WO1995031981A3 - Procedes et compositions de reduction de la resistance a de multiples medicaments - Google Patents

Procedes et compositions de reduction de la resistance a de multiples medicaments Download PDF

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Publication number
WO1995031981A3
WO1995031981A3 PCT/US1995/006167 US9506167W WO9531981A3 WO 1995031981 A3 WO1995031981 A3 WO 1995031981A3 US 9506167 W US9506167 W US 9506167W WO 9531981 A3 WO9531981 A3 WO 9531981A3
Authority
WO
WIPO (PCT)
Prior art keywords
multidrug resistance
compositions
present
methods
cancer
Prior art date
Application number
PCT/US1995/006167
Other languages
English (en)
Other versions
WO1995031981A2 (fr
Inventor
John S Coon
Mannarsamy Balasubramanian
R Martin Emanuele
Himashu Shah
Original Assignee
Rush Presbyterian St Luke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rush Presbyterian St Luke filed Critical Rush Presbyterian St Luke
Priority to AU26894/95A priority Critical patent/AU2689495A/en
Priority to EP95922084A priority patent/EP0759753A1/fr
Publication of WO1995031981A2 publication Critical patent/WO1995031981A2/fr
Publication of WO1995031981A3 publication Critical patent/WO1995031981A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A61K31/77—Polymers containing oxygen of oxiranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des procédés et des compositions permettant de réduire ou d'éliminer la résistance à de multiples médicaments dans des cancers ou certaines infections par des microorganismes résistants aux médicaments chez des patients. Selon le procédé et la composition de la présente invention, un diester amphipathique non ionique d'acides gras ou un poloxmère inverse est administré à un patient dans lequel un cancer ou un microorganisme présente une résistance multimédicament à l'agent chimiothérapeutique. Le procédé et la composition de la présente invention peuvent être utilisés avec une efficacité particulière où une résistance multimédicament à un agent chimiothérapeutique s'est révélée lors d'un traitement d'un cancer.
PCT/US1995/006167 1994-05-19 1995-05-19 Procedes et compositions de reduction de la resistance a de multiples medicaments WO1995031981A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU26894/95A AU2689495A (en) 1994-05-19 1995-05-19 Methods and compositions for reducing multidrug resistance
EP95922084A EP0759753A1 (fr) 1994-05-19 1995-05-19 Procedes et compositions de reduction de la resistance a de multiples medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24603794A 1994-05-19 1994-05-19
US08/246,037 1994-05-19

Publications (2)

Publication Number Publication Date
WO1995031981A2 WO1995031981A2 (fr) 1995-11-30
WO1995031981A3 true WO1995031981A3 (fr) 1996-07-18

Family

ID=22929080

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/006167 WO1995031981A2 (fr) 1994-05-19 1995-05-19 Procedes et compositions de reduction de la resistance a de multiples medicaments

Country Status (4)

Country Link
EP (1) EP0759753A1 (fr)
AU (1) AU2689495A (fr)
CA (1) CA2190636A1 (fr)
WO (1) WO1995031981A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011668A1 (fr) * 1991-12-10 1993-06-24 Rush-Presbyterian-St. Luke's Medical Center Procedes et compositions destines a reduire la multiresistance aux medicaments

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993011668A1 (fr) * 1991-12-10 1993-06-24 Rush-Presbyterian-St. Luke's Medical Center Procedes et compositions destines a reduire la multiresistance aux medicaments

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
A.S.-F- CHONG ET AL.: "Diverse multidrug-resistance-modification agents inhibit cytolytic activity of natural killer cells", CANCER IMMUNOL. IMMUNOTHER., vol. 36, no. 2, 1993, pages 133 - 139, XP002000100 *
DATABASE BIOSIS BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1992, M. PAGE ET AL.: "Elimination of P-170 mediated multidrug resistance by solubilization in pluronic micelles", XP002000101 *
J.S. COON ET AL.: "Solutol HS 15, nontoxic polyoxyethylene esters of 12-hydroxystearic acid reverses multidrug resistance", CANCER RESEARCH, vol. 51, February 1991 (1991-02-01), pages 897 - 902, XP002000098 *
J.S. COON: "Survey of surfactants for reversing multidrug resistance", PROC. AM. ASSOC. CANCER. RES. ANN. MEET., vol. 33, no. 0, 1992, pages 484, XP002000099 *
L.E. BUCKINGHAM ET AL.: "Comparison of Solutol HS 15, Cremophor EL and novel ethoxylated fatty acid surfactants as multidrug resistance modification agents", INT. J. CANCER, vol. 62, no. 4, August 1995 (1995-08-01), pages 436 - 442, XP002000097 *
PROC. AM. ASSOC. CANCER RES. ANNU MEET, vol. 33, no. 0, 1992, pages 552 *
R. PARADIS ET AL.: "Use of pluronic micelles to overcome multidrug resistance", INT. J. ONCOL., vol. 5, no. 6, 1994, pages 1305 - 1308, XP002000096 *

Also Published As

Publication number Publication date
WO1995031981A2 (fr) 1995-11-30
EP0759753A1 (fr) 1997-03-05
CA2190636A1 (fr) 1995-11-30
AU2689495A (en) 1995-12-18

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