WO1996005765A1 - Recording apparatus for electroencephalogram and electrocardiograph - Google Patents

Recording apparatus for electroencephalogram and electrocardiograph Download PDF

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Publication number
WO1996005765A1
WO1996005765A1 PCT/JP1995/001636 JP9501636W WO9605765A1 WO 1996005765 A1 WO1996005765 A1 WO 1996005765A1 JP 9501636 W JP9501636 W JP 9501636W WO 9605765 A1 WO9605765 A1 WO 9605765A1
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WIPO (PCT)
Prior art keywords
electroencephalogram
signal
eeg
electrocardiogram
electrocardiographic
Prior art date
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PCT/JP1995/001636
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French (fr)
Japanese (ja)
Inventor
Satoko Sato
Original Assignee
Satoko Sato
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Publication of WO1996005765A1 publication Critical patent/WO1996005765A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/318Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A61B5/333Recording apparatus specially adapted therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/369Electroencephalography [EEG]
    • A61B5/377Electroencephalography [EEG] using evoked responses
    • A61B5/378Visual stimuli

Definitions

  • the present invention relates to an electroencephalogram and electrocardiogram recording device, and more particularly, to simultaneously display electroencephalogram and electrocardiogram waveforms on the screen of a personal computer so that the functions of the brain and the heart can be simultaneously grasped, and the potential of the electroencephalogram and the electroencephalogram can be obtained. It relates to an EEG recording device that makes it easy to intuitively and visually understand by creating an EEG graph consisting of each electrode part and recording the EEG in the form of a two-dimensional image. is there. Background art
  • brain waves are generally recorded by inducing changes in the electrical activity of the brain over time derived from electrodes on the scalp, with the potential difference fluctuating on the vertical axis and time on the horizontal axis, approximating a sine wave. It is displayed as a curve.
  • the electroencephalogram is a minute electric potential in the unit of uV, so it is greatly amplified by an electroencephalograph, and the amplified electroencephalogram is moved up and down by the pen tip. It is drawn wavy above.
  • This waveform is represented by height (amplitude V) and width (duration, period, milliseconds), and the frequency (cycle) is one cycle.
  • the brain waves are drawn with a width of 3 cm for 1 second, so the width of the recorded waveform wave is 3 cm How much you can enter inside
  • the frequency is determined by measuring the frequency with a scale or the like, and the amplitude is determined by measuring the length on the scale and converting it to voltage.
  • ECG electrocardiogram
  • P waves waveforms
  • QRS groups waveforms
  • T waves waveforms
  • the waveform displayed on the electrocardiogram is an electrical view of the heart's excitement process required to cause the heart to move, and the process of excitement.
  • an ECG is a long recording paper with a firewood line drawn by an electrocardiograph (a graph with a scale, the minimum unit of the scale is 1 mm in length, a small square of 1 mm in height, and a small square between thick lines). (Five squares are squared in), usually 2.5 cm wide per second. Measure the width (milliseconds) and height (amplitude mV) of each wave of P, QRS, ST'T for each beat of the drawn waveform, and measure the heart rate, tuning, and axis deviation. , Hypertrophy, myocardial damage, hard infarction, etc.
  • the present applicant has already disclosed in Japanese Patent Application Laid-Open No. 61-164542 that brain waves are detected as 5, ⁇ , ⁇ , a 2 , ⁇ ,, ordinate potential for each frequency band of the beta 2, the horizontal axis Ri by the a child display polygonal line graph of the electrode sites, quantitative, the recording apparatus intuitively EEG that can have a this measure Proposed.
  • This device uses an electroencephalograph, converts the analog signal of the electroencephalogram measured by the electroencephalograph into a digital signal by an interface device, and outputs the digital signal to a personal computer.
  • the present invention provides an electroencephalogram recording device that calculates the digital signal and displays the graph on a screen.
  • this electroencephalography recording device requires a conventional electroencephalograph, so the device becomes large and complicated.
  • the analog signal of the electroencephalogram obtained by the electroencephalograph records the electroencephalogram in a wave shape on paper.
  • the electroencephalograph displays a clear graph of the electroencephalogram on the screen of the personal computer, because the electroencephalography signal obtained by the electroencephalograph differs depending on the model. In order to do so, it is necessary to use an interface device that matches the EEG signal to be captured, and the interface device must be changed to match the model of the EEG to be used. was there.
  • the present applicant has improved an electroencephalogram recording device using a conventional electroencephalograph described in Japanese Patent Application Laid-Open No. 61-164452, and No. 9 051 and Japanese Patent Application Laid-Open No. Sho 63-8991 41
  • the electroencephalogram signal induced from the electrode attached to the scalp is directly introduced into the personal computer via the interface device without using a conventional electroencephalograph, and is displayed as a line graph.
  • this electroencephalogram recording device has the advantage of not using a conventional electroencephalograph.However, it is not possible to simultaneously grasp other biological functions only by recording the electroencephalogram, and if the measurement conditions are poor, the electroencephalography is not possible. There was a disadvantage that external noise was mixed into the signal.
  • the present invention has been completed as a result of conducting research in view of such conventional problems, and is a recording device that does not use a conventional large and complicated electroencephalograph or electrocardiograph.
  • a recording device that does not use a conventional large and complicated electroencephalograph or electrocardiograph.
  • To the measurement site on the scalp and chest of the subject amplify the EEG and ECG signals obtained from the electrodes, and remove the noise contained in the EEG and ECG signals.
  • the signal is corrected to a signal of purity, the brain wave signal and the electrocardiogram signal are selected simultaneously by the switch, and further analyzed by the digital signal processor, and the information is displayed on the CRT of the personal computer. It is an object of the present invention to provide a recording device capable of simultaneously displaying brain waves and electrocardiogram waveforms at the same time and simultaneously capturing brain functions and heart functions.
  • the present invention selects an electroencephalogram signal from the electroencephalogram signal and the electroencephalogram signal amplified and corrected as described above, further analyzes the electroencephalogram signal with a digital signal processor, and clearly transmits the electroencephalogram to a CRT of a personal computer.
  • ⁇ , aj, ⁇ 2, ⁇ ⁇ the vertical axis potential for each frequency band of beta 0, Ri by the and this horizontal axis is displayed on the polygonal line graph of the electrode sites, give et been from the electrode electroencephalogram
  • a compact device that can directly display signals on a screen and aims to provide a recording device that can measure brain waves quantitatively, intuitively, and accurately. . Disclosure of the invention
  • the present invention provides an electroencephalogram electrode that is attached to each induction site of the scalp and induces an analog signal of an electroencephalogram signal, a preamplifier that amplifies an analog signal of the electroencephalogram signal captured by the electroencephalogram signal, An electroencephalogram circuit ( ⁇ ) having electroencephalogram signal correction means for removing distortion of the electroencephalogram signal amplified by the preamplifier;
  • An electrocardiographic electrode that is attached to each lead site of the chest to induce an electrocardiographic analog signal, and a pre-amplifier that amplifies the electrocardiographic signal captured by the electrocardiographic electrode
  • An electrocardiographic circuit ( ⁇ ) having an amplifier and an electrocardiogram signal correcting means for removing distortion of the electrocardiogram signal amplified by the preamplifier;
  • An analog switch for connecting the electroencephalogram circuit (A) and the electrocardiogram circuit (B), and an AZD converter for converting an analog signal input from the analog switch into a digital signal
  • a digital signal processor that takes in digital signals from the AZD converter, controls the interface, and sends data to the personal computer, and digital signal data from the digital signal processor.
  • a personal computer that simultaneously displays the acquired brain waves and electrocardiogram waveforms, calculates the measured data of the acquired brain waves, and displays the brain waves on the vertical axis on the potential and the horizontal axis on the line graph of each electrode site.
  • a recording device for EEG and electrocardiogram characterized by the following.
  • the apparatus for recording an electroencephalogram and an electrocardiogram amplifies the electroencephalogram signal of at least 12 or 16 channels and the electrocardiogram signal of at least one channel of the electroencephalogram inputted from the electrode.
  • the noise contained in the electroencephalogram signal and the electrocardiogram signal is removed, corrected to a high-purity signal, and sent to a personal computer via a digital signal processor for analysis. Recording or EEG recording is performed automatically.
  • the electroencephalogram and electrocardiogram recording apparatus of the present invention does not use a large and complicated electroencephalograph or electrocardiograph as in the related art, but attaches electrodes to each measurement site of the examiner's scalp and chest and uses the electrodes.
  • the obtained EEG signal and ECG signal are amplified, and at this time, the noise contained in the EEG signal and ECG signal is removed and corrected to a high-purity signal.
  • Select the signal at the same time Analysis the brain wave and electrocardiogram waveforms are simultaneously displayed on the CRT of the personal computer clearly, and the brain function and the heart function can be grasped at the same time. Not only can the patient be treated while observing the symptoms, but also the state of the cessation of the functions of the brain and the heart at the end of life.
  • the present invention selects an electroencephalogram signal from the amplified and corrected electroencephalogram signal and electrocardiogram signal, analyzes the electroencephalogram signal using a digital signal processor, and clearly transmits the electroencephalogram to a CRT of a personal computer.
  • ⁇ 'a ⁇ , ⁇ ⁇ , ⁇ ⁇ , ⁇ 2 For each frequency band, the vertical axis represents the electric potential, and the horizontal axis represents the line graph of each electrode position.
  • the EEG measurement can be performed accurately and quantitatively, and there is no measurement error caused by a conventional measurer.
  • the EEG of a normal person is measured, and a line graph of the EEG of a normal person is created for each waveform based on the potential, based on which a clinical EEG test in the psychiatric field is performed.
  • the degree of deviation can be compared, and it can be applied not only to treatment of pathological people, but also to examination of the functioning of the brain function of ordinary people and other areas.
  • FIG. 1 is a block diagram showing an example of an electroencephalogram and electrocardiogram recording apparatus according to the present invention.
  • FIG. 2 is a diagram showing an example of a graph displaying original waveforms of an electroencephalogram and an electrocardiographic waveform.
  • Fig. 3 compares the measured data of one subject in the ⁇ 5 wave band with the graph of normal subjects.
  • Fig. 4 compares one measurement data of the 0 wave band of the subject with the graph of normal person.
  • Fig. 5 is a diagram comparing one measurement data of the ⁇ - wave band of the subject with that of a normal person.
  • FIG. 6 is a diagram comparing the one measurement data of alpha 2 wave band subjects with normal human grayed off.
  • Fig. 7 is a diagram comparing one measurement data of the subject's ⁇ i wave band with that of a normal person.
  • FIG. 8 is a diagram of one measurement data, compared to normal persons graph of 3 two-wave band of the subject.
  • Fig. 9 is a diagram in which the S-S graph I I shows the lower frequency band (one measurement data) than the SS graph I.
  • Fig. 10 shows a graph of a normal person from the SS graph II, comparing the 5-band (one measurement dart) of the subject.
  • the electroencephalogram and electrocardiogram recording apparatus of the present invention amplifies an electroencephalographic signal of 12 or 16 channels and an electrocardiographic signal of at least one channel of an electroencephalogram input from an electrode. Included in EEG and ECG signals Removes noise and corrects it to a high-purity signal, sends it to a personal computer via a digital signal processor for analysis, and records EEG and ECG waveforms or EEG recordings based on the results. This is a device that automatically performs
  • FIG. 1 is a block diagram showing an example of an electroencephalogram and electrocardiogram recording apparatus according to the present invention.
  • This device consists of an electroencephalogram circuit (A) having an electroencephalogram electrode, a preamplifier, and an electroencephalogram signal correction means, and an electrocardiogram circuit (B) having an electrocardiogram electrode, a preamplifier, and an electrocardiogram signal correction means.
  • the EEG circuit (A) in FIG. 1 will be described.
  • An electroencephalogram electrode is attached to a measurement site on the scalp to capture an electroencephalogram signal.
  • the EEG electrode is attached by the unipolar induction method with the input of 12 or 16 channels conforming to the international 10-20 method.
  • commercially available electrodes for electroencephalogram measurement can be used as the electrodes.
  • the electroencephalogram is directly measured by using the electroencephalogram electrode without using the conventional electroencephalograph, and in the electroencephalogram measurement, the electrode is attached by a monopolar induction method and an international M10-20 method.
