WO1995034274A1 - Composition pour l'hygiene bucco-dentaire - Google Patents
Composition pour l'hygiene bucco-dentaire Download PDFInfo
- Publication number
- WO1995034274A1 WO1995034274A1 PCT/EP1995/002248 EP9502248W WO9534274A1 WO 1995034274 A1 WO1995034274 A1 WO 1995034274A1 EP 9502248 W EP9502248 W EP 9502248W WO 9534274 A1 WO9534274 A1 WO 9534274A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- oral hygiene
- zinc
- species
- alkali metal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
Definitions
- the present invention relates inter alia to improved oral hygiene compositions and to uses of such compositions to control dental caries and gingivitis.
- oral hygiene composition includes inter alia dentifrices, mouthwashes, mouthsprays, toothpastes, tooth gels, toothpowders, chewing gums, lozenges and denture cleansing formulations, as well as coatings for coating or impregnating dental accessories such as dental floss, toothbrush bristles and toothpicks.
- astringent and bitter components examples include antimicrobial/antipiaque agents (such as chlorhexidine and salts thereof and cetyl pyridinium chloride), desensitising agents (such as strontium ions, potassium nitrate and potassium chloride) anticalculus/anti-plaque agents (such as zinc ions) and some surfactants.
- antimicrobial/antipiaque agents such as chlorhexidine and salts thereof and cetyl pyridinium chloride
- desensitising agents such as strontium ions, potassium nitrate and potassium chloride
- anticalculus/anti-plaque agents such as zinc ions
- US-A-4416867 (Lever Brothers) describes the problem of the astringency of zinc ions in an oral hygiene composition.
- the document teaches the reduction of this astringency by addition of glycerine to the composition and adjustment of pH to between 4.5 and 8.
- EP-A-0251542 (Lion Corp) suggests the use of polyoxyethylene hydrogenated castor oil to reduce the astringency of zinc ions in an oral hygiene composition.
- EP-A-0173568 (Johnson & Johnson) discusses the astringency of zinc chloride and suggests use of surfactants such as the coconut fatty acid amide of N-methyltaurine to reduce this property in an oral hygiene composition.
- GB-A-1498537 Cold Palmolive
- GB-A-1498537 Cold Palmolive
- a toothpaste containing an abrasive system comprising a minor proportion of sodium bicarbonate and a major proportion of a water-insoluble dental abrasive material compatible with the sodium bicarbonate in the toothpaste.
- GB-A-2137494 describes a tooth powder comprising at least 50% by weight of sodium bicarbonate particles as a dental abrasive material, wherein the sodium bicarbonate particles have a median particle size within the range of 74 to 210 microns.
- GB-A-2220568 describes a dentifrice gel comprising a sodium bicarbonate abrasive (median particle size range from 10 to 200 microns) in an aqueous carrier.
- alkali metal bicarbonates may be used to improve the palatability of an oral hygiene composition comprising an unpalatable species.
- an alkali metal bicarbonate to improve the palatability of an oral hygiene composition comprising an unpalatable species, especially a bitter or astringent species.
- the alkali metal bicarbonate is sodium bicarbonate, since this has been found to give particularly good improvements in palatability.
- the unpalatable species in the oral hygiene composition is an astringent metal ion such as zinc or strontium ions, preferably zinc ions.
- Zinc ions may be included in an oral hygiene composition for various reasons.
- zinc citrate may be included as an antimicrobial agent and zinc citrate or zinc chloride may be included as anti-calculus agents.
- the unpalatable species may also be a cationic antimicrobial agent such as chlorhexidine or cetyl pyridinium chloride.
- the alkali metal bicarbonate is used in an amount of from about 0.1% to about 95% preferably from about 0.5% to about 50%, suitably from about 0.75% to about 30% by weight of the oral hygiene. composition.
- the preferred amount is about 1% by weight and in a toothpaste/dentifrice-type composition the preferred amount is from about 0.5% to about 50% by weight.
- the concentration of alkali metal bicarbonate is between about 0.5% and about 5% by weight, more suitably between about 1% and about 4% by weight, and for example about 2% by weight of the composition.
- higher levels for example from about 5% to about 60%, for example about 25%
- the bicarbonate also functions as a thickener and/or abrasive.
