WO1996011680A3 - Utilisation d'agonistes de gaba dans le traitement de vomissements - Google Patents

Utilisation d'agonistes de gaba dans le traitement de vomissements Download PDF

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Publication number
WO1996011680A3
WO1996011680A3 PCT/EP1995/004025 EP9504025W WO9611680A3 WO 1996011680 A3 WO1996011680 A3 WO 1996011680A3 EP 9504025 W EP9504025 W EP 9504025W WO 9611680 A3 WO9611680 A3 WO 9611680A3
Authority
WO
WIPO (PCT)
Prior art keywords
emesis
treatment
gaba agonists
agonists
gaba
Prior art date
Application number
PCT/EP1995/004025
Other languages
English (en)
Other versions
WO1996011680A2 (fr
Inventor
David Edmund Bays
Charanjit Bountra
Original Assignee
Glaxo Group Ltd
David Edmund Bays
Charanjit Bountra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, David Edmund Bays, Charanjit Bountra filed Critical Glaxo Group Ltd
Priority to AU37458/95A priority Critical patent/AU3745895A/en
Publication of WO1996011680A2 publication Critical patent/WO1996011680A2/fr
Publication of WO1996011680A3 publication Critical patent/WO1996011680A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

On décrit l'utilisation d'agonistes de l'acide η-aminobutyrique (GABA) possédant une activité agoniste au niveau des récepteurs de GABAB, dans le traitement des vomissements.
PCT/EP1995/004025 1994-10-14 1995-10-12 Utilisation d'agonistes de gaba dans le traitement de vomissements WO1996011680A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU37458/95A AU3745895A (en) 1994-10-14 1995-10-12 Use of gaba antagonists in the treatment of emesis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9420784A GB9420784D0 (en) 1994-10-14 1994-10-14 Medicaments

Publications (2)

Publication Number Publication Date
WO1996011680A2 WO1996011680A2 (fr) 1996-04-25
WO1996011680A3 true WO1996011680A3 (fr) 1996-06-27

Family

ID=10762886

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/004025 WO1996011680A2 (fr) 1994-10-14 1995-10-12 Utilisation d'agonistes de gaba dans le traitement de vomissements

Country Status (3)

Country Link
AU (1) AU3745895A (fr)
GB (1) GB9420784D0 (fr)
WO (1) WO1996011680A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8668598A (en) * 1997-08-20 1999-03-08 University Of Oklahoma, The Gaba analogs to prevent and treat gastrointestinal damage
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
EP0974351A3 (fr) * 1998-04-24 2000-12-13 Jouveinal Médicament pour la prévention et le traitement des dommages gastrointestinaux
CA2327285C (fr) * 1998-05-15 2005-06-14 Warner-Lambert Company Preparations pharmaceutiques stabilisees de derives d'acide gamma-aminobutyrique et procede de fabrication associe
EP1031350A1 (fr) * 1999-02-23 2000-08-30 Warner-Lambert Company Utilisation d'un analogue de la gabapentine pour la fabrication d'un médicament pour la prevention et le traitement des douleurs viscérales
SE9904508D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
SE9904507D0 (sv) 1999-12-09 1999-12-09 Astra Ab New compounds
US7319095B2 (en) 1999-12-09 2008-01-15 Astrazeneca Ab Use of GABAB receptor agonists
AR033779A1 (es) 2001-06-08 2004-01-07 Astrazeneca Ab Compuestos utiles en la enfermedad de reflujo
US20050090554A1 (en) * 2003-09-12 2005-04-28 John Devane Treatment of gastroparesis and nonulcer dyspepsia with GABAB agonists
EP3350187A1 (fr) 2015-09-15 2018-07-25 AbbVie Inc. Isoxazolopyridazinones et isothiazolopyridazinones substituées et procédés d'utilisation
WO2018048868A1 (fr) * 2016-09-07 2018-03-15 The Children's Hospital Of Philadelphia Activateurs non sélectifs du récepteur métabotropique du glutamate pour le traitement de l'anorexie mentale et du trouble de la frénésie alimentaire
CN111603560A (zh) * 2020-06-22 2020-09-01 泉州台商投资区秋鑫茶业有限公司 茶叶γ-氨基丁酸在肿瘤放射治疗上的应用

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896149A (en) * 1972-06-07 1975-07-22 Sakai Chemical Industry Co Novel pyrrolidone derivatives and manufacturing the same
EP0082369A1 (fr) * 1981-12-19 1983-06-29 MERCK PATENT GmbH Imidazo (4,5-c) pyridines, compositions pharmaceutiques les contenant et procédé pour leur préparation
GB2185483A (en) * 1986-01-21 1987-07-22 Nippon Shinyaku Co Ltd Pyroglutamide derivatives
US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
WO1993011138A1 (fr) * 1991-12-02 1993-06-10 John Wyeth & Brother Limited Derives d'amines contenant une fraction d'acide phosphonique, phosphoreux ou phosphinique
WO1993022314A1 (fr) * 1992-04-30 1993-11-11 Neurogen Corporation Certains imidazopyrazinediones d'aryle et de cycloalkyle fusionnes; nouvelle categorie de ligands de neurorecepteurs de gaba
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
WO1994025016A1 (fr) * 1993-04-23 1994-11-10 Glaxo Group Limited NOUVELLE APPLICATION MEDICALE D'AGONISTES D'ACIDE η-AMINOBUTYRIQUE

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896149A (en) * 1972-06-07 1975-07-22 Sakai Chemical Industry Co Novel pyrrolidone derivatives and manufacturing the same
EP0082369A1 (fr) * 1981-12-19 1983-06-29 MERCK PATENT GmbH Imidazo (4,5-c) pyridines, compositions pharmaceutiques les contenant et procédé pour leur préparation
GB2185483A (en) * 1986-01-21 1987-07-22 Nippon Shinyaku Co Ltd Pyroglutamide derivatives
US4952573A (en) * 1988-03-23 1990-08-28 Laboratoirs Alcon S.A. Compounds having GABA like activity, and use of same in tissue irrigating solutions
US5281747A (en) * 1989-05-13 1994-01-25 Ciba-Geigy Corporation Substituted aminoalkylphosphinic acids
US5182290A (en) * 1991-08-27 1993-01-26 Neurogen Corporation Certain oxazoloquinolinones; a new class of GABA brain receptor ligands
WO1993011138A1 (fr) * 1991-12-02 1993-06-10 John Wyeth & Brother Limited Derives d'amines contenant une fraction d'acide phosphonique, phosphoreux ou phosphinique
WO1993022314A1 (fr) * 1992-04-30 1993-11-11 Neurogen Corporation Certains imidazopyrazinediones d'aryle et de cycloalkyle fusionnes; nouvelle categorie de ligands de neurorecepteurs de gaba
WO1994025016A1 (fr) * 1993-04-23 1994-11-10 Glaxo Group Limited NOUVELLE APPLICATION MEDICALE D'AGONISTES D'ACIDE η-AMINOBUTYRIQUE

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Baclofen for intractable vomiting in muscular dystrophy", LANCET, pages 227, XP000563383 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41920E1 (en) 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain

Also Published As

Publication number Publication date
AU3745895A (en) 1996-05-06
GB9420784D0 (en) 1994-11-30
WO1996011680A2 (fr) 1996-04-25

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