  • FP 1 ⁇ FP 2 'F 7-F 8-C 3-C 4' T 5-T 6-0 1 ⁇ 02 ⁇ FZ ⁇ PZ a contact resistance measuring device that measures the contact resistance (impedance) between the electrode and the scalp, two buffer amplifiers (buffer amplifiers) that remove the distortion of the EEG signal, and a point between two points on the scalp
  • An electrode selector that selects two leads for each channel in order to record the potential of each channel, a calibration device that can generate various calibration voltages based on 50 iV as brain wave signals, etc. Provided.
  • the contact resistance measurement device and the first buffer amplifier show the probe part.
  • the analog signal of the electroencephalogram signal captured by the electroencephalogram electrode is amplified by a preamplifier.
  • the preamplifier adjusts the electroencephalogram signal. And amplify.
  • the preamplifier adjusts the electroencephalogram signal.
  • the electroencephalogram signal correction means is a circuit for removing the distortion of the electroencephalogram signal amplified by the preamplifier, for example, a hum filter (differential amplifier) and a buffer amplifier (buffer amplifier). Consists of
  • a hum filter removes in-phase noise such as commercial AC noise (hum).
  • the EEG signal is transmitted by a buffer amplifier. Excluding noise and distortion other than signal.
  • the electrocardiogram circuit (B) is attached to each lead site of the chest and guides the electrocardiographic analog signal, and amplifies the analog signal of the electrocardiographic signal captured by the electrode. It comprises a preamplifier and an electrocardiogram signal correcting means for removing distortion of the electrocardiogram signal amplified by the preamplifier. Electrocardiographic electrodes are attached by standard 12 leads with 6 limb leads and 6 chest leads. In addition, a commercially available electrode for electrocardiogram can be used. For example, an electrode for electrocardiogram measurement can be used. Electrocardiographic electrodes are attached with one channel input.
  • the analog signal of the electrocardiographic signal captured by the electrocardiographic electrode is amplified by a preamplifier.
  • the preamplifier adjusts and amplifies the electrocardiographic signal.
  • specifications of the preamplifier those similar to those used for the measurement of the electroencephalogram can be used.
  • the electrocardiogram signal correction means is a circuit for removing distortion of the electrocardiogram signal amplified by the preamplifier, and includes, for example, a hum filter (differential amplifier) and a buffer amplifier (buffer amplifier). ).
  • the hum filter removes in-phase noise such as commercial AC noise (hum).
  • noise and distortion other than ECG signals are eliminated by a buffer amplifier. These can be the same as those used for EEG measurement.
  • the EEG circuit (A) and the ECG circuit (B) are analog switches Connect with the switch.
  • An analog switch is a device that takes in analog signals from the electrodes by switching the input of 12 channels of EEG signals and the input of 1 channel of electrocardiographic signals to the input of each channel.
  • the analog switch can be configured to capture the EEG and ECG analog signals simultaneously, or to capture either the EEG or ECG analog signal.
  • the programmable amplifier corrects for variations in the analog signals of the electroencephalogram signal and the electrocardiogram signal.
  • the A / D converter converts the electroencephalogram signal and the electrocardiographic analog signal input from the analog switch into digital signals.
  • the AZD converter is connected to a digital signal processor (DSP) via a photocoupler.
  • DSP digital signal processor
  • the digital signal processor captures the digital signal from the AZD converter, controls the interface, and sends the data to the 0 -sonal computer.
  • the interface is connected to a personal computer.
  • the Sonal computer is connected to a digital signal processor, can calculate the measurement data sent from the digital signal processor, can simultaneously display the EEG and ECG waveforms, and The measured data is calculated, and the EEG is displayed on the vertical axis as the potential and the horizontal axis on the line graph of each electrode site.
  • the Sonal computer consists of a computer main unit, color display, keyboard, 10 MB fixed disk device, printer, etc.
  • the personal computer used in the present invention is not particularly limited and may be a commercially available personal computer. Specific examples thereof include an OA personal computer C-7000D, a memory 256 KB 3 8 4 KB.
  • Printer 1 output 2 4 x 24 4 dot 1 2 0 C P S
  • Display colors 83 colors including 3 primary colors, 8 colors, and intermediate colors
  • Printing method Dot matrix impact bi-directional printing Number of prints: 80 lines, 66 lines
  • EEG signals of the 12 channels input from the EEG electrodes attached to the respective lead sites on the scalp are transmitted through the EEG circuit (A) such as the preamplifier and EEG signal correction means shown in Fig. 1. Import to a personal computer.
  • EEG circuit such as the preamplifier and EEG signal correction means shown in Fig. 1. Import to a personal computer.
  • the measurement conditions are fixed for one capture time of 5 seconds (4.88 msec x 1024), and the number of capture times is set to 1 to 100 times.
  • the number of acquisitions was set, and the measured data was transferred from the EEG electrode to the main memory of the personal computer C-700D via the preamplifier and the EEG circuit (A). Is stored in real time.
  • an electrocardiographic circuit such as a preamplifier and electrocardiogram signal detection means shown in Fig. ) To the personal computer.
  • the measurement conditions are set so that the time for each acquisition is fixed at 5 seconds (4.88 s x 1 024), and the number of acquisitions is 1 to 6 times.
  • the analog switch is set so that both the electroencephalogram signal and the electroencephalogram signal can be measured.
  • the EEG of one channel and the ECG of one channel are displayed on the screen in real time.
  • the EEG time series data stored in the main memory is converted into a complex Fourier series by the fast Fourier transform method (FFT), and the power spectrum of the EEG is calculated.
  • FFT fast Fourier transform method
  • the power spectrum obtained as a result of the calculation is stored on the fixed disk.
  • the power spectrum calculation is performed on the sampled data every 5 seconds, and the work of storing the result is repeated for the set number of times.
  • the average power spectrum equally divided by the number of times is displayed on a single screen simultaneously on one or two channels.
  • the power spectrum is written for each channel and each frequency band in the fixed disk measurement value master file, and the measured value master file is read. 50 V, the horizontal axis is the electroencephalogram of the line graph of the electroencephalogram of each electrode site 1 to 12 channel
  • the measured value master file is read, the potential distribution map and SS graphs I and II are read out, displayed in color on the CRT screen, and hard-copyed to the printer for printing. Perform the following processing.
  • the brain waves can be recorded on an electroencephalogram in which the vertical axis is the potential and the horizontal axis is the line graph of each electrode site.
  • a respiratory waveform can be simultaneously displayed in addition to an electroencephalogram and an electrocardiogram waveform.
  • the method from the movement of electrocardiographic electrodes which are attached to the chest captures the movement of the rib cage to display the respiratory waveform by thoracic breathing or by breathing wearing the C 0 2 gas measurement sensors in the nostrils, the change in C 0 2 gas ⁇ contained in breath and out and a method of displaying a respiratory waveform.
  • This respiratory waveform can be displayed simultaneously with the electroencephalogram waveform shown in FIG. 2 as a continuous waveform of peaks and valleys together with the electroencephalogram waveform shown in FIG.
  • the contact resistance measurement device the first buffer amplifier (buffer amplifier), the second buffer amplifier (buffer amplifier), the electrode selector, An electroencephalogram circuit (A) consisting of a calibration device, a preamplifier, a hum filter (differential amplifier), and a buffer amplifier (buffer amplifier).
  • An electrocardiogram system that connects a calibration device, a preamplifier, a Ham filter (differential amplifier), and a buffer amplifier (buffer amplifier) in sequence using commercially available electrodes for electrocardiographs.
  • Circuit (B) An electrocardiogram system that connects a calibration device, a preamplifier, a Ham filter (differential amplifier), and a buffer amplifier (buffer amplifier) in sequence using commercially available electrodes for electrocardiographs. Circuit (B),
  • An analog switch for connecting the electroencephalogram circuit (A) and the electrocardiogram circuit (B), a program amplifier (PGA), an A / D converter, a photocoupler, a digital signal processor, An interface and a personal computer (Matsushita Electric Industrial Co., Ltd., National, Nogu Nafacom C-700D) are used.
  • the EEG was recorded by the processing procedure shown in Table 1.
  • menu N 0.1 When menu N 0.1 is selected from the menu screen, the following items are displayed on the screen.
  • the subject's number, name, date of birth, F ⁇ M (gender), and LP are displayed, and they are entered and registered.
  • the data capacity is for 500 people, and one examiner Can record measurement data for four times.
  • menu N 0.2 When menu N 0.2 is selected from the menu screen, the subject's number, name, age, month, day, time, 1, 2, 3, 4, NOTE, frequency band name, and frequency band are displayed.
  • Fig. 2 shows an example of a graph displaying the original waveform.
  • FP 1, FP 2, F 7, F 8, C 3, C 4, T 5, T 6, 01, 02, FZ, PZ indicate electroencephalogram
  • H 1 indicates electrocardiogram waveform .
  • the number of acquisitions is collected by specifying the number of counts.
  • the start of calculation and the display during calculation are performed.
  • the power spectrum is calculated and added to the power spectrum obtained previously.
  • One count for 5 seconds can be calculated up to 100 counts, and any count can be specified.
  • the capture start time is displayed automatically, and the capture end time is displayed automatically.
  • the result of the power spectrum of the EEG 12 channel is displayed.
  • the vertical axis is compress, the horizontal axis is frequency 0 to 75 Hz, A scale of 5 Hz is displayed. The calculation and count are displayed.
  • the screen of the subject's 6 frequency bands is displayed at the same time.
  • the average potential of each channel obtained by the above calculation is displayed on a vertical axis as a potential, and the horizontal axis is displayed as a line graph of each electrode portion.
  • a potential distribution chart is displayed for each frequency.
  • the magnitude of the potential of the power vector is divided into six levels, and each potential is compared and displayed by pattern, and each frequency band (5, ⁇ , a ⁇ ⁇ ⁇ . ⁇ ⁇ ⁇ ) is compared and displayed by color.
  • Theta band (purple): Frequency 4.0 to 7.8 ⁇
  • Normal graphs are automatically displayed according to the age of the subject.
  • the display of the normal person graph is
  • the average potential of each channel obtained by the calculation is displayed on the vertical axis as a potential, and the horizontal axis is displayed as a line graph of each electrode portion.
  • Frequency band Example (5, ⁇ , aj, 2 , ⁇ j, 6 -frequency band of beta 2 are displayed simultaneously.
  • Figures 3 to 8 show the subject's ⁇ , ⁇ , a ⁇ , ⁇ . ,
  • the data of one measurement of 6 frequency band of beta 0, shows the diagram compared to normal individuals graph.
  • the screen of any frequency band among the 6 frequency bands of the subject will be displayed.
  • the average potential of each channel is indicated by the vertical axis, and the horizontal axis is indicated by a line graph of each electrode portion.
  • the S.S graph II shows a graph of a normal person and allows individual comparison of each of the six frequency bands of the subject.
  • Fig. 9 shows the SS graph II showing the ⁇ 5 wavebands (one measurement datum) from the SS graph I.
  • Fig. 10 shows a graph of a normal person from the SS graph II, and a comparison of the subject's five-wave band (one measurement gutter).
  • menu No. 7 When menu No. 7 is selected from the menu screen, a screen of the measured data values of the 12 channels is displayed for each frequency band. Display a list of potentials for the four subjects.
  • Table 2 shows a list of potentials for one test subject.
  • the vertical axis shows the potential and the horizontal axis shows the time.
  • Pressing the return key prints a list of subjects.
  • Select menu No. 11 from the menu screen to display the screen. Select No and register the subject's name, date of birth, and gender. Modify or delete.
  • the apparatus for recording an electroencephalogram and an electrocardiogram can simultaneously display the original waveform of the electroencephalogram (12 channels) and the original waveform of the electrocardiogram waveform (1 channel) in the original waveform display. It can be displayed, and by continuously observing this screen, it is possible to simultaneously grasp the functions of the brain and the heart.
  • the electroencephalogram and electrocardiogram recording device of the present invention can clearly display electroencephalogram and electrocardiogram waveforms simultaneously on a CRT of a personal computer, and can simultaneously capture brain function and heart function. It is possible to perform treatment while grasping the relationship between the two and grasping the functions of the heart and the heart, and at the end of life, the state of the cessation of the function of the brain and the function of the heart.
  • the EEG signal obtained from the electrodes can be directly displayed on the vertical axis as potential and the horizontal axis as a line graph of each electrode part on a compact device. It can be measured accurately and can be applied to the examination of the function of brain function.

