WO1995035276B1 - Metalloproteinase inhibitors - Google Patents
Metalloproteinase inhibitorsInfo
- Publication number
- WO1995035276B1 WO1995035276B1 PCT/GB1995/001465 GB9501465W WO9535276B1 WO 1995035276 B1 WO1995035276 B1 WO 1995035276B1 GB 9501465 W GB9501465 W GB 9501465W WO 9535276 B1 WO9535276 B1 WO 9535276B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alk
- group
- conh
- amended
- hydrogen
- Prior art date
Links
- 239000003475 metalloproteinase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 claims 1
- 125000005741 alkyl alkenyl group Chemical group 0.000 claims 1
- 150000001370 alpha-amino acid derivatives Chemical class 0.000 claims 1
- 235000008206 alpha-amino acids Nutrition 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 125000005356 cycloalkylalkenyl group Chemical group 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 150000003568 thioethers Chemical group 0.000 claims 1
- 125000002843 carboxylic acid group Chemical group 0.000 abstract 1
- 239000003771 matrix metalloproteinase inhibitor Substances 0.000 abstract 1
- 229940121386 matrix metalloproteinase inhibitors Drugs 0.000 abstract 1
- -1 sulphonyl Chemical group 0.000 abstract 1
Abstract
Compounds of general formula (II), wherein X is a hydroxamic or carboxylic acid group, Y is sulphonyl and R1 and R2 as defined in the claims are matrix metalloproteinase inhibitors.
Claims
39
AMENDED CLAIMS
[received by the International Bureau on 11 December 1995 (11.12.95); original claim 1 amended; remaining claims unchanged (1 page)]
A compound of general formula (II)
wherein
X represents a -CONHOH group;
R1 represents:
(i) the characterising side chain of a natural or non-natural alpha amino acid, in which any functional group present may be protected;
R2 represents a group Z -Q-W- where Z1 represents hydrogen or an optionally substituted aryl, heteroaryl, non-aromatic heterocyclyl, cycloalkyl, or cycloalkenyl group, and
(i) (except when Z1 is 4-methoxyphenyl) -Q-W- taken together represent a bond or
(ii) Q represents -O- or -S- and W represents a divalent C^C^ straight or branched alkyl or C2-C20 alkenyl group which
(a) may be interrupted by one or more non-adjacent ether or thioether linkages or -N(RX)- groups wherein Rx is hydrogen, or C C6 alkyl, and/or
(b) may carry one or more substituents selected from -OH, -SH, -O(Alk), -S(Alk), halogen, -NH2, -NH(Alk), -N(Alk)2, -C02H, -C02(Alk), -CO(Alk), -CHO, -CONH2, -CONH(Alk), -CON(Alk)2, -
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9623675A GB2303850B (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
EP95922639A EP0766665B1 (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
NZ288299A NZ288299A (en) | 1994-06-22 | 1995-06-22 | Substituted (hetero)aryl-sulphonylaminomethyl-hydroxamic acid and medicaments |
US08/765,146 US6022898A (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
AU27466/95A AU690703B2 (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
DK95922639T DK0766665T3 (en) | 1994-06-22 | 1995-06-22 | metalloproteinase |
JP8501848A JPH10507158A (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
DE69511089T DE69511089T2 (en) | 1994-06-22 | 1995-06-22 | METALLOPROTEINASE INHIBITORS |
US09/243,131 US6124333A (en) | 1995-06-22 | 1999-02-03 | Metalloproteinase inhibitors |
GR990402229T GR3031143T3 (en) | 1994-06-22 | 1999-09-02 | Metalloproteinase inhibitors |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9412514.3 | 1994-06-22 | ||
GB9412514A GB9412514D0 (en) | 1994-06-22 | 1994-06-22 | Metalloproteinase inhibitors |
GB9506107.3 | 1995-03-24 | ||
