WO1996002553A3 - AMINO PURINE-β-D-RIBOFURANURONAMIDE DERIVATIVES - Google Patents

AMINO PURINE-β-D-RIBOFURANURONAMIDE DERIVATIVES Download PDF

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Publication number
WO1996002553A3
WO1996002553A3 PCT/EP1995/002837 EP9502837W WO9602553A3 WO 1996002553 A3 WO1996002553 A3 WO 1996002553A3 EP 9502837 W EP9502837 W EP 9502837W WO 9602553 A3 WO9602553 A3 WO 9602553A3
Authority
WO
WIPO (PCT)
Prior art keywords
6alkyl
amino purine
oxopyrrolidin
piperidin
solvates
Prior art date
Application number
PCT/EP1995/002837
Other languages
French (fr)
Other versions
WO1996002553B1 (en
WO1996002553A2 (en
Inventor
Barry Edward Di Ayres
Michael Gregson
George Blanch Ewan
Suzanne Elaine Keeling
Richard Bell
Original Assignee
Glaxo Group Ltd
Ayres Diana Sally & Hf
Michael Gregson
George Blanch Ewan
Suzanne Elaine Keeling
Richard Bell
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Ayres Diana Sally & Hf, Michael Gregson, George Blanch Ewan, Suzanne Elaine Keeling, Richard Bell filed Critical Glaxo Group Ltd
Priority to AU36982/95A priority Critical patent/AU3698295A/en
Publication of WO1996002553A2 publication Critical patent/WO1996002553A2/en
Publication of WO1996002553A3 publication Critical patent/WO1996002553A3/en
Publication of WO1996002553B1 publication Critical patent/WO1996002553B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

Amino purine-β-D-ribofuranuronamide derivatives are described having general formula (I) and salts and solvates thereof, wherein: R1 is hydrogen, C¿3-8?cycloaklyl or C1-6alkyl; A represents O, S, SO, SO2, a saturated hydrocarbon moiety having from 1 to 4 carbon atoms or an unsaturated hydrocarbon moiety having from 2 to 4 carbon atoms; R?2¿ is C¿3-8?cycloalkyl, C3-8cycloalkyl C1-6alkyl, Alk1Y, -(CHR?5)¿m (Alk2)nZ or appropriately substituted C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl or piperidin-4-yl, and Q is oxygen or sulphur with the proviso that when A represents O, S, SO or SO2, Alk1 represents a C2-6alkylene group. Compounds of formula (I) and their salts and solvates have use in medicine as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage.
PCT/EP1995/002837 1994-07-14 1995-07-14 AMINO PURINE-β-D-RIBOFURANURONAMIDE DERIVATIVES WO1996002553A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU36982/95A AU3698295A (en) 1994-07-14 1995-07-14 Amino purine-beta -d-ribofuranuronamide derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9414193.4 1994-07-14
GB9414193A GB9414193D0 (en) 1994-07-14 1994-07-14 Compounds

Publications (3)

Publication Number Publication Date
WO1996002553A2 WO1996002553A2 (en) 1996-02-01
WO1996002553A3 true WO1996002553A3 (en) 1996-03-07
WO1996002553B1 WO1996002553B1 (en) 1996-03-28

Family

ID=10758311

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/002837 WO1996002553A2 (en) 1994-07-14 1995-07-14 AMINO PURINE-β-D-RIBOFURANURONAMIDE DERIVATIVES

Country Status (5)

Country Link
AU (1) AU3698295A (en)
GB (1) GB9414193D0 (en)
IL (1) IL114578A0 (en)
WO (1) WO1996002553A2 (en)
ZA (1) ZA955784B (en)

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WO2008037477A1 (en) 2006-09-29 2008-04-03 Novartis Ag Pyrazolopyrimidines as p13k lipid kinase inhibitors
JP2010508315A (en) 2006-10-30 2010-03-18 ノバルティス アーゲー Heterocyclic compounds as anti-inflammatory agents
WO2009006089A2 (en) * 2007-06-29 2009-01-08 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services A2 adenosine receptor agonists
ES2442930T3 (en) 2008-01-11 2014-02-14 Novartis Ag Pyrimidines as kinase inhibitors
DK2391366T3 (en) 2009-01-29 2013-01-07 Novartis Ag Substituted benzimidazoles for the treatment of astrocytomas
US8389526B2 (en) 2009-08-07 2013-03-05 Novartis Ag 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
AU2010283806A1 (en) 2009-08-12 2012-03-01 Novartis Ag Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation
JP5819831B2 (en) 2009-08-17 2015-11-24 インテリカイン， エルエルシー Heterocyclic compounds and their use
KR20120089463A (en) 2009-08-20 2012-08-10 노파르티스 아게 Heterocyclic oxime compounds
US8518957B2 (en) 2009-12-02 2013-08-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methanocarba adenosine derivatives, pharmaceutical compositions, and method of reducing intraocular pressure
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Also Published As

Publication number Publication date
IL114578A0 (en) 1995-11-27
WO1996002553A2 (en) 1996-02-01
ZA955784B (en) 1996-08-15
AU3698295A (en) 1996-02-16
GB9414193D0 (en) 1994-08-31

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