Abstract

A recording apparatus for electroencephalogram and electrocardiogram, which can clearly display electroencephalogram and electrocardiogram waveforms on a CRT of a computer at the same time and directly compare electroencephalogram signals obtained from electrodes with those of a normal man to display the result with a polygonal line graph. The recording apparatus can amplify 12- or 16-channel electroencephalogram signals inputted from the electrodes and an electrocardiogram signal of at least one-channel to remove noises contained in the electroencephalogram signals and electrocardiogram signal for correction into signals of high purity, forward the signals to a personal computer through a digital signal processor for analysis, display electroencephalogram and electrocardiogram waveforms at the same time on the basis of the result, calculate captured measurement data of electroencephalogram and display electroencephalogram with a polygonal line graph where an axis of ordinates represents potential and an axis of abscissa represents portions of the respective electrodes.

Description

明 細 害 脳波および心電図の記録装置 技術分野  Membrane EEG and ECG recording device
本発明は脳波および心電図の記録装置に関し、 特に脳波と心電図 波形を同時にパー ソナルコ ン ピュ ー タ の画面に表示し脳と心臓の機 能を同時に把握する こ とができ る と共に、 脳波の電位と各電極部位 からなる脳波グラフを作成し、 脳波を二次元画像の形で記録するこ とによ り、 直観的、 視覚的に容易に理解する こ とを可能に した脳波 の記録装置に関する ものである。 背景技術  The present invention relates to an electroencephalogram and electrocardiogram recording device, and more particularly, to simultaneously display electroencephalogram and electrocardiogram waveforms on the screen of a personal computer so that the functions of the brain and the heart can be simultaneously grasped, and the potential of the electroencephalogram and the electroencephalogram can be obtained. It relates to an EEG recording device that makes it easy to intuitively and visually understand by creating an EEG graph consisting of each electrode part and recording the EEG in the form of a two-dimensional image. is there. Background art
従来、 脳波は一般に脳が示す電気的活動の時間に対する変化を頭 皮上の電極から誘導して記録され、 変動する電位差を縱軸に、 時間 を横軸にと り、 正弦波に近似した波形曲線で表示されている。 実際 の記録方法と しては、 脳波は u V単位の微少な電位であるために、 脳波計によ り大き く增幅され、 増幅された脳波はペン先の上下の動 きにより、 流れる紙の上に波状に画かれている。 この波形は高さ (振 幅 V ) と幅 (持続時間、 周期、 ミ リセコ ン ド) で表わされ、 周波 数 (サイ クル) は 1 周期である。  Conventionally, brain waves are generally recorded by inducing changes in the electrical activity of the brain over time derived from electrodes on the scalp, with the potential difference fluctuating on the vertical axis and time on the horizontal axis, approximating a sine wave. It is displayed as a curve. As an actual recording method, the electroencephalogram is a minute electric potential in the unit of uV, so it is greatly amplified by an electroencephalograph, and the amplified electroencephalogram is moved up and down by the pen tip. It is drawn wavy above. This waveform is represented by height (amplitude V) and width (duration, period, milliseconds), and the frequency (cycle) is one cycle.
上記の如く して記録された波形から脳波を読み取るには、 通常、 脳波は 1秒間 3 c mの幅で画かれるのが原則とされているために、 記録された波形の波の横幅が 3 c mの中にい く つ入る割^になつて いるかをスケール等で測定して周波数を求め、 又振幅はスケールで 長さを計り電圧に換算して求めている。 In order to read brain waves from the waveform recorded as described above, it is generally assumed that the brain waves are drawn with a width of 3 cm for 1 second, so the width of the recorded waveform wave is 3 cm How much you can enter inside The frequency is determined by measuring the frequency with a scale or the like, and the amplitude is determined by measuring the length on the scale and converting it to voltage.
他方、 心臓の機能は心電計を使用して心電図の測定を行う こ とに より記録され、 その得られた結果の解析によ り判定が行われている。 心電図は心臓の機能を把握する うえで、 有用な記録であるこ とは 広く知られている。 心電図は心臓の興奮や、 興奮のさめかたを電気 的に計測したものであり、 P波、 Q R S群、 T波といわれる波形で 表わされている。 このあとに心房、 心室の機械的な興奮、 つま り収 縮、 拡張が起こる。 したがって心電図に表示された波形は心臓の運 動を起こ させるのに必要な心臓の興奮過程や、 その興奮のさめてい く過程を電気的にみたものである。  On the other hand, the function of the heart is recorded by measuring the electrocardiogram using an electrocardiograph, and judgment is made by analyzing the obtained results. It is widely known that ECG is a useful record for understanding the function of the heart. An electrocardiogram is an electrical measurement of the heart's excitement and how it is excited, and is represented by waveforms called P waves, QRS groups, and T waves. This is followed by mechanical excitement of the atria and ventricles, ie contraction and dilation. Therefore, the waveform displayed on the electrocardiogram is an electrical view of the heart's excitement process required to cause the heart to move, and the process of excitement.
従来、 心電図は、 心電計により薪線を引いた長い記録紙 (目盛の 入ったグラフ、 目盛の最小単位は長さ 1 m m、 高さ 1 m mの小さな 四角形で、 太い線の間には小さな四角形が 5個平方で入っている) の上に通常 1 秒間に 2 . 5 c mの幅で画かれている。 画かれた波形 を 1 拍毎に P · Q R S · S T ' Tの各波の幅 ( ミ リ セコ ン ド) およ び高さ (振幅 m V ) を計測し、 心拍数、 調律、 軸偏位、 肥大、 心筋 障害、 硬塞等を把握している。  Conventionally, an ECG is a long recording paper with a firewood line drawn by an electrocardiograph (a graph with a scale, the minimum unit of the scale is 1 mm in length, a small square of 1 mm in height, and a small square between thick lines). (Five squares are squared in), usually 2.5 cm wide per second. Measure the width (milliseconds) and height (amplitude mV) of each wave of P, QRS, ST'T for each beat of the drawn waveform, and measure the heart rate, tuning, and axis deviation. , Hypertrophy, myocardial damage, hard infarction, etc.
しかしながら、 脳波を読み取るには記録された脳波の毎頁が読ま れなければならないが、 多数の波形の全てを読み取るには時間がか かるために、 脳波の全体的特徴を代表する部分を読み取り全体を把 握しているが、 正確な読み取りには熟練を要し、 また個人差が生ず るために定量的な判定を行う ことが難しい欠点があった。  However, in order to read the EEG, every page of the recorded EEG must be read, but since it takes time to read all of the many waveforms, the part that represents the overall characteristics of the EEG is read in its entirety. However, accurate reading requires skill, and there are drawbacks in that it is difficult to make quantitative judgments because individual differences occur.
他方、 最近、 脳波の誘発電位のコンピューターによる加算解析を 行い、 カラーグラフ ィ ッ ク C R Tに模様又は色別に電位を表示する 方法が一部で行われているが、 表示が定量的でな く 、 判別が不正確 で、 不明瞭な欠点がある。 On the other hand, recently, computer-assisted analysis of EEG evoked potentials Some methods have been used to display potentials by pattern or color on a color graphic CRT, but the display is not quantitative, discrimination is inaccurate, and there is an unclear disadvantage.
また、 本出願人は、 この様な欠点を解決する方法と して、 既に特 開昭 6 1 - 1 6 4 5 4 2号公報において、 脳波を 5, θ , α , a 2 , β χ , β 2 の各周波数帯域毎に縦軸が電位、 横軸が各電極部位 の折れ線グラ フ に表示するこ と によ り 、 定量的、 直観的に測定する こ とができ る脳波の記録装置を提案した。 こ の装置は、 脳波計を使 用するものであり、 脳波計によ り測定された脳波のァナ口グ信号を、 イ ンターフ ヱ ース装置によ り デジタル信号に変換し、 パー ソナルコ ンピュータによ り前記デジタル信号の演算を行い画面にグラフ表示 する脳波の記録装置である。 As a method of solving such a drawback, the present applicant has already disclosed in Japanese Patent Application Laid-Open No. 61-164542 that brain waves are detected as 5, θ, α, a 2 , β ,, ordinate potential for each frequency band of the beta 2, the horizontal axis Ri by the a child display polygonal line graph of the electrode sites, quantitative, the recording apparatus intuitively EEG that can have a this measure Proposed. This device uses an electroencephalograph, converts the analog signal of the electroencephalogram measured by the electroencephalograph into a digital signal by an interface device, and outputs the digital signal to a personal computer. Thus, the present invention provides an electroencephalogram recording device that calculates the digital signal and displays the graph on a screen.
しかしながら、 この脳波の記録装置では、 従来の脳波計を使用す るために装置が大き く複雑とな り、 また脳波計によ り得られる脳波 信号のアナログ信号は脳波を波形状に紙に記録するよう に増幅、 修 正されており、 さ らに脳波計は機種によ り得られる脳波のァナ口グ 信号が異なるために、 パー ソナルコ ン ピュータの画面に脳波の鲜明 なグラ フ表示を行な う ためには、 イ ンターフ ュース装置は取り込む 脳波信号に適合する ものを用いる必要があり、 また使用する脳波計 の機種に適合する様にィ ンターフ ェース装置を変えなければな らな い欠点があった。  However, this electroencephalography recording device requires a conventional electroencephalograph, so the device becomes large and complicated.In addition, the analog signal of the electroencephalogram obtained by the electroencephalograph records the electroencephalogram in a wave shape on paper. In addition, the electroencephalograph displays a clear graph of the electroencephalogram on the screen of the personal computer, because the electroencephalography signal obtained by the electroencephalograph differs depending on the model. In order to do so, it is necessary to use an interface device that matches the EEG signal to be captured, and the interface device must be changed to match the model of the EEG to be used. was there.
さ らに、 本出願人は、 上記の特開昭 6 1 - 1 6 4 5 4 2号公報の 従来の脳波計を使用する脳波の記録装置を改良し、 既に特開昭 6 2 一 1 8 9 0 5 1号公報および特開昭 6 3 - 8 9 1 4 1号公報におい て、 頭皮に装着した電極から誘導された脳波信号を、 従来の脳波計 を使用しないで直接にイ ンタ ー フ ヱ ース装置を介してパー ソナルコ ンピュー夕に導入し、 折れ線グラフと して画面に表示する脳波の記 録装置を提案した。 In addition, the present applicant has improved an electroencephalogram recording device using a conventional electroencephalograph described in Japanese Patent Application Laid-Open No. 61-164452, and No. 9 051 and Japanese Patent Application Laid-Open No. Sho 63-8991 41 The electroencephalogram signal induced from the electrode attached to the scalp is directly introduced into the personal computer via the interface device without using a conventional electroencephalograph, and is displayed as a line graph. We proposed an EEG recording device to be displayed on the screen.
しかしながら、 この脳波の記録装置は、 従来の脳波計を使用 しな い利点があるが、 脳波の記録のみで他の生体機能を同時に把握する ことができず、 また測定条件が悪い場合には脳波信号に外部からの ノ イ ズが混入してく る欠点があった。  However, this electroencephalogram recording device has the advantage of not using a conventional electroencephalograph.However, it is not possible to simultaneously grasp other biological functions only by recording the electroencephalogram, and if the measurement conditions are poor, the electroencephalography is not possible. There was a disadvantage that external noise was mixed into the signal.
—方、 最近は、 脳波による脳の機能だけではな く 、 同時に他の生 体機能を把握するこ とが要求されている。 例えば、 脳の機能と心臓 の機能を同時に捉える こ とにより、 特に老人における脳の老化現象 と心臓の活動状況を同時に把握でき、 治療に役立つと共に、 また脳 と心臓の機能の停止状態に至る過程を同時に把握するこ とができる。  —On the other hand, recently, it is required to grasp not only the function of the brain by electroencephalography but also other biological functions at the same time. For example, by simultaneously grasping the functions of the brain and the heart, it is possible to simultaneously grasp the aging phenomenon of the brain and the activity of the heart, especially in the elderly, which is useful for treatment and the process that leads to the cessation of the function of the brain and heart. Can be grasped at the same time.