- the astringent species such as a zinc salt, preferably other than zinc oxide
- a zinc salt preferably other than zinc oxide
- the oral hygiene composition is present in an amount of from about 0.1% to about 5%, preferably about 0.5% to about 2% by weight of the oral hygiene composition, providing zinc ions at a concentration of from about 0.05% to about 1% by weight.
- the present invention further provides an oral hygiene composition
- an alkali metal bicarbonate is sodium bicarbonate it is preferably present in an amount of from about 0.5% to about 35% by weight of the composition, more preferably present in an amount from about 1% to about 30% by weight of composition.
- the alkali metal bicarbonate may be either fully or partially dissolved in the composition or may be in the form of suspended particles.
- the bicarbonate is partly dissolved and partly in the form of suspended particles. If present such particles may, for example, have a median particle size of from about 5 to about 250 microns preferably about 10 to about 100 microns, for example about 40 microns.
- the alkali metal bicarbonate is sodium bicarbonate available as sodium bicarbonate BP from, for example, Brunner Mond and Company, UK.
- the oral hygiene compositions of the present invention comprise an alkali metal bicarbonate, preferably sodium bicarbonate and one or more of zinc citrate, zinc chloride, zinc sulphate, potassium chloride, potassium nitrate, strontium chloride, strontium acetate, chlorhexidine, and vitamins with a strong taste.
- alkali metal bicarbonate preferably sodium bicarbonate and one or more of zinc citrate, zinc chloride, zinc sulphate, potassium chloride, potassium nitrate, strontium chloride, strontium acetate, chlorhexidine, and vitamins with a strong taste.
- Such oral hygiene compositions may contain conventional materials such as, for example, humectants, surfactants, gelling agents, abrasives, fluoride sources, desensitising agents, flavourings, colourings, sweeteners, preservatives, structuring agents, bactericides, anti-tartar agents and anti- plaque agents.
- conventional materials such as, for example, humectants, surfactants, gelling agents, abrasives, fluoride sources, desensitising agents, flavourings, colourings, sweeteners, preservatives, structuring agents, bactericides, anti-tartar agents and anti- plaque agents.
- Suitable humectants include polyhydric alcohols such as xylitol, sorbitol, glycerol, propylene glycol and polyethylene glycols. Mixtures of glycerol and sorbitol are particularly effective.
- a humectant helps to prevent dentifrice compositions from hardening on exposure to air, and may also provide a moist feel, smooth texture, flowability, and a desirable sweetness in the mouth.
- such humectants may comprise up to about 85% by weight, preferably up to about 60% by weight .of the oral hygiene composition.
- Suitable surfactants are usually water-soluble organic compounds, and may be anionic, nonionic, cationic or amphoteric species.
- the surfactant used should preferably be reasonably stable and able to produce a foam in use.
- Anionic surfactants include the water-soluble salts of C ⁇ 0 _ 1 8 alkyl sulphates (e.g. sodium lauryl sulphates), water soluble salts of C 1 0 _ 18 ethoxylated alkyl sulphates, water soluble salts of C 10 _ 18 alkyl sarcosinates, the water-soluble salts of sulphonated monoglycerides of
- C-10-18 fatty acids e.g. sodium coconut monoglyceride sulphonates
- alkyl aryl sulphonates e.g. sodium dodecyl benzene sulphonate
- sodium salts of the coconut fatty acid amide of N-methyltaurine e.g. sodium coconut monoglyceride sulphonates
- alkyl aryl sulphonates e.g. sodium dodecyl benzene sulphonate
- sodium salts of the coconut fatty acid amide of N-methyltaurine e.g. sodium coconut monoglyceride sulphonates
- alkyl aryl sulphonates e.g. sodium dodecyl benzene sulphonate
- sodium salts of the coconut fatty acid amide of N-methyltaurine e.g. sodium dodecyl benzene sulphonate
- Nonionic surfactants suitable for use in oral compositions include the products of the condensation of alkylene oxide groups with aliphatic or alkylaromatic species, and may be.for example, polyethylene oxide condensates of alkyl phenols, ethylene oxide/propylene oxide copolymers, available from BASF Wyandotte Chemical Corporation under the trade name 'Pluronic', ethylene oxide/ethylene diamine copolymers, ethylene oxide condensates of aliphatic alcohols, long chain tertiary amine oxides, long chain tertiary phosphine oxides, long chain dialkyi sulphoxides and mixtures thereof.