GBGB9506107.3A GB9506107D0 (en) | 1995-03-24 | 1995-03-24 | Metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995035276A1 WO1995035276A1 (en) | 1995-12-28 |
WO1995035276B1 true WO1995035276B1 (en) | 1996-01-18 |
Family
ID=26305102
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1995/001464 WO1995035275A1 (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
PCT/GB1995/001465 WO1995035276A1 (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB1995/001464 WO1995035275A1 (en) | 1994-06-22 | 1995-06-22 | Metalloproteinase inhibitors |
Country Status (17)
Country | Link |
---|---|
US (4) | US5962529A (en) |
EP (2) | EP0766665B1 (en) |
JP (2) | JPH10507158A (en) |
CN (1) | CN1151157A (en) |
AT (2) | ATE182581T1 (en) |
AU (2) | AU695507B2 (en) |
CA (2) | CA2193692A1 (en) |
DE (2) | DE69511089T2 (en) |
DK (2) | DK0766665T3 (en) |
ES (2) | ES2133785T3 (en) |
FI (1) | FI965153A (en) |
GB (2) | GB2303629B (en) |
GR (2) | GR3031143T3 (en) |
NO (1) | NO965515L (en) |
NZ (2) | NZ288298A (en) |
PT (1) | PT766664E (en) |
WO (2) | WO1995035275A1 (en) |
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IL125378A0 (en) * | 1996-01-23 | 1999-03-12 | Shionogi & Co | Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same |
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-
1995
- 1995-06-22 AU AU27465/95A patent/AU695507B2/en not_active Ceased
- 1995-06-22 GB GB9623809A patent/GB2303629B/en not_active Expired - Fee Related
- 1995-06-22 JP JP8501848A patent/JPH10507158A/en not_active Withdrawn
- 1995-06-22 US US08/765,140 patent/US5962529A/en not_active Expired - Fee Related
- 1995-06-22 EP EP95922639A patent/EP0766665B1/en not_active Expired - Lifetime
- 1995-06-22 CA CA002193692A patent/CA2193692A1/en not_active Abandoned
- 1995-06-22 DK DK95922639T patent/DK0766665T3/en active
- 1995-06-22 AT AT95922639T patent/ATE182581T1/en not_active IP Right Cessation
- 1995-06-22 ES ES95922639T patent/ES2133785T3/en not_active Expired - Lifetime
- 1995-06-22 DE DE69511089T patent/DE69511089T2/en not_active Expired - Fee Related
- 1995-06-22 PT PT95922638T patent/PT766664E/en unknown
- 1995-06-22 ES ES95922638T patent/ES2145913T3/en not_active Expired - Lifetime
- 1995-06-22 JP JP8501847A patent/JPH10501806A/en active Pending
- 1995-06-22 CN CN95193714A patent/CN1151157A/en active Pending
- 1995-06-22 AU AU27466/95A patent/AU690703B2/en not_active Ceased
- 1995-06-22 WO PCT/GB1995/001464 patent/WO1995035275A1/en active IP Right Grant
- 1995-06-22 DK DK95922638T patent/DK0766664T3/en active
- 1995-06-22 CA CA002193691A patent/CA2193691A1/en not_active Abandoned
- 1995-06-22 EP EP95922638A patent/EP0766664B1/en not_active Expired - Lifetime
- 1995-06-22 US US08/765,146 patent/US6022898A/en not_active Expired - Fee Related
- 1995-06-22 WO PCT/GB1995/001465 patent/WO1995035276A1/en active IP Right Grant
- 1995-06-22 NZ NZ288298A patent/NZ288298A/en unknown
- 1995-06-22 DE DE69516143T patent/DE69516143T2/en not_active Expired - Fee Related
- 1995-06-22 AT AT95922638T patent/ATE191468T1/en not_active IP Right Cessation
- 1995-06-22 NZ NZ288299A patent/NZ288299A/en unknown
- 1995-06-22 GB GB9623675A patent/GB2303850B/en not_active Expired - Fee Related
-
1996
- 1996-12-20 NO NO965515A patent/NO965515L/en unknown
- 1996-12-20 FI FI965153A patent/FI965153A/en unknown
-
1999
- 1999-02-03 US US09/243,130 patent/US6124332A/en not_active Expired - Fee Related
- 1999-06-30 US US09/343,087 patent/US6124329A/en not_active Expired - Fee Related
- 1999-09-02 GR GR990402229T patent/GR3031143T3/en unknown
-
2000
- 2000-05-18 GR GR20000401133T patent/GR3033446T3/en not_active IP Right Cessation
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