しかしながら、 従来は脳波と心電図は各々別々 に記録され、 また 心電図は心電計によ り記録された心電図の毎頁を読まれなければな らないが、 多数の波形の全てを読むには時間がかかるために、 波形 の全体的特徵を代表する部分を読み取り全体を把握しているが、 正 確な読み取りには熟練を要し、 また個人差が生ずるために定量的な 判定を行う こ とが難しい欠点があった。  However, in the past, EEG and ECG were recorded separately, and ECG had to read each page of ECG recorded by ECG, but it took time to read all of many waveforms. For this reason, the entire characteristic of the waveform is read to understand the overall characteristics.However, accurate reading requires skill, and quantitative judgment is required because individual differences occur. There was a difficult disadvantage.
本発明は、 この様な従来の問題を鑑みて研究を行なった結果完成 されたものであり、 従来の様な大き く複雑な脳波計や心電計を使用 しない記録装置であり、 電極を検者の頭皮および胸部の各測定部位 に装着し、 その電極より得られる脳波信号および心電信号を増幅し、 この際脳波信号および心電信号に含まれているノ ィズを除去して高 純度の信号に修正し、 スィ ツ チによ り脳波信号および心電信号を同 時に選択し、 さ らにデジタルシグナルプロセ ッ サ一によ り解析し、 パー ソナルコ ン ピュ ータの C R Tに鲜明に脳波と心電図波形を同時 に表示し、 脳の機能と心臓の機能を同時に捉える こ とができる記録 装置を提供するこ とを目的とする ものである。 The present invention has been completed as a result of conducting research in view of such conventional problems, and is a recording device that does not use a conventional large and complicated electroencephalograph or electrocardiograph. To the measurement site on the scalp and chest of the subject, amplify the EEG and ECG signals obtained from the electrodes, and remove the noise contained in the EEG and ECG signals. The signal is corrected to a signal of purity, the brain wave signal and the electrocardiogram signal are selected simultaneously by the switch, and further analyzed by the digital signal processor, and the information is displayed on the CRT of the personal computer. It is an object of the present invention to provide a recording device capable of simultaneously displaying brain waves and electrocardiogram waveforms at the same time and simultaneously capturing brain functions and heart functions.
また、 本発明は、 上記の様に増幅、 修正した脳波信号および心電 信号から脳波信号を選択し、 さ らにデジタルシ グナルプロセッサー により解析し、 パーソナルコ ン ピュータの C R Tに鲜明に脳波を 5, θ , a j , α 2 , β γ , β 0 の各周波数帯域毎に縦軸が電位、 横軸 が各電極部位の折れ線グラ フに表示する こ とによ り 、 電極から得ら れた脳波信号を直接に画面表示するこ とができ る コ ンパク 卜な装置 で、 脳波を定量的、 直観的に、 正確に測定するこ とができる記録装 置を提供することを目的とする ものである。 発明の開示 Further, the present invention selects an electroencephalogram signal from the electroencephalogram signal and the electroencephalogram signal amplified and corrected as described above, further analyzes the electroencephalogram signal with a digital signal processor, and clearly transmits the electroencephalogram to a CRT of a personal computer. , θ, aj, α 2, β γ, the vertical axis potential for each frequency band of beta 0, Ri by the and this horizontal axis is displayed on the polygonal line graph of the electrode sites, give et been from the electrode electroencephalogram A compact device that can directly display signals on a screen and aims to provide a recording device that can measure brain waves quantitatively, intuitively, and accurately. . Disclosure of the invention
本発明は、 頭皮の各誘導部位に装着し脳波信号のアナ口グ信号を 誘導する脳波用電極と、 該脳波用電極によ り取り込まれた脳波信号 のアナログ信号を増幅する前置増幅器と、 該前置増幅器によ り増幅 された脳波信号のひずみを除く脳波信号補正手段を有する脳波系回 路 (Α ) と、  The present invention provides an electroencephalogram electrode that is attached to each induction site of the scalp and induces an analog signal of an electroencephalogram signal, a preamplifier that amplifies an analog signal of the electroencephalogram signal captured by the electroencephalogram signal, An electroencephalogram circuit (Α) having electroencephalogram signal correction means for removing distortion of the electroencephalogram signal amplified by the preamplifier;
胸部の各誘導部位に装着し心電信号のアナ口グ信号を誘導する心 電用電極と、 該心電用電極によ り取り込まれた心電信号のァナ口グ 信号を増幅する前置増幅器と、 該前置増幅器によ り増幅された心電 信号のひずみを除く心電信号補正手段を有する心電系回路 (Β ) と を有し、 さ らに該脳波系回路 (A ) と心電系回路 ( B ) を接続する アナログスィ ッチと、 該アナログスィ ツチから入力されたアナログ 信号をデジタル信号に変換する A Z D コ ンバータ と、 該 A Z D コ ン バー夕からのデジタル信号を取り込み、 イ ンターフェイ スをコ ン ト ロールしてパーソナルコンピュータへデータを送り込むデジタルシ グナルプロセッサーと、 該デジタルシグナルプロセッサーからのデ ジタル信号のデータを取り込み脳波と心電図波形を同時に表示する と共に、 取り込まれた脳波の測定データの演算を行い、 脳波を縦軸 が電位、 横軸が各電極部位の折れ線グラ フに表示するパーソナルコ ンピュータを具備するこ とを特徴とする脳波および心電図の記録装 置である。 An electrocardiographic electrode that is attached to each lead site of the chest to induce an electrocardiographic analog signal, and a pre-amplifier that amplifies the electrocardiographic signal captured by the electrocardiographic electrode An electrocardiographic circuit (Β) having an amplifier and an electrocardiogram signal correcting means for removing distortion of the electrocardiogram signal amplified by the preamplifier; An analog switch for connecting the electroencephalogram circuit (A) and the electrocardiogram circuit (B), and an AZD converter for converting an analog signal input from the analog switch into a digital signal And a digital signal processor that takes in digital signals from the AZD converter, controls the interface, and sends data to the personal computer, and digital signal data from the digital signal processor. A personal computer that simultaneously displays the acquired brain waves and electrocardiogram waveforms, calculates the measured data of the acquired brain waves, and displays the brain waves on the vertical axis on the potential and the horizontal axis on the line graph of each electrode site. A recording device for EEG and electrocardiogram characterized by the following.
本発明の脳波および心電図の記録装置は、 電極よ り入力された脳 波の 1 2又は 1 6 チ ャ ンネルの脳波信号および少な く と も 1 チ ャ ン ネルの心電信号を増幅し、 この際脳波信号および心電信号に含まれ ているノ イズを除去して高純度の信号に修正し、 デジタルシグナル プロセッサーを介してパーソナルコ ンピュータに送り込んで解析を 行い、 その結果から脳波と心電図波形の記録、 または脳波の記録を 自動的に行う ものである。  The apparatus for recording an electroencephalogram and an electrocardiogram according to the present invention amplifies the electroencephalogram signal of at least 12 or 16 channels and the electrocardiogram signal of at least one channel of the electroencephalogram inputted from the electrode. The noise contained in the electroencephalogram signal and the electrocardiogram signal is removed, corrected to a high-purity signal, and sent to a personal computer via a digital signal processor for analysis. Recording or EEG recording is performed automatically.
本発明の脳波および心電図の記録装置は、 従来の様な大き く複雑 な脳波計や心電計を使用しないで、 電極を検者の頭皮および胸部の 各測定部位に装着し、 その電極よ り得られる脳波信号および心電信 号を増幅し、 この際脳波信号および心電信号に含まれているノ イ ズ を除去して高純度の信号に修正し、 スィ ッチによ り脳波信号および 心電信号を同時に選択し、 さ らにデジタルシグナルプロセッサーに よ り解析し、 パーソナルコ ンピュータの C R Tに鲜明に脳波と心電 図波形を同時に表示し、 脳の機能と心臓の機能を同時に捉えること ができ、 脳と心臓の機能を把握して両者の関係をと らえながら治療 を行なう こ とができる と共に、 生命の終焉において、 脳の機能と心 臓の機能の停止の状態を把握するこ とができる。 The electroencephalogram and electrocardiogram recording apparatus of the present invention does not use a large and complicated electroencephalograph or electrocardiograph as in the related art, but attaches electrodes to each measurement site of the examiner's scalp and chest and uses the electrodes. The obtained EEG signal and ECG signal are amplified, and at this time, the noise contained in the EEG signal and ECG signal is removed and corrected to a high-purity signal. Select the signal at the same time Analysis, the brain wave and electrocardiogram waveforms are simultaneously displayed on the CRT of the personal computer clearly, and the brain function and the heart function can be grasped at the same time. Not only can the patient be treated while observing the symptoms, but also the state of the cessation of the functions of the brain and the heart at the end of life.
また、 本発明は、 増幅、 修正した脳波信号および心電信号から脳 波信号を選択し、 さ らにデジタルシグナルプロセ ッサ一によ り解析 し、 パーソナルコ ン ピュータの C R Tに鲜明に脳波を 5 , Θ ' a { , α η , β { , β 2 の各周波数帯域毎に縦軸が電位、 横軸が各電極部 位の折れ線グラフに表示する こ とによ り、 電極から得られた脳波信 号を直接に画面表示するこ とができるコ ンパク トな装置で、 脳波を 定量的、 直観的に、 正確に測定するこ とができる。 In addition, the present invention selects an electroencephalogram signal from the amplified and corrected electroencephalogram signal and electrocardiogram signal, analyzes the electroencephalogram signal using a digital signal processor, and clearly transmits the electroencephalogram to a CRT of a personal computer. 5, Θ 'a { , α η , β { , β 2 For each frequency band, the vertical axis represents the electric potential, and the horizontal axis represents the line graph of each electrode position. This is a compact device that can directly display electroencephalogram signals on a screen, and can measure electroencephalograms quantitatively, intuitively, and accurately.
さ らに、 脳波の記録が折れ線グラフで表示されているので、 脳波 の測定を正確に定量的に行う こ とができ、 従来の様な測定者によ り 測定誤差を生ずるこ とがない。  In addition, since the EEG record is displayed in a line graph, the EEG measurement can be performed accurately and quantitatively, and there is no measurement error caused by a conventional measurer.
また、 正常人の脳波を測定し、 各波形毎に電位による正常人の脳 波の折れ線グラフを作成し、 これに基ずき精神科領域の臨床脳波検 査を行い、 被測定者の脳波が正常人の脳波パターンから、 どの位ず れているかを比較し、 病的な人の治療は勿論のこ と、 一般人の脳の 機能の働きの検査及びその他の領域に応用するこ とができる。 図面の簡単な説明  In addition, the EEG of a normal person is measured, and a line graph of the EEG of a normal person is created for each waveform based on the potential, based on which a clinical EEG test in the psychiatric field is performed. By comparing the EEG patterns of normal people, the degree of deviation can be compared, and it can be applied not only to treatment of pathological people, but also to examination of the functioning of the brain function of ordinary people and other areas. BRIEF DESCRIPTION OF THE FIGURES
第 1 図は本発明の脳波および心電図の記録装置の一例を示すプロ ッ ク図である。 第 2図は脳波と心電波形の原波形を表示したグラフの一例を示す 図である。 FIG. 1 is a block diagram showing an example of an electroencephalogram and electrocardiogram recording apparatus according to the present invention. FIG. 2 is a diagram showing an example of a graph displaying original waveforms of an electroencephalogram and an electrocardiographic waveform.
第 3図は被験者の <5波帯域の 1 回の測定データを、 正常人グラフ と比較した図である。  Fig. 3 compares the measured data of one subject in the <5 wave band with the graph of normal subjects.
第 4図は被験者の 0波帯域の 1 回の測定データを、 正常人グラフ と比較した図である。  Fig. 4 compares one measurement data of the 0 wave band of the subject with the graph of normal person.
第 5図は被験者の Ω ι 波帯域の 1 回の測定データを 正常人グ フと比較した図である。 Fig. 5 is a diagram comparing one measurement data of the Ω- wave band of the subject with that of a normal person.
第 6図は被験者の α 2 波帯域の 1 回の測定データを 正常人グ フと比較した図である。 FIG. 6 is a diagram comparing the one measurement data of alpha 2 wave band subjects with normal human grayed off.
第 7図は被験者の ^ i 波帯域の 1 回の測定データを、 正常人グラ フと比較した図である。  Fig. 7 is a diagram comparing one measurement data of the subject's ^ i wave band with that of a normal person.
第 8図は被験者の 3 2 波帯域の 1 回の測定データを、 正常人グラ フと比較した図である。 FIG. 8 is a diagram of one measurement data, compared to normal persons graph of 3 two-wave band of the subject.
