Sandoz Ltd
Priority to BR9509877A priority Critical patent/BR9509877A/en
Priority to MX9703363A priority patent/MX9703363A/en
Priority to JP8517320A priority patent/JPH10512236A/en
Priority to AU42602/96A priority patent/AU4260296A/en
Priority to EP95941073A priority patent/EP0796259A2/en
Publication of WO1996017843A2 publication Critical patent/WO1996017843A2/en
Publication of WO1996017843A3 publication Critical patent/WO1996017843A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention discloses 2-[4-(2-(pyrimidin-4-yloxy- and -4-ylamino)-ethyl-phenyl]-dioxolanes of formula (I) wherein R1 is hydrogen, C1-4alkyl, C1-4haloalkyl or C3-6cycloalkyl, R2 is hydrogen, C1-10alkyl, C1-8alkoxy-C1-4alkyl, C3-8alkenyloxy-C1-4alkyl, C3-8haloalkenyloxy-C1-4alkyl, C3-8alkynyloxy-C1-4alkyl, C1-8haloalkoxy-C1-4alkyl, C1-8alkylthio-C1-4alkyl, aryl, aryloxy-C1-4alkyl, aryl-C1-4alkoxy-C1-4-alkyl, heteroaryloxy-C1-4alkyl, C1-4alkoxy-C1-4alkoxy-C1-4alkyl or aryl-C1-8alkyl, R3 and R4 independently are halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxy-C1-4alkyl, C1-4alkoxycarbonyl-C1-4alkyl, C1-4alkoxycarbonyl, cyano-C1-4alkyl, cyano, or -COOH, or R3 and R4 together form a bridge member selected from 1,4-butylene, 1,4-butadienylene, or -S-CH=CH-, each optionally substituted by one or two radicals selected from halogen or C1-4alkyl, and Z is NH or oxygen; the use of such compounds for the control of undesired acarinae, fungi, and insects, compositions for facilitating such use, and the preparation of the compounds of formula I.
PCT/EP1995/004795 1994-12-07 1995-12-06 Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives WO1996017843A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
BR9509877A BR9509877A (en) 1994-12-07 1995-12-06 New pyrimidinyloxy-and pyridimidinylamino-ethylphenyl-dioxolane derivatives
MX9703363A MX9703363A (en) 1994-12-07 1995-12-06 Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives.
JP8517320A JPH10512236A (en) 1994-12-07 1995-12-06 New pyrimidyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives
AU42602/96A AU4260296A (en) 1994-12-07 1995-12-06 Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives
EP95941073A EP0796259A2 (en) 1994-12-07 1995-12-06 Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9424676A GB9424676D0 (en) 1994-12-07 1994-12-07 Organic compounds
GB9424676.6 1994-12-07

Publications (2)

Publication Number Publication Date
WO1996017843A2 WO1996017843A2 (en) 1996-06-13
WO1996017843A3 true WO1996017843A3 (en) 1996-08-22

Family

ID=10765538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004795 WO1996017843A2 (en) 1994-12-07 1995-12-06 Novel pyrimidinyloxy- and pyrimidinylamino-ethylphenyl-dioxolane derivatives

Country Status (9)

Country Link
EP (1) EP0796259A2 (en)
JP (1) JPH10512236A (en)
CN (1) CN1168671A (en)
AU (1) AU4260296A (en)
BR (1) BR9509877A (en)
CA (1) CA2206306A1 (en)
GB (1) GB9424676D0 (en)
MX (1) MX9703363A (en)
WO (1) WO1996017843A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006036266A1 (en) 2004-07-16 2006-04-06 Sunesis Pharmaceuticals, Inc. Thienopyrimidines useful as aurora kinase inhibitors
KR20140094626A (en) * 2004-10-21 2014-07-30 다우 아그로사이언시즈 엘엘씨 Thieno-pyrimidine compounds having fungicidal activity
EP1937691A1 (en) * 2005-10-21 2008-07-02 Dow Agrosciences LLC Thieno-pyrimidine compounds having fungicidal activity
MX2012001170A (en) * 2009-07-30 2012-07-20 Merial Ltd Insecticidal 4-amino-thieno[2,3-d]-pyrimidine compounds and methods of their use.
TWI566701B (en) * 2012-02-01 2017-01-21 日本農藥股份有限公司 Arylalkyloxypyrimidine derivatives and agrohorticultural insecticides comprising said derivatives as active ingredients, and method of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU734184A1 (en) * 1977-11-02 1980-05-15 Белорусский Ордена Трудового Красного Знамени Государственный Университет Им.В.И.Ленина Method of preparing p-formylstyrene
EP0665225A1 (en) * 1994-02-01 1995-08-02 Ube Industries, Ltd. 4-Phenethylamino pyrimidine derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU734184A1 (en) * 1977-11-02 1980-05-15 Белорусский Ордена Трудового Красного Знамени Государственный Университет Им.В.И.Ленина Method of preparing p-formylstyrene
EP0665225A1 (en) * 1994-02-01 1995-08-02 Ube Industries, Ltd. 4-Phenethylamino pyrimidine derivative, process for preparing the same and agricultural and horticultural chemical for controlling noxious organisms containing the same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 94, no. 5, 2 February 1981, Columbus, Ohio, US; abstract no. 30360a, page 533; *

Also Published As

Publication number Publication date
AU4260296A (en) 1996-06-26
EP0796259A2 (en) 1997-09-24
GB9424676D0 (en) 1995-02-01
MX9703363A (en) 1998-02-28
CA2206306A1 (en) 1996-06-13
JPH10512236A (en) 1998-11-24
BR9509877A (en) 1997-09-30
CN1168671A (en) 1997-12-24
WO1996017843A2 (en) 1996-06-13

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