- Alternatives include ethoxylated sorbitan esters such as those available from ICI under the trade name "Tween”.
- Zwitterionic surfactants are generally derivatives of aliphatic quaternary ammonium, phosphonium, and sulphonium compounds, in which the aliphatic species may be branched or unbranched, and in which one of the aliphatic species is a Cg_- j g species and another contains an anionic hydrophillic group, such as carboxy, sulphonate, . sulphate, phosphate or orthophosphonate.
- Cationic surfactants are generally quaternary ammonium compounds having one Cg_-
- Amphoteric surfactants are generally aliphatic secondary and tertiary amines comprising aliphatic species which may be branched or unbranched, and in which one of the aliphatic species is a C . 18 species and the other contains an anionic hydrophillic group, for example, sulphonate, carboxylate, sulphate, phosphonate or phosphate.
- anionic hydrophillic group for example, sulphonate, carboxylate, sulphate, phosphonate or phosphate.
- quaternary ammonium compounds are the quaternized imidazole derivatives available under the trade name 'Miranol' from the Miranol Chemical Company.
- the surfactant is included in an amount of up to about 20% by weight, preferably up to about 10% by weight of the oral hygiene composition.
- Structuring agents may be required in, for example, dentifrices and gums to provide desirable textural properties and "mouthfeel". Suitable agents include natural gum binders such as gum tragacanth, xanthan gum, gum karaya and gum arabic, seaweed derivatives such as Irish moss and alginates, smectite clays such as bentonite or hectorite, carboxyvinyl polymers and water-soluble cellulose derivatives such as hydroxyethyl cellulose and sodium carboxymethyl cellulose. Improved texture may also be achieved, for example, by including colloidal magnesium aluminium silicate.
- the structuring agent is included in an amount of up to about 5% by weight, preferably up to about 3% by weight of the oral hygiene composition.
- Abrasives should preferably be capable of cleaning and/or polishing the teeth without causing harm to dental enamel or dentine. They are used most commonly in dentifrices, but may also be used in mouthwashes etc. where desired.
- Suitable abrasives include silica abrasives, such as hydrated silicas. These include silica gels, particularly silica xerogels such as those available under the trade name 'Syloid' from W.R. Grace and Company; and also precipitated silica materials such as those available under the trade name 'Zeodenf from J.M. Huber Corporation. Also suitable are diatomaceous earths such as those available under the trade name 'Celite' from Johns-Manville Corporation.
- Alternative abrasives include alumina, insoluble metaphosphates such as insoluble sodium metaphosphate, calcium carbonate, dicalcium phosphate (in dihydrate and anhydrous forms), calcium pyrophosphate (including ⁇ -phase calcium) polymethoxylates and particulate thermosetting polymerised resins such as, for example, ureas, melamine-ureas, melamine- formaldehydes, urea-formaldehydes, melamine-urea- formaldehydes, cross-linked epoxides, melamines, phenolics, and cross- linked polyesters.
- abrasives are included in an amount of up to about 80%, preferably up to about 60% by weight of the oral hygiene composition. It will be appreciated however that the alkali metal bicarbonate may itself have an abrasive function so that the presence of further abrasives may not be necessary.
- Fluoride sources suitable for use in oral hygiene compositions of the present invention include sodium fluoride, zinc fluoride, potassium fluoride, aluminium fluoride, lithium fluoride, sodium monofluorophosphate, acidulated phosphate fluoride, stannous fluoride, ammonium fluoride, ammonium bifluoride and amine fluoride.
- the fluoride source is present in an amount sufficient to provide from about 50 ppm to about 4,000 ppm fluoride ions in the composition.
- Inclusion of a fluoride source is beneficial, since fluoride ions are known to become incorporated into the hydroxyapatite of tooth enamel, thereby increasing the resistance of the enamel to decay. Fluoride is also now thought to act locally on the tooth enamel, altering the remineralisation - demineralisation balance in favour of remineralisation.
- Inclusion of a fluoride source is also desirable when a polyphosphate anti- calculus agent is included, in order to inhibit the enzymic hydrolysis of such polyphosphates by salivary phosphatase enzymes.
- Suitable desensitising agents include, for example, formaldehyde, potassium nitrate, potassium chloride and strontium chloride (suitably as hexahydrate), strontium acetate (suitably as hemihydrate) and sodium citrate/Pluronic gel.