第 9図は S . Sグラフ I よ り ά波帯域 ( 1 回の測定ダ一夕) を S . S グラフ I I に表示した図である。  Fig. 9 is a diagram in which the S-S graph I I shows the lower frequency band (one measurement data) than the SS graph I.
第 1 0図は S . S グラフ I I よ り、 正常人グラフを表示し、 被験 者の 5波帯域 ( 1 回の測定ダータ) の比較をした図である。 発明を実施するための最良の形態  Fig. 10 shows a graph of a normal person from the SS graph II, comparing the 5-band (one measurement dart) of the subject. BEST MODE FOR CARRYING OUT THE INVENTION
以下、 本発明を詳細に説明する。  Hereinafter, the present invention will be described in detail.
本発明の脳波および心電図の記録装置は、 電極よ り入力された脳 波の 1 2又は 1 6 チ ャ ンネルの脳波信号および少な く と も 1 チャ ン ネルの心罨信号を増幅し、 この際脳波信号および心電信号に含まれ ている ノ ィ ズを除去して高純度の信号に修正し、 デジタルシグナル プロセ ッ サーを介してパー ソナルコ ン ピュータに送り込んで解析を 行い、 その結果から脳波と心電図波形の記録、 または脳波の記録を 自動的に行う装置である。 The electroencephalogram and electrocardiogram recording apparatus of the present invention amplifies an electroencephalographic signal of 12 or 16 channels and an electrocardiographic signal of at least one channel of an electroencephalogram input from an electrode. Included in EEG and ECG signals Removes noise and corrects it to a high-purity signal, sends it to a personal computer via a digital signal processor for analysis, and records EEG and ECG waveforms or EEG recordings based on the results. This is a device that automatically performs
第 1図は本発明の脳波および心電図の記録装置の一例を示すプロ ッ ク図である。  FIG. 1 is a block diagram showing an example of an electroencephalogram and electrocardiogram recording apparatus according to the present invention.
本装置は、 脳波用電極、 前置増幅器、 脳波信号補正手段を有する 脳波系回路 (A) と、 心電用電極、 前置増幅器、 心電信号補正手段 を有する心電系回路 (B ) とを有し、 さ らに該脳波系回路 (A) と 心電系回路 (B ) を接続するアナログスィ ッチと、 A/Dコ ンバー 夕、 デジタルシグナルプロセ ッサー (D S P) 、 イ ンター フ ェ イ ス、 コ ン ピュ ータ一本体、 C R T、 プリ ンタ ー、 光刺激装置及びデー夕 解析ソ フ ト等よ りなる。  This device consists of an electroencephalogram circuit (A) having an electroencephalogram electrode, a preamplifier, and an electroencephalogram signal correction means, and an electrocardiogram circuit (B) having an electrocardiogram electrode, a preamplifier, and an electrocardiogram signal correction means. An analog switch for connecting the electroencephalogram circuit (A) and the electrocardiogram circuit (B), an A / D converter, a digital signal processor (DSP), and an interface. It consists of an issu, a computer, a CRT, a printer, a photostimulator, and data analysis software.
同第 1図の脳波系回路 (A) について説明する。  The EEG circuit (A) in FIG. 1 will be described.
脳波用電極は頭皮の測定部位に装着して脳波信号を取り込む。 脳 波の測定において、 脳波用電極は国際式 1 0 - 2 0法に適合する 1 2 又は 1 6チ ャ ンネルの入力で単極誘導法によ り取り付ける。 また、 電極は一般に市販されている脳波測定用電極を使用するこ とができ る。  An electroencephalogram electrode is attached to a measurement site on the scalp to capture an electroencephalogram signal. In the measurement of the EEG, the EEG electrode is attached by the unipolar induction method with the input of 12 or 16 channels conforming to the international 10-20 method. In addition, commercially available electrodes for electroencephalogram measurement can be used as the electrodes.
本発明は従来の脳波計を使用しないで前記脳波用電極を用いて直 接、 脳波の測定を行う ものであり、 脳波測定において電極の装着は 単極誘導法で国際式 M 1 0 - 20法により頭皮上 1 2力所の部位 F P 1 · F P 2 ' F 7 - F 8 - C 3 - C 4 ' T 5 - T 6 - 0 1 · 02 · F Z · P Zに電極を装着し測定を行う。 さ らに、 電極と頭皮のあいだの接触抵抗 (イ ン ピーダンス) を測 定する接触抵抗測定装置、 脳波信号のひずみを除く 2個の緩衝増幅 器 (バッ フ ァアンプ) 、 頭皮上の 2点間の電位を記録するために各 チ ャ ンネルごとに 2本の導出線を選択する電極選択器、 脳波信号と して 5 0 i Vを基本と した種々の較正電圧を発生でき る較正装置等 が設けられる。 According to the present invention, the electroencephalogram is directly measured by using the electroencephalogram electrode without using the conventional electroencephalograph, and in the electroencephalogram measurement, the electrode is attached by a monopolar induction method and an international M10-20 method. FP 1 · FP 2 'F 7-F 8-C 3-C 4' T 5-T 6-0 1 · 02 · FZ · PZ In addition, a contact resistance measuring device that measures the contact resistance (impedance) between the electrode and the scalp, two buffer amplifiers (buffer amplifiers) that remove the distortion of the EEG signal, and a point between two points on the scalp An electrode selector that selects two leads for each channel in order to record the potential of each channel, a calibration device that can generate various calibration voltages based on 50 iV as brain wave signals, etc. Provided.
接触抵抗測定装置と第 1 の緩衝増幅器 (バッ フ ァア ンプ) はプロ一 ブ部を示す。  The contact resistance measurement device and the first buffer amplifier show the probe part.
上記の脳波用電極により取り込まれた脳波信号のアナ口グ信号は、 前置増幅器で増幅する。  The analog signal of the electroencephalogram signal captured by the electroencephalogram electrode is amplified by a preamplifier.
本発明において、 電極が装着される頭皮の抵抗値が高いために通 常数 V〜数 1 0 Vの極めて低い電位の脳波信号が電極よ り取り 込まれるが、 前置増幅器は前記脳波信号を調整して増幅を行う。 前置増幅器の仕様の一例を示すと、  In the present invention, since the resistance value of the scalp on which the electrode is mounted is high, an electroencephalogram signal of an extremely low potential of usually several V to several 10 V is taken in from the electrode, but the preamplifier adjusts the electroencephalogram signal. And amplify. As an example of the specifications of the preamplifier,
イ ン ピーダンス 5 メ ガ Ω Impedance 5 Mega Ω
F E T 入力  F E T input
前後増幅度 2 0倍 Front-back amplification 20 times
入力雑音 0 . 6 7 V Input noise 0.6 V
である。 It is.
本発明において、 脳波信号補正手段は、 前置増幅器によ り増幅さ れた脳波信号のひずみを除く回路であり、 例えばハムフ ィ ルター (差 動増幅器) と緩衝増幅器 (バ ッ フ ァ ア ンプ) からなる。  In the present invention, the electroencephalogram signal correction means is a circuit for removing the distortion of the electroencephalogram signal amplified by the preamplifier, for example, a hum filter (differential amplifier) and a buffer amplifier (buffer amplifier). Consists of
ハムフ ィ ルタ 一は、 商用交流雑音 (ハム) な どの同位相の雑音を 除去する。 さ らに、 緩衝増幅器 (バッ フ ァ ア ンプ) によ り 、 脳波信 号以外の雑音やひずみを除く 。 A hum filter removes in-phase noise such as commercial AC noise (hum). In addition, the EEG signal is transmitted by a buffer amplifier. Excluding noise and distortion other than signal.
尚、 光刺激装置を設け、 脳波の測定時に検者に光刺激を与え、 そ の時の脳波信号の解析を行う こ と もでき る。  It is also possible to provide a light stimulator to apply light stimulus to the examiner at the time of measuring the electroencephalogram and analyze the electroencephalogram signal at that time.
次に、 心電系回路 ( B ) について説明する。  Next, the electrocardiographic circuit (B) will be described.
心電系回路 ( B ) は、 胸部の各誘導部位に装着し心電信号のアナ ログ信号を誘導する心電用電極と、 該電極によ り取り込まれた心電 信号のアナログ信号を増幅する前置増幅器と、 該前置増幅器によ り 増幅された心電信号のひずみを除く心電信号補正手段からなる。 心電用電極は標準の 1 2誘導で 6つの肢誘導と 6つの胸部誘導に よ り取り付ける。 また、 心電用電極は一般に市販されている ものを 用いるこ とができ、 例えば心電図測定用電極を使用する こ とができ る。 心電用電極は 1 チ ャ ンネルの入力で取り付ける。  The electrocardiogram circuit (B) is attached to each lead site of the chest and guides the electrocardiographic analog signal, and amplifies the analog signal of the electrocardiographic signal captured by the electrode. It comprises a preamplifier and an electrocardiogram signal correcting means for removing distortion of the electrocardiogram signal amplified by the preamplifier. Electrocardiographic electrodes are attached by standard 12 leads with 6 limb leads and 6 chest leads. In addition, a commercially available electrode for electrocardiogram can be used. For example, an electrode for electrocardiogram measurement can be used. Electrocardiographic electrodes are attached with one channel input.
上記の心電用電極によ り取り込まれた心電信号のアナ口グ信号は、 前置増幅器で増幅する。 前置増幅器は前記心電信号を調整して増幅 を行う。 前置増幅器の仕様の一例を示と しては、 脳波の測定に使用 したものと同様のものを使用する ことができる。  The analog signal of the electrocardiographic signal captured by the electrocardiographic electrode is amplified by a preamplifier. The preamplifier adjusts and amplifies the electrocardiographic signal. As an example of the specifications of the preamplifier, those similar to those used for the measurement of the electroencephalogram can be used.
本発明において、 心電信号補正手段は、 前置増幅器によ り増幅さ れた心電信号のひずみを除く回路であり、 例えばハムフ ィ ルター (差 動増幅器) と緩衝増幅器 (バ ッ フ ァア ンプ) からなる。  In the present invention, the electrocardiogram signal correction means is a circuit for removing distortion of the electrocardiogram signal amplified by the preamplifier, and includes, for example, a hum filter (differential amplifier) and a buffer amplifier (buffer amplifier). ).
ハムフ ィ ルタ一は、 商用交流雑音 (ハム) などの同位相の雑音を 除去する。 さ らに、 緩衝増幅器 (バ ッ フ ァ ア ンプ) によ り、 心電信 号以外の雑音やひずみを除く 。 これらは脳波の測定と同様のものを 使用するこ とができ る。  The hum filter removes in-phase noise such as commercial AC noise (hum). In addition, noise and distortion other than ECG signals are eliminated by a buffer amplifier. These can be the same as those used for EEG measurement.
上記の脳波系回路 (A ) と心電系回路 ( B ) は、 アナログスイ ツ チと接続する。 The EEG circuit (A) and the ECG circuit (B) are analog switches Connect with the switch.
アナログスィ ツチは脳波信号の 1 2 チ ャ ンネルの入力と心電信号 の 1 チャ ンネルの入力を 1 つのチャ ンネル毎の入力に切り換えて電 極からアナログ信号を取り込む装置である。  An analog switch is a device that takes in analog signals from the electrodes by switching the input of 12 channels of EEG signals and the input of 1 channel of electrocardiographic signals to the input of each channel.
アナログスィ ッ チは、 脳波信号と心電信号のアナ口グ信号を同時 に取り込むか、 または脳波信号あるいは心電信号のいずれかのァナ ログ信号を取り込む様に設定する こ とができ る。  The analog switch can be configured to capture the EEG and ECG analog signals simultaneously, or to capture either the EEG or ECG analog signal.
プログラマルアンプ ( P G A ) は脳波信号と心電信号のアナログ 信号のバラツキを補正する。  The programmable amplifier (PGA) corrects for variations in the analog signals of the electroencephalogram signal and the electrocardiogram signal.
