WO1996009399A3 - Adenovirus chimerique permettant l'apport de genes - Google Patents

Adenovirus chimerique permettant l'apport de genes Download PDF

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Publication number
WO1996009399A3
WO1996009399A3 PCT/US1995/011537 US9511537W WO9609399A3 WO 1996009399 A3 WO1996009399 A3 WO 1996009399A3 US 9511537 W US9511537 W US 9511537W WO 9609399 A3 WO9609399 A3 WO 9609399A3
Authority
WO
WIPO (PCT)
Prior art keywords
chimeric adenovirus
gene delivery
useful
chimeric
delivery
Prior art date
Application number
PCT/US1995/011537
Other languages
English (en)
Other versions
WO1996009399A2 (fr
Inventor
Srinivas Shankara
Varavani Dwarki
Tarlochan Nijjar
Original Assignee
Somatix Therapy Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Somatix Therapy Corp filed Critical Somatix Therapy Corp
Priority to AU35511/95A priority Critical patent/AU3551195A/en
Publication of WO1996009399A2 publication Critical patent/WO1996009399A2/fr
Publication of WO1996009399A3 publication Critical patent/WO1996009399A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne un adénovirus chimérique pouvant effectuer la transduction de cellules mammaliennes avec un ADN d'intérêt. Ces adénovirus servent à introduire des gènes clonés dans l'organisme d'un individu et sont donc également utilisés pour traiter les maladies et les troubles génétiques chez les mammifères.
PCT/US1995/011537 1994-09-23 1995-09-12 Adenovirus chimerique permettant l'apport de genes WO1996009399A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU35511/95A AU3551195A (en) 1994-09-23 1995-09-12 Chimeric adenovirus for gene delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31148594A 1994-09-23 1994-09-23
US311,485 1994-09-23

Publications (2)

Publication Number Publication Date
WO1996009399A2 WO1996009399A2 (fr) 1996-03-28
WO1996009399A3 true WO1996009399A3 (fr) 1996-07-18

Family

ID=23207088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/011537 WO1996009399A2 (fr) 1994-09-23 1995-09-12 Adenovirus chimerique permettant l'apport de genes

Country Status (2)

Country Link
AU (1) AU3551195A (fr)
WO (1) WO1996009399A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837511A (en) * 1995-10-02 1998-11-17 Cornell Research Foundation, Inc. Non-group C adenoviral vectors
WO1997015679A1 (fr) * 1995-10-27 1997-05-01 The Trustees Of The University Of Pennsylvania Virus recombines contenant des elements genetiques mobiles et procedes d'utilisation desdits virus en therapie genique
FR2741358B1 (fr) * 1995-11-17 1998-01-02 Centre Nat Rech Scient Production de vecteurs retroviraux par l'intermediaire de vecteurs viraux a base de virus a adn
ATE550429T1 (de) 1996-11-20 2012-04-15 Crucell Holland Bv Adenovirus-zusammensetzungen erhältlich durch ein verbessertes produktions- und reinigungsverfahren
US7732129B1 (en) 1998-12-01 2010-06-08 Crucell Holland B.V. Method for the production and purification of adenoviral vectors
US5849561A (en) * 1997-05-22 1998-12-15 Cornell Research Foundation, Inc. Method for the production of non-group C adenoviral vectors
US6689600B1 (en) 1998-11-16 2004-02-10 Introgen Therapeutics, Inc. Formulation of adenovirus for gene therapy
WO2002022080A2 (fr) * 2000-09-15 2002-03-21 Merck & Co., Inc. Vaccins adenoviraux de premiere generation evolues, exprimant les proteines gag, pol et nef du vih-1 a optimisation des codons et leurs modifications
CN100361710C (zh) 2004-06-07 2008-01-16 成都康弘生物科技有限公司 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用
JP2008518632A (ja) 2004-11-03 2008-06-05 イントロゲン セラピューティックス， インコーポレイテッド アデノウイルスベクターの製造および精製のための新規方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003163A1 (fr) * 1991-08-01 1993-02-18 Fondation Nationale De Transfusion Sanguine Expression dans des lignees lymphoblastoides humaines non-tumorales avec un vecteur integratif

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993003163A1 (fr) * 1991-08-01 1993-02-18 Fondation Nationale De Transfusion Sanguine Expression dans des lignees lymphoblastoides humaines non-tumorales avec un vecteur integratif

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C.CAILLAUD ET AL.: "Adenoviral vector as a gene delivery system into cultured rat neuronal and glial cells", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 5, no. 10, 1 October 1993 (1993-10-01), pages 1287 - 1291, XP002002600 *
S-H CHEN ET AL.: "Gene therapy for brain tumors:Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 91, 12 April 1994 (1994-04-12), WASHINGTON US, pages 3054 - 3057, XP002002601 *

Also Published As

Publication number Publication date
WO1996009399A2 (fr) 1996-03-28
AU3551195A (en) 1996-04-09

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