- Flavouring agents may be added to increase palatability and may include, for example, levo-menthol, oils of peppermint, spearmint, wintergreen, sassafras and clove. Sweetening agents may also be used, and these include D-tryptophan, saccharin, dextrose, aspartame, levulose, acesulfam, dihydrochalcones and sodium cyclamate.
- flavouring agents are included in amounts of up to about 5% by weight, preferably up to about 2% by weight of the oral hygiene composition.
- Colouring agents and pigments may be added to improve the visual appeal of the composition. Suitable colourants include dyes, such as FD & C blue No.1 , D & C yellow No.10 and D & C yellow No.3.
- a suitable and commonly used pigment is titanium dioxide, which provides a strong white colour.
- compositions of the invention may include an antimicrobial agent as a preservative and/or anti-plaque agent.
- Suitable antimicrobial agents include zinc salts such as zinc citrate, cetyl pyridinium chloride, aliphatic amines, bis-biguanides, such as chlorhexidine, bromochlorophene, hexachlorophene, salicylanilides, quaternary ammonium compounds and triclosan.
- Enzymic systems providing a source of a natural biocide may be used as alternatives to or in combination with the biocides listed.
- a system comprising lactoperoxidase and glucose oxidase may be used to generate hydrogen peroxide in the presence of glucose, water and oxygen.
- the composition may also comprise an anti-calculus agent.
- Suitable anti-calculus agents include polyphosphates, preferably pyrophosphates.
- a preferred source of pyrophosphate is a mixture of tetrasodium pyrophosphate and tetrapotassium pyrophosphate.
- the ratio of tetrasodium pyrophosphate to tetrapotassium pyrophosphate is 0:1 to 3:1 , preferably 0:1 to 1 :1.
- tetrapotassium pyrophosphate is the predominant species.
- composition may also comprise alcohol.
- This component is particularly useful in mouthwash formulations, where it may be used to solubilise components which have low solubility in water.
- compositions are those in the form of a toothpaste or liquid dentifrice.
- a liquid dentifrice contains components commonly associated with a paste eg abrasives, humectants and actives, but the viscosity is considerably lower, and is preferably below about
- the present invention further provides a method of cleansing the mouth for cosmetic purposes by oral application of a composition as defined above.
- compositions as defined above in the treatment and/or prevention of dental caries and/or gingivitis and the use of such a composition in the manufacture of a medicament for the treatment and/or prevention of dental caries and/or gingivitis.
- a toothpaste is prepared to the following composition:
- silica abrasive
- silica thickener
- sodium carboxymethylcellulose sodium bicarbonate
- titanium dioxide titanium dioxide
- zinc citrate trihydrate sodium lauryl sulphate
- This formulation showed a noticeable reduction in dry aftertaste when compared to a corresponding formulation which was made up without sodium bicarbonate.
- a toothpaste is prepared to the following composition:
- the toothpaste was prepared generally according to the method in
- a toothpaste is prepared to the following composition:
- the toothpaste was prepared generally according to the method in Example 1 above with the modification inter alia that no bromochlorophene was added.
- This formulation showed a noticeable reduction in dry aftertaste when compared to a corresponding formulation which was made up without sodium bicarbonate.