次に、 A / D コ ン ノ 一夕により、 アナログスィ ッ チから入力され た脳波信号と心電信号のアナ口グ信号をデジタル信号に変換する。 前記 A Z Dコ ンバータはフ ォ ト カブラを介しデジタルシグナルプ 口セッサ一 (D S P ) と接続される。 デジタルシグナルプロセッサー は、 A Z Dコンバータからのデジタル信号を取り込み、 イ ンタ一フ エイ スをコ ン ト ローノレ してノ、0— ソナルコ ン ピュー タへデー タを送り 込む。 Next, the A / D converter converts the electroencephalogram signal and the electrocardiographic analog signal input from the analog switch into digital signals. The AZD converter is connected to a digital signal processor (DSP) via a photocoupler. The digital signal processor captures the digital signal from the AZD converter, controls the interface, and sends the data to the 0 -sonal computer.
ィ ンターフ —スはパー ソナルコ ン ピュータを接続する接続器で める  The interface is connected to a personal computer.
本発明において、 ノ、。 一ソナルコ ン ピュータは、 デジタルシグナル プロセッサ一と接続され、 デジタルシグナルプロセッサーより送り 込まれた測定データの演算を行ない、 脳波と心電図波形を同時に表 示するこ とができ、 またその取り込まれた脳波の測定データの演算 を行い、 脳波を縦軸が電位、 横軸が各電極部位の折れ線グラフに表 示する。 —ソナルコ ン ピュータはコ ン ピュ ータ本体部、 カ ラーディ スプ レイ、 キーボー ド、 1 0 M B固定ディ スク装置及びプリ ンタ 一等よ りなる。 In the present invention, no. One sonal computer is connected to a digital signal processor, can calculate the measurement data sent from the digital signal processor, can simultaneously display the EEG and ECG waveforms, and The measured data is calculated, and the EEG is displayed on the vertical axis as the potential and the horizontal axis on the line graph of each electrode site. —The Sonal computer consists of a computer main unit, color display, keyboard, 10 MB fixed disk device, printer, etc.
本発明に用いられるパー ソナルコ ン ピュータは特に制限すること はな く市販されている ものを用いるこ とができるが、 その具体例を 示すと、 OAパーソナルコンピュータ C一 7000 D, メモリ 25 6 KB 3 8 4 K Bが挙げられる。  The personal computer used in the present invention is not particularly limited and may be a commercially available personal computer. Specific examples thereof include an OA personal computer C-7000D, a memory 256 KB 3 8 4 KB.
次に、 本発明に用いられるパー ソナルコ ン ビ 夕の仕様を示す と下記のとおりである。  Next, the specifications of the personal computer used in the present invention are as follows.
〇コ ン ピュ ータ本体部  本体 Computer body
メ モ リ容量 R OM 8 Kバイ ト  Memory capacity ROM 8 Kbytes
R AM 3 8 4 Kバイ ト  R AM 3 8 4 K bytes
カ ラー C R T出力 6 4 0 X 4 8 0 ド ッ ト 0レ ッ ト機能 同 時 8色表示 Color CRT output 6 4 0 X 4 8 0 Dots 0 LESSON door function the same time 8-color display
プリ ンタ 一出力 2 4 x 2 4 ド ッ ト 1 2 0 C P S  Printer 1 output 2 4 x 24 4 dot 1 2 0 C P S
カ レ ンダーク ロ ッ ク 内臓  Calendar lock internal organs
電 源 A C 1 0 0 V ± 1 0 %  Power supply AC 100 V ± 10%
消費電力 0. 9 K V A  Power consumption 0.9 K V A
重 量 2 3 K g  Weight 23 kg
大 き さ : 4 8 0 (W) x 4 4 5 (D ) x 1 6 5 (H) m m  Size: 4800 (W) x 445 (D) x 165 (H) mm
〇カ ラーディ スプレイ部  〇Carardy spray part
ブラ ウ ン管 : 1 2イ ンチ  Brown tube: 1 2 inch
表 示 色 : 三原色、 8色、 中間色を含め 8 3色 画面構成 グラ フ ィ ッ ク画面 X 9 +文字面面 電 源 A C 1 0 0 V ± 1 0 % Display colors: 83 colors including 3 primary colors, 8 colors, and intermediate colors Screen configuration Graphic screen X 9 + text surface power supply AC 100 V ± 10%
消費鬈カ 9 0 V A以下  Power consumption 90 V A or less
重 量 1 2 K g  Weight 12 kg
大 き さ 3 2 0 (H) x 4 1 5 (D) x 3 4 7 (W) チル ト台付  Size 3 2 0 (H) x 4 15 (D) x 3 4 7 (W) With tilt stand
表示文字数 8 0字 x 2 4行 x 9画面  Display characters 80 characters x 2 4 lines x 9 screens
〇キーボー ド 〇 Keyboard
キー配列 標準 J I S (テ ンキー付)  Key layout Standard JIS (with numeric keypad)
出力データ J I S 8 ビ ッ ト コー ド (パラ レル) 重 量 2. 3 K g  Output data JIS 8-bit code (parallel) Weight 2.3 Kg
〇 1 0 M B固定ディ ス ク装置  〇 10 MB fixed disk device
記憶容量 1 0メ ガバイ 卜  Storage capacity 10 megabytes
データ容量 1 0 0 0人  Data capacity 1 0 0 0
〇プ リ ンタ ー 〇 Printer
印字速度 : 8 0字ノ秒  Printing speed: 80 characters
印字方式 : ドッ ト マ ト リ ク スイ ンパク ト両方向印字 印 字 数 : 8 0字ノ行, 6 6行 ペー ジ  Printing method: Dot matrix impact bi-directional printing Number of prints: 80 lines, 66 lines
電 源 : A C 1 0 0 V ± 1 0 %  Power supply: AC 100 V ± 10%
消費電力 : 1 2 0 V A  Power consumption: 120 V A
重 量 : 1 6 K g  Weight: 16 kg
大 き さ : 5 7 0 CW) X 4 5 5 ( D ) x 1 7 5 (H) 次に、 本発明の脳波および心電図の記録装置を用いて脳波および 1:、電図波形を記録する方法について説明する。 先ず、 頭皮の各誘導部位に装着した脳波用電極より入力された 1 2 チヤ ンネルの脳波信号を第 1 図に示す前置増幅器および脳波信号補 正手段等の脳波系回路 (A) を介してパー ソナルコ ン ピュ ータ に取 り込む。 Size: 570 CW) X 455 (D) x 175 (H) Next, a method for recording an electroencephalogram and an electrogram waveform using the electroencephalogram and electrocardiogram recording apparatus of the present invention. Will be described. First, the EEG signals of the 12 channels input from the EEG electrodes attached to the respective lead sites on the scalp are transmitted through the EEG circuit (A) such as the preamplifier and EEG signal correction means shown in Fig. 1. Import to a personal computer.
測定条件は、 1回の取込み時間 5秒間固定 ( 4. 8 8 m s e c x 1 0 2 4 ) 、 取込回数範囲 1回〜 1 0 0回に設定する。  The measurement conditions are fixed for one capture time of 5 seconds (4.88 msec x 1024), and the number of capture times is set to 1 to 100 times.
次に、 取込回数を設定し、 脳波用電極から前置増幅器および脳波 系回路 (A ) を介してパー ソナルコ ン ピュ ータ C一 7 0 0 0 Dの主 メ モ リ 一に測定デー タを リ アルタ イ ムに格納する。  Next, the number of acquisitions was set, and the measured data was transferred from the EEG electrode to the main memory of the personal computer C-700D via the preamplifier and the EEG circuit (A). Is stored in real time.
チ ャ ンネル数 1 2チ ャ ンネル  Number of channels 1 2 channels
サ ンプリ ングク ロ ッ ク 4. 8 m s  Sampling clock 4.8 ms
サ ンプリ ング数 1 0 2 4 ポイ ン トノチ ャ ンネル  Number of samples 1 0 2 4 Point notch channel
一方、 胸部の各誘導部位に装着した心電用電極よ り入力された 1 チャ ンネルの心電信号を第 1図に示す前置増幅器および心電信号捕 正手段等の心電系回路 ( B ) を介してパー ソナルコ ン ピュ ー タ に取 り込む。  On the other hand, an electrocardiographic circuit (B) such as a preamplifier and electrocardiogram signal detection means shown in Fig. ) To the personal computer.
測定条件は、 1回の取込み時間 5秒間固定 (4. 88m s X 1 024) , 取込回数範囲 1回〜 6回に設定する。  The measurement conditions are set so that the time for each acquisition is fixed at 5 seconds (4.88 s x 1 024), and the number of acquisitions is 1 to 6 times.
次に、 取込回数を設定し、 電極からイ ンタ ー フ ヱ ース装置を介し てパー ソナルコ ン ピュータ C— 7 0 0 0 Dの主メ モ リ ーに測定デー タを リ アルタイ ムに格納する。  Next, set the number of acquisitions and store the measurement data in real time from the electrode to the main memory of the personal computer C-700D via the interface device. I do.
チ ャ ンネル数 : 1 2チ ャ ンネル  Number of channels: 1 2 channels
サンプリ ングク ロ ッ ク : 4. 8 m s  Sampling clock: 4.8 ms
サンプリ ング数 : 1 0 2 4ポイ ン ト /チ ャ ンネル この場合、 アナログスィ ツチは、 脳波信号と心電信号の両方を測 定できるように設定してお く 。 1 2 チ ャ ンネルの脳波および 1 チヤ ンネルの心電波形が画面に リ アルタイムに表示される。 Number of samplings: 102 4 points / channel In this case, the analog switch is set so that both the electroencephalogram signal and the electroencephalogram signal can be measured. The EEG of one channel and the ECG of one channel are displayed on the screen in real time.
一方、 主メモ リ ーに格納された脳波の時系列データを高速フーリ ュ変換法 (F F T ) により複素フーリ ヱ級数に変換し、 脳波のパワー スぺク トルを演算する。  On the other hand, the EEG time series data stored in the main memory is converted into a complex Fourier series by the fast Fourier transform method (FFT), and the power spectrum of the EEG is calculated.
F F T演算精度 3 2 ビッ ト  F F T operation precision 32 2-bit
周波数分解能 0 · 5 H z  Frequency resolution 05 Hz
周波数帯域 0 〜 8 0 H z  Frequency band 0 to 80 Hz
演算の結果求められたパワースぺク トルを固定ディ スク に記憶す る。 サンプリ ングしたデータを 5秒毎にパワースぺク トル演算し、 結果を記憶する作業を設定回数分繰り返し行う。  The power spectrum obtained as a result of the calculation is stored on the fixed disk. The power spectrum calculation is performed on the sampled data every 5 seconds, and the work of storing the result is repeated for the set number of times.
設定された回数分のパワ ースぺク トルが記憶される と、 回数で等 分した平均パワースぺク トルを 1 2 チ ャ ンネル同時に一画面にグラ フ表示する。  When the set number of power vectors is stored, the average power spectrum equally divided by the number of times is displayed on a single screen simultaneously on one or two channels.
パワースぺク トルをチ ャ ンネル別、 周波帯別に固定ディ ス ク の測 定値マスタ ーフ ァイ ルに書き込み、 この測定値マスター フ ァイ ルを 読み込んで電位分布図及び縦軸が電位 0 〜 5 0 V、 横軸が各電極 部位 1 〜 1 2 チ ヤ ンネルの脳波の折れ線グラ フの脳波グラ フである The power spectrum is written for each channel and each frequency band in the fixed disk measurement value master file, and the measured value master file is read. 50 V, the horizontal axis is the electroencephalogram of the line graph of the electroencephalogram of each electrode site 1 to 12 channel
S . S グラ フ I I I を作成する。 Create the S.S graph I I I.
周波帯区分  Band classification
δ 波 2 . 0 〜 3 . 8 H z  δ wave 2.0 to 3.8 Hz
Θ 波 4 . 0 〜 7 . 8 H z  Wave 4.0 to 7.8 Hz
a 波 8 . 0 〜 9 . 8 H z a 波 1 0 . 0 〜 : I 2 . 8 H z a wave 8.0 to 9.8 Hz a wave 10.0-: I 2.8 Hz
β 波 1 3 . 0 〜 : I 9 . 8 H z  β wave 13.0-: I9.8 Hz
2 0 . 0 〜 2 9 . 8 H z  20.0 to 29.8 Hz
 Waves
電位分布図及び S S グラ フ I, I I はメ ニュ ー画面よ り N o . を指定する事により 測定値マスター フ ァ イ ルを読み込んで C R T 画面にカラー表示し プリ ンターにハー ドコ ピー して印字する処理 を行う。  By specifying No. from the menu screen, the measured value master file is read, the potential distribution map and SS graphs I and II are read out, displayed in color on the CRT screen, and hard-copyed to the printer for printing. Perform the following processing.