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Abstract
Composition pour l'hygiène bucco-dentaire comprenant un ingrédient désagréable au goût (tel que des ions de zinc) ainsi qu'une quantité suffisante d'un bicarbonate de métal alcalin pour améliorer le goût de cette composition.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU27904/95A AU2790495A (en) | 1994-06-11 | 1995-06-09 | Oral hygiene composition |
GB9625648A GB2307640B (en) | 1994-06-11 | 1995-06-09 | Oral hygiene composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9411747.0 | 1994-06-11 | ||
GB9411747A GB9411747D0 (en) | 1994-06-11 | 1994-06-11 | Oral hygiene composition |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995034274A1 true WO1995034274A1 (fr) | 1995-12-21 |
Family
ID=10756595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1995/002248 WO1995034274A1 (fr) | 1994-06-11 | 1995-06-09 | Composition pour l'hygiene bucco-dentaire |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2790495A (fr) |
GB (2) | GB9411747D0 (fr) |
WO (1) | WO1995034274A1 (fr) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996037183A2 (fr) * | 1995-05-26 | 1996-11-28 | Warner-Lambert Company | Compositions capables de masquer les sensations du gout astringent |
US5939048A (en) * | 1994-09-20 | 1999-08-17 | Block Drug Co., Inc. | Taste masked desensitizing compositions |
EP1035847A1 (fr) * | 1997-10-27 | 2000-09-20 | CHURCH & DWIGHT COMPANY, INC. | Solution stable de zinc et d'ions de bicarbonate |
EP1043937A1 (fr) * | 1997-12-30 | 2000-10-18 | Wm. Wrigley Jr. Company | Procede permettant de reguler la liberation d'agents antimicrobiens dans une gomme a macher et gomme a macher produite selon ce procede |
WO2002080872A1 (fr) * | 2001-03-29 | 2002-10-17 | Curozone Ireland Limited | Preparations pour remineralisation des dents |
US6955827B2 (en) | 1997-12-30 | 2005-10-18 | Wm. Wrigley Jr. Company | Method of controlling release of antimicrobial agents in chewing gum |
EP1935397A1 (fr) * | 2006-12-20 | 2008-06-25 | Henkel AG & Co. KGaA | Agent de nettoyage buccal et de soin dentaire destiné à la lutte contre l'halitose |
US8778311B2 (en) | 2006-03-22 | 2014-07-15 | The Procter & Gamble Company | Oral zinc compositions |
RU2701374C2 (ru) * | 2014-12-26 | 2019-09-26 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2201866A1 (fr) * | 1972-10-04 | 1974-05-03 | Colgate Palmolive Co | |
FR2201865A1 (fr) * | 1972-10-04 | 1974-05-03 | Colgate Palmolive Co | |
FR2275191A1 (fr) * | 1974-05-30 | 1976-01-16 | Colgate Palmolive Co | Pate dentifrice |
US4160022A (en) * | 1975-09-15 | 1979-07-03 | Colgate Palmolive Company | Toothpaste |
US4414203A (en) * | 1977-11-07 | 1983-11-08 | Cabardo Jr Alberto M | Periodontal powder containing exsiccated potassium alum |
GB2137494A (en) * | 1983-03-14 | 1984-10-10 | Church & Dwight Co Inc | Sodium bicarbonate-containing tooth powder |
WO1985004098A1 (fr) * | 1984-03-13 | 1985-09-26 | The Trustees Of Columbia University In The City Of | Procede pour desensibiliser la dentine hypersensible en recourant a des compositions contenant des sels de potassium |
US4623536A (en) * | 1985-06-13 | 1986-11-18 | Church & Dwight Co., Inc. | Sodium bicarbonate containing toothpaste |
JPS63192712A (ja) * | 1987-02-06 | 1988-08-10 | Nippon Zeora Kk | 練歯磨 |
GB2220568A (en) * | 1988-05-23 | 1990-01-17 | Church & Dwight Co Inc | Dentifrice gels comprising sodium bicarbonate |
WO1994026244A1 (fr) * | 1993-05-19 | 1994-11-24 | Church & Dwight Co., Inc. | Compositions de soin par voie orale contenant des particules d'oxyde de zinc et du bicarbonate de sodium |
US5372803A (en) * | 1993-09-02 | 1994-12-13 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Dental compositions with zinc and bicarbonate salts |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888976A (en) * | 1972-09-21 | 1975-06-10 | William P Mlkvy | Zinc and strontium ion containing effervescent mouthwash tablet |
US4416867A (en) * | 1979-06-20 | 1983-11-22 | Lever Brothers Company | Oral compositions |
-
1994
- 1994-06-11 GB GB9411747A patent/GB9411747D0/en active Pending
-