この様に して脳波を縦軸が電位、 横軸が各電極部位の折れ線グラ フに表示した脳波グラ フに記録するこ とができ る。  In this way, the brain waves can be recorded on an electroencephalogram in which the vertical axis is the potential and the horizontal axis is the line graph of each electrode site.
尚、 光刺激装置を設け、 脳波の測定時に検者に光刺激を与え、 そ の時の脳波信号の解析を行う こ と もでき る。  It is also possible to provide a light stimulator to apply light stimulus to the examiner at the time of measuring the electroencephalogram and analyze the electroencephalogram signal at that time.
また、 本発明においては、 脳波および心電図波形に加えて呼吸波 形も同時に表示する こ とができ る。 具体的には、 胸部に装着された 心電用電極の動きから胸郭の動きを捉えて胸郭呼吸による呼吸波形 を表示する方法、 または鼻孔に C 02ガス測定用セ ンサーを装着して 呼吸により出入する息に含有される C 02ガス澳度の変化を呼吸波形 と して表示する方法が挙げられる。 この呼吸波形は、 第 2図に示す 脳波および心電図波形と共に、 山と谷の連続波形と して同図に同時 に表示する こ とができ る。 Further, in the present invention, a respiratory waveform can be simultaneously displayed in addition to an electroencephalogram and an electrocardiogram waveform. Specifically, the method from the movement of electrocardiographic electrodes which are attached to the chest captures the movement of the rib cage to display the respiratory waveform by thoracic breathing or by breathing wearing the C 0 2 gas measurement sensors in the nostrils, the change in C 0 2 gas澳度contained in breath and out and a method of displaying a respiratory waveform. This respiratory waveform can be displayed simultaneously with the electroencephalogram waveform shown in FIG. 2 as a continuous waveform of peaks and valleys together with the electroencephalogram waveform shown in FIG.
[実施例]  [Example]
次に、 実施例を示し、 本発明をさ らに具体的に説明する。  Next, examples are shown, and the present invention will be described more specifically.
実施例 1  Example 1
第 1 図に示す脳波および心電図の記録装置を用いて記録を行なつ た。 市販の脳波計用罨極を用いて順次に、 接触抵抗測定装置、 第 1 の 緩衝増幅器 (バッ フ ァ ア ンプ) 、 第 2の緩衝増幅器 (バ ッ フ ァ ア ン プ) 、 電極選択器、 較正装置、 前置増幅器、 ハムフ ィ ルタ ー (差動 増幅器) 、 緩衝増幅器 (バ ッ フ ァ ア ンプ) を接続してなる脳波系回 路 (A) と、 Recording was performed using the electroencephalogram and electrocardiogram recorder shown in Fig. 1. The contact resistance measurement device, the first buffer amplifier (buffer amplifier), the second buffer amplifier (buffer amplifier), the electrode selector, An electroencephalogram circuit (A) consisting of a calibration device, a preamplifier, a hum filter (differential amplifier), and a buffer amplifier (buffer amplifier).
市販の心電計用電極を用いて順次に、 較正装置、 前置増幅器、 ハ ムフ ィ ルタ ー (差動増幅器) 、 緩衝増幅器 (バ ッ フ ァ ア ンプ) を接 続してなる心電系回路 ( B ) と、  An electrocardiogram system that connects a calibration device, a preamplifier, a Ham filter (differential amplifier), and a buffer amplifier (buffer amplifier) in sequence using commercially available electrodes for electrocardiographs. Circuit (B),
前記脳波系回路 (A) と心電系回路 ( B ) を接続するアナログス イ ッ チと、 プロ グラマルア ンプ ( P G A) 、 A/Dコ ンバータ、 フ オ ト 力プラ、 デジタルシグナルプロセ ッ サー、 イ ンタ ー フ ェ イ ス、 さ らにパー ソナルコ ン ピュ ータ (松下電器産業株式会社製、 ナ シ ョ ナル、 ノぐナフ ァ コム C一 7 0 0 0 D) とからなる装置を用いて、 表 1 に示す処理手順によ り脳波の記録を行なつた。 An analog switch for connecting the electroencephalogram circuit (A) and the electrocardiogram circuit (B), a program amplifier (PGA), an A / D converter, a photocoupler, a digital signal processor, An interface and a personal computer (Matsushita Electric Industrial Co., Ltd., National, Nogu Nafacom C-700D) are used. The EEG was recorded by the processing procedure shown in Table 1.
N o . 似 安 No
1 被験者の登録 1 Subject registration
2 被験者のデータ表示  2 Subject data display
3 原波形表示 演算開始  3 Original waveform display Start calculation
4 スぺ ク トノレ グラ フ の表示  4 Display of the stick tone graph
5 6 周波帯域同時表示 ( S . S グラ フ I ) 5 6 Frequency band simultaneous display (SS graph I)
6 任意の周波帯域表示 ( S . S グ ラ フ I I )6 Arbitrary frequency band display (SS graph I I)
7 周波帯域別電位一覧表 7 List of potentials by frequency band
8 S . S グラ フ I I I  8 S. S Graph I I I I
9 被験者一 Ϊ 表印刷  9 Subjects Ϊ Table printing
1 0 正常人グラ フー鷺表  1 0 Normal person graph
1 1 被験者の登録削除  1 1 Deletion of subject registration
1 2 日付 · 時間の設定  1 2 Date and time setting
1 3 プ リ ン タ の選択  1 3 Printer Selection
1 4 シ ス テ ム の終了  1 4 End of system
[処理手順] [Processing procedure]
1 . 被験者の登録  1. Registration of subjects
メニュー画面より メニュー N 0 . 1 を選択すると、 下記の事項が 画面に表示される。  When menu N 0.1 is selected from the menu screen, the following items are displayed on the screen.
被験者の番号、 名前、 誕生日、 F · M (性別) 、 L Pが表示され、 それらを入力して登録する。 データの容量は 5 0 0名分で、 1験者 について 4回分の測定データを記録するこ とができ る。 The subject's number, name, date of birth, F · M (gender), and LP are displayed, and they are entered and registered. The data capacity is for 500 people, and one examiner Can record measurement data for four times.
2 . 被験者のデータ表示  2. Display of subject data
メ ニュー画面よりメニュー N 0 . 2を選択する と、 被験者の番号、 名前、 年令、 月 日、 時間、 1 , 2, 3 , 4、 N O T E、 周波数帯域 名、 及び周波数帯域が表示される。  When menu N 0.2 is selected from the menu screen, the subject's number, name, age, month, day, time, 1, 2, 3, 4, NOTE, frequency band name, and frequency band are displayed.
3 . 原波形表示 演算開始  3. Original waveform display Start calculation
メ ニュ ー画面よ り メ ニュ ー N o . 3を選択する。  Select Menu No. 3 from the menu screen.
電極からデータが自動的に収集され、 被験者の番号、 名前が表示 され、 カ ウ ン ト数、 各部位 ( 1 2 チ ャ ンネル + 1 チ ャ ン ネル) の原 波形 (最初の 1 カ ウ ン 卜 : 5秒間) がリアレゥタイ ムで表示される。 第 2図に原波形を表示したグラフの一例を示す。 第 2図において、 F P 1 , F P 2 , F 7 , F 8 , C 3 , C 4 , T 5 , T 6 , 0 1, 0 2, F Z , P Zは脳波を示し、 H 1 は心電図波形を示す。  Data is automatically collected from the electrodes, the subject's number and name are displayed, the number of counts, and the original waveform (the first one channel) of each part (12 channels + 1 channel). (For 5 seconds) is displayed in real time. Fig. 2 shows an example of a graph displaying the original waveform. In FIG. 2, FP 1, FP 2, F 7, F 8, C 3, C 4, T 5, T 6, 01, 02, FZ, PZ indicate electroencephalogram, and H 1 indicates electrocardiogram waveform .
取込回数はカ ウ ン ト数を指定して収集される。  The number of acquisitions is collected by specifying the number of counts.
次に、 演算開始及び計算中の表示が行われる。 演算は全チ ャ ンネ ルの信号を 5秒間取り込んだ後パワ ー スぺク ト ルを計算し、 前に求 めたパワ ースぺク ト ルに加算する という こ とを繰り返し行う。 5秒 間 1 カ ウ ン 卜 と し 1 0 0 カ ウ ン 卜 まで演算でき任意のカ ウ ン ト数を 指定できる。 取込み開始時間は自動表示、 及び取り込み終了時間は 自動表示で行う。  Next, the start of calculation and the display during calculation are performed. In the calculation, after taking the signals of all the channels for 5 seconds, the power spectrum is calculated and added to the power spectrum obtained previously. One count for 5 seconds can be calculated up to 100 counts, and any count can be specified. The capture start time is displayed automatically, and the capture end time is displayed automatically.
4 . スぺク 卜 ノレグラ フ の表示  4. Display of noct graphs
メ ニュ ー画面よ り メ ニュ ー N 0 . 4 を選択する とパワースぺク ト ルグラフの画面が表示される。 脳波の 1 2 チ ャ ンネルのパワースぺ ク トルの結果が表示される。 縦軸に罨位、 横軸に周波数 0 ~ 7 5 H z、 1 目盛 5 H z の表示がなされる。 演算、 カ ウ ン ト数が表示される。 Select menu N0.4 from the menu screen to display the power spectrum graph screen. The result of the power spectrum of the EEG 12 channel is displayed. The vertical axis is compress, the horizontal axis is frequency 0 to 75 Hz, A scale of 5 Hz is displayed. The calculation and count are displayed.
5 . 6周波帯域同時表示  5.5 Simultaneous display of 6 frequency bands
メニュー画面より メニュー N o . 5を選択すると被験者の 6周波 帯域の画面が同時に表示される。 前記の演算によ り得られた各チヤ ンネルの平均電位を縦軸が電位、 横軸が各電極部位の折れ線グラフ で表示される。 周波数別に電位分布図の表示をする。 この場合、 パ ワースぺク トルの電位の大き さを 6段階に分け各電位を柄別に、 又 各周波帯域(5、 Θ、 a { ^ α . β χ ^ β を色別で比較表示する。 デルタ帯域 (青) : 周波数 2 . 0 〜 3 . 8 Η ζ When menu No. 5 is selected from the menu screen, the screen of the subject's 6 frequency bands is displayed at the same time. The average potential of each channel obtained by the above calculation is displayed on a vertical axis as a potential, and the horizontal axis is displayed as a line graph of each electrode portion. A potential distribution chart is displayed for each frequency. In this case, the magnitude of the potential of the power vector is divided into six levels, and each potential is compared and displayed by pattern, and each frequency band (5, Θ, a { ^ α.βχ ^ β) is compared and displayed by color. Delta band (blue): Frequency 2.0 to 3.8Η
シータ帯域 (紫) : 周波数 4 . 0〜 7 . 8 Η ζ  Theta band (purple): Frequency 4.0 to 7.8 Η
アルフ ァ帯域 (赤) : 周波数 8 . 0 〜 1 2 . 8 Η ζ  Alpha band (red): Frequency 8.0 to 12.8
ベータ帯域 (緑) : 周波数 1 3 . 0 〜 2 9 . 8 Η ζ  Beta band (green): Frequency 13.0 to 29.8Η
O S . S グラ フ I O S. S Graph I
メニュー画面よ り、 F · 8を選択すると正常人グラ フの表示、 非 表示が切り換えでき る。 正常人グラ フを表示したい場合は Yを、 し ない場合は Nを指定する。  On the menu screen, select F · 8 to switch between displaying and not displaying the normal person graph. Specify Y if you want to display a graph of normal people, N if not.
正常人グラ フは、 被験者の年令に応じて、 その年代別グラ フが自 動的に表示される。 正常人グラ フの表示は、  Normal graphs are automatically displayed according to the age of the subject. The display of the normal person graph is
最小値〜最大値 白の縦線  Minimum to maximum value White vertical line
平 均 値 白の太線  Average value Thick white line
で表わされる。 Is represented by
演算によ り得られた各チ ヤ ンネルの平均電位を縦軸が電位、 横軸 が各電極部位の折れ線グラフで表示する。  The average potential of each channel obtained by the calculation is displayed on the vertical axis as a potential, and the horizontal axis is displayed as a line graph of each electrode portion.