1995
- 1995-06-09 WO PCT/EP1995/002248 patent/WO1995034274A1/fr active Application Filing
- 1995-06-09 GB GB9625648A patent/GB2307640B/en not_active Expired - Fee Related
- 1995-06-09 AU AU27904/95A patent/AU2790495A/en not_active Abandoned
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2201866A1 (fr) * | 1972-10-04 | 1974-05-03 | Colgate Palmolive Co | |
FR2201865A1 (fr) * | 1972-10-04 | 1974-05-03 | Colgate Palmolive Co | |
FR2275191A1 (fr) * | 1974-05-30 | 1976-01-16 | Colgate Palmolive Co | Pate dentifrice |
GB1498537A (en) * | 1974-05-30 | 1978-01-18 | Colgate Palmolive Co | Toothpastes |
US4160022A (en) * | 1975-09-15 | 1979-07-03 | Colgate Palmolive Company | Toothpaste |
US4414203A (en) * | 1977-11-07 | 1983-11-08 | Cabardo Jr Alberto M | Periodontal powder containing exsiccated potassium alum |
GB2137494A (en) * | 1983-03-14 | 1984-10-10 | Church & Dwight Co Inc | Sodium bicarbonate-containing tooth powder |
WO1985004098A1 (fr) * | 1984-03-13 | 1985-09-26 | The Trustees Of Columbia University In The City Of | Procede pour desensibiliser la dentine hypersensible en recourant a des compositions contenant des sels de potassium |
US4623536A (en) * | 1985-06-13 | 1986-11-18 | Church & Dwight Co., Inc. | Sodium bicarbonate containing toothpaste |
JPS63192712A (ja) * | 1987-02-06 | 1988-08-10 | Nippon Zeora Kk | 練歯磨 |
GB2220568A (en) * | 1988-05-23 | 1990-01-17 | Church & Dwight Co Inc | Dentifrice gels comprising sodium bicarbonate |
WO1994026244A1 (fr) * | 1993-05-19 | 1994-11-24 | Church & Dwight Co., Inc. | Compositions de soin par voie orale contenant des particules d'oxyde de zinc et du bicarbonate de sodium |
US5372803A (en) * | 1993-09-02 | 1994-12-13 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Dental compositions with zinc and bicarbonate salts |
Non-Patent Citations (1)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 12, no. 472 (C - 551)<3319> 9 December 1988 (1988-12-09) * |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5939048A (en) * | 1994-09-20 | 1999-08-17 | Block Drug Co., Inc. | Taste masked desensitizing compositions |
WO1996037183A3 (fr) * | 1995-05-26 | 1997-03-13 | Warner Lambert Co | Compositions capables de masquer les sensations du gout astringent |
WO1996037183A2 (fr) * | 1995-05-26 | 1996-11-28 | Warner-Lambert Company | Compositions capables de masquer les sensations du gout astringent |
EP1035847A4 (fr) * | 1997-10-27 | 2004-12-08 | Church & Dwight Co Inc | Solution stable de zinc et d'ions de bicarbonate |
EP1035847A1 (fr) * | 1997-10-27 | 2000-09-20 | CHURCH & DWIGHT COMPANY, INC. | Solution stable de zinc et d'ions de bicarbonate |
US6955827B2 (en) | 1997-12-30 | 2005-10-18 | Wm. Wrigley Jr. Company | Method of controlling release of antimicrobial agents in chewing gum |
EP1043937A4 (fr) * | 1997-12-30 | 2004-05-12 | Wrigley W M Jun Co | Procede permettant de reguler la liberation d'agents antimicrobiens dans une gomme a macher et gomme a macher produite selon ce procede |
EP1043937A1 (fr) * | 1997-12-30 | 2000-10-18 | Wm. Wrigley Jr. Company | Procede permettant de reguler la liberation d'agents antimicrobiens dans une gomme a macher et gomme a macher produite selon ce procede |
US6669931B2 (en) | 2001-03-29 | 2003-12-30 | Curozone Ireland Limited | Formulation for the remineralization of teeth |
WO2002080872A1 (fr) * | 2001-03-29 | 2002-10-17 | Curozone Ireland Limited | Preparations pour remineralisation des dents |
US8778311B2 (en) | 2006-03-22 | 2014-07-15 | The Procter & Gamble Company | Oral zinc compositions |
EP1935397A1 (fr) * | 2006-12-20 | 2008-06-25 | Henkel AG & Co. KGaA | Agent de nettoyage buccal et de soin dentaire destiné à la lutte contre l'halitose |
RU2701374C2 (ru) * | 2014-12-26 | 2019-09-26 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта и способы их применения |
Also Published As
Publication number | Publication date |
---|---|
AU2790495A (en) | 1996-01-05 |
GB2307640B (en) | 1998-12-09 |
GB2307640A (en) | 1997-06-04 |
GB9625648D0 (en) | 1997-01-29 |
GB9411747D0 (en) | 1994-08-03 |
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