正常人グラ フを入力し 2 0代〜 6 0代の各年代のグラ フ と比較し て見るこ とができる。 (年代別グラフは検者の年令に応じ、 その年 代別グラフが表示される) Enter a normal person's graph and compare it to the graphs of each age in the 20s to 60s. You can see it. (The graph according to the age is displayed according to the age of the examiner, and the graph according to the age is displayed.)
周波帯域例(5、 θ、 a j , 2 , ^ j , β 2 の 6周波帯域が同時 表示される。 Frequency band Example (5, θ, aj, 2 , ^ j, 6 -frequency band of beta 2 are displayed simultaneously.
1 回目赤、 2回目黄、 3回目綠、 4回目青の 4回分の測定結果の 表示ができ、 比較検討する こ とができ る。 また、 S . S グラフ I に 正常人グラ フが表示され被験者のデータを比較検討する こ とができ る  Four measurement results can be displayed: red for the first time, yellow for the second time, yellow for the third time, and blue for the fourth time for comparison. In addition, a normal person graph is displayed on the SS graph I so that the data of the subjects can be compared and examined.
第 3図〜第 8図に被験者の δ、 θ , a ι 、 α。 、 、 β 0 の 6 周波帯域の 1 回の測定のデータを、 正常人グラ フ と比較した図を示 す。 Figures 3 to 8 show the subject's δ, θ, , α. , The data of one measurement of 6 frequency band of beta 0, shows the diagram compared to normal individuals graph.
6 . 任意の周波帯域表示  6. Arbitrary frequency band display
メ ニュ ー画面よ り メ ニュ ー Ν ο . 6 を選択する と被験者の 6周波 帯域の中の任意の周波帯域の画面が表示される。 各チ ャ ンネルの平 均電位を縦軸が電位、 横軸が各電極部位の折れ線グラ フで表示され る。  If you select menu .ο.6 from the menu screen, the screen of any frequency band among the 6 frequency bands of the subject will be displayed. The average potential of each channel is indicated by the vertical axis, and the horizontal axis is indicated by a line graph of each electrode portion.
〇 S . S グラ フ I I  〇 S I
メ ニュ ー画面より、 F · 8を選択する と正常人グラ フの表示、 非 表示が切り換えでき る。 正常人グラ フを表示したい場合は Υを、 し ない場合は Νを指定する。  Select F · 8 from the menu screen to switch between displaying and not displaying the normal person graph. Specify Υ if you want to display the graph of normal people, otherwise specify は.
S . S グラ フ I よ り 5、 Θ α χ . a n , β 1 , 2 の各々 1 つ の任意の周波帯域を選択して表示するこ とができる。 S. S graph I I Ri 5, Θ α χ. A n , β 1, 2 of each one of any possible and the view by selecting a frequency band.
S . S グラ フ I I よ り、 正常人グラ フを表示し、 被験者の 6周波 帯域の各々を個々に比較をするこ とができる。 第 9図に、 S . Sグラフ I よ り <5波帯域 ( 1回の測定ダータ) を S . Sグラフ I I に表示した図を示す。 The S.S graph II shows a graph of a normal person and allows individual comparison of each of the six frequency bands of the subject. Fig. 9 shows the SS graph II showing the <5 wavebands (one measurement datum) from the SS graph I.
また、 第 1 0図に、 S . Sグラフ I I よ り、 正常人グラフを表示 し、 被験者の 5波帯域 ( 1回の測定グータ) の比較をした図を示す。  Also, Fig. 10 shows a graph of a normal person from the SS graph II, and a comparison of the subject's five-wave band (one measurement gutter).
7. 周波帯域別電位一覧表  7. List of potentials by frequency band
メニュー画面より メニュー N o . 7を選択する と周波帯別に 1 2 チ ヤ ンネルの測定データ値の画面が表示される。 被験者の 4回分の 電位一覧表を表示する。  When menu No. 7 is selected from the menu screen, a screen of the measured data values of the 12 channels is displayed for each frequency band. Display a list of potentials for the four subjects.
表 2に被験者の 1 回分の電位一覧表を示す。 Table 2 shows a list of potentials for one test subject.
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メニュー画面よ り メニュー N o . 8 を選択する と縦軸が電位、 横 軸が時間の画面が表示される。  When menu No. 8 is selected from the menu screen, the vertical axis shows the potential and the horizontal axis shows the time.
生体電位の時間的経過を測定し機能を観察する こ とができる。 9 . 被験者一覧表印刷  The function can be observed by measuring the time course of bioelectric potential. 9. Subject list printing
メニュー画面より メニュー N o . 9を選択する。  Select Menu No. 9 from the menu screen.
リ ターンキーを押すと、 被験者の一覧表が印刷される。  Pressing the return key prints a list of subjects.
1 0 . 正常人グラフー寛表  1 0. Normal person graph
メニュー画面よ り メ ニュ ー N o . 1 0を選択する と正常人の画面 が表示される。  Select Menu No. 10 from the menu screen to display the screen of a normal person.
周波数を指定し、 1 2チャ ンネル毎の平均値、 最大値、 最小値の 登録をする。  Specify the frequency and register the average, maximum, and minimum values for each of the 12 channels.
1 1 . 被験者の登録削除  1 1. Deletion of subjects
メ ニュ ー画面より メニュー N o . 1 1 を選択する と画面が表示さ れる。 N o · を選択し被験者の名前 · 生年月日 · 性別を登録 . 修正、 または削除を行う。  Select menu No. 11 from the menu screen to display the screen. Select No and register the subject's name, date of birth, and gender. Modify or delete.
以上の様に、 本発明の脳波および心電図の記録装置は、 3 . 原波 形表示において、 脳波 ( 1 2 チ ャ ンネル) の原波形と、 心電図波形 ( 1 チ ャ ンネル) の原波形を同時に表示する こ とができ、 この画面 を継続して観察する こ と によ り 、 脳の機能と心臓の機能を同時に捉 えるこ とができ る。  As described above, the apparatus for recording an electroencephalogram and an electrocardiogram according to the present invention can simultaneously display the original waveform of the electroencephalogram (12 channels) and the original waveform of the electrocardiogram waveform (1 channel) in the original waveform display. It can be displayed, and by continuously observing this screen, it is possible to simultaneously grasp the functions of the brain and the heart.
したがって、 脳と心臓の機能を把握して両者の関係をと らえなが ら治療を行なう こ とができ ると共に、 生命の終焉において、 脳の機 能と心臓の機能の停止の状態を把握するこ とができる。 産業上の利用可能性 Therefore, it is possible to perform treatment while grasping the relationship between the brain and the heart and grasping the relationship between the two, and at the end of life, grasping the state of cessation of the function of the brain and the function of the heart at the end of life be able to. Industrial applicability
以上説明した様に、 本発明の脳波および心電図の記録装置は、 パー ソナルコ ンピュータの C R Tに鲜明に脳波と心電図波形を同時に表 示し、 脳の機能と心臓の機能を同時に捉えるこ とができ、 脳と心臓 の機能を把握して両者の関係をと らえながら治療を行なう こ とがで きると共に、 生命の終焉において、 脳の機能と心臓の機能の停止の 状態を把握することができ る。  As described above, the electroencephalogram and electrocardiogram recording device of the present invention can clearly display electroencephalogram and electrocardiogram waveforms simultaneously on a CRT of a personal computer, and can simultaneously capture brain function and heart function. It is possible to perform treatment while grasping the relationship between the two and grasping the functions of the heart and the heart, and at the end of life, the state of the cessation of the function of the brain and the function of the heart.
また、 電極から得られた脳波信号を直接に縦軸が電位、 横軸が各 電極部位の折れ線グラフに画面表示するこ とができ るコ ンパク トな 装置で、 脳波を定量的、 直観的に、 正確に測定でき、 脳機能の働き の検査に応用するこ とができ る。  In addition, the EEG signal obtained from the electrodes can be directly displayed on the vertical axis as potential and the horizontal axis as a line graph of each electrode part on a compact device. It can be measured accurately and can be applied to the examination of the function of brain function.

Claims

請 求 の 範 囲 The scope of the claims
1 . 頭皮の各誘導部位に装着し脳波信号のアナ口グ信号を誘導する 脳波用電極と、 該脳波用電極によ り取り込まれた脳波信号のアナ口 グ信号を増幅する前置増幅器と、 該前置増幅器によ り増幅された脳 波信号のひずみを除く脳波信号補正手段を有する脳波系回路 (A ) と、 1. An electroencephalogram electrode that is attached to each induction site of the scalp to induce an analog signal of an electroencephalogram signal, a preamplifier that amplifies the analog signal of the electroencephalogram signal captured by the electroencephalogram signal, An electroencephalogram-based circuit (A) having electroencephalogram signal correction means for removing distortion of the electroencephalogram signal amplified by the preamplifier;
胸部の各誘導部位に装着し心電信号のアナ口グ信号を誘導する心 電用電極と、 該心電用電極によ り取り込まれた心電信号のアナログ 信号を増幅する前置増幅器と、 該前置増幅器によ り増幅された心電 信号のひずみを除く心電信号補正手段を有する心電系回路 ( B ) と を有し、 さ らに該脳波系回路 (A ) と心電系回路 ( B ) を接続する アナログスィ ツチと、 該アナログスィ ツチから入力されたアナログ 信号をデジ タ ル信号に変換する A Z D コ ンバータ と、 該 A / D コ ン バー夕からのデジタル信号を取り込み、 ィ ンターフェイ スをコ ン ト ロールしてパーソナルコ ンピュータへデータを送り込むデジタル シグナルプロセッサーと、 該デジ夕ノレシグナルプロセッサーからの デジ タ ル信号のデータを取り込み脳波と心電図波形を同時に表示す ると共に、 取り込まれた脳波の測定データの演算を行い、 脳波を縦 軸が電位、 横軸が各電極部位の折れ線グラフ に表示するパー ソ ナル コンピュータを具備するこ とを特徴とする脳波および心電図の記録 装置。  An electrocardiographic electrode which is attached to each lead site of the chest to induce an analog signal of an electrocardiographic signal; a preamplifier which amplifies an analog signal of the electrocardiographic signal captured by the electrocardiographic electrode; An electrocardiographic circuit (B) having an electrocardiographic signal correction means for removing distortion of the electrocardiographic signal amplified by the preamplifier; and further comprising an electroencephalographic circuit (A) and an electrocardiographic system. An analog switch for connecting the circuit (B), an AZD converter for converting an analog signal input from the analog switch into a digital signal, and a digital signal from the A / D converter. A digital signal processor that controls the interface and sends data to the personal computer, and takes in digital signal data from the digital signal processor and captures EEG and ECG waveforms. A personal computer that displays the EEG at the same time, calculates the acquired EEG measurement data, and displays the EEG on the potential axis on the vertical axis and on the line graph of each electrode on the horizontal axis. EEG and ECG recording device.
2 . 前記脳波信号補正手段がハム フ ィ ルタ ー とバ ッ フ ァ ーア ン プか らなる請求の範囲第 1項記載の脳波および心電図の記録装置。 2. Whether the EEG signal correction means is a hum filter and a buffer amplifier 2. The apparatus for recording an electroencephalogram and an electrocardiogram according to claim 1, further comprising:
3 . 前記心電信号補正手段がハム フ ィ ルタ ー とバッ フ ァ ーア ンプか らなる請求の範囲第 1項記載の脳波および心電図の記録装蘆。  3. The apparatus for recording electroencephalogram and electrocardiogram according to claim 1, wherein said electrocardiogram signal correction means comprises a ham filter and a buffer amplifier.
4 . 前記 A Z D コ ンバータ とデジタルシ グナルプロセ ッ サーがフ ォ トカブラを介して接続されている請求の範囲第 1 項記載の脳波およ び心電図の記録装置。  4. The electroencephalogram and electrocardiogram recording apparatus according to claim 1, wherein the AZD converter and the digital signal processor are connected via a photo camera.
PCT/JP1995/001636 1994-08-23 1995-08-18 Recording apparatus for electroencephalogram and electrocardiograph WO1996005765A1 (en)

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WO2002003861A1 (en) * 2000-07-12 2002-01-17 Instrumentarium Corporation Monitoring of patient's electrical characteristics
EP1794694B1 (en) * 2004-09-24 2020-11-11 Philips Intellectual Property & Standards GmbH Method of medical monitoring

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